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Article

miR-944 inhibits cell migration and invasion by targeting MACC1 in colorectal cancer

  • Authors:
    • Liqiang Wen
    • Yingru Li
    • Zhipeng Jiang
    • Yuchao Zhang
    • Bin Yang
    • Fanghai Han
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, P.R. China, Department of Gastroenterology, Hernia and Abdominal Wall Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510655, P.R. China
  • Pages: 3415-3422
    |
    Published online on: April 28, 2017
       https://doi.org/10.3892/or.2017.5611
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Abstract

Dysfunction of microRNAs (miRNAs) is strongly proved to participate in the pathogenesis and tumorigenicity of colorectal cancer (CRC). miR-944 was reported to play either oncogenic or tumor suppressive roles in human cancers. A recent study reported that the levels of miR-944 in recurrent CRC patients were evidently lower than that in non-recurrent cases, suggesting that miR-944 may function as a tumor suppressive miRNA in CRC. Yet, the clinical value and biological function of miR-944 remain rarely known in CRC. In the present study, we present that miR-944 level in CRC tissues is notably reduced compared to matched non-cancerous specimens. Its decreased level is evidently correlated with malignant clinical parameters and poor prognosis of CRC patients. Accordingly, the levels of miR-944 were obviously downregulated in CRC cells. Ectopic expression of miR-944 in CRC cells prominently inhibits the migration and invasion of tumor cells, while miR-944 knockdown increased these effects of CRC cells. Mechanically, miR-944 negatively regulated the metastasis-associated in colon cancer-1 (MACC1) abundance in CRC cells. Herein, MACC1 was found to be a downstream molecule of miR-944 in CRC. An inversely correlation between miR-944 and MACC1 was confirmed in CRC specimens. Furthermore, restoration of MACC1 expression could abrogate the anti-metastatic effects of miR-944 on CRC cells with enhanced cell migration and invasion. MACC1/Met/AKT signaling may be implicated with the function of miR-944 in CRC cells. Altogether, miR-944 potentially act as a prognostic predictor and a drug-target for CRC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Wen L, Li Y, Jiang Z, Zhang Y, Yang B and Han F: miR-944 inhibits cell migration and invasion by targeting MACC1 in colorectal cancer. Oncol Rep 37: 3415-3422, 2017.
APA
Wen, L., Li, Y., Jiang, Z., Zhang, Y., Yang, B., & Han, F. (2017). miR-944 inhibits cell migration and invasion by targeting MACC1 in colorectal cancer. Oncology Reports, 37, 3415-3422. https://doi.org/10.3892/or.2017.5611
MLA
Wen, L., Li, Y., Jiang, Z., Zhang, Y., Yang, B., Han, F."miR-944 inhibits cell migration and invasion by targeting MACC1 in colorectal cancer". Oncology Reports 37.6 (2017): 3415-3422.
Chicago
Wen, L., Li, Y., Jiang, Z., Zhang, Y., Yang, B., Han, F."miR-944 inhibits cell migration and invasion by targeting MACC1 in colorectal cancer". Oncology Reports 37, no. 6 (2017): 3415-3422. https://doi.org/10.3892/or.2017.5611
Copy and paste a formatted citation
x
Spandidos Publications style
Wen L, Li Y, Jiang Z, Zhang Y, Yang B and Han F: miR-944 inhibits cell migration and invasion by targeting MACC1 in colorectal cancer. Oncol Rep 37: 3415-3422, 2017.
APA
Wen, L., Li, Y., Jiang, Z., Zhang, Y., Yang, B., & Han, F. (2017). miR-944 inhibits cell migration and invasion by targeting MACC1 in colorectal cancer. Oncology Reports, 37, 3415-3422. https://doi.org/10.3892/or.2017.5611
MLA
Wen, L., Li, Y., Jiang, Z., Zhang, Y., Yang, B., Han, F."miR-944 inhibits cell migration and invasion by targeting MACC1 in colorectal cancer". Oncology Reports 37.6 (2017): 3415-3422.
Chicago
Wen, L., Li, Y., Jiang, Z., Zhang, Y., Yang, B., Han, F."miR-944 inhibits cell migration and invasion by targeting MACC1 in colorectal cancer". Oncology Reports 37, no. 6 (2017): 3415-3422. https://doi.org/10.3892/or.2017.5611
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