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Article

High expression of PIWIL2 promotes tumor cell proliferation, migration and predicts a poor prognosis in glioma

  • Authors:
    • Jinquan Li
    • Li Xu
    • Zhen Bao
    • Peng Xu
    • Hao Chang
    • Jingjing Wu
    • Yuanqi Bei
    • Liuwan Xia
    • Peizhang Wu
    • Gang Cui
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Targets, Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Neurosurgery, Affiliated Wuxi Second Hospital of Nanjing Medical University, Wuxi, Jiangsu 214002, P.R. China, Department of Oncology, Nantong Rich Hospital, Nantong, Jiangsu 226001, P.R. China
  • Pages: 183-192
    |
    Published online on: May 17, 2017
       https://doi.org/10.3892/or.2017.5647
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Abstract

Piwi-like RNA-mediated gene silencing 2 (PIWIL2), has been reported as an oncogene tightly associated with the genesis and progression of various malignancies. Nevertheless, the function of the PIWIL2 protein in human gliomas has not yet been clarified. In this study, we sought to investigate the clinical significance of PIWIL2 expression and reveal its function in the pathological process of gliomas. Through western blot and immunohistochemical analyses we found that PIWIL2 was overexpressed in glioma tissues. Moreover, the expression level of PIWIL2 was also significantly correlated with the WHO grades of human gliomas and Ki-67 expression. Kaplan‑Meier curves indicated that PIWIL2 was a prognostic factor for the survival of glioma patients and a high expression of PIWIL2 was correlated with a poor prognosis. In vitro, knockdown of PIWIL2 in glioma cells was shown to induce cell cycle arrest and increase apoptosis. Furthermore, silencing of PIWIL2 expression also obviously suppressed the migration of glioma cells. All the results demonstrated that PIWIL2 plays a significant role in the pathogenesis of human gliomas and may be used as a potential diagnostic marker and a therapeutic target of glioma in the future.
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Copy and paste a formatted citation
Spandidos Publications style
Li J, Xu L, Bao Z, Xu P, Chang H, Wu J, Bei Y, Xia L, Wu P, Cui G, Cui G, et al: High expression of PIWIL2 promotes tumor cell proliferation, migration and predicts a poor prognosis in glioma. Oncol Rep 38: 183-192, 2017.
APA
Li, J., Xu, L., Bao, Z., Xu, P., Chang, H., Wu, J. ... Cui, G. (2017). High expression of PIWIL2 promotes tumor cell proliferation, migration and predicts a poor prognosis in glioma. Oncology Reports, 38, 183-192. https://doi.org/10.3892/or.2017.5647
MLA
Li, J., Xu, L., Bao, Z., Xu, P., Chang, H., Wu, J., Bei, Y., Xia, L., Wu, P., Cui, G."High expression of PIWIL2 promotes tumor cell proliferation, migration and predicts a poor prognosis in glioma". Oncology Reports 38.1 (2017): 183-192.
Chicago
Li, J., Xu, L., Bao, Z., Xu, P., Chang, H., Wu, J., Bei, Y., Xia, L., Wu, P., Cui, G."High expression of PIWIL2 promotes tumor cell proliferation, migration and predicts a poor prognosis in glioma". Oncology Reports 38, no. 1 (2017): 183-192. https://doi.org/10.3892/or.2017.5647
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Xu L, Bao Z, Xu P, Chang H, Wu J, Bei Y, Xia L, Wu P, Cui G, Cui G, et al: High expression of PIWIL2 promotes tumor cell proliferation, migration and predicts a poor prognosis in glioma. Oncol Rep 38: 183-192, 2017.
APA
Li, J., Xu, L., Bao, Z., Xu, P., Chang, H., Wu, J. ... Cui, G. (2017). High expression of PIWIL2 promotes tumor cell proliferation, migration and predicts a poor prognosis in glioma. Oncology Reports, 38, 183-192. https://doi.org/10.3892/or.2017.5647
MLA
Li, J., Xu, L., Bao, Z., Xu, P., Chang, H., Wu, J., Bei, Y., Xia, L., Wu, P., Cui, G."High expression of PIWIL2 promotes tumor cell proliferation, migration and predicts a poor prognosis in glioma". Oncology Reports 38.1 (2017): 183-192.
Chicago
Li, J., Xu, L., Bao, Z., Xu, P., Chang, H., Wu, J., Bei, Y., Xia, L., Wu, P., Cui, G."High expression of PIWIL2 promotes tumor cell proliferation, migration and predicts a poor prognosis in glioma". Oncology Reports 38, no. 1 (2017): 183-192. https://doi.org/10.3892/or.2017.5647
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