Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
August-2017 Volume 38 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2017 Volume 38 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Progress in mass spectrometry-based proteomic research of tumor hypoxia (Review)

  • Authors:
    • Zhiqi Gao
    • Gang Luo
    • Bing Ni
  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology and High Altitude Pathology/Key Laboratory of High Altitude Environment Medicine (Third Military Medical University), Ministry of Education/Key Laboratory of High Altitude Medicine, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, P.R. China
  • Pages: 676-684
    |
    Published online on: June 23, 2017
       https://doi.org/10.3892/or.2017.5748
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

A hypoxic microenvironment effects various signaling pathways in the human body, including those that are critical for normal physiology and those that support tumorigenesis or cancer progression. A hypoxic tumor microenvironment, in particular, modulates cell migration, invasion and resistance to radiotherapy and chemotherapy. Development of the mass spectrometry (MS) technique has allowed for expansion of proteomic study to a wide variety of fields, with the study of tumor hypoxia being among the latest to enjoy its benefits. In such studies, changes in the proteome of tumor tissue or cells induced by the hypoxic conditions are analyzed. A multitude of hypoxic regulatory proteins have already been identified, increasing our understanding of the mechanisms underlying tumor occurrence and development and representing candidate reference markers for tumor diagnosis and therapy. The present review provides the first summary of the collective studies on tumor microenvironment hypoxia that have been completed using MS-based proteomic techniques, providing a systematic discussion of the benefits and current challenges of the various applications.
View Figures

Figure 1

View References

1 

Carroll VA and Ashcroft M: Targeting the molecular basis for tumour hypoxia. Expert Rev Mol Med. 7:1–16. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Dewhirst MW, Cao Y and Moeller B: Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer. 8:425–437. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Vaupel P and Mayer A: Hypoxia in cancer: Significance and impact on clinical outcome. Cancer Metastasis Rev. 26:225–239. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Bertout JA, Patel SA and Simon MC: The impact of O2 availability on human cancer. Nat Rev Cancer. 8:967–975. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Young SD, Marshall RS and Hill RP: Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells. Proc Natl Acad Sci USA. 85:9533–9537. 1988. View Article : Google Scholar : PubMed/NCBI

6 

Ruan K, Song G and Ouyang G: Role of hypoxia in the hallmarks of human cancer. J Cell Biochem. 107:1053–1062. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Vaupel P, Kelleher DK and Höckel M: Oxygen status of malignant tumors: Pathogenesis of hypoxia and significance for tumor therapy. Semin Oncol. 28:(Suppl 8). 29–35. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Gray LH, Conger AD, Ebert M, Hornsey S and Scott OC: The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol. 26:638–648. 1953. View Article : Google Scholar : PubMed/NCBI

9 

Moulder JE and Rockwell S: Tumor hypoxia: Its impact on cancer therapy. Cancer Metastasis Rev. 5:313–341. 1987. View Article : Google Scholar : PubMed/NCBI

10 

Chaudary N and Hill RP: Hypoxia and metastasis. Clin Cancer Res. 13:1947–1949. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Moyer MW: Targeting hypoxia brings breath of fresh air to cancer therapy. Nat Med. 18:636–637. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Wasinger VC, Cordwell SJ, Cerpa-Poljak A, Yan JX, Gooley AA, Wilkins MR, Duncan MW, Harris R, Williams KL and Humphery-Smith I: Progress with gene-product mapping of the Mollicutes: Mycoplasma genitalium. Electrophoresis. 16:1090–1094. 1995. View Article : Google Scholar : PubMed/NCBI

13 

Chen B, Zhang D, Wang X, Ma W, Deng S, Zhang P, Zhu H, Xu N and Liang S: Proteomics progresses in microbial physiology and clinical antimicrobial therapy. Eur J Clin Microbiol Infect Dis. 36:403–413. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Ion A, Popa IM, Papagheorghe LM, Lisievici C, Lupu M, Voiculescu V, Caruntu C and Boda D: Proteomic approaches to biomarker discovery in cutaneous T-cell lymphoma. Dis Markers. 2016:96024722016. View Article : Google Scholar : PubMed/NCBI

15 

Li J, Tian W and Song J: Proteomics applications in dental derived stem cells. J Cell Physiol. 232:1602–1610. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Aebersold R and Mann M: Mass spectrometry-based proteomics. Nature. 422:198–207. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Cravatt BF, Simon GM and Yates JR III: The biological impact of mass-spectrometry-based proteomics. Nature. 450:991–1000. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Nesvizhskii AI, Vitek O and Aebersold R: Analysis and validation of proteomic data generated by tandem mass spectrometry. Nat Methods. 4:787–797. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Shapiro AL, Viñuela E and Maizel JV Jr: Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. Biochem Biophys Res Commun. 28:815–820. 1967. View Article : Google Scholar : PubMed/NCBI

20 

Shapiro HD, Miller KD and Harris AH: Low-pH disc electrophoresis of spinal fluid; changes in multiple sclerosis. Exp Mol Pathol. 7:362–365. 1967. View Article : Google Scholar : PubMed/NCBI

21 

Weber K and Osborn M: The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. J Biol Chem. 244:4406–4412. 1969.PubMed/NCBI

22 

O'Farrell PH: High resolution two-dimensional electrophoresis of proteins. J Biol Chem. 250:4007–4021. 1975.PubMed/NCBI

23 

Unlü M, Morgan ME and Minden JS: Difference gel electrophoresis: A single gel method for detecting changes in protein extracts. Electrophoresis. 18:2071–2077. 1997. View Article : Google Scholar : PubMed/NCBI

24 

Alban A, David SO, Bjorkesten L, Andersson C, Sloge E, Lewis S and Currie I: A novel experimental design for comparative two-dimensional gel analysis: Two-dimensional difference gel electrophoresis incorporating a pooled internal standard. Proteomics. 3:36–44. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Strittmatter EF, Ferguson PL, Tang K and Smith RD: Proteome analyses using accurate mass and elution time peptide tags with capillary LC time-of-flight mass spectrometry. J Am Soc Mass Spectrom. 14:980–991. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Lundgren DH, Hwang SI, Wu L and Han DK: Role of spectral counting in quantitative proteomics. Expert Rev Proteomics. 7:39–53. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Ong SE, Blagoev B, Kratchmarova I, Kristensen DB, Steen H, Pandey A and Mann M: Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics. 1:376–386. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Schmidt A, Kellermann J and Lottspeich F: A novel strategy for quantitative proteomics using isotope-coded protein labels. Proteomics. 5:4–15. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Wiese S, Reidegeld KA, Meyer HE and Warscheid B: Protein labeling by iTRAQ: A new tool for quantitative mass spectrometry in proteome research. Proteomics. 7:340–350. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Thompson A, Schäfer J, Kuhn K, Kienle S, Schwarz J, Schmidt G, Neumann T, Johnstone R, Mohammed AK and Hamon C: Tandem mass tags: A novel quantification strategy for comparative analysis of complex protein mixtures by MS/MS. Anal Chem. 75:1895–1904. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Chen Y, Shi G, Xia W, Kong C, Zhao S, Gaw AF, Chen EY, Yang GP, Giaccia AJ, Le QT, et al: Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling. Cancer Res. 64:7302–7310. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Li Q, Van Antwerp D, Mercurio F, Lee KF and Verma IM: Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science. 284:321–325. 1999. View Article : Google Scholar : PubMed/NCBI

33 

Magagnin MG, Sergeant K, van den Beucken T, Rouschop KM, Jutten B, Seigneuric R, Lambin P, Devreese B, Koritzinsky M and Wouters BG: Proteomic analysis of gene expression following hypoxia and reoxygenation reveals proteins involved in the recovery from endoplasmic reticulum and oxidative stress. Radiother Oncol. 83:340–345. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Woodman PG: p97, a protein coping with multiple identities. J Cell Sci. 116:4283–4290. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Koritzinsky M, Magagnin MG, van den Beucken T, Seigneuric R, Savelkouls K, Dostie J, Pyronnet S, Kaufman RJ, Weppler SA, Voncken JW, et al: Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J. 25:1114–1125. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Koritzinsky M, Seigneuric R, Magagnin MG, van den Beucken T, Lambin P and Wouters BG: The hypoxic proteome is influenced by gene-specific changes in mRNA translation. Radiother Oncol. 76:177–186. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Lü X, de la Peña L, Barker C, Camphausen K and Tofilon PJ: Radiation-induced changes in gene expression involve recruitment of existing messenger RNAs to and away from polysomes. Cancer Res. 66:1052–1061. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Nordsmark M, Loncaster J, Aquino-Parsons C, Chou SC, Gebski V, West C, Lindegaard JC, Havsteen H, Davidson SE, Hunter R, et al: The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: A prospective international multi-center study. Radiother Oncol. 80:123–131. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Magagnin MG, van den Beucken T, Sergeant K, Lambin P, Koritzinsky M, Devreese B and Wouters BG: The mTOR target 4E-BP1 contributes to differential protein expression during normoxia and hypoxia through changes in mRNA translation efficiency. Proteomics. 8:1019–1028. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P and Giallongo A: Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem. 271:32529–32537. 1996. View Article : Google Scholar : PubMed/NCBI

41 

Buono RJ and Lang RK: Hypoxic repression of lactate dehydrogenase-B in retina. Exp Eye Res. 69:685–693. 1999. View Article : Google Scholar : PubMed/NCBI

42 

Choi KJ, Piao YJ, Lim MJ, Kim JH, Ha J, Choe W and Kim SS: Overexpressed cyclophilin A in cancer cells renders resistance to hypoxia- and cisplatin-induced cell death. Cancer Res. 67:3654–3662. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Dundas SR, Lawrie LC, Rooney PH and Murray GI: Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival. J Pathol. 205:74–81. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Cui Y, Zhang D, Jia Q, Li T, Zhang W and Han J: Proteomic and tissue array profiling identifies elevated hypoxia-regulated proteins in pancreatic ductal adenocarcinoma. Cancer Invest. 27:747–755. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Vaupel P: The role of hypoxia-induced factors in tumor progression. Oncologist. 9:(Suppl 5). S10–S17. 2004. View Article : Google Scholar

46 

Hu R, Jin H, Zhou S, Yang P and Li X: Proteomic analysis of hypoxia-induced responses in the syncytialization of human placental cell line BeWo. Placenta. 28:399–407. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Furuta E, Pai SK, Zhan R, Bandyopadhyay S, Watabe M, Mo YY, Hirota S, Hosobe S, Tsukada T, Miura K, et al: Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1. Cancer Res. 68:1003–1011. 2008. View Article : Google Scholar : PubMed/NCBI

48 

Lee AS: Mammalian stress response: Induction of the glucose-regulated protein family. Curr Opin Cell Biol. 4:267–273. 1992. View Article : Google Scholar : PubMed/NCBI

49 

Fajardo I, Svensson L, Bucht A and Pejler G: Increased levels of hypoxia-sensitive proteins in allergic airway inflammation. Am J Respir Crit Care Med. 170:477–484. 2004. View Article : Google Scholar : PubMed/NCBI

50 

Larsen M, Tazzyman S, Lund EL, Junker N, Lewis CE, Kristjansen PE and Murdoch C: Hypoxia-induced secretion of macrophage migration-inhibitory factor from MCF-7 breast cancer cells is regulated in a hypoxia-inducible factor-independent manner. Cancer Lett. 265:239–249. 2008. View Article : Google Scholar : PubMed/NCBI

51 

Liao SH, Zhao XY, Han YH, Zhang J, Wang LS, Xia L, Zhao KW, Zheng Y, Guo M and Chen GQ: Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells. Proteomics. 9:3901–3912. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Pellieux C, Desgeorges A, Pigeon CH, Chambaz C, Yin H, Hayoz D and Silacci P: Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress. J Biol Chem. 278:29136–29144. 2003. View Article : Google Scholar : PubMed/NCBI

53 

Garrett SC, Varney KM, Weber DJ and Bresnick AR: S100A4, a mediator of metastasis. J Biol Chem. 281:677–680. 2006. View Article : Google Scholar : PubMed/NCBI

54 

Tarabykina S, Griffiths TR, Tulchinsky E, Mellon JK, Bronstein IB and Kriajevska M: Metastasis-associated protein S100A4: Spotlight on its role in cell migration. Curr Cancer Drug Targets. 7:217–228. 2007. View Article : Google Scholar : PubMed/NCBI

55 

Bartkowiak K, Effenberger KE, Harder S, Andreas A, Buck F, Peter-Katalinic J, Pantel K and Brandt BH: Discovery of a novel unfolded protein response phenotype of cancer stem/progenitor cells from the bone marrow of breast cancer patients. J Proteome Res. 9:3158–3168. 2010. View Article : Google Scholar : PubMed/NCBI

56 

Grandjean M, Sermeus A, Branders S, Defresne F, Dieu M, Dupont P, Raes M, De Ridder M and Feron O: Hypoxia integration in the serological proteome analysis unmasks tumor antigens and fosters the identification of anti-phospho-eEF2 antibodies as potential cancer biomarkers. PLoS One. 8:e765082013. View Article : Google Scholar : PubMed/NCBI

57 

Yoon JH, Kim J, Kim KL, Kim DH, Jung SJ, Lee H, Ghim J, Kim D, Park JB, Ryu SH, et al: Proteomic analysis of hypoxia-induced U373MG glioma secretome reveals novel hypoxia-dependent migration factors. Proteomics. 14:1494–1502. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Chang AC, Janosi J, Hulsbeek M, de Jong D, Jeffrey KJ, Noble JR and Reddel RR: A novel human cDNA highly homologous to the fish hormone stanniocalcin. Mol Cell Endocrinol. 112:241–247. 1995. View Article : Google Scholar : PubMed/NCBI

59 

Varghese R, Wong CK, Deol H, Wagner GF and DiMattia GE: Comparative analysis of mammalian stanniocalcin genes. Endocrinology. 139:4714–4725. 1998. View Article : Google Scholar : PubMed/NCBI

60 

Tamura S, Oshima T, Yoshihara K, Kanazawa A, Yamada T, Inagaki D, Sato T, Yamamoto N, Shiozawa M, Morinaga S, et al: Clinical significance of STC1 gene expression in patients with colorectal cancer. Anticancer Res. 31:325–329. 2011.PubMed/NCBI

61 

Nakagawa T, Martinez SR, Goto Y, Koyanagi K, Kitago M, Shingai T, Elashoff DA, Ye X, Singer FR, Giuliano AE, et al: Detection of circulating tumor cells in early-stage breast cancer metastasis to axillary lymph nodes. Clin Cancer Res. 13:4105–4110. 2007. View Article : Google Scholar : PubMed/NCBI

62 

Cheng J, Gao F, Chen X, Wu J, Xing C, Lv Z, Xu W, Xie Q, Wu L, Ye S, et al: Prohibitin-2 promotes hepatocellular carcinoma malignancy progression in hypoxia based on a label-free quantitative proteomics strategy. Mol Carcinog. 53:820–832. 2014. View Article : Google Scholar : PubMed/NCBI

63 

Bogenhagen DF, Wang Y, Shen EL and Kobayashi R: Protein components of mitochondrial DNA nucleoids in higher eukaryotes. Mol Cell Proteomics. 2:1205–1216. 2003. View Article : Google Scholar : PubMed/NCBI

64 

McClung JK, Jupe ER, Liu XT and Dell'Orco RT: Prohibitin: Potential role in senescence, development, and tumor suppression. Exp Gerontol. 30:99–124. 1995. View Article : Google Scholar : PubMed/NCBI

65 

Nijtmans LG, de Jong L, Sanz Artal M, Coates PJ, Berden JA, Back JW, Muijsers AO, van der Spek H and Grivell LA: Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins. EMBO J. 19:2444–2451. 2000. View Article : Google Scholar : PubMed/NCBI

66 

Osman C, Merkwirth C and Langer T: Prohibitins and the functional compartmentalization of mitochondrial membranes. J Cell Sci. 122:3823–3830. 2009. View Article : Google Scholar : PubMed/NCBI

67 

Valli A, Rodriguez M, Moutsianas L, Fischer R, Fedele V, Huang HL, Van Stiphout R, Jones D, Mccarthy M, Vinaxia M, et al: Hypoxia induces a lipogenic cancer cell phenotype via HIF1α-dependent and -independent pathways. Oncotarget. 6:1920–1941. 2015. View Article : Google Scholar : PubMed/NCBI

68 

Delcourt N, Quevedo C, Nonne C, Fons P, O'Brien D, Loyaux D, Diez M, Autelitano F, Guillemot JC, Ferrara P, et al: Targeted identification of sialoglycoproteins in hypoxic endothelial cells and validation in zebrafish reveal roles for proteins in angiogenesis. J Biol Chem. 290:3405–3417. 2015. View Article : Google Scholar : PubMed/NCBI

69 

Nagao K and Oka K: HIF-2 directly activates CD82 gene expression in endothelial cells. Biochem Biophys Res Commun. 407:260–265. 2011. View Article : Google Scholar : PubMed/NCBI

70 

Lee P, Goishi K, Davidson AJ, Mannix R, Zon L and Klagsbrun M: Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish. Proc Natl Acad Sci USA. 99:10470–10475. 2002. View Article : Google Scholar : PubMed/NCBI

71 

Mura M, Swain RK, Zhuang X, Vorschmitt H, Reynolds G, Durant S, Beesley JF, Herbert JM, Sheldon H, Andre M, et al: Identification and angiogenic role of the novel tumor endothelial marker CLEC14A. Oncogene. 31:293–305. 2012. View Article : Google Scholar : PubMed/NCBI

72 

Stockwin LH, Blonder J, Bumke MA, Lucas DA, Chan KC, Conrads TP, Issaq HJ, Veenstra TD, Newton DL and Rybak SM: Proteomic analysis of plasma membrane from hypoxia-adapted malignant melanoma. J Proteome Res. 5:2996–3007. 2006. View Article : Google Scholar : PubMed/NCBI

73 

Yang W, Thompson JW, Wang Z, Wang L, Sheng H, Foster MW, Moseley MA and Paschen W: Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. J Proteome Res. 11:1108–1117. 2012. View Article : Google Scholar : PubMed/NCBI

74 

Djidja MC, Chang J, Hadjiprocopis A, Schmich F, Sinclair J, Mršnik M, Schoof EM, Barker HE, Linding R, Jørgensen C, et al: Identification of hypoxia-regulated proteins using MALDI-mass spectrometry imaging combined with quantitative proteomics. J Proteome Res. 13:2297–2313. 2014. View Article : Google Scholar : PubMed/NCBI

75 

Malec V, Coulson JM, Urbé S and Clague MJ: Combined analyses of the VHL and hypoxia signaling axes in an isogenic pairing of renal clear cell carcinoma cells. J Proteome Res. 14:5263–5272. 2015. View Article : Google Scholar : PubMed/NCBI

76 

Chan DA, Sutphin PD, Nguyen P, Turcotte S, Lai EW, Banh A, Reynolds GE, Chi JT, Wu J, Solow-Cordero DE, et al: Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci Transl Med. 3:94ra702011. View Article : Google Scholar : PubMed/NCBI

77 

Yamasaki T, Seki N, Yoshino H, Itesako T, Yamada Y, Tatarano S, Hidaka H, Yonezawa T, Nakagawa M and Enokida H: Tumor-suppressive microRNA-1291 directly regulates glucose transporter 1 in renal cell carcinoma. Cancer Sci. 104:1411–1419. 2013. View Article : Google Scholar : PubMed/NCBI

78 

Hosoya N, Sakumoto M, Nakamura Y, Narisawa T, Bilim V, Motoyama T, Tomita Y and Kondo T: Proteomics identified nuclear N-myc downstream-regulated gene 1 as a prognostic tissue biomarker candidate in renal cell carcinoma. Biochim Biophys Acta. 1834:2630–2639. 2013. View Article : Google Scholar : PubMed/NCBI

79 

Ren Y, Hao P, Dutta B, Cheow ES, Sim KH, Gan CS, Lim SK and Sze SK: Hypoxia modulates A431 cellular pathways association to tumor radioresistance and enhanced migration revealed by comprehensive proteomic and functional studies. Mol Cell Proteomics. 12:485–498. 2013. View Article : Google Scholar : PubMed/NCBI

80 

Lara PC, Lloret M, Clavo B, Apolinario RM, Bordón E, Rey A, Falcón O, Alonso AR and Belka C: Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors. Radiother Oncol. 89:222–226. 2008. View Article : Google Scholar : PubMed/NCBI

81 

Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK and Sze SK: Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes. Mol Cell Proteomics. 9:1085–1099. 2010. View Article : Google Scholar : PubMed/NCBI

82 

Ren Y, Hao P, Law SK and Sze SK: Hypoxia-induced changes to integrin α 3 glycosylation facilitate invasion in epidermoid carcinoma cell line A431. Mol Cell Proteomics. 13:3126–3137. 2014. View Article : Google Scholar : PubMed/NCBI

83 

Dutta B, Yan R, Lim SK, Tam JP and Sze SK: Quantitative profiling of chromatome dynamics reveals a novel role for HP1BP3 in hypoxia-induced oncogenesis. Mol Cell Proteomics. 13:3236–3249. 2014. View Article : Google Scholar : PubMed/NCBI

84 

Yanagisawa K, Konishi H, Arima C, Tomida S, Takeuchi T, Shimada Y, Yatabe Y, Mitsudomi T, Osada H and Takahashi T: Novel metastasis-related gene CIM functions in the regulation of multiple cellular stress-response pathways. Cancer Res. 70:9949–9958. 2010. View Article : Google Scholar : PubMed/NCBI

85 

McMahon KM, Volpato M, Chi HY, Musiwaro P, Poterlowicz K, Peng Y, Scally AJ, Patterson LH, Phillips RM and Sutton CW: Characterization of changes in the proteome in different regions of 3D multicell tumor spheroids. J Proteome Res. 11:2863–2875. 2012. View Article : Google Scholar : PubMed/NCBI

86 

Yates JR III, Morgan SF, Gatlin CL, Griffin PR and Eng JK: Method to compare collision-induced dissociation spectra of peptides: Potential for library searching and subtractive analysis. Anal Chem. 70:3557–3565. 1998. View Article : Google Scholar : PubMed/NCBI

87 

Craig R, Cortens JC, Fenyo D and Beavis RC: Using annotated peptide mass spectrum libraries for protein identification. J Proteome Res. 5:1843–1849. 2006. View Article : Google Scholar : PubMed/NCBI

88 

Frewen BE, Merrihew GE, Wu CC, Noble WS and MacCoss MJ: Analysis of peptide MS/MS spectra from large-scale proteomics experiments using spectrum libraries. Anal Chem. 78:5678–5684. 2006. View Article : Google Scholar : PubMed/NCBI

89 

Lam H, Deutsch EW, Eddes JS, Eng JK, King N, Stein SE and Aebersold R: Development and validation of a spectral library searching method for peptide identification from MS/MS. Proteomics. 7:655–667. 2007. View Article : Google Scholar : PubMed/NCBI

90 

Nesvizhskii AI, Roos FF, Grossmann J, Vogelzang M, Eddes JS, Gruissem W, Baginsky S and Aebersold R: Dynamic spectrum quality assessment and iterative computational analysis of shotgun proteomic data: Toward more efficient identification of post-translational modifications, sequence polymorphisms, and novel peptides. Mol Cell Proteomics. 5:652–670. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gao Z, Luo G and Ni B: Progress in mass spectrometry-based proteomic research of tumor hypoxia (Review). Oncol Rep 38: 676-684, 2017.
APA
Gao, Z., Luo, G., & Ni, B. (2017). Progress in mass spectrometry-based proteomic research of tumor hypoxia (Review). Oncology Reports, 38, 676-684. https://doi.org/10.3892/or.2017.5748
MLA
Gao, Z., Luo, G., Ni, B."Progress in mass spectrometry-based proteomic research of tumor hypoxia (Review)". Oncology Reports 38.2 (2017): 676-684.
Chicago
Gao, Z., Luo, G., Ni, B."Progress in mass spectrometry-based proteomic research of tumor hypoxia (Review)". Oncology Reports 38, no. 2 (2017): 676-684. https://doi.org/10.3892/or.2017.5748
Copy and paste a formatted citation
x
Spandidos Publications style
Gao Z, Luo G and Ni B: Progress in mass spectrometry-based proteomic research of tumor hypoxia (Review). Oncol Rep 38: 676-684, 2017.
APA
Gao, Z., Luo, G., & Ni, B. (2017). Progress in mass spectrometry-based proteomic research of tumor hypoxia (Review). Oncology Reports, 38, 676-684. https://doi.org/10.3892/or.2017.5748
MLA
Gao, Z., Luo, G., Ni, B."Progress in mass spectrometry-based proteomic research of tumor hypoxia (Review)". Oncology Reports 38.2 (2017): 676-684.
Chicago
Gao, Z., Luo, G., Ni, B."Progress in mass spectrometry-based proteomic research of tumor hypoxia (Review)". Oncology Reports 38, no. 2 (2017): 676-684. https://doi.org/10.3892/or.2017.5748
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team