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Article

MicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer

Retraction in: /10.3892/or.2024.8745
  • Authors:
    • Wenfeng Li
    • Jingjing Liang
    • Zhechao Zhang
    • Hongyan Lou
    • Liang Zhao
    • Yunsheng Xu
    • Rongying Ou
  • View Affiliations / Copyright

    Affiliations: Laboratory for Advanced Interdisciplinary Research, Center for Personalized Medicine/Institutes of Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
  • Pages: 2743-2750
    |
    Published online on: April 5, 2017
       https://doi.org/10.3892/or.2017.5555
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Abstract

Cervical cancer is the second most common gynecological cancer worldwide and remains as one of the leading causes of cancer-related death among women. Despite great progress in the treatment of cervical cancer, the 5-year overall survival rate for patients with this disease remains unsatisfactory. Over the past decade, an increasing number of studies indicate a central role for microRNAs in the initiation and progression of cervical cancer. microRNA‑329-3p (miR-329-3p) has been studied in many types of human cancer; however, the expression level, biological role and the underlying mechanism of miR-329-3p in cervical cancer has not yet been investigated. In the present study, we found that the expression levels of miR-329-3p were reduced in both cervical cancer tissues and cell lines. Low miR-329-3p expression was negatively correlated with histological grade, International Federation of Gynecology and Obstetrics (FIGO) stage, and lymph node metastasis of cervical cancer patients. In addition, upregulation of miR‑329-3p suppressed cell proliferation, migration and invasion of cervical cancer. Furthermore, MAPK1 was identified as a direct target gene of miR-329-3p. MAPK1 was significantly upregulated in cervical cancer tissues and was inversely correlated with miR-329-3p expression in the cervical cancer tissues. Silencing of MAPK1 by RNA interference mimicked the effects of miR-329-3p overexpression on cell proliferation, migration and invasion in cervical cancer. Moreover, rescue experiments showed that restoration of the expression of MAPK1 reversed the effects of miR‑329-3p overexpression in cervical cancer cells. Taken together, these findings suggest that miR-329-3p has a critical tumor-suppressive roles by directly targeting MAPK1 in cervical cancer, and it may be investigated as a novel therapeutic target for the treatment of patients with this disease.
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Copy and paste a formatted citation
Spandidos Publications style
Li W, Liang J, Zhang Z, Lou H, Zhao L, Xu Y and Ou R: MicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer Retraction in /10.3892/or.2024.8745. Oncol Rep 37: 2743-2750, 2017.
APA
Li, W., Liang, J., Zhang, Z., Lou, H., Zhao, L., Xu, Y., & Ou, R. (2017). MicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer Retraction in /10.3892/or.2024.8745. Oncology Reports, 37, 2743-2750. https://doi.org/10.3892/or.2017.5555
MLA
Li, W., Liang, J., Zhang, Z., Lou, H., Zhao, L., Xu, Y., Ou, R."MicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer Retraction in /10.3892/or.2024.8745". Oncology Reports 37.5 (2017): 2743-2750.
Chicago
Li, W., Liang, J., Zhang, Z., Lou, H., Zhao, L., Xu, Y., Ou, R."MicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer Retraction in /10.3892/or.2024.8745". Oncology Reports 37, no. 5 (2017): 2743-2750. https://doi.org/10.3892/or.2017.5555
Copy and paste a formatted citation
x
Spandidos Publications style
Li W, Liang J, Zhang Z, Lou H, Zhao L, Xu Y and Ou R: MicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer Retraction in /10.3892/or.2024.8745. Oncol Rep 37: 2743-2750, 2017.
APA
Li, W., Liang, J., Zhang, Z., Lou, H., Zhao, L., Xu, Y., & Ou, R. (2017). MicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer Retraction in /10.3892/or.2024.8745. Oncology Reports, 37, 2743-2750. https://doi.org/10.3892/or.2017.5555
MLA
Li, W., Liang, J., Zhang, Z., Lou, H., Zhao, L., Xu, Y., Ou, R."MicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer Retraction in /10.3892/or.2024.8745". Oncology Reports 37.5 (2017): 2743-2750.
Chicago
Li, W., Liang, J., Zhang, Z., Lou, H., Zhao, L., Xu, Y., Ou, R."MicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer Retraction in /10.3892/or.2024.8745". Oncology Reports 37, no. 5 (2017): 2743-2750. https://doi.org/10.3892/or.2017.5555
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