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Article

NHERF1 inhibits proliferation of triple-negative breast cancer cells by suppressing GPER signaling

  • Authors:
    • Yan Wang
    • Zhiqiang Peng
    • Ran Meng
    • Tao Tao
    • Qiqi Wang
    • Chunjuan Zhao
    • Hua Liu
    • Ran Song
    • Junfang Zheng
    • Qiong Qin
    • Junqi He
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Capital Medical University, Beijing 100069, P.R. China
  • Pages: 221-228
    |
    Published online on: May 18, 2017
       https://doi.org/10.3892/or.2017.5649
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Abstract

G protein-coupled estrogen receptor (GPER) signaling is activated in triple-negative breast cancer (TNBC); however, the detailed mechanisms of its regulation remain unclear. The present study aimed to elucidate the molecular mechanisms involved in GPER activation in TNBC. In MDA-MB-231 cells, a TNBC cell line, NHERF1 interaction with GPER was verified by co-immunoprecipitation and immunofluorescent staining assays. Overexpression of NHERF1 in MDA-MB-231 cells inhibited GPER-mediated proliferation and phosphorylation of ERK1/2 and Akt. Furthermore, NHERF1 expression levels were negatively correlated with the gene signatures of GPER activation, ERK1/2 and Akt signaling, and cell proliferation in early stage of TNBC tumors from the TCGA data set. Taken together, NHERF1 inhibited the activation of GPER-mediated signaling and suppressed the proliferation of triple-negative breast cancer cells. Loss of NHERF1 expression may play a pivotal role in the early stage of TNBC carcinogenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Peng Z, Meng R, Tao T, Wang Q, Zhao C, Liu H, Song R, Zheng J, Qin Q, Qin Q, et al: NHERF1 inhibits proliferation of triple-negative breast cancer cells by suppressing GPER signaling. Oncol Rep 38: 221-228, 2017.
APA
Wang, Y., Peng, Z., Meng, R., Tao, T., Wang, Q., Zhao, C. ... He, J. (2017). NHERF1 inhibits proliferation of triple-negative breast cancer cells by suppressing GPER signaling. Oncology Reports, 38, 221-228. https://doi.org/10.3892/or.2017.5649
MLA
Wang, Y., Peng, Z., Meng, R., Tao, T., Wang, Q., Zhao, C., Liu, H., Song, R., Zheng, J., Qin, Q., He, J."NHERF1 inhibits proliferation of triple-negative breast cancer cells by suppressing GPER signaling". Oncology Reports 38.1 (2017): 221-228.
Chicago
Wang, Y., Peng, Z., Meng, R., Tao, T., Wang, Q., Zhao, C., Liu, H., Song, R., Zheng, J., Qin, Q., He, J."NHERF1 inhibits proliferation of triple-negative breast cancer cells by suppressing GPER signaling". Oncology Reports 38, no. 1 (2017): 221-228. https://doi.org/10.3892/or.2017.5649
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Peng Z, Meng R, Tao T, Wang Q, Zhao C, Liu H, Song R, Zheng J, Qin Q, Qin Q, et al: NHERF1 inhibits proliferation of triple-negative breast cancer cells by suppressing GPER signaling. Oncol Rep 38: 221-228, 2017.
APA
Wang, Y., Peng, Z., Meng, R., Tao, T., Wang, Q., Zhao, C. ... He, J. (2017). NHERF1 inhibits proliferation of triple-negative breast cancer cells by suppressing GPER signaling. Oncology Reports, 38, 221-228. https://doi.org/10.3892/or.2017.5649
MLA
Wang, Y., Peng, Z., Meng, R., Tao, T., Wang, Q., Zhao, C., Liu, H., Song, R., Zheng, J., Qin, Q., He, J."NHERF1 inhibits proliferation of triple-negative breast cancer cells by suppressing GPER signaling". Oncology Reports 38.1 (2017): 221-228.
Chicago
Wang, Y., Peng, Z., Meng, R., Tao, T., Wang, Q., Zhao, C., Liu, H., Song, R., Zheng, J., Qin, Q., He, J."NHERF1 inhibits proliferation of triple-negative breast cancer cells by suppressing GPER signaling". Oncology Reports 38, no. 1 (2017): 221-228. https://doi.org/10.3892/or.2017.5649
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