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Article Open Access

Fangchinoline suppresses growth and metastasis of melanoma cells by inhibiting the phosphorylation of FAK

Retraction in: /10.3892/or.2024.8740
  • Authors:
    • Jie Shi
    • Bingyu Guo
    • Qiang Hui
    • Peng Chang
    • Kai Tao
  • View Affiliations / Copyright

    Affiliations: Department of Reconstructive and Plastic Surgery, The General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, P.R. China
    Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 63-70
    |
    Published online on: May 30, 2017
       https://doi.org/10.3892/or.2017.5678
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Abstract

Melanoma is a malignant tumor with high degree of malignancy, metastasis and high mortality. The etiology of melanoma has not been fully elucidated, and there is no effective drug for the complete treatment of melanoma. In recent years, many traditional Chinese herbal medicines have played an important role in clinical treatment and experimental research on cancer. As a natural product, fangchinoline has the characteristics of enhancing immune function, low toxicity and good liver protection features, so it is considered to be a new type of anticancer drug. In the present study, we found that fangchinoline has inhibitory effects on the proliferation and metastasis of A375 and A875 cells in a concentration-dependent manner. Fangchinoline inhibited the proliferation of A375 and A875 cell activity with IC50 values of 12.41 and 16.20 µM. We also found that fangchinoline could significantly reduce the phosphorylation of Focal adhesion kinase (FAK). In summary, we demonstrated that fangchinoline inhibits the proliferation and metastasis of melanoma cells by suppressing FAK and its downstream signaling pathway. More importantly, we provide a novel mechanism that fangchinoline could be an effective candidate for the treatment of melanoma.
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1 

Satow R, Nakamura T, Kato C, Endo M, Tamura M, Batori R, Tomura S, Murayama Y and Fukami K: ZIC5 drives melanoma aggressiveness by PDGFD-mediated activation of FAK and STAT3. Cancer Res. 77:366–377. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Yang J, Price MA, Neudauer CL, Wilson C, Ferrone S, Xia H, Iida J, Simpson MA and McCarthy JB: Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms. J Cell Biol. 165:881–891. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Frame MC and Serrels A: FAK to the rescue: Activated stroma promotes a ‘safe haven’ for BRAF-mutant melanoma cells by inducing FAK signaling. Cancer Cell. 27:429–431. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Kolli-Bouhafs K, Sick E, Noulet F, Gies JP, De Mey J and Rondé P: FAK competes for Src to promote migration against invasion in melanoma cells. Cell Death Dis. 5:e13792014. View Article : Google Scholar : PubMed/NCBI

5 

Kurenova E, Ucar D, Liao J, Yemma M, Gogate P, Bshara W, Sunar U, Seshadri M, Hochwald SN and Cance WG: A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cells. Cell Cycle. 13:2542–2553. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Luo X, Peng JM, Su LD, Wang DY and Yu YJ: Fangchinoline inhibits the proliferation of SPC-A-1 lung cancer cells by blocking cell cycle progression. Exp Ther Med. 11:613–618. 2016.PubMed/NCBI

7 

Li D, Lu Y, Sun P, Feng LX, Liu M, Hu LH, Wu WY, Jiang BH, Yang M, Qu XB, et al: Inhibition on proteasome β1 subunit might contribute to the anti-cancer effects of fangchinoline in human prostate cancer cells. PLoS One. 10:e01416812015. View Article : Google Scholar : PubMed/NCBI

8 

Sun YF and Wink M: Tetrandrine and fangchinoline, bisbenzylisoquinoline alkaloids from Stephania tetrandra can reverse multidrug resistance by inhibiting P-glycoprotein activity in multidrug resistant human cancer cells. Phytomedicine. 21:1110–1119. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Wang CD, Huang JG, Gao X, Li Y, Zhou SY, Yan X, Zou A, Chang JL, Wang YS, Yang GX, et al: Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograft. Biosci Biotechnol Biochem. 74:488–493. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Wang CD, Yuan CF, Bu YQ, Wu XM, Wan JY, Zhang L, Hu N, Liu XJ, Zu Y, Liu GL, et al: Fangchinoline inhibits cell proliferation via Akt/GSK-3beta/cyclin D1 signaling and induces apoptosis in MDA-MB-231 breast cancer cells. Asian Pac J Cancer Prev. 15:769–773. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Xing Z, Zhang Y, Zhang X, Yang Y, Ma Y and Pang D: Fangchinoline induces G1 arrest in breast cancer cells through cell-cycle regulation. Phytother Res. 27:1790–1794. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Smith CS, Golubovskaya VM, Peck E, Xu LH, Monia BP, Yang X and Cance WG: Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines. Melanoma Res. 15:357–362. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Sonoda Y, Hada N, Kaneda T, Suzuki T, Ohshio T, Takeda T and Kasahara T: A synthetic glycosphingolipid-induced antiproliferative effect in melanoma cells is associated with suppression of FAK, Akt, and Erk activation. Biol Pharm Bull. 31:1279–1283. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Thapa B, Koo BH, Kim YH, Kwon HJ and Kim DS: Plasminogen activator inhibitor-1 regulates infiltration of macrophages into melanoma via phosphorylation of FAK-Tyr925. Biochem Biophys Res Commun. 450:1696–1701. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Kurenova E, Xu LH, Yang X, Baldwin AS Jr, Craven RJ, Hanks SK, Liu ZG and Cance WG: Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein. Mol Cell Biol. 24:4361–4371. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Golubovskaya VM, Finch R and Cance WG: Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. J Biol Chem. 280:25008–25021. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Sonoda Y, Matsumoto Y, Funakoshi M, Yamamoto D, Hanks SK and Kasahara T: Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60. J Biol Chem. 275:16309–16315. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Golubovskaya VM: Targeting FAK in human cancer: From finding to first clinical trials. Front Biosci (Landmark Ed). 19:687–706. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Shibue T and Weinberg RA: Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc Natl Acad Sci USA. 106:10290–10295. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Kaneda T, Sonoda Y, Ando K, Suzuki T, Sasaki Y, Oshio T, Tago M and Kasahara T: Mutation of Y925F in focal adhesion kinase (FAK) suppresses melanoma cell proliferation and metastasis. Cancer Lett. 270:354–361. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Krifa M, El Meshri SE, Bentouati N, Pizzi A, Sick E, Chekir-Ghedira L and Rondé P: In vitro and in vivo anti-melanoma effects of pituranthos tortuosus essential oil via inhibition of FAK and Src activities. J Cell Biochem. 117:1167–1175. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Yajima I, Kumasaka MY, Yamanoshita O, Zou C, Li X, Ohgami N and Kato M: GNG2 inhibits invasion of human malignant melanoma cells with decreased FAK activity. Am J Cancer Res. 4:182–188. 2014.PubMed/NCBI

23 

Tian F, Ding D and Li D: Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells. Int J Oncol. 46:2355–2363. 2015.PubMed/NCBI

24 

Wang N, Pan W, Zhu M, Zhang M, Hao X, Liang G and Feng Y: Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells. Br J Pharmacol. 164:731–742. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Xing ZB, Yao L, Zhang GQ, Zhang XY, Zhang YX and Pang D: Fangchinoline inhibits breast adenocarcinoma proliferation by inducing apoptosis. Chem Pharm Bull (Tokyo). 59:1476–1480. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Guo B, Su J, Zhang T, Wang K and Li X: Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549. J Drug Target. 23:266–274. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Guo B, Xie P, Su J, Zhang T, Li X and Liang G: Fangchinoline suppresses the growth and invasion of human glioblastoma cells by inhibiting the kinase activity of Akt and Akt-mediated signaling cascades. Tumour Biol. 37:2709–2719. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shi J, Guo B, Hui Q, Chang P and Tao K: Fangchinoline suppresses growth and metastasis of melanoma cells by inhibiting the phosphorylation of FAK Retraction in /10.3892/or.2024.8740. Oncol Rep 38: 63-70, 2017.
APA
Shi, J., Guo, B., Hui, Q., Chang, P., & Tao, K. (2017). Fangchinoline suppresses growth and metastasis of melanoma cells by inhibiting the phosphorylation of FAK Retraction in /10.3892/or.2024.8740. Oncology Reports, 38, 63-70. https://doi.org/10.3892/or.2017.5678
MLA
Shi, J., Guo, B., Hui, Q., Chang, P., Tao, K."Fangchinoline suppresses growth and metastasis of melanoma cells by inhibiting the phosphorylation of FAK Retraction in /10.3892/or.2024.8740". Oncology Reports 38.1 (2017): 63-70.
Chicago
Shi, J., Guo, B., Hui, Q., Chang, P., Tao, K."Fangchinoline suppresses growth and metastasis of melanoma cells by inhibiting the phosphorylation of FAK Retraction in /10.3892/or.2024.8740". Oncology Reports 38, no. 1 (2017): 63-70. https://doi.org/10.3892/or.2017.5678
Copy and paste a formatted citation
x
Spandidos Publications style
Shi J, Guo B, Hui Q, Chang P and Tao K: Fangchinoline suppresses growth and metastasis of melanoma cells by inhibiting the phosphorylation of FAK Retraction in /10.3892/or.2024.8740. Oncol Rep 38: 63-70, 2017.
APA
Shi, J., Guo, B., Hui, Q., Chang, P., & Tao, K. (2017). Fangchinoline suppresses growth and metastasis of melanoma cells by inhibiting the phosphorylation of FAK Retraction in /10.3892/or.2024.8740. Oncology Reports, 38, 63-70. https://doi.org/10.3892/or.2017.5678
MLA
Shi, J., Guo, B., Hui, Q., Chang, P., Tao, K."Fangchinoline suppresses growth and metastasis of melanoma cells by inhibiting the phosphorylation of FAK Retraction in /10.3892/or.2024.8740". Oncology Reports 38.1 (2017): 63-70.
Chicago
Shi, J., Guo, B., Hui, Q., Chang, P., Tao, K."Fangchinoline suppresses growth and metastasis of melanoma cells by inhibiting the phosphorylation of FAK Retraction in /10.3892/or.2024.8740". Oncology Reports 38, no. 1 (2017): 63-70. https://doi.org/10.3892/or.2017.5678
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