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Article Open Access

RON and c-Met facilitate metastasis through the ERK signaling pathway in prostate cancer cells

Corrigendum in: /10.3892/or.2022.8388
  • Authors:
    • Binbin Yin
    • Zhenping Liu
    • Yiyun Wang
    • Xuchu Wang
    • Weiwei Liu
    • Pan Yu
    • Xiuzhi Duan
    • Chunhua Liu
    • Yuhua Chen
    • Yurong Zhang
    • Xiaoyan Pan
    • Hangping Yao
    • Zhaoping Liao
    • Zhihua Tao
  • View Affiliations / Copyright

    Affiliations: Laboratory of Medical Genetics, College of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China, Department of Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China, Department of Blood Transfusion, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China, Key Laboratory of Laboratory Medicine, Chinese Ministry of Education, Zhejiang Provincial Key State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital of Zhejiang University School of Medicine Hangzhou, Hangzhou, Zhejiang, P.R. China
    Copyright: © Yin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3209-3218
    |
    Published online on: April 19, 2017
       https://doi.org/10.3892/or.2017.5585
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Abstract

Prostate cancer (PCa) is a metastatic malignant cancer driven by complex pathological mechanisms and characterized by poor long-term prognosis. Metastasis is the main cause of death of PCa patients, yet the molecular mechanisms of this process are poorly understood. In the present study, positive co-expression of RON and c-Met was observed in human clinical PCa tissues (biopsy material), as detected by immunohistochemical staining and quantitative real-time PCR. We investigated this further in PCa cells, demonstrating that the inhibition of RON and c-Met with foretinib (GSK1363089) suppressed metastasis and promoted the reversal of the epithelial-to-mesenchymal transition (EMT) in PCa cells. Furthermore, the invasion and migration of PCa cells were enhanced by the exogenous activation of RON with MSP and c-Met with HGF, whereas silencing of RON and c-Met attenuated the invasion and metastasis of the PCa cells. Our data also demonstrated that HGF/c-Met, but not the MSP-RON signaling pathway may be the dominant mechanism for PCa EMT. We further revealed that RON and c-Met facilitate metastasis via ERK1/2 signaling. These findings indicate that RON and c-Met facilitate metastasis through ERK1/2 signaling and that targeting RON and c-Met with foretinib may be an attractive therapeutic option for suppressing PCa metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Yin B, Liu Z, Wang Y, Wang X, Liu W, Yu P, Duan X, Liu C, Chen Y, Zhang Y, Zhang Y, et al: RON and c-Met facilitate metastasis through the ERK signaling pathway in prostate cancer cells Corrigendum in /10.3892/or.2022.8388. Oncol Rep 37: 3209-3218, 2017.
APA
Yin, B., Liu, Z., Wang, Y., Wang, X., Liu, W., Yu, P. ... Tao, Z. (2017). RON and c-Met facilitate metastasis through the ERK signaling pathway in prostate cancer cells Corrigendum in /10.3892/or.2022.8388. Oncology Reports, 37, 3209-3218. https://doi.org/10.3892/or.2017.5585
MLA
Yin, B., Liu, Z., Wang, Y., Wang, X., Liu, W., Yu, P., Duan, X., Liu, C., Chen, Y., Zhang, Y., Pan, X., Yao, H., Liao, Z., Tao, Z."RON and c-Met facilitate metastasis through the ERK signaling pathway in prostate cancer cells Corrigendum in /10.3892/or.2022.8388". Oncology Reports 37.6 (2017): 3209-3218.
Chicago
Yin, B., Liu, Z., Wang, Y., Wang, X., Liu, W., Yu, P., Duan, X., Liu, C., Chen, Y., Zhang, Y., Pan, X., Yao, H., Liao, Z., Tao, Z."RON and c-Met facilitate metastasis through the ERK signaling pathway in prostate cancer cells Corrigendum in /10.3892/or.2022.8388". Oncology Reports 37, no. 6 (2017): 3209-3218. https://doi.org/10.3892/or.2017.5585
Copy and paste a formatted citation
x
Spandidos Publications style
Yin B, Liu Z, Wang Y, Wang X, Liu W, Yu P, Duan X, Liu C, Chen Y, Zhang Y, Zhang Y, et al: RON and c-Met facilitate metastasis through the ERK signaling pathway in prostate cancer cells Corrigendum in /10.3892/or.2022.8388. Oncol Rep 37: 3209-3218, 2017.
APA
Yin, B., Liu, Z., Wang, Y., Wang, X., Liu, W., Yu, P. ... Tao, Z. (2017). RON and c-Met facilitate metastasis through the ERK signaling pathway in prostate cancer cells Corrigendum in /10.3892/or.2022.8388. Oncology Reports, 37, 3209-3218. https://doi.org/10.3892/or.2017.5585
MLA
Yin, B., Liu, Z., Wang, Y., Wang, X., Liu, W., Yu, P., Duan, X., Liu, C., Chen, Y., Zhang, Y., Pan, X., Yao, H., Liao, Z., Tao, Z."RON and c-Met facilitate metastasis through the ERK signaling pathway in prostate cancer cells Corrigendum in /10.3892/or.2022.8388". Oncology Reports 37.6 (2017): 3209-3218.
Chicago
Yin, B., Liu, Z., Wang, Y., Wang, X., Liu, W., Yu, P., Duan, X., Liu, C., Chen, Y., Zhang, Y., Pan, X., Yao, H., Liao, Z., Tao, Z."RON and c-Met facilitate metastasis through the ERK signaling pathway in prostate cancer cells Corrigendum in /10.3892/or.2022.8388". Oncology Reports 37, no. 6 (2017): 3209-3218. https://doi.org/10.3892/or.2017.5585
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