Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
June-2017 Volume 37 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2017 Volume 37 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Prognostic significance of altered miRNA expression in whole blood of OSCC patients

  • Authors:
    • Jutta Ries
    • Christoph Baran
    • Falk Wehrhan
    • Manuel Weber
    • Friedrich W. Neukam
    • Andrea Krautheim-Zenk
    • Emeka Nkenke
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Erlangen University Hospital, D-91054 Erlangen, Germany, Department of Oral and Maxillofacial Surgery, Medical University Vienna, A-1090 Vienna, Austria
  • Pages: 3467-3474
    |
    Published online on: May 11, 2017
       https://doi.org/10.3892/or.2017.5639
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Currently, there is a lack of blood markers for the detection of recurrent oral squamous cell carcinoma (OSCC). The present study aimed to investigate whether the aberrant expression of single microRNAs (miRNAs) in whole blood of patients could serve as a biomarker for persistent or recurrent OSCC. Whole blood of 2 groups of formerly treated OSCC patients was investigated by RT-qPCR for their circulating miRNA profiles. The R-OC group included patients with recurrence of OSCC (n=21) and the NR-OC group included patients without recurrence (n=21). Fold-changes and significance of the differences in miRNA expression levels between the groups were determined. A cut-off point (COP) for the discrimination between the R-OC and NR-OC groups was calculated and the significance between over/under expression of the miRNAs and the recurrence of malignancy was determined. Significant differences in the miRNA expression in whole blood of the R-OC and NR-OC groups were found. The levels of miR-3651 and miR-494 were significantly increased and the level of miR-186 was significantly decreased in whole blood of the R-OC patients (pmiR-3651=0.001, pmiR-494=0.003 and pmiR-186=0.001). By the determination of the COP, increased or decreased expression of the markers was significantly correlated to the recurrence of the disease. Altered expression of miR-494, miR-3651 and miR-186 appears to be associated with the recurrence of OSCC. The present study may form the basis for establishing a blood test as a minimally invasive method for the detection of the recurrence of OSCC.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Yanamoto S, Yamada S, Takahashi H, Yoshitomi I, Kawasaki G, Ikeda H, Minamizato T, Shiraishi T, Fujita S, Ikeda T, et al: Clinicopathological risk factors for local recurrence in oral squamous cell carcinoma. Int J Oral Maxillofac Surg. 41:1195–1200. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Wang B, Zhang S, Yue K and Wang XD: The recurrence and survival of oral squamous cell carcinoma: A report of 275 cases. Chin J Cancer. 32:614–618. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Agra IM, Carvalho AL, Pinto CA, Martins EP, Filho JG, Soares FA and Kowalski LP: Biological markers and prognosis in recurrent oral cancer after salvage surgery. Arch Otolaryngol Head Neck Surg. 134:743–749. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Kalavrezos N and Bhandari R: Current trends and future perspectives in the surgical management of oral cancer. Oral Oncol. 46:429–432. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Ord RA, Kolokythas A and Reynolds MA: Surgical salvage for local and regional recurrence in oral cancer. J Oral Maxillofac Surg. 64:1409–1414. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Schwartz GJ, Mehta RH, Wenig BL, Shaligram C and Portugal LG: Salvage treatment for recurrent squamous cell carcinoma of the oral cavity. Head Neck. 22:34–41. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Søland TM and Brusevold IJ: Prognostic molecular markers in cancer - quo vadis? Histopathology. 63:297–308. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Huang TY, Hsu LP, Wen YH, Huang TT, Chou YF, Lee CF, Yang MC, Chang YK and Chen PR: Predictors of locoregional recurrence in early stage oral cavity cancer with free surgical margins. Oral Oncol. 46:49–55. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Chauhan SS, Kaur J, Kumar M, Matta A, Srivastava G, Alyass A, Assi J, Leong I, MacMillan C, Witterick I, et al: Prediction of recurrence-free survival using a protein expression-based risk classifier for head and neck cancer. Oncogenesis. 4:e1472015. View Article : Google Scholar : PubMed/NCBI

11 

Komatsu S, Ichikawa D, Hirajima S, Kawaguchi T, Miyamae M, Okajima W, Ohashi T, Arita T, Konishi H, Shiozaki A, et al: Plasma microRNA profiles: Identification of miR-25 as a novel diagnostic and monitoring biomarker in oesophageal squamous cell carcinoma. Br J Cancer. 111:1614–1624. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Lewis BP, Burge CB and Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 120:15–20. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 6:857–866. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, et al: MicroRNA expression profiles classify human cancers. Nature. 435:834–838. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Cortez MA and Calin GA: MicroRNA identification in plasma and serum: A new tool to diagnose and monitor diseases. Expert Opin Biol Ther. 9:703–711. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Momen-Heravi F, Trachtenberg AJ, Kuo WP and Cheng YS: Genomewide study of salivary microRNAs for detection of oral cancer. J Dent Res. 93 Suppl 7:86S–93S. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant KC, Allen A, et al: Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA. 105:pp. 10513–10518. 2008; View Article : Google Scholar : PubMed/NCBI

18 

Witwer KW: Circulating microRNA biomarker studies: Pitfalls and potential solutions. Clin Chem. 61:56–63. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Cappelletti V, Appierto V, Tiberio P, Fina E, Callari M and Daidone MG: Circulating biomarkers for prediction of treatment response. J Natl Cancer Inst Monogr. 2015:60–63. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Tiberio P, Callari M, Angeloni V, Daidone MG and Appierto V: Challenges in using circulating miRNAs as cancer biomarkers. BioMed Res Int. 2015:7314792015. View Article : Google Scholar : PubMed/NCBI

21 

Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K, Guo J, Zhang Y, Chen J, Guo X, et al: Characterization of microRNAs in serum: A novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 18:997–1006. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Allegra A, Alonci A, Campo S, Penna G, Petrungaro A, Gerace D and Musolino C: Circulating microRNAs: New biomarkers in diagnosis, prognosis and treatment of cancer (Review). Int J Oncol. 41:1897–1912. 2012.PubMed/NCBI

23 

Schwarzenbach H, Nishida N, Calin GA and Pantel K: Clinical relevance of circulating cell-free microRNAs in cancer. Nat Rev Clin Oncol. 11:145–156. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Iorio MV and Croce CM: MicroRNA dysregulation in cancer: Diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med. 4:143–159. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Gomes CC, de Sousa SF and Gomez RS: MicroRNAs: Small molecules with a potentially role in oral squamous cell carcinoma. Curr Pharm Des. 19:1285–1291. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Wu BH, Xiong XP, Jia J and Zhang WF: MicroRNAs: New actors in the oral cancer scene. Oral Oncol. 47:314–319. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Soga D, Yoshiba S, Shiogama S, Miyazaki H, Kondo S and Shintani S: microRNA expression profiles in oral squamous cell carcinoma. Oncol Rep. 30:579–583. 2013.PubMed/NCBI

28 

Zahran F, Ghalwash D, Shaker O, Al-Johani K and Scully C: Salivary microRNAs in oral cancer. Oral Dis. 21:739–747. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Hanash SM, Baik CS and Kallioniemi O: Emerging molecular biomarkers - blood-based strategies to detect and monitor cancer. Nat Rev Clin Oncol. 8:142–150. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Wu JY, Yi C, Chung HR, Wang DJ, Chang WC, Lee SY, Lin CT, Yang YC and Yang WC: Potential biomarkers in saliva for oral squamous cell carcinoma. Oral Oncol. 46:226–231. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Ries J, Vairaktaris E, Agaimy A, Kintopp R, Baran C, Neukam FW and Nkenke E: miR-186, miR-3651 and miR-494: Potential biomarkers for oral squamous cell carcinoma extracted from whole blood. Oncol Rep. 31:1429–1436. 2014.PubMed/NCBI

32 

Ries J, Vairaktaris E, Kintopp R, Baran C, Neukam FW and Nkenke E: Alterations in miRNA expression patterns in whole blood of OSCC patients. In Vivo. 28:851–861. 2014.PubMed/NCBI

33 

Masood Y, Kqueen CY and Rajadurai P: Role of miRNA in head and neck squamous cell carcinoma. Expert Rev Anticancer Ther. 15:183–197. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Ganci F, Sacconi A, Manciocco V, Sperduti I, Battaglia P, Covello R, Muti P, Strano S, Spriano G, Fontemaggi G, et al: MicroRNA expression as predictor of local recurrence risk in oral squamous cell carcinoma. Head Neck. 38 Suppl 1:E189–E197. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Xiao W, Bao ZX, Zhang CY, Zhang XY, Shi LJ, Zhou ZT and Jiang WW: Upregulation of miR-31* is negatively associated with recurrent/newly formed oral leukoplakia. PLoS One. 7:e386482012. View Article : Google Scholar : PubMed/NCBI

36 

Gorenchtein M, Poh CF, Saini R and Garnis C: MicroRNAs in an oral cancer context - from basic biology to clinical utility. J Dent Res. 91:440–446. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Kowalski LP and Sanabria A: Elective neck dissection in oral carcinoma: A critical review of the evidence. Acta Otorhinolaryngol Ital. 27:113–117. 2007.PubMed/NCBI

39 

Grimm M, Kraut W, Hoefert S, Krimmel M, Biegner T, Teriete P, Cetindis M, Polligkeit J, Kluba S, Munz A, et al: Evaluation of a biomarker based blood test for monitoring surgical resection of oral squamous cell carcinomas. Clin Oral Investig. 20:329–338. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Gomes CC and Gomez RS: MicroRNA and oral cancer: Future perspectives. Oral Oncol. 44:910–914. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Yoshizawa JM and Wong DT: Salivary microRNAs and oral cancer detection. Methods Mol Biol. 936:313–324. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Zen K and Zhang CY: Circulating microRNAs: A novel class of biomarkers to diagnose and monitor human cancers. Med Res Rev. 32:326–348. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Summerer I, Niyazi M, Unger K, Pitea A, Zangen V, Hess J, Atkinson MJ, Belka C, Moertl S and Zitzelsberger H: Changes in circulating microRNAs after radiochemotherapy in head and neck cancer patients. Radiat Oncol. 8:2962013. View Article : Google Scholar : PubMed/NCBI

44 

Gombos K, Horváth R, Szele E, Juhász K, Gocze K, Somlai K, Pajkos G, Ember I and Olasz L: miRNA expression profiles of oral squamous cell carcinomas. Anticancer Res. 33:1511–1517. 2013.PubMed/NCBI

45 

Komatsu S, Ichikawa D, Takeshita H, Tsujiura M, Morimura R, Nagata H, Kosuga T, Iitaka D, Konishi H, Shiozaki A, et al: Circulating microRNAs in plasma of patients with oesophageal squamous cell carcinoma. Br J Cancer. 105:104–111. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Liu CJ, Kao SY, Tu HF, Tsai MM, Chang KW and Lin SC: Increase of microRNA miR-31 level in plasma could be a potential marker of oral cancer. Oral Dis. 16:360–364. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Lin SC, Liu CJ, Lin JA, Chiang WF, Hung PS and Chang KW: miR-24 up-regulation in oral carcinoma: Positive association from clinical and in vitro analysis. Oral Oncol. 46:204–208. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Wong TS, Liu XB, Wong BY, Ng RW, Yuen AP and Wei WI: Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clin Cancer Res. 14:2588–2592. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Liu CJ, Lin SC, Yang CC, Cheng HW and Chang KW: Exploiting salivary miR-31 as a clinical biomarker of oral squamous cell carcinoma. Head Neck. 34:219–224. 2012. View Article : Google Scholar : PubMed/NCBI

50 

Grimm M, Schmitt S, Teriete P, Biegner T, Stenzl A, Hennenlotter J, Muhs HJ, Munz A, Nadtotschi T, König K, et al: A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells. BMC Cancer. 13:5692013. View Article : Google Scholar : PubMed/NCBI

51 

Friedman EB, Shang S, de Miera EV, Fog JU, Teilum MW, Ma MW, Berman RS, Shapiro RL, Pavlick AC, Hernando E, et al: Serum microRNAs as biomarkers for recurrence in melanoma. J Transl Med. 10:1552012. View Article : Google Scholar : PubMed/NCBI

52 

Schwarzenbach H, Hoon DS and Pantel K: Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer. 11:426–437. 2011. View Article : Google Scholar : PubMed/NCBI

53 

Maclellan SA, Lawson J, Baik J, Guillaud M, Poh CF and Garnis C: Differential expression of miRNAs in the serum of patients with high-risk oral lesions. Cancer Med. 1:268–274. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ries J, Baran C, Wehrhan F, Weber M, Neukam FW, Krautheim-Zenk A and Nkenke E: Prognostic significance of altered miRNA expression in whole blood of OSCC patients. Oncol Rep 37: 3467-3474, 2017.
APA
Ries, J., Baran, C., Wehrhan, F., Weber, M., Neukam, F.W., Krautheim-Zenk, A., & Nkenke, E. (2017). Prognostic significance of altered miRNA expression in whole blood of OSCC patients. Oncology Reports, 37, 3467-3474. https://doi.org/10.3892/or.2017.5639
MLA
Ries, J., Baran, C., Wehrhan, F., Weber, M., Neukam, F. W., Krautheim-Zenk, A., Nkenke, E."Prognostic significance of altered miRNA expression in whole blood of OSCC patients". Oncology Reports 37.6 (2017): 3467-3474.
Chicago
Ries, J., Baran, C., Wehrhan, F., Weber, M., Neukam, F. W., Krautheim-Zenk, A., Nkenke, E."Prognostic significance of altered miRNA expression in whole blood of OSCC patients". Oncology Reports 37, no. 6 (2017): 3467-3474. https://doi.org/10.3892/or.2017.5639
Copy and paste a formatted citation
x
Spandidos Publications style
Ries J, Baran C, Wehrhan F, Weber M, Neukam FW, Krautheim-Zenk A and Nkenke E: Prognostic significance of altered miRNA expression in whole blood of OSCC patients. Oncol Rep 37: 3467-3474, 2017.
APA
Ries, J., Baran, C., Wehrhan, F., Weber, M., Neukam, F.W., Krautheim-Zenk, A., & Nkenke, E. (2017). Prognostic significance of altered miRNA expression in whole blood of OSCC patients. Oncology Reports, 37, 3467-3474. https://doi.org/10.3892/or.2017.5639
MLA
Ries, J., Baran, C., Wehrhan, F., Weber, M., Neukam, F. W., Krautheim-Zenk, A., Nkenke, E."Prognostic significance of altered miRNA expression in whole blood of OSCC patients". Oncology Reports 37.6 (2017): 3467-3474.
Chicago
Ries, J., Baran, C., Wehrhan, F., Weber, M., Neukam, F. W., Krautheim-Zenk, A., Nkenke, E."Prognostic significance of altered miRNA expression in whole blood of OSCC patients". Oncology Reports 37, no. 6 (2017): 3467-3474. https://doi.org/10.3892/or.2017.5639
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team