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Article

Inactivation of AKT, ERK and NF-κB by genistein derivative, 7-difluoromethoxyl-5,4'-di-n-octylygenistein, reduces ovarian carcinoma oncogenicity

  • Authors:
    • Yingxia Ning
    • Meng Xu
    • Xiaocheng Cao
    • Xiangding Chen
    • Xin Luo
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China, Department of Oncology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510120, P.R. China, Laboratory of Molecular and Statistical Genetics, Hunan Normal University, Changsha, Hunan 410081, P.R. China
  • Pages: 949-958
    |
    Published online on: June 9, 2017
       https://doi.org/10.3892/or.2017.5709
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Abstract

Cancer stem cells (CSCs) have central functions in cancer formation and development. Aberrant expression of AKT, ERK and NF-κB signaling pathways have been reported in several types of CSCs. Phytochemicals from dietary compounds possess anti-CSC properties, and have been characterized as promising therapeutic agents for the prevention and treatment of many types of cancers. We previously showed that the newly synthesized genistein derivative, 7-difluoromethoxyl-5,4'-di-n-octylygenistein (DFOG), can inhibit the self-renewal ability of ovarian cancer stem cells (OVCSLCs). In the present study, we further assessed whether various signaling pathways are regulated by DFOG. We found that spheroids derived from the SKOV3 cell line possessed OVCSLC properties and DFOG efficiently inhibited the stemness of the OVCSLCs. In addition, the suppression of spheroid and colony formation by DFOG was associated with inhibition of AKT and ERK1/2 protein phosphorylation, and NF-κB activity in OVCSLCs from the SKOV3 cells. Importantly, DFOG inhibited the oncogenicity of the OVCSLCs by activation of FoxO3a and/or inactivation of FoxM1 by the targeting of multiple pro-survival (AKT and ERK1/2) and proinflammatory (NF-κB) pathways, providing a new avenue for the treatment of ovarian carcinoma in humans.
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Copy and paste a formatted citation
Spandidos Publications style
Ning Y, Xu M, Cao X, Chen X and Luo X: Inactivation of AKT, ERK and NF-κB by genistein derivative, 7-difluoromethoxyl-5,4'-di-n-octylygenistein, reduces ovarian carcinoma oncogenicity. Oncol Rep 38: 949-958, 2017.
APA
Ning, Y., Xu, M., Cao, X., Chen, X., & Luo, X. (2017). Inactivation of AKT, ERK and NF-κB by genistein derivative, 7-difluoromethoxyl-5,4'-di-n-octylygenistein, reduces ovarian carcinoma oncogenicity. Oncology Reports, 38, 949-958. https://doi.org/10.3892/or.2017.5709
MLA
Ning, Y., Xu, M., Cao, X., Chen, X., Luo, X."Inactivation of AKT, ERK and NF-κB by genistein derivative, 7-difluoromethoxyl-5,4'-di-n-octylygenistein, reduces ovarian carcinoma oncogenicity". Oncology Reports 38.2 (2017): 949-958.
Chicago
Ning, Y., Xu, M., Cao, X., Chen, X., Luo, X."Inactivation of AKT, ERK and NF-κB by genistein derivative, 7-difluoromethoxyl-5,4'-di-n-octylygenistein, reduces ovarian carcinoma oncogenicity". Oncology Reports 38, no. 2 (2017): 949-958. https://doi.org/10.3892/or.2017.5709
Copy and paste a formatted citation
x
Spandidos Publications style
Ning Y, Xu M, Cao X, Chen X and Luo X: Inactivation of AKT, ERK and NF-κB by genistein derivative, 7-difluoromethoxyl-5,4'-di-n-octylygenistein, reduces ovarian carcinoma oncogenicity. Oncol Rep 38: 949-958, 2017.
APA
Ning, Y., Xu, M., Cao, X., Chen, X., & Luo, X. (2017). Inactivation of AKT, ERK and NF-κB by genistein derivative, 7-difluoromethoxyl-5,4'-di-n-octylygenistein, reduces ovarian carcinoma oncogenicity. Oncology Reports, 38, 949-958. https://doi.org/10.3892/or.2017.5709
MLA
Ning, Y., Xu, M., Cao, X., Chen, X., Luo, X."Inactivation of AKT, ERK and NF-κB by genistein derivative, 7-difluoromethoxyl-5,4'-di-n-octylygenistein, reduces ovarian carcinoma oncogenicity". Oncology Reports 38.2 (2017): 949-958.
Chicago
Ning, Y., Xu, M., Cao, X., Chen, X., Luo, X."Inactivation of AKT, ERK and NF-κB by genistein derivative, 7-difluoromethoxyl-5,4'-di-n-octylygenistein, reduces ovarian carcinoma oncogenicity". Oncology Reports 38, no. 2 (2017): 949-958. https://doi.org/10.3892/or.2017.5709
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