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P18 peptide, a functional fragment of pigment epithelial-derived factor, inhibits angiogenesis in hepatocellular carcinoma via modulating VEGF/VEGFR2 signalling pathway

  • Authors:
    • Xin Wang
    • Peng Xiu
    • Fuhai Wang
    • Jingtao Zhong
    • Honglong Wei
    • Zongzhen Xu
    • Feng Liu
    • Jie Li
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong 250014, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 755-766
    |
    Published online on: June 14, 2017
       https://doi.org/10.3892/or.2017.5719
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Abstract

The P18 peptide is a functional fragment of pigment epithelial-derived factor (PEDF), which is an endogenic angiogenesis inhibitor. This study sought to determine the anti-angiogenic bioactivity of the P18 peptide in hepato­cellular carcinoma (HCC) and to elucidate the underlying mechanism. Xenograft tumour growth assays demonstrated the P18 peptide suppressed angiogenesis of HCC in vivo. Wound healing, Transwell and Matrigel-culture assays indicated that the P18 peptide inhibited the cell migration and tube formation of endothelial cells (ECs) in vitro. Cell viability and apoptosis assessed by Cell Counting Kit-8 (CCK-8) and flow cytometry assays suggested that the P18 peptide inhibited angiogenesis by inducing apoptosis of ECs. Angiogenesis- and signal transduction-associated molecules analysed by western blot demonstrated that the P18 peptide targets vascular endothelial cell growth factor receptor 2 (VEGFR2) on ECs. In conclusion, by inhibiting the phosphorylation of VEGFR2, the P18 peptide modulates signalling transduction between VEGF/VEGFR2 and suppresses activation of the PI3K/Akt cascades, leading to an increase in mitochondrial-mediated apoptosis and anti-angiogenic activity. This bioactivity of the P18 peptide may represent a novel therapeutic strategy for the treatment of HCC.
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View References

1 

Carmeliet P: Angiogenesis in life, disease and medicine. Nature. 438:932–936. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Hanahan D and Folkman J: Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 86:353–364. 1996. View Article : Google Scholar : PubMed/NCBI

3 

Schlieve CR, Mojica SG, Holoyda KA, Hou X, Fowler KL and Grikscheit TC: Vascular endothelial growth factor (VEGF) bioavailability regulates angiogenesis and intestinal stem and progenitor cell proliferation during postnatal small intestinal development. PLoS One. 11:e01513962016. View Article : Google Scholar : PubMed/NCBI

4 

Li Y, Turpin CP and Wang S: Role of thrombospondin 1 in liver diseases. Hepatol Res. Aug 4–2016.(Epub ahead of print).

5 

Zhu AX, Duda DG, Sahani DV and Jain RK: HCC and angiogenesis: Possible targets and future directions. Nat Rev Clin Oncol. 8:292–301. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Atta MM, Atta HM, Gad MA, Rashed LA, Said EM, Hassanien Sel-S and Kaseb AO: Clinical significance of vascular endothelial growth factor in hepatitis C related hepatocellular carcinoma in Egyptian patients. J Hepatocell Carcinoma. 3:19–24. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Welker MW and Trojan J: Anti-angiogenesis in hepatocellular carcinoma treatment: Current evidence and future perspectives. World J Gastroenterol. 17:3075–3081. 2011.PubMed/NCBI

8 

Edeline J, Boucher E, Rolland Y, Vauléon E, Pracht M, Perrin C, Le Roux C and Raoul JL: Comparison of tumor response by Response Evaluation Criteria in Solid Tumors (RECIST) and modified RECIST in patients treated with sorafenib for hepatocellular carcinoma. Cancer. 118:147–156. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Dawson DW, Volpert OV, Gillis P, Crawford SE, Xu H, Benedict W and Bouck NP: Pigment epithelium-derived factor: A potent inhibitor of angiogenesis. Science. 285:245–248. 1999. View Article : Google Scholar : PubMed/NCBI

10 

He X, Cheng R, Benyajati S and Ma JX: PEDF and its roles in physiological and pathological conditions: Implication in diabetic and hypoxia-induced angiogenic diseases. Clin Sci (Lond). 128:805–823. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Belkacemi L and Zhang SX: Anti-tumor effects of pigment epithelium-derived factor (PEDF): Implication for cancer therapy. A mini-review. J Exp Clin Cancer Res. 35:42016. View Article : Google Scholar : PubMed/NCBI

12 

Smith ND, Schulze-Hoepfner FT, Veliceasa D, Filleur S, Shareef S, Huang L, Huang XM and Volpert OV: Pigment epithelium-derived factor and interleukin-6 control prostate neuroendocrine differentiation via feed-forward mechanism. J Urol. 179:2427–2434. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Filleur S, Volz K, Nelius T, Mirochnik Y, Huang H, Zaichuk TA, Aymerich MS, Becerra SP, Yap R, Veliceasa D, et al: Two functional epitopes of pigment epithelial-derived factor block angiogenesis and induce differentiation in prostate cancer. Cancer Res. 65:5144–5152. 2005. View Article : Google Scholar : PubMed/NCBI

14 

He SS, Shi HS, Yin T, Li YX, Luo ST, Wu QJ, Lu L, Wei YQ and Yang L: AAV-mediated gene transfer of human pigment epithelium-derived factor inhibits Lewis lung carcinoma growth in mice. Oncol Rep. 27:1142–1148. 2012.PubMed/NCBI

15 

Broadhead ML, Dass CR and Choong PF: Systemically administered PEDF against primary and secondary tumours in a clinically relevant osteosarcoma model. Br J Cancer. 105:1503–1511. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Hase R, Miyamoto M, Uehara H, Kadoya M, Ebihara Y, Murakami Y, Takahashi R, Mega S, Li L, Shichinohe T, et al: Pigment epithelium-derived factor gene therapy inhibits human pancreatic cancer in mice. Clin Cancer Res. 11:8737–8744. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Mirochnik Y, Aurora A, Schulze-Hoepfner FT, Deabes A, Shifrin V, Beckmann R, Polsky C and Volpert OV: Short pigment epithelial-derived factor-derived peptide inhibits angiogenesis and tumor growth. Clin Cancer Res. 15:1655–1663. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Hicklin DJ and Ellis LM: Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol. 23:1011–1027. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Zsebik B, Symonowicz K, Saleh Y, Ziolkowski P, Bronowicz A and Vereb G: Photodynamic therapy combined with a cysteine proteinase inhibitor synergistically decrease VEGF production and promote tumour necrosis in a rat mammary carcinoma. Cell Prolif. 40:38–49. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Kazemi M, Carrer A, Moimas S, Zandonà L, Bussani R, Casagranda B, Palmisano S, Prelazzi P, Giacca M, Zentilin L, et al: VEGF121 and VEGF165 differentially promote vessel maturation and tumor growth in mice and humans. Cancer Gene Ther. 23:125–132. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Frezzetti D, Gallo M, Roma C, D'Alessio A, Maiello MR, Bevilacqua S, Normanno N and De Luca A: Vascular endothelial growth factor a regulates the secretion of different angiogenic factors in lung cancer cells. J Cell Physiol. 231:1514–1521. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Olsson AK, Dimberg A, Kreuger J and Claesson-Welsh L: VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol. 7:359–371. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Robinson CJ and Stringer SE: The splice variants of vascular endothelial growth factor (VEGF) and their receptors. J Cell Sci. 114:853–865. 2001.PubMed/NCBI

24 

Domigan CK, Ziyad S and Iruela-Arispe ML: Canonical and noncanonical vascular endothelial growth factor pathways: New developments in biology and signal transduction. Arterioscler Thromb Vasc Biol. 35:30–39. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Smith NR, Baker D, James NH, Ratcliffe K, Jenkins M, Ashton SE, Sproat G, Swann R, Gray N, Ryan A, et al: Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers. Clin Cancer Res. 16:3548–3561. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Holmqvist K, Cross MJ, Rolny C, Hägerkvist R, Rahimi N, Matsumoto T, Claesson-Welsh L and Welsh M: The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration. J Biol Chem. 279:22267–22275. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Johnston EK, Francis MK and Knepper JE: Recombinant pigment epithelium-derived factor PEDF binds vascular endothelial growth factor receptors 1 and 2. In Vitro Cell Dev Biol Anim. 51:730–738. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Wu LF, Ye YQ, Huang GY, Li HB, Li GP, Pu ZJ, Wei BL and Feng JL: Involvement of endoplasmic reticulum stress in adenosine-induced human hepatoma HepG2 cell apoptosis. Oncol Rep. 26:73–79. 2011.PubMed/NCBI

29 

Donato MTTL, Tolosa L and Gómez-Lechón MJ: Culture and functional characterization of human hepatoma HepG2 cells. Methods Mol Biol. 1250:77–93. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Kisielewska J, Ligeza J and Klein A: The effect of tyrosine kinase inhibitors, tyrphostins: AG1024 and SU1498, on autocrine growth of prostate cancer cells (DU145). Folia Histochem Cytobiol. 46:185–191. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Laurino L, Wang XX, de la Houssaye BA, Sosa L, Dupraz S, Cáceres A, Pfenninger KH and Quiroga S: PI3K activation by IGF-1 is essential for the regulation of membrane expansion at the nerve growth cone. J Cell Sci. 118:3653–3662. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Gong Q, Qiu S, Li S, Ma Y, Chen M, Yao Y, Che D, Feng J, Cai W, Ma J, et al: Proapoptotic PEDF functional peptides inhibit prostate tumor growth - a mechanistic study. Biochem Pharmacol. 92:425–437. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Coon BG, Baeyens N, Han J, Budatha M, Ross TD, Fang JS, Yun S, Thomas JL and Schwartz MA: Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex. J Cell Biol. 208:975–986. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Liao D and Johnson RS: Hypoxia: A key regulator of angiogenesis in cancer. Cancer Metastasis Rev. 26:281–290. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Sternlicht MD and Werb Z: How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol. 17:463–516. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Li H, Daculsi R, Bareille R, Bourget C and Amedee J: uPA and MMP-2 were involved in self-assembled network formation in a two dimensional co-culture model of bone marrow stromal cells and endothelial cells. J Cell Biochem. 114:650–657. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Zhao Y, Peng S, Jia C, Xu F, Xu Y and Dai C: Armc8 regulates the invasive ability of hepatocellular carcinoma through E-cadherin/catenin complex. Tumour Biol. 37:11219–11224. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Yu AQ, Ding Y, Li CL, Yang Y, Yan SR and Li DS: TALEN-induced disruption of Nanog expression results in reduced proliferation, invasiveness and migration, increased chemosensitivity and reversal of EMT in HepG2 cells. Oncol Rep. 35:1657–1663. 2016.PubMed/NCBI

39 

Cory S, Huang DC and Adams JM: The Bcl-2 family: Roles in cell survival and oncogenesis. Oncogene. 22:8590–8607. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Cory S and Adams JM: The Bcl2 family: Regulators of the cellular life-or-death switch. Nat Rev Cancer. 2:647–656. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Li LY, Luo X and Wang X: Endonuclease G is an apoptotic DNase when released from mitochondria. Nature. 412:95–99. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Tian X, Shi Y, Liu N, Yan Y, Li T, Hua P and Liu B: Upregulation of DAPK contributes to homocysteine-induced endothelial apoptosis via the modulation of Bcl2/Bax and activation of caspase 3. Mol Med Rep. 14:4173–4179. 2016.PubMed/NCBI

43 

Cao Y, Jiang Z, Zeng Z, Liu Y, Gu Y, Ji Y, Zhao Y and Li Y: Bcl-2 silencing attenuates hypoxia-induced apoptosis resistance in pulmonary microvascular endothelial cells. Apoptosis. 21:69–84. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Xiu P, Wang F, Zhong J, Wei H, Xu Z, Liu F and Li J: P18 peptide, a functional fragment of pigment epithelial-derived factor, inhibits angiogenesis in hepatocellular carcinoma via modulating VEGF/VEGFR2 signalling pathway. Oncol Rep 38: 755-766, 2017.
APA
Wang, X., Xiu, P., Wang, F., Zhong, J., Wei, H., Xu, Z. ... Li, J. (2017). P18 peptide, a functional fragment of pigment epithelial-derived factor, inhibits angiogenesis in hepatocellular carcinoma via modulating VEGF/VEGFR2 signalling pathway. Oncology Reports, 38, 755-766. https://doi.org/10.3892/or.2017.5719
MLA
Wang, X., Xiu, P., Wang, F., Zhong, J., Wei, H., Xu, Z., Liu, F., Li, J."P18 peptide, a functional fragment of pigment epithelial-derived factor, inhibits angiogenesis in hepatocellular carcinoma via modulating VEGF/VEGFR2 signalling pathway". Oncology Reports 38.2 (2017): 755-766.
Chicago
Wang, X., Xiu, P., Wang, F., Zhong, J., Wei, H., Xu, Z., Liu, F., Li, J."P18 peptide, a functional fragment of pigment epithelial-derived factor, inhibits angiogenesis in hepatocellular carcinoma via modulating VEGF/VEGFR2 signalling pathway". Oncology Reports 38, no. 2 (2017): 755-766. https://doi.org/10.3892/or.2017.5719
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Xiu P, Wang F, Zhong J, Wei H, Xu Z, Liu F and Li J: P18 peptide, a functional fragment of pigment epithelial-derived factor, inhibits angiogenesis in hepatocellular carcinoma via modulating VEGF/VEGFR2 signalling pathway. Oncol Rep 38: 755-766, 2017.
APA
Wang, X., Xiu, P., Wang, F., Zhong, J., Wei, H., Xu, Z. ... Li, J. (2017). P18 peptide, a functional fragment of pigment epithelial-derived factor, inhibits angiogenesis in hepatocellular carcinoma via modulating VEGF/VEGFR2 signalling pathway. Oncology Reports, 38, 755-766. https://doi.org/10.3892/or.2017.5719
MLA
Wang, X., Xiu, P., Wang, F., Zhong, J., Wei, H., Xu, Z., Liu, F., Li, J."P18 peptide, a functional fragment of pigment epithelial-derived factor, inhibits angiogenesis in hepatocellular carcinoma via modulating VEGF/VEGFR2 signalling pathway". Oncology Reports 38.2 (2017): 755-766.
Chicago
Wang, X., Xiu, P., Wang, F., Zhong, J., Wei, H., Xu, Z., Liu, F., Li, J."P18 peptide, a functional fragment of pigment epithelial-derived factor, inhibits angiogenesis in hepatocellular carcinoma via modulating VEGF/VEGFR2 signalling pathway". Oncology Reports 38, no. 2 (2017): 755-766. https://doi.org/10.3892/or.2017.5719
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