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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July-2017 Volume 38 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

A sketch of known and novel MYCN-associated miRNA networks in neuroblastoma

Francesca Megiorni, Moreno Colaiacovo, Samantha Cialfi, Heather P. McDowell, Alessandro Guffanti, Simona Camero, Armando Felsani, Paul D. Losty, Barry Pizer, Rajeev Shukla, Carlo Cappelli, Eva Ferrara, Antonio Pizzuti, Anna Moles, Carlo Dominici
Pages: 3-20
Published online on: 06 June 2017

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Article Open Access

GROα overexpression drives cell migration and invasion in triple negative breast cancer cells

Kruttika Bhat, Marianna Sarkissyan, Yanyuan Wu, Jaydutt V. Vadgama
Pages: 21-30
Published online on: 24 May 2017

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Article Open Access

Synthetic lethal interaction of CDK inhibition and autophagy inhibition in human solid cancer cell lines

Yoshinari Okada, Shunsuke Kato, Yasuhiro Sakamoto, Takayuki Oishi, Chikashi Ishioka
Pages: 31-42
Published online on: 30 May 2017

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Article Open Access

TRIM59 facilitates the proliferation of colorectal cancer and promotes metastasis via the PI3K/AKT pathway

Ye Sun, Bing Ji, Yifei Feng, Yue Zhang, Dongjian Ji, Chunyan Zhu, Sen Wang, Chuan Zhang, Dongsheng Zhang, Yueming Sun
Pages: 43-52
Published online on: 22 May 2017

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Article Open Access

Fisetin inhibits liver cancer growth in a mouse model: Relation to dopamine receptor

Xiang-Feng Liu, Hai-Jiao Long, Xiong-Ying Miao, Guo-Li Liu, Hong-Liang Yao
Pages: 53-62
Published online on: 30 May 2017

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Article Open Access

Fangchinoline suppresses growth and metastasis of melanoma cells by inhibiting the phosphorylation of FAK Retraction in /10.3892/or.2024.8740

Jie Shi, Bingyu Guo, Qiang Hui, Peng Chang, Kai Tao
Pages: 63-70
Published online on: 30 May 2017

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Article Open Access

Improved xenograft efficiency of esophageal adenocarcinoma cell lines through in vivo selection

Elodie Melsens, Elly De Vlieghere, Benedicte Descamps, Christian Vanhove, Olivier De Wever, Wim Ceelen, Piet Pattyn
Pages: 71-81
Published online on: 15 May 2017

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Article Open Access

MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4 Retraction in /10.3892/or.2023.8570

Chengyi Jiang, Hongtao Wang, Lei Zhou, Tao Jiang, Yajia Xu, Lin Xia
Pages: 82-88
Published online on: 15 May 2017

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Article Open Access

Standardization of A375 human melanoma models on chicken embryo chorioallantoic membrane and Balb/c nude mice

Stefana Avram, Dorina‑Elena Coricovac, Ioana Zinuca Pavel, Iulia Pinzaru, Roxana Ghiulai, Flavia Baderca, Codruta Soica, Danina Muntean, Daciana E. Branisteanu, Demetrios A. Spandidos, Aristides M. Tsatsakis, Cristina Adriana Dehelean
Pages: 89-99
Published online on: 22 May 2017

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Article Open Access

Upregulation of miR-101 enhances the cytotoxic effect of anticancer drugs through inhibition of colon cancer cell proliferation

Le-Gao Chen, Ying-Jie Xia, Ying Cui
Pages: 100-108
Published online on: 24 May 2017

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Article Open Access

Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer

Yu-Zhen Feng, Qing-Yan Zhang, Mei-Ting Fu, Zhen-Fei Zhang, Min Wei, Jue-Yu Zhou, Rong Shi
Pages: 109-119
Published online on: 02 June 2017

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Article

Hypoxia-induced angiopoietin-like protein 4 as a clinical biomarker and treatment target for human prostate cancer

Shinro Hata, Takeo Nomura, Kazunori Iwasaki, Ryuta Sato, Mutsushi Yamasaki, Fuminori Sato, Hiromitsu Mimata
Pages: 120-128
Published online on: 24 May 2017

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Article

New bioactive peptide reduces the toxicity of chemotherapy drugs and increases drug sensitivity

Xian Li, Huijun Wu, Xiaohui Ouyang, Bo Zhang, Xiulan Su
Pages: 129-140
Published online on: 26 May 2017

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Article

Overexpression of microRNA-133b is associated with the increased survival of patients with hepatocellular carcinoma after curative hepatectomy: Involvement of the EGFR/PI3K/Akt/mTOR signaling pathway

Xuedong Wang, Jianping Zeng, Liang Wang, Xinjing Zhang, Zhiqian Liu, Hongyi Zhang, Jiahong Dong
Pages: 141-150
Published online on: 06 June 2017

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Article

MicroRNA-200c regulates cisplatin resistance by targeting ZEB2 in human gastric cancer cells

Tao Jiang, Pengfei Dong, Long Li, Xiao Ma, Pei Xu, He Zhu, Yanqiu Wang, Baotong Yang, Kuangge Liu, Jinwei Liu, Juan Xue, Runzhe Lv, Panke Su, Guoqiang Kong, Yongchao Chang, Chonggao Zhao, Lidong Wang
Pages: 151-158
Published online on: 22 May 2017

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Article

Long non-coding RNA XLOC_006390 promotes cervical cancer proliferation and metastasis through the regulation of SET domain containing 8

Xiaotian Luan, Yankui Wang
Pages: 159-166
Published online on: 23 May 2017

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Article

miR-130b regulates the proliferation, invasion and apoptosis of glioma cells via targeting of CYLD

Zhi-Qiang Xiao, Teng-Kun Yin, Ya-Xing Li, Jian-He Zhang, Jian-Jun Gu
Pages: 167-174
Published online on: 19 May 2017

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Article

miR-455 inhibits cell proliferation and migration via negative regulation of EGFR in human gastric cancer

Tao Ning, Zhijuan Peng, Shuang Li, Yanjun Qu, Haiyang Zhang, Jingjing Duan, Xinyi Wang, Haiou Yang, Rui Liu, Ting Deng, Ming Bai, Yi Wang, Yiran Si, Le Zhang, Xia Wang, Shaohua Ge, Likun Zhou, Guoguang Ying, Yi Ba
Pages: 175-182
Published online on: 22 May 2017

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Article

High expression of PIWIL2 promotes tumor cell proliferation, migration and predicts a poor prognosis in glioma

Jinquan Li, Li Xu, Zhen Bao, Peng Xu, Hao Chang, Jingjing Wu, Yuanqi Bei, Liuwan Xia, Peizhang Wu, Gang Cui
Pages: 183-192
Published online on: 17 May 2017

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Article

p21-activated protein kinase 1 induces the invasion of gastric cancer cells through c-Jun NH2-terminal kinase-mediated activation of matrix metalloproteinase-2

Liang-Hui Li, Guo-Yang Wu, Yi-Zhuo Lu, Xue-Hua Chen, Bing‑Ya Liu, Min-Hua Zheng, Jian-Chun Cai
Pages: 193-200
Published online on: 16 May 2017

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Article

Expression of the EP300, TP53 and BAX genes in colorectal cancer: Correlations with clinicopathological parameters and survival

Anna E. Kowalczyk, Bartlomiej E. Krazinski, Janusz Godlewski, Jolanta Kiewisz, Przemyslaw Kwiatkowski, Agnieszka Sliwinska-Jewsiewicka, Jacek Kiezun, Marian Sulik, Zbigniew Kmiec
Pages: 201-210
Published online on: 01 June 2017

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Article

Functional significance of the long non-coding RNA RP11-169D4.1 as a metastasis suppressor in laryngeal squamous cell carcinoma by regulating CDH1

Jing Zhao, Kexing Lv, Zeng-Hong Li, Jianhui Wu, Wei Gao, Thian-Sze Wong, Jie Luo, Hao Qin, Bin Wang, Qingling Fu, Wen-Bin Lei
Pages: 211-220
Published online on: 16 May 2017

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Article

NHERF1 inhibits proliferation of triple-negative breast cancer cells by suppressing GPER signaling

Yan Wang, Zhiqiang Peng, Ran Meng, Tao Tao, Qiqi Wang, Chunjuan Zhao, Hua Liu, Ran Song, Junfang Zheng, Qiong Qin, Junqi He
Pages: 221-228
Published online on: 18 May 2017

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Article

HDAC6 inhibition suppresses chondrosarcoma by restoring the expression of primary cilia

Wei Xiang, Fengjing Guo, Weiting Cheng, Jiaming Zhang, Junming Huang, Rui Wang, Zhongxi Ma, Kai Xu
Pages: 229-236
Published online on: 02 June 2017

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Article

MARK2 inhibits the growth of HeLa cells through AMPK and reverses epithelial-mesenchymal transition

Ge Xu, Yinggang Ge, Xiaohong Tao, Qing Gao, Xiaoyan Liang
Pages: 237-244
Published online on: 30 May 2017

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Article

Synergistic role of Cul1 and c-Myc: Prognostic and predictive biomarkers in colorectal cancer

Weimin Wang, Jianliang Deng, Qianqian Wang, Qiang Yao, Wenjiao Chen, Yongfei Tan, Zhijun Ge, Jianwei Zhou, Yan Zhou
Pages: 245-252
Published online on: 25 May 2017

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Article

Silencing of type Iγ phosphatidylinositol phosphate kinase suppresses ovarian cancer cell proliferation, migration and invasion Corrigendum in /10.3892/or.2021.7982

Siyu Cao, Chunhua Chen, Junli Xue, Yan Huang, Xiaofeng Yang, Kun Ling
Pages: 253-262
Published online on: 25 May 2017

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Article

EphA2 receptor activation with ephrin-A1 ligand restores cetuximab efficacy in NRAS-mutant colorectal cancer cells

Elisabet Cuyàs, Bernardo Queralt, Begoña Martin-Castillo, Joaquim Bosch-Barrera, Javier A. Menendez
Pages: 263-270
Published online on: 30 May 2017

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Article

Cucurbitacin B induces autophagy and apoptosis by suppressing CIP2A/PP2A/mTORC1 signaling axis in human cisplatin resistant gastric cancer cells

Xuewen Liu, Chao Duan, Juanli Ji, Te Zhang, Xiaoning Yuan, Yunfei Zhang, Wenjing Ma, Jingyuan Yang, Linsen Yang, Zhiguo Jiang, Huiliang Yu, Ying Liu
Pages: 271-278
Published online on: 18 May 2017

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Article

Genetic testing and counseling of a recipient after bone marrow transplant from a sibling harboring a germline BRCA1 pathogenic mutation

Petra Škerl, Mateja Krajc, Ana Blatnik, Srdjan Novaković
Pages: 279-282
Published online on: 06 June 2017

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Article

Loss of CSMD1 expression disrupts mammary duct formation while enhancing proliferation, migration and invasion

Mohamed Kamal, Deborah L. Holliday, Ewan E. Morrison, Valerie Speirs, Carmel Toomes, Sandra M. Bell
Pages: 283-292
Published online on: 22 May 2017

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Article

Microarray expression profile of long non-coding RNAs in paclitaxel-resistant human lung adenocarcinoma cells

Xin Tian, Hongyan Zhang, Bijun Zhang, Jianzhu Zhao, Tingting Li, Yanyan Zhao
Pages: 293-300
Published online on: 01 June 2017

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Article

MicroRNA-148a suppresses epithelial-mesenchymal transition and invasion of pancreatic cancer cells by targeting Wnt10b and inhibiting the Wnt/β-catenin signaling pathway Retraction in /10.3892/or.2023.8493

Long Peng, Zhanying Liu, Jian Xiao, Yi Tu, Zhen Wan, Haiwei Xiong, Yong Li, Weidong Xiao
Pages: 301-308
Published online on: 06 June 2017

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Article

Silencing of BAG3 promotes the sensitivity of ovarian cancer cells to cisplatin via inhibition of autophagy

Shuang Qiu, Liang Sun, Ye Jin, Qi An, Changjiang Weng, Jianhua Zheng
Pages: 309-316
Published online on: 06 June 2017

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Article

DOC-2/DAB2 interactive protein regulates proliferation and mobility of nasopharyngeal carcinoma cells by targeting PI3K/Akt pathway

Bin Wang, Qianqian Gu, Jian Li
Pages: 317-324
Published online on: 06 June 2017

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Article

Silencing of ATM expression by siRNA technique contributes to glioma stem cell radiosensitivity in vitro and in vivo

Yan Li, Luchun Li, Zhijuan Wu, Lulu Wang, Yongzhong Wu, Dairong Li, Uiwen Ma, Jianghe Shao, Huiqing Yu, Donglin Wang
Pages: 325-335
Published online on: 24 May 2017

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Article

HIF-1α inhibits IDH-1 expression in osteosarcoma

Deng-Cheng Liu, Xun Zheng, Yong Zho, Wan-Rong Yi, Zong-Huan Li, Xiang Hu, Ai-Xi Yu
Pages: 336-342
Published online on: 22 May 2017

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Article

miR-1247-5p functions as a tumor suppressor in human hepatocellular carcinoma by targeting Wnt3

Yuankui Chu, Weining Fan, Wenwei Guo, Yixin Zhang, Lixin Wang, Le Guo, Xiangguo Duan, Jun Wei, Guangxian Xu
Pages: 343-351
Published online on: 06 June 2017

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Article

Overexpression of miR-15b-5p promotes gastric cancer metastasis by regulating PAQR3

Chengcheng Zhao, Yan Li, Gang Chen, Fen Wang, Zhili Shen, Rongping Zhou
Pages: 352-358
Published online on: 26 May 2017

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Article

Ginsenoside Rd regulates the Akt/mTOR/p70S6K signaling cascade and suppresses angiogenesis and breast tumor growth

Eryun Zhang, Hailian Shi, Li Yang, Xiaojun Wu, Zhengtao Wang
Pages: 359-367
Published online on: 19 May 2017

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Article

miR-204 regulates the biological behavior of breast cancer MCF-7 cells by directly targeting FOXA1

Si-Qiao Shen, Lan-Shan Huang, Xiao-Ling Xiao, Xiao-Fei Zhu, Dan-Dan Xiong, Xue-Mei Cao, Kang-Lai Wei, Gang Chen, Zhen-Bo Feng
Pages: 368-376
Published online on: 16 May 2017

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Article

DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression

Hongling Zhang, Xuhong Chen, Dongming Li, Lulu Cui, Xin Li, Xiufeng Ye, Xiaochun Wan
Pages: 377-383
Published online on: 30 May 2017

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Article

miR-370 regulates cell proliferation and migration by targeting EGFR in gastric cancer Corrigendum in /10.3892/or.2022.8409

Tao Ning, Haiyang Zhang, Xinyi Wang, Shuang Li, Le Zhang, Ting Deng, Likun Zhou, Rui Liu, Xia Wang, Ming Bai, Shaohua Ge, Hongli Li, Dingzhi Huang, Guoguang Ying, Yi Ba
Pages: 384-392
Published online on: 23 May 2017

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Article

miR-30e acts as a tumor suppressor in hepatocellular carcinoma partly via JAK1/STAT3 pathway

Junjie Mao, Xiaojun Hu, Pengfei Pang, Bin Zhou, Dan Li, Hong Shan
Pages: 393-401
Published online on: 30 May 2017

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Article

XAF1 expression levels in a non-small cell lung cancer cohort and its potential association with carcinogenesis

Luciene Schluckebier, Veronica Aran, Joyce De Moraes, Heitor Paiva, Cinthya Sternberg, Carlos Gil Ferreira
Pages: 402-410
Published online on: 30 May 2017

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Article

Construction of disease-specific transcriptional regulatory networks identifies co-activation of four gene in esophageal squamous cell carcinoma

Yu Zhao, Li Min, Changqin Xu, Linlin Shao, Shuilong Guo, Rui Cheng, Jie Xing, Shengtao Zhu, Shutian Zhang
Pages: 411-417
Published online on: 30 May 2017

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Article

Low HtrA1 expression in patients with long‑standing ulcerative colitis and colorectal cancer

Emma Altobelli, Giovanni Latella, Manrico Morroni, Caterina Licini, Giovanni Tossetta, Roberta Mazzucchelli, Valerio F. Profeta, Gino Coletti, Pietro Leocata, Mario Castellucci, Mario Guerrieri, Reimondo Petrocelli, Berardo De Berardis, Marina De Padova, Gabriella Di Leonardo, Antonella Paladini, Filippo Mignosi, Gina Quaglione, Roberto Fagnano, Daniela Marzioni
Pages: 418-426
Published online on: 06 June 2017

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Article

Overexpression of the YAP1 oncogene in clear cell renal cell carcinoma is associated with poor outcome

Agnieszka Rybarczyk, Jakub Klacz, Agata Wronska, Marcin Matuszewski, Zbigniew Kmiec, Piotr M. Wierzbicki
Pages: 427-439
Published online on: 15 May 2017

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Article

N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma

Kimihiro Nishino, Eiko Yamamoto, Kaoru Niimi, Yoko Sekiya, Yoriko Yamashita, Fumitaka Kikkawa
Pages: 440-448
Published online on: 23 May 2017

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Article

Tumor growth limited to subcutaneous site vs tumor growth in pulmonary site exhibit differential effects on systemic immunities

Junko Masuda, Eiji Takayama, Warren Strober, Ayano Satoh, Yuji Morimoto, Yasuko Honjo, Tatsuo Ichinohe, Shin-Ichi Tokuno, Toshiaki Ishizuka, Takahiro Nakata, Akifumi Mizutani, Naoki Umemura, Atsushi Kitani, Ivan J. Fuss, Tsukasa Shigehiro, Harumi Kawaki, Masako Mizuno-kamiya, Nobuo Kondoh, Masaharu Seno
Pages: 449-455
Published online on: 17 May 2017

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Article

Resveratrol inactivates PI3K/Akt signaling through upregulating BMP7 in human colon cancer cells

Yu-Hua Zeng, Lin-Yun Zhou, Qian-Zhao Chen, Yang Li, Ying Shao, Wen-Yan Ren, Yun-Peng Liao, Han Wang, Jia-Hui Zhu, Ming Huang, Fang He, Jin Wang, Ke Wu, Bai-Cheng He
Pages: 456-464
Published online on: 23 May 2017

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Article

Amplification and the clinical significance of circulating cell-free DNA of PVT1 in breast cancer

Xujing Li, Weijuan Chen, Hui Wang, Qun Wei, Xiaodi Ding, Wentong Li
Pages: 465-471
Published online on: 18 May 2017

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Article

The circadian clock gene PER2 plays an important role in tumor suppression through regulating tumor-associated genes in human oral squamous cell carcinoma Retraction in /10.3892/or.2025.8888

Xiaoli Su, Dan Chen, Kai Yang, Qin Zhao, Dan Zhao, Xiaoqiang Lv, Yiran Ao
Pages: 472-480
Published online on: 19 May 2017

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Article

KML001 and doxercalciferol induce synergistic antileukemic effect in acute lymphoid leukemia cells

Yang Liu, Dong-Yeop Shin, Somi Oh, Sujong Kim, Youngil Koh, Inho Kim
Pages: 481-487
Published online on: 01 June 2017

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Article

The blueberry component pterostilbene has potent anti-myeloma activity in bortezomib-resistant cells

Gege Chen, Zhijian Xu, Gaomei Chang, Jun Hou, Liangning Hu, Yiwen Zhang, Dandan Yu, Bo Li, Shuaikang Chang, Yongsheng Xie, Yong Zhang, Rong Wei, Huiqun Wu, Wenqin Xiao, Xi Sun, Yi Tao, Lu Gao, Bojie Dai, Jumei Shi, Weiliang Zhu
Pages: 488-496
Published online on: 30 May 2017

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Article

MicroRNA-497 acts as a tumor suppressor in gastric cancer and is downregulated by DNA methylation

Jichao Liu, Yongshuang Li, Ying Zou, Jiakui Zhang, Jiaxiang An, Jiao Guo, Minghui Ma, Dongqiu Dai
Pages: 497-505
Published online on: 06 June 2017

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Effects of galectin-9 on apoptosis, cell cycle and autophagy in human esophageal adenocarcinoma cells

Emiko Akashi, Shintaro Fujihara, Asahiro Morishita, Tomoko Tadokoro, Taiga Chiyo, Keiko Fujikawa, Hideki Kobara, Hirohito Mori, Hisakazu Iwama, Keiichi Okano, Yasuyuki Suzuki, Toshiro Niki, Mitsuomi Hirashima, Tsutomu Masaki
Pages: 506-514
Published online on: 01 June 2017

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Knockdown of homeobox containing 1 increases the radiosensitivity of cervical cancer cells through telomere shortening

Shuliang Zhou, Youde Xiao, Yafei Zhuang, Yinyin Liu, Hong Zhao, Hui Yang, Conghua Xie, Fuxiang Zhou, Yunfeng Zhou
Pages: 515-521
Published online on: 06 June 2017

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Article

Exosomes derived from hypoxic epithelial ovarian cancer deliver microRNA-940 to induce macrophage M2 polarization

Xin Chen, Xiang Ying, Xinjing Wang, Xiaoli Wu, Qinyi Zhu, Xipeng Wang
Pages: 522-528
Published online on: 06 June 2017

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Article

Methylated +322-327 CpG site decreases hOGG1 mRNA expression in non-small cell lung cancer

Yuanyuan Zeng, Jianjie Zhu, Hualong Qin, Dan Shen, Zhe Lei, Wei Li, Zongli Ding, Jian-An Huang, Zeyi Liu
Pages: 529-537
Published online on: 01 June 2017

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Coptidis Rhizoma induces intrinsic apoptosis through BAX and BAK activation in human melanoma

Xiaoou Xu, Satoru Yokoyama, Yoshihiro Hayakawa, Ikuo Saiki
Pages: 538-544
Published online on: 26 May 2017

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Article

Reciprocal antagonistic regulation of N-myc mRNA by miR‑17 and the neuronal-specific RNA-binding protein HuD

Leleesha Samaraweera, Barbara A. Spengler, Robert A. Ross
Pages: 545-550
Published online on: 24 May 2017

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Therapy-relevant aberrant expression of MRP3 and BCRP mRNA in TCC-/SCC-bladder cancer tissue of untreated patients

Mona Rady, Marwa Mostageer, Jan Rohde, Ashraf Zaghloul, Ruth Knüchel-Clarke, Shady Saad, Deena Attia, Laila Mahran, Hilde Spahn-Langguth
Pages: 551-560
Published online on: 02 June 2017

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Article

Treatment of colon cancer cells with 5-fluorouracil can improve the effectiveness of RNA-transfected antitumor dendritic cell vaccine

Carolina V. De Almeida, Jofer A. Zamame, Graziela G. Romagnoli, Cecilia P. Rodrigues, Marianna B. Magalhães, Amedeo Amedei, Ramon Kaneno
Pages: 561-568
Published online on: 01 June 2017

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Article

3,3'-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells

Xiaobo Zhang, Pakin Sukamporn, Shiqiang Zhang, Kyung-Won Min, Seung Joon Baek
Pages: 569-574
Published online on: 01 June 2017

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Article

Isoliquiritigenin inhibits the proliferation of human renal carcinoma Caki cells through the ROS-mediated regulation of the Jak2/STAT3 pathway

Do-Hee Kim, Ji Eun Park, In Gyeong Chae, Geumi Park, Sooyeun Lee, Kyung-Soo Chun
Pages: 575-583
Published online on: 30 May 2017

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Article

KLF2 inhibits cell growth via regulating HIF-1α/Notch-1 signal pathway in human colorectal cancer HCT116 cells

Hai-Gang Wang, Bin Cao, Li-Xian Zhang, Nan Song, Hui Li, Wen-Zeng Zhao, Yan-Shu Li, Shun-Mao Ma, Dong-Jian Yin
Pages: 584-590
Published online on: 06 June 2017

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Article

Intermittent low dose irradiation enhances the effectiveness of radio- and chemo-therapy for human colorectal adenocarcinoma cell line HT-29

Yang Wang, Yezhou Li, Li Yang, Dexin Yin
Pages: 591-597
Published online on: 30 May 2017

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Article

Arctigenin inhibits triple-negative breast cancers by targeting CIP2A to reactivate protein phosphatase 2A Corrigendum in /10.3892/or.2025.8925

Qiuyue Huang, Shanshan Qin, Xiaoning Yuan, Liang Zhang, Juanli Ji, Xuewen Liu, Wenjing Ma, Yunfei Zhang, Pengfei Liu, Zhiting Sun, Jingxuan Zhang, Ying Liu
Pages: 598-606
Published online on: 24 May 2017

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Journal Cover
May-2026 Volume 55 Issue 5

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

ZBTB7A promotes malignant phenotypes in ovarian cancer through transcriptional activation of CRLF1

Xiaobai Hao, Yu Chen
Article Number: 102
Published online on: 24 March 2026

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Article Open Access

MS4322 is a selective protein arginine methyltransferase 5 degrader with antitumor effects in cervical cancer cells

Rui Luo, Jingping Chen, Zhaojie Chen, Surong Wang, Tianfeng Liu, Yang Xu
Article Number: 101
Published online on: 24 March 2026

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Retraction Open Access

[Retracted] Roles of the SNHG7/microRNA‑9‑5p/DPP4 ceRNA network in the growth and 131I resistance of thyroid carcinoma cells through PI3K/Akt activation

Wanzhi Chen, Jichun Yu, Rong Xie, Tao Zhou, Chengfeng Xiong, Shuyong Zhang, Meijun Zhong
Article Number: 100
Published online on: 23 March 2026

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Andrographis exerts antitumor effects and enhances 5‑FU efficacy via the alteration of ferroptosis‑related genes in esophageal squamous cell carcinoma

Kosuke Yoshimura, Tadanobu Shimura, Ruiya Ma, Yaxuan Huang, Takahito Kitajima, Shinji Yamashita, Yuki Sato, Koki Higashi, Mikio Kawamura, Hiromi Yasuda, Yuhki Koike, Yoshiki Okita, Shigeyuki Yoshiyama, Minako Kobayashi, Masaki Ohi, Hiroki Ohge, Shinya Takahashi, Ajay Goel, Yoshinaga Okugawa, Yuji Toiyama
Article Number: 99
Published online on: 20 March 2026

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Sphingosine‑1‑phosphate receptor 1 enhances olfactory receptor 51E1‑mediated inhibition of proliferation via Src/JNK signaling in prostate cancer cells

Kiheon Kim, Jinwoo Lee, Chulwon Choi, Jungnam Bae, Hee-Jung Choi, Won-Ki Huh
Article Number: 98
Published online on: 19 March 2026

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Review Open Access

Mechanistic insights into the roles of astragalosides and Astragalus polysaccharides in gynecological and breast cancers (Review)

Ruixin Liu, Zhanyu Lin, Yuelin Li, Yuetong Ci, Zhengqi Guo, Zhenguo Xu
Article Number: 97
Published online on: 19 March 2026

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Retraction Open Access

[Retracted] Inhibition of tankyrase 1 in human gastric cancer cells enhances telomere shortening by telomerase inhibitors 

Hao Zhang, Meng-Hua Yang, Jing-Jing Zhao, Ling Chen, Song-Tao Yu, Xu-Dong Tang, Dian-Chun Fang, Shi-Ming Yang
Article Number: 96
Published online on: 16 March 2026

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Silencing of SIVA‑1 promotes cisplatin resistance in gastric cancer via the Bcl‑2/BAX‑mediated mitochondria‑dependent apoptosis pathway

Zheng-Yi Shi, Zheng-Rong Ding, Yu-Liang Huang, Yuan-Rui Lei, Hai-Bin Huang, Yan Qing, Miao-Ren Deng, Xu-Man Lu, Xu-Dong Dong, Long-Jie Xia, Sheng Xu, Xiao-Gang Zhong, Lei Li, Fan-Biao Kong, Xiao-Tong Wang
Article Number: 95
Published online on: 13 March 2026

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Article Open Access

Depleting HIF‑1α attenuates the progression of osteosarcoma, but tumorigenicity is sustained through HIF‑independent pathways

Ayaka Kunishima, Takatsune Shimizu, Tetsuya Takimoto, Atsunobu Sagara, Hiroyuki Nobusue, Hidetoshi Hasuwa, Shinya Hasegawa, Yuka Tamaoki, Hitomi Miyake, Yumi Fukuchi, Hideyuki Saya, Akihiro Muto
Article Number: 94
Published online on: 12 March 2026

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Unveiling the role of ANGPT2 in esophageal cancer: A prognostic factor and potential oncogene

Zhigang Zhai, Zhenyu Xue, Yuan Fang, Yixu Fan, Shijiao Li, Yunpeng Yu, Chuansheng Chen, Kaijun Zhang, Deyu Chen, Xiang Tang, Rui Ling
Article Number: 93
Published online on: 12 March 2026

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Article Open Access

POLQ promotes tumor progression and immunosuppression via ATM‑P53 signaling in endometrial cancer

Ningning Zhu, Juanjuan Wang, Xiaoli Zhang, Kai Tang, Lei Gong, Yi Hu
Article Number: 92
Published online on: 11 March 2026

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Correction Open Access

[Corrigendum] 3‑Bromopyruvate and sodium citrate target glycolysis, suppress survivin, and induce mitochondrial‑mediated apoptosis in gastric cancer cells and inhibit gastric orthotopic transplantation tumor growth

Ting-An Wang, Xiao-Dong Zhang, Xing-Yu Guo, Shu-Lin Xian, Yun-Fei Lu
Article Number: 91
Published online on: 11 March 2026

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Review Open Access

Unveiling the molecular landscape: Long non-coding RNAs in neuroblastoma (Review)

Zidong Xia, Huishan Zhai, Lei Zheng, Cheng Wang
Article Number: 90
Published online on: 09 March 2026

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Retraction Open Access

[Retracted] Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine‑γ‑lyase function

Liangyu Chen, Xinxing Li, Libo Liu, Bo Yu, Yixue Xue, Yunhui Liu
Article Number: 89
Published online on: 09 March 2026

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Review Open Access

Advances in the application of frailty scoring in the diagnosis and management of elderly patients with multiple myeloma (Review)

Junlun Liu, Danyu Li, Chao Li, Zhuoren Chen
Article Number: 88
Published online on: 06 March 2026

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Expression of Concern Open Access

[Expression of Concern] c‑Fos/ERK promotes the progression from pancreatic intraepithelial neoplasia to pancreatic ductal adenocarcinoma 

Lei You, Xiaoxia Ren, Yongxing Du, Wenjing Zhao, Ming Cui, Ge Chen, Yupei Zhao
Article Number: 87
Published online on: 05 March 2026

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Review Open Access

CXCL1 in triple‑negative breast cancer: Mechanisms, challenges, and therapeutic opportunities (Review)

Hiba Al Sayegh, Zahraa Assi, Amjad Kanaan, Mirvat El Sibai
Article Number: 86
Published online on: 03 March 2026

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Article Open Access

Cellular and inflammatory characteristics of patient‑derived glioblastoma organoids during in vitro cultivation

Jessica Nojszewski, Nils Oliver Schröder, Jacqueline Clüver, Jonna Holler, Hajrullah Ahmeti, Michael Synowitz, Janka Held-Feindt
Article Number: 85
Published online on: 02 March 2026

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Retraction Open Access

[Retracted] Growth and differentiation factor‑9 promotes adhesive and motile capacity of prostate cancer cells by up‑regulating FAK and Paxillin via Smad dependent pathway 

Sivan M. Bokobza, Lin Ye, Howard G. Kynaston, Wen G. Jiang
Article Number: 84
Published online on: 02 March 2026

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Article Open Access

Platycodin D sensitizes head and neck squamous cell carcinoma to cisplatin by inducing autophagy arrest

Minji Bae, Min Kyeong Lee, Mi Gyeong Jeong, Yeonseo Lee, Harim Joo, Young Chan Lee, Jung Woo Lee, Su Il Kim, Seong-Gyu Ko, Young-Gyu Eun
Article Number: 83
Published online on: 27 February 2026

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Article Open Access

ACSBG1‑driven lipid reprogramming unveiled: A fatty acid metabolism‑associated prognostic model for lung adenocarcinoma

Panxin Hu, Anan Li
Article Number: 82
Published online on: 27 February 2026

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Article Open Access

Knockdown of CCT2 inhibits the malignant progression of hepatocellular carcinoma cells by impairing STAT3 activation

Chao Li, Lei Yang, Yudong Zhang, Baocheng Zhao, Hao Qu
Article Number: 81
Published online on: 25 February 2026

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Retraction Open Access

[Retracted] Songorine suppresses cell growth and metastasis in epithelial ovarian cancer via the Bcl‑2/Bax and GSK3β/β‑catenin signaling pathways

Hongxia Zhang, Ruifeng Dong, Ping Zhang, Yankui Wang
Article Number: 80
Published online on: 25 February 2026

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Journal Cover
June-2026 Volume 55 Issue 6

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Expression of Concern Open Access

[Expression of Concern] Adenovirus‑mediated truncated Bid overexpression induced by the Cre/LoxP system promotes the cell apoptosis of CD133+ ovarian cancer stem cells

Qifang Long, Ru Yang, Weixian Lu, Weipei Zhu, Jundong Zhou, Cui Zheng, Dongmei Zhou, Ling Yu, Jinchang Wu
Article Number: 116
Published online on: 15 April 2026

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Incorporating artificial intelligence into morphological diagnosis of acute leukemias: Current landscape, challenges and prospects (Review)

Hui Cheng, Guodong Zheng, Yuanyuan Yang, Chun Xu, Gusheng Tang, Chongmei Huang
Article Number: 115
Published online on: 15 April 2026

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Article Open Access

Mechanistic study of MUC3A in promoting progression of clear cell renal cell carcinoma via the JAK‑STAT pathway

Yongyang Yun, Xing Ji, Shuai Hu, Tianyu Wu, Yixiao Liu, Zheng Li, Zhoujie Sun, Peimin Zhou, Lei Yang, Wei Yu
Article Number: 114
Published online on: 14 April 2026

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Article Open Access

Perturbation of BRD4 and p300 activity suppresses super enhancer‑driven KLF6 expression in renal carcinoma

Nurul Nadia Mohamad Zamberi, Asmaa Y. Abuhamad, Siti Nur Hasanah Mohd Yusuf, Nur Qurratu Athirah A. Rahman, Mohamad Aimanuddin Mohtar, Saiful Effendi Syafruddin
Article Number: 113
Published online on: 14 April 2026

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PINK1‑mediated mitophagy enhances breast cancer proliferation through metabolic reprogramming

Zong Jin Guo, Qian Yu, Rui Sha, Wei Li, Hui Juan Dai
Article Number: 112
Published online on: 14 April 2026

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Expression of Concern Open Access

[Expression of Concern] Metformin inhibits growth and sensitizes osteosarcoma cell lines to cisplatin through cell cycle modulation

Irene Quattrini, Amalia Conti, Laura Pazzaglia, Chiara Novello, Stefano Ferrari, Piero Picci, Maria Serena Benassi
Article Number: 111
Published online on: 08 April 2026

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NF‑κB‑driven LUZP1 promotes metastasis and chemoresistance in head and neck squamous cell carcinoma

Chen-Yuan Lin, Ching-Yun Hsieh, Hsin-Chi Lan, Ching-Chan Lin, Tzu-Ting Chen, Wei-Chi Tseng, Yung-An Tsou, Wei-Chao Chang
Article Number: 110
Published online on: 07 April 2026

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Article Open Access

Hypoxic CAF studies unveil PTHrP‑vitamin D‑RAS axis as pivotal in the CAF

Shoichiro Nakajo, Mamoru Uemura, Hiroshi Kusafuka, Mao Osaki, Chikako Kusunoki, Nobuo Takiguchi, Mitsunobu Takeda, Yuki Sekido, Tsuyoshi Hata, Atsushi Hamabe, Takayuki Ogino, Norikatsu Miyoshi, Mitsuyoshi Tei, Yoshinori Kagawa, Hirofumi Yamamoto, Yuichiro Doki, Hidetoshi Eguchi
Article Number: 109
Published online on: 07 April 2026

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Retraction Open Access

[Retracted] miR‑24‑3p regulates bladder cancer cell proliferation, migration, invasion and autophagy by targeting DEDD

Guoqiang Yu, Zhaohui Jia, Zhongling Dou
Article Number: 108
Published online on: 06 April 2026

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Role of CHD4 in tumor progression, DNA damage response and treatment resistance (Review)

Shuo Li, Quan Ma, Keying Lian, Zhisheng Jiang, Yun Ma
Article Number: 107
Published online on: 02 April 2026

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T cell fate regulation in EBV‑associated nasopharyngeal carcinoma (Review)

Liuyang Zhang, Shun Ding, Dongzhui Chen, Benchi Cai, Zhonglin Mu
Article Number: 106
Published online on: 02 April 2026

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Retraction Open Access

[Retracted] Ultrasound‑targeted microbubble destruction‑mediated overexpression of Sirtuin 3 inhibits the progression of ovarian cancer

Li Cheng, Dongmei Zhang, Wei Yan
Article Number: 105
Published online on: 02 April 2026

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Review Open Access

HMGB3: A pivotal orchestrator of therapy resistance and cancer stemness in human malignancies (Review)

Ju Zhang, Yifan Sun, Lanyu Wang, Jiayu Gu, Ye Hua, Jianfeng Shao, Ninghan Feng
Article Number: 104
Published online on: 01 April 2026

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Expression of Concern Open Access

[Expression of Concern] 5‑Azacytidine inhibits the proliferation of bladder cancer cells via reversal of the aberrant hypermethylation of the hepaCAM gene

Xiaorong Wang, E. Chen, Xue Yang, Yin Wang, Zhen Quan, Xiaohou Wu, Chunli Luo
Article Number: 103
Published online on: 30 March 2026

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