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Article

Inverse relationship between insulin receptor expression and progression in renal cell carcinoma

  • Authors:
    • Makoto Takahashi
    • Takamitsu Inoue
    • Mingguo Huang
    • Kazuyuki Numakura
    • Hiroshi Tsuruta
    • Mitsuru Saito
    • Atsushi Maeno
    • Eijiro Nakamura
    • Shintaro Narita
    • Norihiko Tsuchiya
    • Tomonori Habuchi
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Akita University Graduate School of Medicine, Akita, Japan, Laboratory for Malignancy Control Research, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, Department of Urology, Yamagata University Faculty of Medicine, Yamagata, Japan
  • Pages: 2929-2941
    |
    Published online on: April 5, 2017
       https://doi.org/10.3892/or.2017.5552
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Abstract

We investigated the relationship among serum insulin level, insulin receptor (IR) expression in renal cell carcinoma (RCC), and outcomes in patients with RCC who underwent nephrectomy. We also explored the role of insulin signaling in RCC progression in a murine RCC allograft RENCA model using metformin to treat hyperinsulinemia induced by a high-carbohydrate diet. Clinically, the IR expression level in RCC tissue was significantly lower in patients with tumor stage pT2-4 and/or distant metastases. The IR expression level in RCC tissue was significantly lower in patients with preoperative serum C-peptide levels greater than or equal to the median than in patients with levels less than the median. High IR expression level was significantly associated with better disease-free and overall survival after nephrectomy. The IR expression level was significantly higher in murine subcutaneous flank tumors of the low-carbohydrate diet group and high-carbohydrate diet plus metformin group than of the high‑carbohydrate diet group. In vivo progression of murine tumors was not significantly enhanced by hyperinsulinemia induced by a high-carbohydrate diet and was significantly inhibited by metformin in both the low- and high‑carbohydrate diet groups. IR expression in RCC tissue was inversely associated with cancer progression in the clinical and murine experimental model studies. The clinical and murine allograft model study results suggested that hyperinsulinemia does not promote RCC progression. Decreased IR expression in high‑stage RCC tumors with poor prognosis may be the result of downregulation induced by the host's hyperinsulinemia.
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View References

1 

Cohen DH and LeRoith D: Obesity, type 2 diabetes, and cancer: The insulin and IGF connection. Endocr Relat Cancer. 19:F27–F45. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Ohnishi H, Saitoh S, Takagi S, Ohata J, Takeuchi H, Isobe T, Katoh N, Chiba Y, Fujiwara T, Akasaka H, et al: Incidence of insulin resistance in obese subjects in a rural Japanese population: The Tanno and Sobetsu study. Diabetes Obes Metab. 7:83–87. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Pollak M: Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer. 8:915–928. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Nepple KG, Yang L, Grubb RL III and Strope SA: Population based analysis of the increasing incidence of kidney cancer in the United States: Evaluation of age specific trends from 1975 to 2006. J Urol. 187:32–38. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Bergström A, Hsieh CC, Lindblad P, Lu CM, Cook NR and Wolk A: Obesity and renal cell cancer - a quantitative review. Br J Cancer. 85:984–990. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Calle EE, Rodriguez C, Walker-Thurmond K and Thun MJ: Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 348:1625–1638. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Renehan AG, Tyson M, Egger M, Heller RF and Zwahlen M: Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies. Lancet. 371:569–578. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Sawada N, Inoue M, Sasazuki S, Iwasaki M, Yamaji T, Shimazu T and Tsugane S: JPHC Study Group: Body mass index and subsequent risk of kidney cancer: A prospective cohort study in Japan. Ann Epidemiol. 20:466–472. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Wideroff L, Gridley G, Mellemkjaer L, Chow WH, Linet M, Keehn S, Borch-Johnsen K and Olsen JH: Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark. J Natl Cancer Inst. 89:1360–1365. 1997. View Article : Google Scholar : PubMed/NCBI

10 

Inoue M, Iwasaki M, Otani T, Sasazuki S, Noda M and Tsugane S: Diabetes mellitus and the risk of cancer: Results from a large-scale population-based cohort study in Japan. Arch Intern Med. 166:1871–1877. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Washio M, Mori M, Khan M, Sakauchi F, Watanabe Y, Ozasa K, Hayashi K, Miki T, Nakao M, Mikami K, et al: JACC Study Group: Diabetes mellitus and kidney cancer risk: The results of Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). Int J Urol. 14:393–397. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Pierce BL, Plymate S, Ostrander EA and Stanford JL: Diabetes mellitus and prostate cancer risk. Prostate. 68:1126–1132. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Kasper JS and Giovannucci E: A meta-analysis of diabetes mellitus and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 15:2056–2062. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Parker AS, Lohse CM, Cheville JC, Thiel DD, Leibovich BC and Blute ML: Greater body mass index is associated with better pathologic features and improved outcome among patients treated surgically for clear cell renal cell carcinoma. Urology. 68:741–746. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Awakura Y, Nakamura E, Ito N, Yamasaki T, Kamba T, Kamoto T and Ogawa O: Influence of body mass index on prognosis of Japanese patients with renal cell carcinoma. Urology. 70:50–54. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Schrader AJ, Rustemeier J, Rustemeier JC, Timmesfeld N, Varga Z, Hegele A, Olbert PJ and Hofmann R: Overweight is associated with improved cancer-specific survival in patients with organ-confined renal cell carcinoma. J Cancer Res Clin Oncol. 135:1693–1699. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Jeon HG, Jeong IG, Lee JH, Lee CJ, Kwak C, Kim HH, Lee SE and Lee E: Prognostic value of body mass index in Korean patients with renal cell carcinoma. J Urol. 183:448–454. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Waalkes S, Merseburger AS, Kramer MW, Herrmann TR, Wegener G, Rustemeier J, Hofmann R, Schrader M, Kuczyk MA and Schrader AJ: Obesity is associated with improved survival in patients with organ-confined clear-cell kidney cancer. Cancer Causes Control. 21:1905–1910. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Carnethon MR, De Chavez PJ, Biggs ML, Lewis CE, Pankow JS, Bertoni AG, Golden SH, Liu K, Mukamal KJ, Campbell-Jenkins B, et al: Association of weight status with mortality in adults with incident diabetes. JAMA. 308:581–590. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Choi Y, Park B, Jeong BC, Seo SI, Jeon SS, Choi HY, Adami HO, Lee JE and Lee HM: Body mass index and survival in patients with renal cell carcinoma: A clinical-based cohort and meta-analysis. Int J Cancer. 132:625–634. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Hakimi AA, Furberg H, Zabor EC, Jacobsen A, Schultz N, Ciriello G, Mikklineni N, Fiegoli B, Kim PH, Voss MH, et al: An epidemiologic and genomic investigation into the obesity paradox in renal cell carcinoma. J Natl Cancer Inst. 105:1862–1870. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Freedland SJ, Aronson WJ, Kane CJ, Presti JC Jr, Amling CL, Elashoff D and Terris MK: Impact of obesity on biochemical control after radical prostatectomy for clinically localized prostate cancer: A report by the Shared Equal Access Regional Cancer Hospital database study group. J Clin Oncol. 22:446–453. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Ho T, Gerber L, Aronson WJ, Terris MK, Presti JC, Kane CJ, Amling CL and Freedland SJ: Obesity, prostate-specific antigen nadir, and biochemical recurrence after radical prostatectomy: Biology or technique? Results from the SEARCH database. Eur Urol. 62:910–916. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Bhindi B, Kulkarni GS, Finelli A, Alibhai SM, Hamilton RJ, Toi A, van der Kwast TH, Evans A, Hersey K, Jewett MA, et al: Obesity is associated with risk of progression for low-risk prostate cancers managed expectantly. Eur Urol. 66:841–848. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Ladoire S, Dalban C, Roché H, Spielmann M, Fumoleau P, Levy C, Martin AL, Ecarnot F, Bonnetain F and Ghiringhelli F: Effect of obesity on disease-free and overall survival in node-positive breast cancer patients in a large French population: A pooled analysis of two randomised trials. Eur J Cancer. 50:506–516. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Gennari A, Nanni O, Puntoni M, DeCensi A, Scarpi E, Conte P, Antonucci G, Amadori D and Bruzzi P: Body mass index and prognosis of metastatic breast cancer patients receiving first-line chemotherapy. Cancer Epidemiol Biomarkers Prev. 22:1862–1867. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Psutka SP, Stewart SB, Boorjian SA, Lohse CM, Tollefson MK, Cheville JC, Leibovich BC and Thompson RH: Diabetes mellitus is independently associated with an increased risk of mortality in patients with clear cell renal cell carcinoma. J Urol. 192:1620–1627. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Antonelli A, Arrighi N, Corti S, Zanotelli T, Cozzoli A, Cunico Cosciani S and Simeone C: Pre-existing type 2 diabetes is not an adverse prognostic factor in patients with renal cell carcinoma: A single-center retrospective study. Urol Oncol. 31:1310–1315. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Kellerer M, von Eye Corleta H, Mühlhöfer A, Capp E, Mosthaf L, Bock S, Petrides PE and Häring HU: Insulin- and insulin-like growth-factor-I receptor tyrosine-kinase activities in human renal carcinoma. Int J Cancer. 62:501–507. 1995. View Article : Google Scholar : PubMed/NCBI

30 

Lkhagvadorj S, Oh SS, Lee MR, Jung JH, Chung HC, Cha SK and Eom M: Insulin receptor expression in clear cell renal cell carcinoma and its relation to prognosis. Yonsei Med J. 55:861–870. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Law JH, Habibi G, Hu K, Masoudi H, Wang MY, Stratford AL, Park E, Gee JM, Finlay P, Jones HE, et al: Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival. Cancer Res. 68:10238–10246. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Mulligan AM, O'Malley FP, Ennis M, Fantus IG and Goodwin PJ: Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer. Breast Cancer Res Treat. 106:39–47. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Mathieu MC, Clark GM, Allred DC, Goldfine ID and Vigneri R: Insulin receptor expression and clinical outcome in node-negative breast cancer. Proc Assoc Am Physicians. 109:565–571. 1997.PubMed/NCBI

34 

Goodwin PJ, Ennis M, Pritchard KI, Trudeau ME, Koo J, Madarnas Y, Hartwick W, Hoffman B and Hood N: Fasting insulin and outcome in early-stage breast cancer: Results of a prospective cohort study. J Clin Oncol. 20:42–51. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Muti P, Quattrin T, Grant BJ, Krogh V, Micheli A, Schünemann HJ, Ram M, Freudenheim JL, Sieri S, Trevisan M, et al: Fasting glucose is a risk factor for breast cancer: A prospective study. Cancer Epidemiol Biomarkers Prev. 11:1361–1368. 2002.PubMed/NCBI

36 

Cox ME, Gleave ME, Zakikhani M, Bell RH, Piura E, Vickers E, Cunningham M, Larsson O, Fazli L and Pollak M: Insulin receptor expression by human prostate cancers. Prostate. 69:33–40. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Ma J, Li H, Giovannucci E, Mucci L, Qiu W, Nguyen PL, Gaziano JM, Pollak M and Stampfer MJ: Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: A long-term survival analysis. Lancet Oncol. 9:1039–1047. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Venkateswaran V, Haddad AQ, Fleshner NE, Fan R, Sugar LM, Nam R, Klotz LH and Pollak M: Association of diet-induced hyperinsulinemia with accelerated growth of prostate cancer (LNCaP) xenografts. J Natl Cancer Inst. 99:1793–1800. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Allred DC, Harvey JM, Berardo M and Clark GM: Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol. 11:155–168. 1998.PubMed/NCBI

40 

Algire C, Zakikhani M, Blouin MJ, Shuai JH and Pollak M: Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth. Endocr Relat Cancer. 15:833–839. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Goodyear LJ, Giorgino F, Sherman LA, Carey J, Smith RJ and Dohm GL: Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J Clin Invest. 95:2195–2204. 1995. View Article : Google Scholar : PubMed/NCBI

42 

Liu J, Li M, Song B, Jia C, Zhang L, Bai X and Hu W: Metformin inhibits renal cell carcinoma in vitro and in vivo xenograft. Urol Oncol. 31:264–270. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Othman EM, Hintzsche H and Stopper H: Signaling steps in the induction of genomic damage by insulin in colon and kidney cells. Free Radic Biol Med. 68:247–257. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Takahashi M, Inoue T, Huang M, Numakura K, Tsuruta H, Saito M, Maeno A, Nakamura E, Narita S, Tsuchiya N, Tsuchiya N, et al: Inverse relationship between insulin receptor expression and progression in renal cell carcinoma. Oncol Rep 37: 2929-2941, 2017.
APA
Takahashi, M., Inoue, T., Huang, M., Numakura, K., Tsuruta, H., Saito, M. ... Habuchi, T. (2017). Inverse relationship between insulin receptor expression and progression in renal cell carcinoma. Oncology Reports, 37, 2929-2941. https://doi.org/10.3892/or.2017.5552
MLA
Takahashi, M., Inoue, T., Huang, M., Numakura, K., Tsuruta, H., Saito, M., Maeno, A., Nakamura, E., Narita, S., Tsuchiya, N., Habuchi, T."Inverse relationship between insulin receptor expression and progression in renal cell carcinoma". Oncology Reports 37.5 (2017): 2929-2941.
Chicago
Takahashi, M., Inoue, T., Huang, M., Numakura, K., Tsuruta, H., Saito, M., Maeno, A., Nakamura, E., Narita, S., Tsuchiya, N., Habuchi, T."Inverse relationship between insulin receptor expression and progression in renal cell carcinoma". Oncology Reports 37, no. 5 (2017): 2929-2941. https://doi.org/10.3892/or.2017.5552
Copy and paste a formatted citation
x
Spandidos Publications style
Takahashi M, Inoue T, Huang M, Numakura K, Tsuruta H, Saito M, Maeno A, Nakamura E, Narita S, Tsuchiya N, Tsuchiya N, et al: Inverse relationship between insulin receptor expression and progression in renal cell carcinoma. Oncol Rep 37: 2929-2941, 2017.
APA
Takahashi, M., Inoue, T., Huang, M., Numakura, K., Tsuruta, H., Saito, M. ... Habuchi, T. (2017). Inverse relationship between insulin receptor expression and progression in renal cell carcinoma. Oncology Reports, 37, 2929-2941. https://doi.org/10.3892/or.2017.5552
MLA
Takahashi, M., Inoue, T., Huang, M., Numakura, K., Tsuruta, H., Saito, M., Maeno, A., Nakamura, E., Narita, S., Tsuchiya, N., Habuchi, T."Inverse relationship between insulin receptor expression and progression in renal cell carcinoma". Oncology Reports 37.5 (2017): 2929-2941.
Chicago
Takahashi, M., Inoue, T., Huang, M., Numakura, K., Tsuruta, H., Saito, M., Maeno, A., Nakamura, E., Narita, S., Tsuchiya, N., Habuchi, T."Inverse relationship between insulin receptor expression and progression in renal cell carcinoma". Oncology Reports 37, no. 5 (2017): 2929-2941. https://doi.org/10.3892/or.2017.5552
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