Klotho suppresses tumor progression via inhibiting IGF-1R signaling in T‑cell lymphoma

  • Authors:
    • Xiangxiang Zhou
    • Ya Zhang
    • Ying Li
    • Yangyang Xu
    • Lingyan Zhang
    • Ying Li
    • Xin Wang
  • View Affiliations

  • Published online on: June 22, 2017     https://doi.org/10.3892/or.2017.5744
  • Pages: 967-974
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Abstract

Klotho is a transmembrane protein and acts as an upstream modulator of insulin-like growth factor-1 receptor (IGF-1R) signaling, which was indicated to be involved in the pathogenesis of solid cancer and hematological malignancies, including T‑cell lymphoma. Although Klotho was recently identified as a tumor suppressor in several types of human malignancies, the potential role of Klotho in T‑cell lymphoma has not been reported. In the present study, we investigated the expression level and the molecular events of Klotho in T‑cell lymphoma. Significantly lower expression of Klotho was observed in T‑cell lymphoma patient samples compared to normal lymph nodes. Functional analysis after Klotho overexpression revealed significantly inhibited tumor cell viability in T‑cell lymphoma. Moreover, apoptosis of T‑cell lymphoma cells were induced after transfected with Klotho-overexpressing vectors. Forced expression of Klotho resulted in decline of activation of IGF-1R signaling, accompanied by decreased phosphorylation of its downstream targets, including AKT and ERK1/2. These data indicated that Klotho acts as a tumor suppressor via inhibiting IGF-1R signaling, thus suppressing the viability and promoting apoptosis in T‑cell lymphoma. Taken together, Klotho may serve as a potential target for the therapeutic intervention of T‑cell lymphoma.
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August-2017
Volume 38 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhou X, Zhang Y, Li Y, Xu Y, Zhang L, Li Y and Wang X: Klotho suppresses tumor progression via inhibiting IGF-1R signaling in T‑cell lymphoma. Oncol Rep 38: 967-974, 2017
APA
Zhou, X., Zhang, Y., Li, Y., Xu, Y., Zhang, L., Li, Y., & Wang, X. (2017). Klotho suppresses tumor progression via inhibiting IGF-1R signaling in T‑cell lymphoma. Oncology Reports, 38, 967-974. https://doi.org/10.3892/or.2017.5744
MLA
Zhou, X., Zhang, Y., Li, Y., Xu, Y., Zhang, L., Li, Y., Wang, X."Klotho suppresses tumor progression via inhibiting IGF-1R signaling in T‑cell lymphoma". Oncology Reports 38.2 (2017): 967-974.
Chicago
Zhou, X., Zhang, Y., Li, Y., Xu, Y., Zhang, L., Li, Y., Wang, X."Klotho suppresses tumor progression via inhibiting IGF-1R signaling in T‑cell lymphoma". Oncology Reports 38, no. 2 (2017): 967-974. https://doi.org/10.3892/or.2017.5744