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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
June-2017 Volume 37 Issue 6

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Preclinical studies for the combination of paclitaxel and curcumin in cancer therapy (Review)

Yumeng Wei, Xinlin Pu, Ling Zhao
Pages: 3159-3166
Published online on: 20 April 2017

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Article Open Access

PCDH10 gene inhibits cell proliferation and induces cell apoptosis by inhibiting the PI3K/Akt signaling pathway in hepatocellular carcinoma cells

Mingxin Ye, Jinzheng Li, Jianping Gong
Pages: 3167-3174
Published online on: 05 May 2017

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Article Open Access

Cathepsin B expression in colorectal cancer in a Middle East population: Potential value as a tumor biomarker for late disease stages

Maha-Hamadien Abdulla, Mansoor-Ali Valli-Mohammed, Khayal Al-Khayal, Abdulmalik Al Shkieh, Ahmad Zubaidi, Rehan Ahmad, Khalid Al-Saleh, Omar Al-Obeed, James McKerrow
Pages: 3175-3180
Published online on: 18 April 2017

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Article Open Access

Identification of SETD2-NF1 fusion gene in a pediatric spindle cell tumor with the chromosomal translocation t(3;17)(p21;q12)

Ioannis Panagopoulos, Ludmila Gorunova, Ingvild Lobmaier, Bodil Bjerkehagen, Sverre Heim
Pages: 3181-3188
Published online on: 04 May 2017

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Article Open Access

CD24 expression is a marker for predicting clinical outcome and regulates the epithelial-mesenchymal transition in ovarian cancer via both the Akt and ERK pathways

Kiyoko Nakamura, Yoshito Terai, Akiko Tanabe, Yoshihiro J. Ono, Masami Hayashi, Kazuya Maeda, Satoe Fujiwara, Keisuke Ashihara, Michihiko Nakamura, Yoshimichi Tanaka, Tomohito Tanaka, Satoshi Tsunetoh, Hiroshi Sasaki, Masahide Ohmichi
Pages: 3189-3200
Published online on: 19 April 2017

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Article Open Access

β-catenin induces expression of prohibitin gene in acute leukemic cells

Dong Min Kim, Hanbit Jang, Myung Geun Shin, Jeong-Hoon Kim, Sang Mo Shin, Sang-Hyun Min, Il-Chul Kim
Pages: 3201-3208
Published online on: 25 April 2017

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Article Open Access

RON and c-Met facilitate metastasis through the ERK signaling pathway in prostate cancer cells Corrigendum in /10.3892/or.2022.8388

Binbin Yin, Zhenping Liu, Yiyun Wang, Xuchu Wang, Weiwei Liu, Pan Yu, Xiuzhi Duan, Chunhua Liu, Yuhua Chen, Yurong Zhang, Xiaoyan Pan, Hangping Yao, Zhaoping Liao, Zhihua Tao
Pages: 3209-3218
Published online on: 19 April 2017

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Article Open Access

Comparison of three different methods for the detection of circulating tumor cells in mice with lung metastasis

Weifeng Xu, Bing Wu, Lengxi Fu, Junying Chen, Zeng Wang, Fei Huang, Jinrong Chen, Mei Zhang, Zhenhuan Zhang, Jingan Lin, Ruilong Lan, Ruiqing Chen, Wei Chen, Long Chen, Jinsheng Hong, Weijian Zhang, Yuxiong Ding, Paul Okunieff, Jianhua Lin, Lurong Zhang
Pages: 3219-3226
Published online on: 02 May 2017

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Article Open Access

MicroRNA-1299 is a negative regulator of STAT3 in colon cancer

Yong Wang, Zhi Lu, Ningning Wang, Man Zhang, Xiandong Zeng, Wei Zhao
Pages: 3227-3234
Published online on: 26 April 2017

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Article Open Access

Identification and expression of MMSA-8, and its clinical significance in multiple myeloma

Rui He, Nan Yang, Pengyu Zhang, Jie Liu, Junhui Li, Fulin Zhou, Wanggang Zhang
Pages: 3235-3243
Published online on: 28 April 2017

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Article Open Access

miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1

Zaiting Ye, Bingmu Fang, Jiongwei Pan, Ning Zhang, Jinwei Huang, Congying Xie, Tianzheng Lou, Zhuo Cao
Pages: 3244-3252
Published online on: 03 May 2017

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Article

Association of long-chain acyl-coenzyme A synthetase 5 expression in human breast cancer by estrogen receptor status and its clinical significance

Meng-Chi Yen, Jung-Yu Kan, Chia-Jung Hsieh, Po-Lin Kuo, Ming-Feng Hou, Ya-Ling Hsu
Pages: 3253-3260
Published online on: 28 April 2017

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Article

AXL and GAS6 co-expression in lung adenocarcinoma as a prognostic classifier

Masahiro Seike, Cheol-Hong Kim, Fenfei Zou, Rintaro Noro, Mika Chiba, Arimi Ishikawa, Shinobu Κunugi, Kaoru Kubota, Akihiko Gemma
Pages: 3261-3269
Published online on: 21 April 2017

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Article

Silibinin downregulates MMP2 expression via Jak2/STAT3 pathway and inhibits the migration and invasive potential in MDA-MB-231 cells

Hyo Joo Byun, Pramod Darvin, Dong Young Kang, Nipin Sp, Youn Hee Joung, Jong Hwan Park, Sun Jin Kim, Young Mok Yang
Pages: 3270-3278
Published online on: 19 April 2017

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Article

CXCR6 predicts poor prognosis in gastric cancer and promotes tumor metastasis through epithelial-mesenchymal transition

Jie-Jie Jin, Fa-Xiang Dai, Zi-Wen Long, Hong Cai, Xiao-Wen Liu, Ye Zhou, Qi Hong, Qiong-Zhu Dong, Ya-Nong Wang, Hua Huang
Pages: 3279-3286
Published online on: 25 April 2017

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Article

Modified Panax ginseng extract regulates autophagy by AMPK signaling in A549 human lung cancer cells

Hwa-Seung Yoo, Jung Min Kim, Eunbi Jo, Chong-Kwan Cho, Seung-Yeul Lee, Hwan Su Kang, Min-Goo Lee, Pei-Ying Yang, Ik-Soon Jang
Pages: 3287-3296
Published online on: 20 April 2017

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Article

A nine-miRNA signature as a potential diagnostic marker for breast carcinoma: An integrated study of 1,110 cases

Dan-Dan Xiong, Jun Lv, Kang-Lai Wei, Zhen-Bo Feng, Ji-Tian Chen, Ke-Cheng Liu, Gang Chen, Dian-Zhong Luo
Pages: 3297-3304
Published online on: 25 April 2017

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Article

MicroRNA-15b promotes proliferation and invasion of non‑small cell lung carcinoma cells by directly targeting TIMP2 Retraction in /10.3892/or.2023.8611

Haowen Wang, Yu Zhan, Jingjing Jin, Chunhong Zhang, Wenfeng Li
Pages: 3305-3312
Published online on: 26 April 2017

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Article

Novel role of semaphorin 3A in the growth and progression of hepatocellular carcinoma

Xuedong Li, Qing Chen, Dan Yin, Shiming Shi, Lei Yu, Shaolai Zhou, Erbao Chen, Zhengjun Zhou, Yinghong Shi, Jia Fan, Jian Zhou, Zhi Dai
Pages: 3313-3320
Published online on: 02 May 2017

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Article

Salinomycin induces endoplasmic reticulum stress‑mediated autophagy and apoptosis through generation of reactive oxygen species in human glioma U87MG cells

Sun-Nyoung Yu, Sang-Hun Kim, Kwang-Youn Kim, Jae-Hoon Ji, Young-Kyo Seo, Hak Sun Yu, Soon-Cheol Ahn
Pages: 3321-3328
Published online on: 02 May 2017

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Article

A ligand-based and enediyne-energized bispecific fusion protein targeting epidermal growth factor receptor and insulin-like growth factor-1 receptor shows potent antitumor efficacy against esophageal cancer

Hai-Ying Cao, Xiao-Fang Guo, Xiao-Fei Zhu, Sai-Sai Li, Yong-Su Zhen
Pages: 3329-3340
Published online on: 27 April 2017

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Article

Low-dose paclitaxel suppresses the induction of M2 macrophages in gastric cancer

Takahisa Yamaguchi, Sachio Fushida, Yasuhiko Yamamoto, Tomoya Tsukada, Jun Kinoshita, Katsunobu Oyama, Tomoharu Miyashita, Hidehiro Tajima, Itasu Ninomiya, Seiichi Munesue, Ai Harashima, Shinichi Harada, Hiroshi Yamamoto, Tetsuo Ohta
Pages: 3341-3350
Published online on: 19 April 2017

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Article

Evaluation of expression of cancer stem cell markers and fusion gene in synovial sarcoma: Insights into histogenesis and pathogenesis

Yang Zhou, Dongdong Chen, Yan Qi, Ruixue Liu, Shugang Li, Hong Zou, Jiaojiao Lan, Xinxin Ju, Jinfang Jiang, Weihua Liang, Yaoyuan Shen, Lijuan Pang, Feng Li
Pages: 3351-3360
Published online on: 02 May 2017

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Article

Knockdown of CREB1 inhibits tumor growth of human gastric cancer in vitro and in vivo Retraction in /10.3892/or.2021.8202

Min Rao, Yonggang Zhu, Xiaoxia Cong, Qianxun Li
Pages: 3361-3368
Published online on: 11 May 2017

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Article

TXNIP overexpression suppresses proliferation and induces apoptosis in SMMC7221 cells through ROS generation and MAPK pathway activation

Jian Li, Zhongyi Yue, Wancheng Xiong, Peisheng Sun, Kun You, Jianguo Wang
Pages: 3369-3376
Published online on: 18 April 2017

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Article

Inhibition of ATR potentiates the cytotoxic effect of gemcitabine on pancreatic cancer cells through enhancement of DNA damage and abrogation of ribonucleotide reductase induction by gemcitabine

Shuang Liu, Yubin Ge, Tingting Wang, Holly Edwards, Qihang Ren, Yiqun Jiang, Chengshi Quan, Guan Wang
Pages: 3377-3386
Published online on: 19 April 2017

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Article

AdipoR1-mediated miR-3908 inhibits glioblastoma tumorigenicity through downregulation of STAT2 associated with the AMPK/SIRT1 pathway Retraction in /10.3892/or.2024.8697

Xiangming Liu, Jinglong Chen, Jinqian Zhang
Pages: 3387-3396
Published online on: 20 April 2017

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Article

Imperatorin efficiently blocks TNF-α-mediated activation of ROS/PI3K/Akt/NF-κB pathway

Ke Si Wang, Ying Lv, Zhe Wang, Juan Ma, Chunliu Mi, Xuezheng Li, Guang Hua Xu, Lian Xun Piao, Sheng Zhe Zheng, Xuejun Jin
Pages: 3397-3404
Published online on: 19 April 2017

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Article

Nifuroxazide prompts antitumor immune response of TCL-loaded DC in mice with orthotopically-implanted hepatocarcinoma

Tiesuo Zhao, Huijie Jia, Qian Cheng, Yali Xiao, Minming Li, Wenjing Ren, Chen Li, Yuchen Feng, Zhiwei Feng, Hui Wang, Junnian Zheng
Pages: 3405-3414
Published online on: 05 May 2017

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Article

miR-944 inhibits cell migration and invasion by targeting MACC1 in colorectal cancer

Liqiang Wen, Yingru Li, Zhipeng Jiang, Yuchao Zhang, Bin Yang, Fanghai Han
Pages: 3415-3422
Published online on: 28 April 2017

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Article

Plumbagin enhances TRAIL-induced apoptosis of human leukemic Kasumi‑1 cells through upregulation of TRAIL death receptor expression, activation of caspase-8 and inhibition of cFLIP

Xiaoyang Kong, Jing Luo, Tongpeng Xu, Yunjiao Zhou, Zengkai Pan, Yinghua Xie, Limin Zhao, Yingting Lu, Xiyao Han, Zhixiong Li, Ligen Liu
Pages: 3423-3432
Published online on: 04 May 2017

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Article

SUVmax of 18F-FDG PET/CT correlates to expression of major chemotherapy-related tumor markers and serum tumor markers in gastric adenocarcinoma patients

Lu Bai, Chi-Hua Guo, Yan Zhao, Jun-Gang Gao, Miao Li, Cong Shen, You-Min Guo, Xiao-Yi Duan
Pages: 3433-3440
Published online on: 05 May 2017

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Article

CpG oligodeoxynucleotides augment antitumor efficacy of folate receptor α based DNA vaccine

Zheng Qiu, Lijun Xing, Xueqing Zhang, Xu Qiang, Yifeng Xu, Mei Zhang, Zhengpin Zhou, Juan Zhang, Fang Zhang, Min Wang
Pages: 3441-3448
Published online on: 08 May 2017

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Article

SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways

Fang Tang, Pengchao Hu, Zetian Yang, Chao Xue, Jun Gong, Shaoxing Sun, Liu Shi, Shimin Zhang, Zhenzhen Li, Chunxu Yang, Junhong Zhang, Conghua Xie
Pages: 3449-3458
Published online on: 10 May 2017

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Article

Curcumin induces apoptotic cell death and protective autophagy in human gastric cancer cells

Wei Li, Ying Zhou, Jin Yang, Haining Li, Huanhuan Zhang, Ping Zheng
Pages: 3459-3466
Published online on: 11 May 2017

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Article

Prognostic significance of altered miRNA expression in whole blood of OSCC patients

Jutta Ries, Christoph Baran, Falk Wehrhan, Manuel Weber, Friedrich W. Neukam, Andrea Krautheim-Zenk, Emeka Nkenke
Pages: 3467-3474
Published online on: 11 May 2017

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Article

Effect of miR-1244 on cisplatin-treated non-small cell lung cancer via MEF2D expression

Guang-Jian Li, Guang-Qiang Zhao, Jia-Peng Yang, Yong-Chun Zhou, Kai-Yun Yang, Yu-Jie Lei, Yun-Chao Huang
Pages: 3475-3483
Published online on: 04 May 2017

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Article

CENP-H regulates the cell growth of human hepatocellular carcinoma cells through the mitochondrial apoptotic pathway

Guifang Lu, Helei Hou, Xinlan Lu, Xiquan Ke, Xin Wang, Dan Zhang, Yan Zhao, Jun Zhang, Mudan Ren, Shuixiang He
Pages: 3484-3492
Published online on: 26 April 2017

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Article

Exploration of miR-1202 and miR-196a in human endometrial cancer based on high throughout gene screening analysis

Hong Chen, Yujuan Fan, Wensheng Xu, Junying Chen, Yugang Meng, Di Fang, Jingran Wang
Pages: 3493-3501
Published online on: 24 April 2017

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Article

MicroRNA-379-5p plays a tumor-suppressive role in human bladder cancer growth and metastasis by directly targeting MDM2 Corrigendum in /10.3892/or.2022.8413

Deyao Wu, Xiaobing Niu, Jun Tao, Pengchao Li, Qiang Lu, Aiming Xu, Wei Chen, Zengjun Wang
Pages: 3502-3508
Published online on: 27 April 2017

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Article

Effective cytotoxic activity of OSW-1 on colon cancer by inducing apoptosis in vitro and in vivo

Yanhong Zhang, Fengqi Fang, Kai Fan, Yanli Zhang, Jie Zhang, Huishu Guo, Peiyao Yu, Jianmei Ma
Pages: 3509-3519
Published online on: 19 April 2017

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Article

The inhibition of microRNA-15a suppresses hepatitis B virus-associated liver cancer cell growth through the Smad/TGF-β pathway

Yan Wang
Pages: 3520-3526
Published online on: 02 May 2017

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Article

MicroRNA-26a inhibits proliferation and metastasis of human hepatocellular carcinoma by regulating DNMT3B-MEG3 axis

Yarui Li, Mudan Ren, Yan Zhao, Xinlan Lu, Mengyao Wang, Junbi Hu, Guifang Lu, Shuixiang He
Pages: 3527-3535
Published online on: 19 April 2017

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Article

PRKDC regulates chemosensitivity and is a potential prognostic and predictive marker of response to adjuvant chemotherapy in breast cancer patients

Gang Sun, Le Yang, Chao Dong, Bin Ma, Meihui Shan, Binlin Ma
Pages: 3536-3542
Published online on: 09 May 2017

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Article

Differential expression profiles of microRNAs as potential biomarkers for the early diagnosis of lung cancer

Yanqiu Zhang, Jing Sui, Xian Shen, Chengyun Li, Wenzhuo Yao, Weiwei Hong, Hui Peng, Yuepu Pu, Lihong Yin, Geyu Liang
Pages: 3543-3553
Published online on: 28 April 2017

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Article

miR‑27a promotes proliferation, migration, and invasion of colorectal cancer by targeting FAM172A and acts as a diagnostic and prognostic biomarker Corrigendum in /10.3892/or.2024.8742

Wenjun Liu, Kai Qian, Xing Wei, Haijun Deng, Bei Zhao, Qing Chen, Jinqian Zhang, Hao Liu
Pages: 3554-3564
Published online on: 20 April 2017

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Article

CRISPR/Cas9-mediated genome engineering of CXCR4 decreases the malignancy of hepatocellular carcinoma cells in vitro and in vivo

Xiaoli Wang, Wenmei Zhang, Yan Ding, Xingrong Guo, Yahong Yuan, Dongsheng Li
Pages: 3565-3571
Published online on: 25 April 2017

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Article

Loss of Reelin suppresses cell survival and mobility in non-Hodgkin lymphoma

Aixia Dou, Zhilun Wang, Ni Zhang, Junli Liu
Pages: 3572-3580
Published online on: 04 May 2017

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Article

Demethylation of miR-495 inhibits cell proliferation, migration and promotes apoptosis by targeting STAT-3 in breast cancer

Yi Chen, Donglin Luo, Wuguo Tian, Zhirong Li, Xiaohua Zhang
Pages: 3581-3589
Published online on: 03 May 2017

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Article

MCM7 amplification and overexpression promote cell proliferation, colony formation and migration in esophageal squamous cell carcinoma by activating the AKT1/mTOR signaling pathway Corrigendum in /10.3892/or.2025.8898

Yun-Tan Qiu, Wen-Jun Wang, Bing Zhang, Li-Li Mei, Zhi-Zhou Shi
Pages: 3590-3596
Published online on: 02 May 2017

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Article

TRIM28 knockdown increases sensitivity to etoposide by upregulating E2F1 in non-small cell lung cancer

Lei Liu, Lijun Xiao, Xiujun Liang, Long Chen, Luyang Cheng, Lei Zhang, Xiaoguang Wu, Qian Xu, Chunhu Ma
Pages: 3597-3605
Published online on: 11 May 2017

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Article

Miconazole induces apoptosis via the death receptor 5-dependent and mitochondrial-mediated pathways in human bladder cancer cells

Sheau-Yun Yuan, Ming-Yuh Shiau, Yen-Chuan Ou, Yu-Chia Huang, Cheng-Che Chen, Chen-Li Cheng, Kun-Yuan Chiu, Shian-Shiang Wang, Kan-Jen Tsai
Pages: 3606-3616
Published online on: 27 April 2017

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Article

UVA-induced upregulation of progerin suppresses 53BP1‑mediated NHEJ DSB repair in human keratinocytes via progerin-lamin A complex formation

Xin Huang, Yun Pan, Di Cao, Sheng Fang, Kun Huang, Jin Chen, Aijun Chen
Pages: 3617-3624
Published online on: 26 April 2017

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Article

Time- and oxygen-dependent expression and regulation of NDRG1 in human brain cancer cells

Harun Muayad Said, Roghaiyeh Safari, Ghada Al-Kafaji, Ralf-Ingo Ernestus, Mario Löhr, Astrid Katzer, Michael Flentje, Carsten Hagemann
Pages: 3625-3634
Published online on: 03 May 2017

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Article

Marine actinomycete crude extracts with potent TRAIL-resistance overcoming activity against breast cancer cells

Mohammed I.Y. Elmallah, Olivier Micheau, Mennat Allah G. Eid, Ali M.S. Hebishy, Mohamed S. Abdelfattah
Pages: 3635-3642
Published online on: 21 April 2017

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Article

Annexin A2 inhibition suppresses ovarian cancer progression via regulating β-catenin/EMT

Yan Liu, Hongyu Li, Zhenying Ban, Manman Nai, Li Yang, Yannan Chen, Yiming Xu
Pages: 3643-3650
Published online on: 18 April 2017

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Article

Calpain and AR-V7: Two potential therapeutic targets to overcome acquired docetaxel resistance in castration-resistant prostate cancer cells

Lei Liu, Ning Lou, Xiang Li, Guanghua Xu, Hailong Ruan, Wen Xiao, Bin Qiu, Lin Bao, Changfei Yuan, Xinmian Huang, Keshan Wang, Qi Cao, Ke Chen, Hongmei Yang, Xiaoping Zhang
Pages: 3651-3659
Published online on: 04 May 2017

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Sulforaphane sensitizes human cholangiocarcinoma to cisplatin via the downregulation of anti-apoptotic proteins Corrigendum in /10.3892/or.2023.8646 Retraction in /10.3892/or.2024.8728

Rokas Račkauskas, Dachen Zhou, Simonas Ūselis, Kęstutis Strupas, Ingrid Herr, Peter Schemmer
Pages: 3660-3666
Published online on: 03 May 2017

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Article

Livin enhances chemoresistance in head and neck squamous cell carcinoma

Tae Mi Yoon, Sun-Ae Kim, Dong Hoon Lee, Joon Kyoo Lee, Young-Lan Park, Kyung-Hwa Lee, Ik-Joo Chung, Young-Eun Joo, Sang Chul Lim
Pages: 3667-3673
Published online on: 19 April 2017

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Article

Migration of oral squamous cell carcinoma cells are induced by HGF/c-Met signalling via lamellipodia and filopodia formation

Hiroki Yasui, Yuichi Ohnishi, Masahiro Nakajima, Masami Nozaki
Pages: 3674-3680
Published online on: 19 April 2017

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Article

Modulation of MMP-2 and -9 secretion by cytokines, inducers and inhibitors in human melanoma A-2058 cells

M. Waheed Roomi, Tatiana Kalinovsky, Aleksandra Niedzwiecki, Matthias Rath
Pages: 3681-3687
Published online on: 24 April 2017

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Article

Optimization of antitumor treatment conditions for transcutaneous CO2 application: An in vivo study

Takeshi Ueha, Teruya Kawamoto, Yasuo Onishi, Risa Harada, Masaya Minoda, Mitsunori Toda, Hitomi Hara, Naomasa Fukase, Masahiro Kurosaka, Ryosuke Kuroda, Toshihiro Akisue, Yoshitada Sakai
Pages: 3688-3694
Published online on: 20 April 2017

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Article

Chloroform fraction of Scutellaria barbata D. Don inhibits the growth of colorectal cancer cells by activating miR‑34a

Ling Zhang, Yi Fang, Jian-Yu Feng, Qiao-Yan Cai, Li-Hui Wei, Shan Lin, Jun Peng
Pages: 3695-3701
Published online on: 04 May 2017

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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Article Open Access

S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review)

Wenpu Zhu, Zikun Wu, Chai Luv, Banghe Bao, Weijie Zhao, Guanglong Chen, Hang Yang, Huihan Ai, Faqiang Liu, Zhi Li
Article Number: 31
Published online on: 05 December 2025

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Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Article Open Access

Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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