Inverse relationship between insulin receptor expression and progression in renal cell carcinoma

  • Authors:
    • Makoto Takahashi
    • Takamitsu Inoue
    • Mingguo Huang
    • Kazuyuki Numakura
    • Hiroshi Tsuruta
    • Mitsuru Saito
    • Atsushi Maeno
    • Eijiro Nakamura
    • Shintaro Narita
    • Norihiko Tsuchiya
    • Tomonori Habuchi
  • View Affiliations

  • Published online on: April 5, 2017     https://doi.org/10.3892/or.2017.5552
  • Pages: 2929-2941
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Abstract

We investigated the relationship among serum insulin level, insulin receptor (IR) expression in renal cell carcinoma (RCC), and outcomes in patients with RCC who underwent nephrectomy. We also explored the role of insulin signaling in RCC progression in a murine RCC allograft RENCA model using metformin to treat hyperinsulinemia induced by a high-carbohydrate diet. Clinically, the IR expression level in RCC tissue was significantly lower in patients with tumor stage pT2-4 and/or distant metastases. The IR expression level in RCC tissue was significantly lower in patients with preoperative serum C-peptide levels greater than or equal to the median than in patients with levels less than the median. High IR expression level was significantly associated with better disease-free and overall survival after nephrectomy. The IR expression level was significantly higher in murine subcutaneous flank tumors of the low-carbohydrate diet group and high-carbohydrate diet plus metformin group than of the high‑carbohydrate diet group. In vivo progression of murine tumors was not significantly enhanced by hyperinsulinemia induced by a high-carbohydrate diet and was significantly inhibited by metformin in both the low- and high‑carbohydrate diet groups. IR expression in RCC tissue was inversely associated with cancer progression in the clinical and murine experimental model studies. The clinical and murine allograft model study results suggested that hyperinsulinemia does not promote RCC progression. Decreased IR expression in high‑stage RCC tumors with poor prognosis may be the result of downregulation induced by the host's hyperinsulinemia.
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May-2017
Volume 37 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Takahashi M, Inoue T, Huang M, Numakura K, Tsuruta H, Saito M, Maeno A, Nakamura E, Narita S, Tsuchiya N, Tsuchiya N, et al: Inverse relationship between insulin receptor expression and progression in renal cell carcinoma. Oncol Rep 37: 2929-2941, 2017
APA
Takahashi, M., Inoue, T., Huang, M., Numakura, K., Tsuruta, H., Saito, M. ... Habuchi, T. (2017). Inverse relationship between insulin receptor expression and progression in renal cell carcinoma. Oncology Reports, 37, 2929-2941. https://doi.org/10.3892/or.2017.5552
MLA
Takahashi, M., Inoue, T., Huang, M., Numakura, K., Tsuruta, H., Saito, M., Maeno, A., Nakamura, E., Narita, S., Tsuchiya, N., Habuchi, T."Inverse relationship between insulin receptor expression and progression in renal cell carcinoma". Oncology Reports 37.5 (2017): 2929-2941.
Chicago
Takahashi, M., Inoue, T., Huang, M., Numakura, K., Tsuruta, H., Saito, M., Maeno, A., Nakamura, E., Narita, S., Tsuchiya, N., Habuchi, T."Inverse relationship between insulin receptor expression and progression in renal cell carcinoma". Oncology Reports 37, no. 5 (2017): 2929-2941. https://doi.org/10.3892/or.2017.5552