miR-138 inhibits gastric cancer growth by suppressing SOX4

Retraction in: /10.3892/or.2022.8258

  • Authors:
    • Lei Pang
    • Bai Li
    • Baisong Zheng
    • Liang Niu
    • Liang Ge
  • View Affiliations

  • Published online on: June 22, 2017     https://doi.org/10.3892/or.2017.5745
  • Pages: 1295-1302
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Abstract

MicroRNA-138 (miR-138) has been reported to be downregulated and function as a tumor suppressor in several cancers. However, the role and molecular mechanisms of miR-138 in the progression of gastric cancer (GC) remain to be clarified. The aim of the present study was to determine the role of miR-138 in GC progression. In the present study we found that miR-138 expression was downregulated in GC tissues and cell lines. Statistical analysis demonstrated that low expression levels of miR-138 were associated with advanced tumor-node-metastasis (TNM) stage, and lymph node metastasis. Function assays demonstrated that overexpression of miR-138 impaired GC cell proliferation, colony formation, migration and invasion in vitro, as well as suppressed tumor growth in vivo. Through reporter gene, qRT-PCR and western blot assays, SRY-related high mobility group box 4 (SOX4), a master mediator in epithelial-mesenchymal transition (EMT), was confirmed to be a direct target of miR-138 in GC cells. Western blot assay revealed that miR-138 overexpression inhibited EMT procession in GC cells by upregulation of epithelial marker E-cadherin and downregulation of mesenchymal markers, N-cadherin and vimentin. Furthermore, the levels of miR-138 were inversely correlated with those of SOX4 expression in GC tissues. Overexpression of SOX4 rescued the inhibition effect in GC cells caused by miR-138. Collectively, these findings indicate that miR-138 may be a potential therapeutic target for GC.
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August-2017
Volume 38 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Pang L, Li B, Zheng B, Niu L and Ge L: miR-138 inhibits gastric cancer growth by suppressing SOX4 Retraction in /10.3892/or.2022.8258. Oncol Rep 38: 1295-1302, 2017
APA
Pang, L., Li, B., Zheng, B., Niu, L., & Ge, L. (2017). miR-138 inhibits gastric cancer growth by suppressing SOX4 Retraction in /10.3892/or.2022.8258. Oncology Reports, 38, 1295-1302. https://doi.org/10.3892/or.2017.5745
MLA
Pang, L., Li, B., Zheng, B., Niu, L., Ge, L."miR-138 inhibits gastric cancer growth by suppressing SOX4 Retraction in /10.3892/or.2022.8258". Oncology Reports 38.2 (2017): 1295-1302.
Chicago
Pang, L., Li, B., Zheng, B., Niu, L., Ge, L."miR-138 inhibits gastric cancer growth by suppressing SOX4 Retraction in /10.3892/or.2022.8258". Oncology Reports 38, no. 2 (2017): 1295-1302. https://doi.org/10.3892/or.2017.5745