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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July-2017 Volume 38 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

A sketch of known and novel MYCN-associated miRNA networks in neuroblastoma

Francesca Megiorni, Moreno Colaiacovo, Samantha Cialfi, Heather P. McDowell, Alessandro Guffanti, Simona Camero, Armando Felsani, Paul D. Losty, Barry Pizer, Rajeev Shukla, Carlo Cappelli, Eva Ferrara, Antonio Pizzuti, Anna Moles, Carlo Dominici
Pages: 3-20
Published online on: 06 June 2017

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Article Open Access

GROα overexpression drives cell migration and invasion in triple negative breast cancer cells

Kruttika Bhat, Marianna Sarkissyan, Yanyuan Wu, Jaydutt V. Vadgama
Pages: 21-30
Published online on: 24 May 2017

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Article Open Access

Synthetic lethal interaction of CDK inhibition and autophagy inhibition in human solid cancer cell lines

Yoshinari Okada, Shunsuke Kato, Yasuhiro Sakamoto, Takayuki Oishi, Chikashi Ishioka
Pages: 31-42
Published online on: 30 May 2017

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Article Open Access

TRIM59 facilitates the proliferation of colorectal cancer and promotes metastasis via the PI3K/AKT pathway

Ye Sun, Bing Ji, Yifei Feng, Yue Zhang, Dongjian Ji, Chunyan Zhu, Sen Wang, Chuan Zhang, Dongsheng Zhang, Yueming Sun
Pages: 43-52
Published online on: 22 May 2017

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Article Open Access

Fisetin inhibits liver cancer growth in a mouse model: Relation to dopamine receptor

Xiang-Feng Liu, Hai-Jiao Long, Xiong-Ying Miao, Guo-Li Liu, Hong-Liang Yao
Pages: 53-62
Published online on: 30 May 2017

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Article Open Access

Fangchinoline suppresses growth and metastasis of melanoma cells by inhibiting the phosphorylation of FAK Retraction in /10.3892/or.2024.8740

Jie Shi, Bingyu Guo, Qiang Hui, Peng Chang, Kai Tao
Pages: 63-70
Published online on: 30 May 2017

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Article Open Access

Improved xenograft efficiency of esophageal adenocarcinoma cell lines through in vivo selection

Elodie Melsens, Elly De Vlieghere, Benedicte Descamps, Christian Vanhove, Olivier De Wever, Wim Ceelen, Piet Pattyn
Pages: 71-81
Published online on: 15 May 2017

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Article Open Access

MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4 Retraction in /10.3892/or.2023.8570

Chengyi Jiang, Hongtao Wang, Lei Zhou, Tao Jiang, Yajia Xu, Lin Xia
Pages: 82-88
Published online on: 15 May 2017

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Article Open Access

Standardization of A375 human melanoma models on chicken embryo chorioallantoic membrane and Balb/c nude mice

Stefana Avram, Dorina‑Elena Coricovac, Ioana Zinuca Pavel, Iulia Pinzaru, Roxana Ghiulai, Flavia Baderca, Codruta Soica, Danina Muntean, Daciana E. Branisteanu, Demetrios A. Spandidos, Aristides M. Tsatsakis, Cristina Adriana Dehelean
Pages: 89-99
Published online on: 22 May 2017

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Article Open Access

Upregulation of miR-101 enhances the cytotoxic effect of anticancer drugs through inhibition of colon cancer cell proliferation

Le-Gao Chen, Ying-Jie Xia, Ying Cui
Pages: 100-108
Published online on: 24 May 2017

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Article Open Access

Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer

Yu-Zhen Feng, Qing-Yan Zhang, Mei-Ting Fu, Zhen-Fei Zhang, Min Wei, Jue-Yu Zhou, Rong Shi
Pages: 109-119
Published online on: 02 June 2017

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Article

Hypoxia-induced angiopoietin-like protein 4 as a clinical biomarker and treatment target for human prostate cancer

Shinro Hata, Takeo Nomura, Kazunori Iwasaki, Ryuta Sato, Mutsushi Yamasaki, Fuminori Sato, Hiromitsu Mimata
Pages: 120-128
Published online on: 24 May 2017

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Article

New bioactive peptide reduces the toxicity of chemotherapy drugs and increases drug sensitivity

Xian Li, Huijun Wu, Xiaohui Ouyang, Bo Zhang, Xiulan Su
Pages: 129-140
Published online on: 26 May 2017

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Article

Overexpression of microRNA-133b is associated with the increased survival of patients with hepatocellular carcinoma after curative hepatectomy: Involvement of the EGFR/PI3K/Akt/mTOR signaling pathway

Xuedong Wang, Jianping Zeng, Liang Wang, Xinjing Zhang, Zhiqian Liu, Hongyi Zhang, Jiahong Dong
Pages: 141-150
Published online on: 06 June 2017

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Article

MicroRNA-200c regulates cisplatin resistance by targeting ZEB2 in human gastric cancer cells

Tao Jiang, Pengfei Dong, Long Li, Xiao Ma, Pei Xu, He Zhu, Yanqiu Wang, Baotong Yang, Kuangge Liu, Jinwei Liu, Juan Xue, Runzhe Lv, Panke Su, Guoqiang Kong, Yongchao Chang, Chonggao Zhao, Lidong Wang
Pages: 151-158
Published online on: 22 May 2017

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Article

Long non-coding RNA XLOC_006390 promotes cervical cancer proliferation and metastasis through the regulation of SET domain containing 8

Xiaotian Luan, Yankui Wang
Pages: 159-166
Published online on: 23 May 2017

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Article

miR-130b regulates the proliferation, invasion and apoptosis of glioma cells via targeting of CYLD

Zhi-Qiang Xiao, Teng-Kun Yin, Ya-Xing Li, Jian-He Zhang, Jian-Jun Gu
Pages: 167-174
Published online on: 19 May 2017

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Article

miR-455 inhibits cell proliferation and migration via negative regulation of EGFR in human gastric cancer

Tao Ning, Zhijuan Peng, Shuang Li, Yanjun Qu, Haiyang Zhang, Jingjing Duan, Xinyi Wang, Haiou Yang, Rui Liu, Ting Deng, Ming Bai, Yi Wang, Yiran Si, Le Zhang, Xia Wang, Shaohua Ge, Likun Zhou, Guoguang Ying, Yi Ba
Pages: 175-182
Published online on: 22 May 2017

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Article

High expression of PIWIL2 promotes tumor cell proliferation, migration and predicts a poor prognosis in glioma

Jinquan Li, Li Xu, Zhen Bao, Peng Xu, Hao Chang, Jingjing Wu, Yuanqi Bei, Liuwan Xia, Peizhang Wu, Gang Cui
Pages: 183-192
Published online on: 17 May 2017

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Article

p21-activated protein kinase 1 induces the invasion of gastric cancer cells through c-Jun NH2-terminal kinase-mediated activation of matrix metalloproteinase-2

Liang-Hui Li, Guo-Yang Wu, Yi-Zhuo Lu, Xue-Hua Chen, Bing‑Ya Liu, Min-Hua Zheng, Jian-Chun Cai
Pages: 193-200
Published online on: 16 May 2017

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Article

Expression of the EP300, TP53 and BAX genes in colorectal cancer: Correlations with clinicopathological parameters and survival

Anna E. Kowalczyk, Bartlomiej E. Krazinski, Janusz Godlewski, Jolanta Kiewisz, Przemyslaw Kwiatkowski, Agnieszka Sliwinska-Jewsiewicka, Jacek Kiezun, Marian Sulik, Zbigniew Kmiec
Pages: 201-210
Published online on: 01 June 2017

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Article

Functional significance of the long non-coding RNA RP11-169D4.1 as a metastasis suppressor in laryngeal squamous cell carcinoma by regulating CDH1

Jing Zhao, Kexing Lv, Zeng-Hong Li, Jianhui Wu, Wei Gao, Thian-Sze Wong, Jie Luo, Hao Qin, Bin Wang, Qingling Fu, Wen-Bin Lei
Pages: 211-220
Published online on: 16 May 2017

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Article

NHERF1 inhibits proliferation of triple-negative breast cancer cells by suppressing GPER signaling

Yan Wang, Zhiqiang Peng, Ran Meng, Tao Tao, Qiqi Wang, Chunjuan Zhao, Hua Liu, Ran Song, Junfang Zheng, Qiong Qin, Junqi He
Pages: 221-228
Published online on: 18 May 2017

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Article

HDAC6 inhibition suppresses chondrosarcoma by restoring the expression of primary cilia

Wei Xiang, Fengjing Guo, Weiting Cheng, Jiaming Zhang, Junming Huang, Rui Wang, Zhongxi Ma, Kai Xu
Pages: 229-236
Published online on: 02 June 2017

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Article

MARK2 inhibits the growth of HeLa cells through AMPK and reverses epithelial-mesenchymal transition

Ge Xu, Yinggang Ge, Xiaohong Tao, Qing Gao, Xiaoyan Liang
Pages: 237-244
Published online on: 30 May 2017

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Article

Synergistic role of Cul1 and c-Myc: Prognostic and predictive biomarkers in colorectal cancer

Weimin Wang, Jianliang Deng, Qianqian Wang, Qiang Yao, Wenjiao Chen, Yongfei Tan, Zhijun Ge, Jianwei Zhou, Yan Zhou
Pages: 245-252
Published online on: 25 May 2017

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Article

Silencing of type Iγ phosphatidylinositol phosphate kinase suppresses ovarian cancer cell proliferation, migration and invasion Corrigendum in /10.3892/or.2021.7982

Siyu Cao, Chunhua Chen, Junli Xue, Yan Huang, Xiaofeng Yang, Kun Ling
Pages: 253-262
Published online on: 25 May 2017

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Article

EphA2 receptor activation with ephrin-A1 ligand restores cetuximab efficacy in NRAS-mutant colorectal cancer cells

Elisabet Cuyàs, Bernardo Queralt, Begoña Martin-Castillo, Joaquim Bosch-Barrera, Javier A. Menendez
Pages: 263-270
Published online on: 30 May 2017

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Article

Cucurbitacin B induces autophagy and apoptosis by suppressing CIP2A/PP2A/mTORC1 signaling axis in human cisplatin resistant gastric cancer cells

Xuewen Liu, Chao Duan, Juanli Ji, Te Zhang, Xiaoning Yuan, Yunfei Zhang, Wenjing Ma, Jingyuan Yang, Linsen Yang, Zhiguo Jiang, Huiliang Yu, Ying Liu
Pages: 271-278
Published online on: 18 May 2017

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Article

Genetic testing and counseling of a recipient after bone marrow transplant from a sibling harboring a germline BRCA1 pathogenic mutation

Petra Škerl, Mateja Krajc, Ana Blatnik, Srdjan Novaković
Pages: 279-282
Published online on: 06 June 2017

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Article

Loss of CSMD1 expression disrupts mammary duct formation while enhancing proliferation, migration and invasion

Mohamed Kamal, Deborah L. Holliday, Ewan E. Morrison, Valerie Speirs, Carmel Toomes, Sandra M. Bell
Pages: 283-292
Published online on: 22 May 2017

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Article

Microarray expression profile of long non-coding RNAs in paclitaxel-resistant human lung adenocarcinoma cells

Xin Tian, Hongyan Zhang, Bijun Zhang, Jianzhu Zhao, Tingting Li, Yanyan Zhao
Pages: 293-300
Published online on: 01 June 2017

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Article

MicroRNA-148a suppresses epithelial-mesenchymal transition and invasion of pancreatic cancer cells by targeting Wnt10b and inhibiting the Wnt/β-catenin signaling pathway Retraction in /10.3892/or.2023.8493

Long Peng, Zhanying Liu, Jian Xiao, Yi Tu, Zhen Wan, Haiwei Xiong, Yong Li, Weidong Xiao
Pages: 301-308
Published online on: 06 June 2017

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Article

Silencing of BAG3 promotes the sensitivity of ovarian cancer cells to cisplatin via inhibition of autophagy

Shuang Qiu, Liang Sun, Ye Jin, Qi An, Changjiang Weng, Jianhua Zheng
Pages: 309-316
Published online on: 06 June 2017

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Article

DOC-2/DAB2 interactive protein regulates proliferation and mobility of nasopharyngeal carcinoma cells by targeting PI3K/Akt pathway

Bin Wang, Qianqian Gu, Jian Li
Pages: 317-324
Published online on: 06 June 2017

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Article

Silencing of ATM expression by siRNA technique contributes to glioma stem cell radiosensitivity in vitro and in vivo

Yan Li, Luchun Li, Zhijuan Wu, Lulu Wang, Yongzhong Wu, Dairong Li, Uiwen Ma, Jianghe Shao, Huiqing Yu, Donglin Wang
Pages: 325-335
Published online on: 24 May 2017

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Article

HIF-1α inhibits IDH-1 expression in osteosarcoma

Deng-Cheng Liu, Xun Zheng, Yong Zho, Wan-Rong Yi, Zong-Huan Li, Xiang Hu, Ai-Xi Yu
Pages: 336-342
Published online on: 22 May 2017

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Article

miR-1247-5p functions as a tumor suppressor in human hepatocellular carcinoma by targeting Wnt3

Yuankui Chu, Weining Fan, Wenwei Guo, Yixin Zhang, Lixin Wang, Le Guo, Xiangguo Duan, Jun Wei, Guangxian Xu
Pages: 343-351
Published online on: 06 June 2017

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Article

Overexpression of miR-15b-5p promotes gastric cancer metastasis by regulating PAQR3

Chengcheng Zhao, Yan Li, Gang Chen, Fen Wang, Zhili Shen, Rongping Zhou
Pages: 352-358
Published online on: 26 May 2017

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Article

Ginsenoside Rd regulates the Akt/mTOR/p70S6K signaling cascade and suppresses angiogenesis and breast tumor growth

Eryun Zhang, Hailian Shi, Li Yang, Xiaojun Wu, Zhengtao Wang
Pages: 359-367
Published online on: 19 May 2017

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Article

miR-204 regulates the biological behavior of breast cancer MCF-7 cells by directly targeting FOXA1

Si-Qiao Shen, Lan-Shan Huang, Xiao-Ling Xiao, Xiao-Fei Zhu, Dan-Dan Xiong, Xue-Mei Cao, Kang-Lai Wei, Gang Chen, Zhen-Bo Feng
Pages: 368-376
Published online on: 16 May 2017

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Article

DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression

Hongling Zhang, Xuhong Chen, Dongming Li, Lulu Cui, Xin Li, Xiufeng Ye, Xiaochun Wan
Pages: 377-383
Published online on: 30 May 2017

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Article

miR-370 regulates cell proliferation and migration by targeting EGFR in gastric cancer Corrigendum in /10.3892/or.2022.8409

Tao Ning, Haiyang Zhang, Xinyi Wang, Shuang Li, Le Zhang, Ting Deng, Likun Zhou, Rui Liu, Xia Wang, Ming Bai, Shaohua Ge, Hongli Li, Dingzhi Huang, Guoguang Ying, Yi Ba
Pages: 384-392
Published online on: 23 May 2017

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Article

miR-30e acts as a tumor suppressor in hepatocellular carcinoma partly via JAK1/STAT3 pathway

Junjie Mao, Xiaojun Hu, Pengfei Pang, Bin Zhou, Dan Li, Hong Shan
Pages: 393-401
Published online on: 30 May 2017

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Article

XAF1 expression levels in a non-small cell lung cancer cohort and its potential association with carcinogenesis

Luciene Schluckebier, Veronica Aran, Joyce De Moraes, Heitor Paiva, Cinthya Sternberg, Carlos Gil Ferreira
Pages: 402-410
Published online on: 30 May 2017

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Article

Construction of disease-specific transcriptional regulatory networks identifies co-activation of four gene in esophageal squamous cell carcinoma

Yu Zhao, Li Min, Changqin Xu, Linlin Shao, Shuilong Guo, Rui Cheng, Jie Xing, Shengtao Zhu, Shutian Zhang
Pages: 411-417
Published online on: 30 May 2017

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Article

Low HtrA1 expression in patients with long‑standing ulcerative colitis and colorectal cancer

Emma Altobelli, Giovanni Latella, Manrico Morroni, Caterina Licini, Giovanni Tossetta, Roberta Mazzucchelli, Valerio F. Profeta, Gino Coletti, Pietro Leocata, Mario Castellucci, Mario Guerrieri, Reimondo Petrocelli, Berardo De Berardis, Marina De Padova, Gabriella Di Leonardo, Antonella Paladini, Filippo Mignosi, Gina Quaglione, Roberto Fagnano, Daniela Marzioni
Pages: 418-426
Published online on: 06 June 2017

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Article

Overexpression of the YAP1 oncogene in clear cell renal cell carcinoma is associated with poor outcome

Agnieszka Rybarczyk, Jakub Klacz, Agata Wronska, Marcin Matuszewski, Zbigniew Kmiec, Piotr M. Wierzbicki
Pages: 427-439
Published online on: 15 May 2017

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Article

N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma

Kimihiro Nishino, Eiko Yamamoto, Kaoru Niimi, Yoko Sekiya, Yoriko Yamashita, Fumitaka Kikkawa
Pages: 440-448
Published online on: 23 May 2017

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Article

Tumor growth limited to subcutaneous site vs tumor growth in pulmonary site exhibit differential effects on systemic immunities

Junko Masuda, Eiji Takayama, Warren Strober, Ayano Satoh, Yuji Morimoto, Yasuko Honjo, Tatsuo Ichinohe, Shin-Ichi Tokuno, Toshiaki Ishizuka, Takahiro Nakata, Akifumi Mizutani, Naoki Umemura, Atsushi Kitani, Ivan J. Fuss, Tsukasa Shigehiro, Harumi Kawaki, Masako Mizuno-kamiya, Nobuo Kondoh, Masaharu Seno
Pages: 449-455
Published online on: 17 May 2017

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Article

Resveratrol inactivates PI3K/Akt signaling through upregulating BMP7 in human colon cancer cells

Yu-Hua Zeng, Lin-Yun Zhou, Qian-Zhao Chen, Yang Li, Ying Shao, Wen-Yan Ren, Yun-Peng Liao, Han Wang, Jia-Hui Zhu, Ming Huang, Fang He, Jin Wang, Ke Wu, Bai-Cheng He
Pages: 456-464
Published online on: 23 May 2017

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Article

Amplification and the clinical significance of circulating cell-free DNA of PVT1 in breast cancer

Xujing Li, Weijuan Chen, Hui Wang, Qun Wei, Xiaodi Ding, Wentong Li
Pages: 465-471
Published online on: 18 May 2017

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Article

The circadian clock gene PER2 plays an important role in tumor suppression through regulating tumor-associated genes in human oral squamous cell carcinoma Retraction in /10.3892/or.2025.8888

Xiaoli Su, Dan Chen, Kai Yang, Qin Zhao, Dan Zhao, Xiaoqiang Lv, Yiran Ao
Pages: 472-480
Published online on: 19 May 2017

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Article

KML001 and doxercalciferol induce synergistic antileukemic effect in acute lymphoid leukemia cells

Yang Liu, Dong-Yeop Shin, Somi Oh, Sujong Kim, Youngil Koh, Inho Kim
Pages: 481-487
Published online on: 01 June 2017

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Article

The blueberry component pterostilbene has potent anti-myeloma activity in bortezomib-resistant cells

Gege Chen, Zhijian Xu, Gaomei Chang, Jun Hou, Liangning Hu, Yiwen Zhang, Dandan Yu, Bo Li, Shuaikang Chang, Yongsheng Xie, Yong Zhang, Rong Wei, Huiqun Wu, Wenqin Xiao, Xi Sun, Yi Tao, Lu Gao, Bojie Dai, Jumei Shi, Weiliang Zhu
Pages: 488-496
Published online on: 30 May 2017

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Article

MicroRNA-497 acts as a tumor suppressor in gastric cancer and is downregulated by DNA methylation

Jichao Liu, Yongshuang Li, Ying Zou, Jiakui Zhang, Jiaxiang An, Jiao Guo, Minghui Ma, Dongqiu Dai
Pages: 497-505
Published online on: 06 June 2017

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Effects of galectin-9 on apoptosis, cell cycle and autophagy in human esophageal adenocarcinoma cells

Emiko Akashi, Shintaro Fujihara, Asahiro Morishita, Tomoko Tadokoro, Taiga Chiyo, Keiko Fujikawa, Hideki Kobara, Hirohito Mori, Hisakazu Iwama, Keiichi Okano, Yasuyuki Suzuki, Toshiro Niki, Mitsuomi Hirashima, Tsutomu Masaki
Pages: 506-514
Published online on: 01 June 2017

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Knockdown of homeobox containing 1 increases the radiosensitivity of cervical cancer cells through telomere shortening

Shuliang Zhou, Youde Xiao, Yafei Zhuang, Yinyin Liu, Hong Zhao, Hui Yang, Conghua Xie, Fuxiang Zhou, Yunfeng Zhou
Pages: 515-521
Published online on: 06 June 2017

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Article

Exosomes derived from hypoxic epithelial ovarian cancer deliver microRNA-940 to induce macrophage M2 polarization

Xin Chen, Xiang Ying, Xinjing Wang, Xiaoli Wu, Qinyi Zhu, Xipeng Wang
Pages: 522-528
Published online on: 06 June 2017

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Article

Methylated +322-327 CpG site decreases hOGG1 mRNA expression in non-small cell lung cancer

Yuanyuan Zeng, Jianjie Zhu, Hualong Qin, Dan Shen, Zhe Lei, Wei Li, Zongli Ding, Jian-An Huang, Zeyi Liu
Pages: 529-537
Published online on: 01 June 2017

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Coptidis Rhizoma induces intrinsic apoptosis through BAX and BAK activation in human melanoma

Xiaoou Xu, Satoru Yokoyama, Yoshihiro Hayakawa, Ikuo Saiki
Pages: 538-544
Published online on: 26 May 2017

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Reciprocal antagonistic regulation of N-myc mRNA by miR‑17 and the neuronal-specific RNA-binding protein HuD

Leleesha Samaraweera, Barbara A. Spengler, Robert A. Ross
Pages: 545-550
Published online on: 24 May 2017

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Therapy-relevant aberrant expression of MRP3 and BCRP mRNA in TCC-/SCC-bladder cancer tissue of untreated patients

Mona Rady, Marwa Mostageer, Jan Rohde, Ashraf Zaghloul, Ruth Knüchel-Clarke, Shady Saad, Deena Attia, Laila Mahran, Hilde Spahn-Langguth
Pages: 551-560
Published online on: 02 June 2017

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Treatment of colon cancer cells with 5-fluorouracil can improve the effectiveness of RNA-transfected antitumor dendritic cell vaccine

Carolina V. De Almeida, Jofer A. Zamame, Graziela G. Romagnoli, Cecilia P. Rodrigues, Marianna B. Magalhães, Amedeo Amedei, Ramon Kaneno
Pages: 561-568
Published online on: 01 June 2017

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3,3'-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells

Xiaobo Zhang, Pakin Sukamporn, Shiqiang Zhang, Kyung-Won Min, Seung Joon Baek
Pages: 569-574
Published online on: 01 June 2017

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Isoliquiritigenin inhibits the proliferation of human renal carcinoma Caki cells through the ROS-mediated regulation of the Jak2/STAT3 pathway

Do-Hee Kim, Ji Eun Park, In Gyeong Chae, Geumi Park, Sooyeun Lee, Kyung-Soo Chun
Pages: 575-583
Published online on: 30 May 2017

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Article

KLF2 inhibits cell growth via regulating HIF-1α/Notch-1 signal pathway in human colorectal cancer HCT116 cells

Hai-Gang Wang, Bin Cao, Li-Xian Zhang, Nan Song, Hui Li, Wen-Zeng Zhao, Yan-Shu Li, Shun-Mao Ma, Dong-Jian Yin
Pages: 584-590
Published online on: 06 June 2017

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Article

Intermittent low dose irradiation enhances the effectiveness of radio- and chemo-therapy for human colorectal adenocarcinoma cell line HT-29

Yang Wang, Yezhou Li, Li Yang, Dexin Yin
Pages: 591-597
Published online on: 30 May 2017

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Article

Arctigenin inhibits triple-negative breast cancers by targeting CIP2A to reactivate protein phosphatase 2A Corrigendum in /10.3892/or.2025.8925

Qiuyue Huang, Shanshan Qin, Xiaoning Yuan, Liang Zhang, Juanli Ji, Xuewen Liu, Wenjing Ma, Yunfei Zhang, Pengfei Liu, Zhiting Sun, Jingxuan Zhang, Ying Liu
Pages: 598-606
Published online on: 24 May 2017

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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