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Article

miR-138 inhibits gastric cancer growth by suppressing SOX4

Retraction in: /10.3892/or.2022.8258
  • Authors:
    • Lei Pang
    • Bai Li
    • Baisong Zheng
    • Liang Niu
    • Liang Ge
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Colorectal and Anal Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Operating Room, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 1295-1302
    |
    Published online on: June 22, 2017
       https://doi.org/10.3892/or.2017.5745
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Abstract

MicroRNA-138 (miR-138) has been reported to be downregulated and function as a tumor suppressor in several cancers. However, the role and molecular mechanisms of miR-138 in the progression of gastric cancer (GC) remain to be clarified. The aim of the present study was to determine the role of miR-138 in GC progression. In the present study we found that miR-138 expression was downregulated in GC tissues and cell lines. Statistical analysis demonstrated that low expression levels of miR-138 were associated with advanced tumor-node-metastasis (TNM) stage, and lymph node metastasis. Function assays demonstrated that overexpression of miR-138 impaired GC cell proliferation, colony formation, migration and invasion in vitro, as well as suppressed tumor growth in vivo. Through reporter gene, qRT-PCR and western blot assays, SRY-related high mobility group box 4 (SOX4), a master mediator in epithelial-mesenchymal transition (EMT), was confirmed to be a direct target of miR-138 in GC cells. Western blot assay revealed that miR-138 overexpression inhibited EMT procession in GC cells by upregulation of epithelial marker E-cadherin and downregulation of mesenchymal markers, N-cadherin and vimentin. Furthermore, the levels of miR-138 were inversely correlated with those of SOX4 expression in GC tissues. Overexpression of SOX4 rescued the inhibition effect in GC cells caused by miR-138. Collectively, these findings indicate that miR-138 may be a potential therapeutic target for GC.
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Copy and paste a formatted citation
Spandidos Publications style
Pang L, Li B, Zheng B, Niu L and Ge L: miR-138 inhibits gastric cancer growth by suppressing SOX4 Retraction in /10.3892/or.2022.8258. Oncol Rep 38: 1295-1302, 2017.
APA
Pang, L., Li, B., Zheng, B., Niu, L., & Ge, L. (2017). miR-138 inhibits gastric cancer growth by suppressing SOX4 Retraction in /10.3892/or.2022.8258. Oncology Reports, 38, 1295-1302. https://doi.org/10.3892/or.2017.5745
MLA
Pang, L., Li, B., Zheng, B., Niu, L., Ge, L."miR-138 inhibits gastric cancer growth by suppressing SOX4 Retraction in /10.3892/or.2022.8258". Oncology Reports 38.2 (2017): 1295-1302.
Chicago
Pang, L., Li, B., Zheng, B., Niu, L., Ge, L."miR-138 inhibits gastric cancer growth by suppressing SOX4 Retraction in /10.3892/or.2022.8258". Oncology Reports 38, no. 2 (2017): 1295-1302. https://doi.org/10.3892/or.2017.5745
Copy and paste a formatted citation
x
Spandidos Publications style
Pang L, Li B, Zheng B, Niu L and Ge L: miR-138 inhibits gastric cancer growth by suppressing SOX4 Retraction in /10.3892/or.2022.8258. Oncol Rep 38: 1295-1302, 2017.
APA
Pang, L., Li, B., Zheng, B., Niu, L., & Ge, L. (2017). miR-138 inhibits gastric cancer growth by suppressing SOX4 Retraction in /10.3892/or.2022.8258. Oncology Reports, 38, 1295-1302. https://doi.org/10.3892/or.2017.5745
MLA
Pang, L., Li, B., Zheng, B., Niu, L., Ge, L."miR-138 inhibits gastric cancer growth by suppressing SOX4 Retraction in /10.3892/or.2022.8258". Oncology Reports 38.2 (2017): 1295-1302.
Chicago
Pang, L., Li, B., Zheng, B., Niu, L., Ge, L."miR-138 inhibits gastric cancer growth by suppressing SOX4 Retraction in /10.3892/or.2022.8258". Oncology Reports 38, no. 2 (2017): 1295-1302. https://doi.org/10.3892/or.2017.5745
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