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Article

High ATP2A2 expression correlates with better prognosis of diffuse astrocytic tumor patients

  • Authors:
    • Wei-Qing Li
    • Nan-Zhe Zhong
    • Jin He
    • Yi-Ming Li
    • Li-Jun Hou
    • Hui-Min Liu
    • Chun-Yan Xia
    • Liang-Zhe Wang
    • Yi-Cheng Lu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China, Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China, Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China
  • Pages: 2865-2874
    |
    Published online on: March 24, 2017
       https://doi.org/10.3892/or.2017.5528
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Abstract

Novel molecular markers are required for defining subsets of diffuse astrocytic tumor patients with differing prognoses. Here, we examined ATP2A2 expression in 109 human diffuse astrocytic tumor samples (39 grade II diffuse astrocytoma (DA), 19 grade III anaplastic astrocytoma (AA), 51 grade IV glioblastoma) and its correlation with patient clinicopathologic characteristics. ATP2A2 expression significantly correlated with tumor grade and survival (P<0.05). High ATP2A2 expression was detected in 35.3% (18/51) of glioblastoma patients, compared to 61.5% (24/39) in grade II, and 52.6% (10/19) in grade III astrocytoma patients (P=0.043). The median survival was 45±5.3 (95% CI, 34.7-55.3) months in patients with high ATP2A2 expression and 16±5.0 (95% CI, 6.3-25.7) months in patients with low ATP2A2 expression (P<0.0001). Additionally, high grade astrocytoma patients with high ATP2A2 expression showed longer survival (median, 31.0±4.9 months, 95% CI, 21.4-40.7) than those with low ATP2A2 expression (median: 13.0±1.6 months, 95% CI, 9.9-16.1; P=0.027). Furthermore, both ATP2A2 overexpression and IDH1 mutation were detected in secondary glioblastoma, AA developed from DA and oligodendrogiomas with IDH1 mutation. The MTT assays showed that lentiviral ATP2A2 overexpression significantly suppressed the clonogenic growth of glioblastoma U251MG cells (P<0.05). Xenografts stably overexpressing ATP2A2 were markedly smaller in size 4 weeks post inoculation (P<0.05). Our findings identified high ATP2A2 expression in a subset of astrocytoma patients that was associated with better prognosis and ATP2A2 suppressed astrocytoma growth.
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Copy and paste a formatted citation
Spandidos Publications style
Li W, Zhong N, He J, Li Y, Hou L, Liu H, Xia C, Wang L and Lu Y: High ATP2A2 expression correlates with better prognosis of diffuse astrocytic tumor patients. Oncol Rep 37: 2865-2874, 2017.
APA
Li, W., Zhong, N., He, J., Li, Y., Hou, L., Liu, H. ... Lu, Y. (2017). High ATP2A2 expression correlates with better prognosis of diffuse astrocytic tumor patients. Oncology Reports, 37, 2865-2874. https://doi.org/10.3892/or.2017.5528
MLA
Li, W., Zhong, N., He, J., Li, Y., Hou, L., Liu, H., Xia, C., Wang, L., Lu, Y."High ATP2A2 expression correlates with better prognosis of diffuse astrocytic tumor patients". Oncology Reports 37.5 (2017): 2865-2874.
Chicago
Li, W., Zhong, N., He, J., Li, Y., Hou, L., Liu, H., Xia, C., Wang, L., Lu, Y."High ATP2A2 expression correlates with better prognosis of diffuse astrocytic tumor patients". Oncology Reports 37, no. 5 (2017): 2865-2874. https://doi.org/10.3892/or.2017.5528
Copy and paste a formatted citation
x
Spandidos Publications style
Li W, Zhong N, He J, Li Y, Hou L, Liu H, Xia C, Wang L and Lu Y: High ATP2A2 expression correlates with better prognosis of diffuse astrocytic tumor patients. Oncol Rep 37: 2865-2874, 2017.
APA
Li, W., Zhong, N., He, J., Li, Y., Hou, L., Liu, H. ... Lu, Y. (2017). High ATP2A2 expression correlates with better prognosis of diffuse astrocytic tumor patients. Oncology Reports, 37, 2865-2874. https://doi.org/10.3892/or.2017.5528
MLA
Li, W., Zhong, N., He, J., Li, Y., Hou, L., Liu, H., Xia, C., Wang, L., Lu, Y."High ATP2A2 expression correlates with better prognosis of diffuse astrocytic tumor patients". Oncology Reports 37.5 (2017): 2865-2874.
Chicago
Li, W., Zhong, N., He, J., Li, Y., Hou, L., Liu, H., Xia, C., Wang, L., Lu, Y."High ATP2A2 expression correlates with better prognosis of diffuse astrocytic tumor patients". Oncology Reports 37, no. 5 (2017): 2865-2874. https://doi.org/10.3892/or.2017.5528
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