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MicroRNA-1299 is a negative regulator of STAT3 in colon cancer

  • Authors:
    • Yong Wang
    • Zhi Lu
    • Ningning Wang
    • Man Zhang
    • Xiandong Zeng
    • Wei Zhao
  • View Affiliations / Copyright

    Affiliations: The 4th Department of Orthopedic Surgery, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning, P.R. China, Department of Nuclear Medicine, The 1st Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, P.R. China, The 2nd Department of Cardiology, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning, P.R. China, Department of Surgical Oncology, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3227-3234
    |
    Published online on: April 26, 2017
       https://doi.org/10.3892/or.2017.5605
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Abstract

Signal transducers and activators of transcription (STAT) is a family of transcription factors which regulate cell proliferation, differentiation, apoptosis, metastasis, immune and inflammatory responses, and angiogenesis. STAT3 is a latent cytoplasmic transcription factor that belongs to STATs. STAT3 has been reported be regulates genes involved with cellular growth, proliferation and metastasis. Worldwide, colon cancer is one of the leading causes of cancer-related deaths. Cumulative evidence has established that STAT3 is essential for colon cancer progression to advanced malignancy. In our study, we showed that microRNA-1299 (miR-1299) was closely related to the TNM stage of colon cancer, and that the expression of miR-1299 was negatively correlated with the expression of STAT3 in colon cancer which means that miR-1299 can be a negative regulator of STAT3 in colon cancer. A total of 60 cases of different grades of colon samples were used to detect the expression of miR-1299. Results showed that miR-1299 was significantly lower in high-grade colons both in mRNA and protein levels. Furthermore, Overall survival (OS) in patients with low miR-1299 is shorter than 25.6 months, as compared with an OS of 28.4 months in patients with high level of miR-1299. We also confirmed that the overexpression of miR-1299 can not only downregulate the STAT3 pathway, but also inhibited colon cancer cell growth. Our findings could provide new insights into the molecular therapeutic of colon cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Lu Z, Wang N, Zhang M, Zeng X and Zhao W: MicroRNA-1299 is a negative regulator of STAT3 in colon cancer. Oncol Rep 37: 3227-3234, 2017.
APA
Wang, Y., Lu, Z., Wang, N., Zhang, M., Zeng, X., & Zhao, W. (2017). MicroRNA-1299 is a negative regulator of STAT3 in colon cancer. Oncology Reports, 37, 3227-3234. https://doi.org/10.3892/or.2017.5605
MLA
Wang, Y., Lu, Z., Wang, N., Zhang, M., Zeng, X., Zhao, W."MicroRNA-1299 is a negative regulator of STAT3 in colon cancer". Oncology Reports 37.6 (2017): 3227-3234.
Chicago
Wang, Y., Lu, Z., Wang, N., Zhang, M., Zeng, X., Zhao, W."MicroRNA-1299 is a negative regulator of STAT3 in colon cancer". Oncology Reports 37, no. 6 (2017): 3227-3234. https://doi.org/10.3892/or.2017.5605
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Lu Z, Wang N, Zhang M, Zeng X and Zhao W: MicroRNA-1299 is a negative regulator of STAT3 in colon cancer. Oncol Rep 37: 3227-3234, 2017.
APA
Wang, Y., Lu, Z., Wang, N., Zhang, M., Zeng, X., & Zhao, W. (2017). MicroRNA-1299 is a negative regulator of STAT3 in colon cancer. Oncology Reports, 37, 3227-3234. https://doi.org/10.3892/or.2017.5605
MLA
Wang, Y., Lu, Z., Wang, N., Zhang, M., Zeng, X., Zhao, W."MicroRNA-1299 is a negative regulator of STAT3 in colon cancer". Oncology Reports 37.6 (2017): 3227-3234.
Chicago
Wang, Y., Lu, Z., Wang, N., Zhang, M., Zeng, X., Zhao, W."MicroRNA-1299 is a negative regulator of STAT3 in colon cancer". Oncology Reports 37, no. 6 (2017): 3227-3234. https://doi.org/10.3892/or.2017.5605
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