Open Access

RON and c-Met facilitate metastasis through the ERK signaling pathway in prostate cancer cells

Corrigendum in: /10.3892/or.2022.8388

  • Authors:
    • Binbin Yin
    • Zhenping Liu
    • Yiyun Wang
    • Xuchu Wang
    • Weiwei Liu
    • Pan Yu
    • Xiuzhi Duan
    • Chunhua Liu
    • Yuhua Chen
    • Yurong Zhang
    • Xiaoyan Pan
    • Hangping Yao
    • Zhaoping Liao
    • Zhihua Tao
  • View Affiliations

  • Published online on: April 19, 2017     https://doi.org/10.3892/or.2017.5585
  • Pages: 3209-3218
  • Copyright: © Yin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Prostate cancer (PCa) is a metastatic malignant cancer driven by complex pathological mechanisms and characterized by poor long-term prognosis. Metastasis is the main cause of death of PCa patients, yet the molecular mechanisms of this process are poorly understood. In the present study, positive co-expression of RON and c-Met was observed in human clinical PCa tissues (biopsy material), as detected by immunohistochemical staining and quantitative real-time PCR. We investigated this further in PCa cells, demonstrating that the inhibition of RON and c-Met with foretinib (GSK1363089) suppressed metastasis and promoted the reversal of the epithelial-to-mesenchymal transition (EMT) in PCa cells. Furthermore, the invasion and migration of PCa cells were enhanced by the exogenous activation of RON with MSP and c-Met with HGF, whereas silencing of RON and c-Met attenuated the invasion and metastasis of the PCa cells. Our data also demonstrated that HGF/c-Met, but not the MSP-RON signaling pathway may be the dominant mechanism for PCa EMT. We further revealed that RON and c-Met facilitate metastasis via ERK1/2 signaling. These findings indicate that RON and c-Met facilitate metastasis through ERK1/2 signaling and that targeting RON and c-Met with foretinib may be an attractive therapeutic option for suppressing PCa metastasis.
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June-2017
Volume 37 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Yin B, Liu Z, Wang Y, Wang X, Liu W, Yu P, Duan X, Liu C, Chen Y, Zhang Y, Zhang Y, et al: RON and c-Met facilitate metastasis through the ERK signaling pathway in prostate cancer cells Corrigendum in /10.3892/or.2022.8388. Oncol Rep 37: 3209-3218, 2017.
APA
Yin, B., Liu, Z., Wang, Y., Wang, X., Liu, W., Yu, P. ... Tao, Z. (2017). RON and c-Met facilitate metastasis through the ERK signaling pathway in prostate cancer cells Corrigendum in /10.3892/or.2022.8388. Oncology Reports, 37, 3209-3218. https://doi.org/10.3892/or.2017.5585
MLA
Yin, B., Liu, Z., Wang, Y., Wang, X., Liu, W., Yu, P., Duan, X., Liu, C., Chen, Y., Zhang, Y., Pan, X., Yao, H., Liao, Z., Tao, Z."RON and c-Met facilitate metastasis through the ERK signaling pathway in prostate cancer cells Corrigendum in /10.3892/or.2022.8388". Oncology Reports 37.6 (2017): 3209-3218.
Chicago
Yin, B., Liu, Z., Wang, Y., Wang, X., Liu, W., Yu, P., Duan, X., Liu, C., Chen, Y., Zhang, Y., Pan, X., Yao, H., Liao, Z., Tao, Z."RON and c-Met facilitate metastasis through the ERK signaling pathway in prostate cancer cells Corrigendum in /10.3892/or.2022.8388". Oncology Reports 37, no. 6 (2017): 3209-3218. https://doi.org/10.3892/or.2017.5585