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Article

miR-367 promotes tumor growth by inhibiting FBXW7 in NSCLC

  • Authors:
    • Guodong Xiao
    • Xiao Gao
    • Xin Sun
    • Chengcheng Yang
    • Boxiang Zhang
    • Ruiying Sun
    • Guanghong Huang
    • Xiang Li
    • Jian Liu
    • Ning Du
    • Dapeng Liu
    • Rui Liang
    • Hong Ren
    • Sida Qin
  • View Affiliations / Copyright

    Affiliations: Second Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China, Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China, Department of Respiratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China, Department of Hepatobiliary Chest Surgery, Shaanxi Provincial Corps Hospital of Chinese People's Armed Police Force, Taiyuan, Shanxi, P.R. China
  • Pages: 1190-1198
    |
    Published online on: June 27, 2017
       https://doi.org/10.3892/or.2017.5755
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Abstract

miR-367 is one of the most abundant miRNAs in human embryonic stem cells (hESCs) and is mainly involved in maintaining the pluripotency of stem cells. However, its role in cancer development remains poorly understood. In the present study, we explored the function and mechanism of the endogenous miR-367 in non-small cell lung cancer (NSCLC). In the present study, we demonstrated that the level of miR-367 in NSCLC was significantly higher than that in adjacent normal tissues, and its upregulation was positively correlated with tumor size, tumor differentiation and tumor-node-metastasis (TNM) stage. miR-367 was an indicator of a poorer prognosis in NSCLC patients. Furthermore, overexpression of miR-367 significantly inhibited apoptosis and enhanced proliferation by promoting cell cycle transition from G1 to S phase. In contrast, knockdown of miR-367 markedly reversed the cellular events observed with miR-367 overexpression. Moreover, we identified that F-box and WD repeat domain-containing 7 (FBXW7) is a novel target of miR-367. It reverses the oncogenic effects of miR-367 by downregulating its substrates, c-Myc and c-Jun, in NSCLC cells. Finally, studies in vivo revealed that knockdown of miR-367 inhibited the growth of xenografts in the nude mice by increasing the expression of FBXW7. In summary, our findings indicate that miR-367 exerts tumor-promoting effect by negatively regulating FBXW7 in NSCLC, and it could become a potential therapeutic target for NSCLC intervention.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Taylor MD, Nagji AS, Bhamidipati CM, Theodosakis N, Kozower BD, Lau CL and Jones DR: Tumor recurrence after complete resection for non-small cell lung cancer. Ann Thorac Surg. 93:1813–1821. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Gao Z, Zhu X and Dou Y: The miR-302/367 cluster: A comprehensive update on its evolution and functions. Open Biol. 5:1501382015. View Article : Google Scholar : PubMed/NCBI

4 

Barroso-del Jesus A, Lucena-Aguilar G and Menendez P: The miR-302-367 cluster as a potential stemness regulator in ESCs. Cell Cycle. 8:394–398. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Meng X, Lu P and Fan Q: miR-367 promotes proliferation and invasion of hepatocellular carcinoma cells by negatively regulating PTEN. Biochem Biophys Res Commun. 470:187–191. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Kaid C, Silva PBG, Cortez BA, Rodini CO, Semedo-Kuriki P and Okamoto OK: miR-367 promotes proliferation and stem-like traits in medulloblastoma cells. Cancer Sci. 106:1188–1195. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Zhu Z, Xu Y, Zhao J, Liu Q, Feng W, Fan J and Wang P: miR-367 promotes epithelial-to-mesenchymal transition and invasion of pancreatic ductal adenocarcinoma cells by targeting the Smad7-TGF-β signalling pathway. Br J Cancer. 112:1367–1375. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Bin Z, Dedong H, Xiangjie F, Hongwei X and Qinghui Y: The microRNA-367 inhibits the invasion and metastasis of gastric cancer by directly repressing Rab23. Genet Test Mol Biomarkers. 19:69–74. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Campayo M, Navarro A, Viñolas N, Diaz T, Tejero R, Gimferrer JM, Molins L, Cabanas ML, Ramirez J, Monzo M, et al: Low miR-145 and high miR-367 are associated with unfavourable prognosis in resected nonsmall cell lung cancer. Eur Respir J. 41:1172–1178. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Akhoondi S, Sun D, von der Lehr N, Apostolidou S, Klotz K, Maljukova A, Cepeda D, Fiegl H, Dafou D, Marth C, et al: FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res. 67:9006–9012. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Li J, Guo Y, Liang X, Sun M, Wang G, De W and Wu W: MicroRNA-223 functions as an oncogene in human gastric cancer by targeting FBXW7/hCdc4. J Cancer Res Clin Oncol. 138:763–774. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Gong J, Cui Z, Li L, Ma Q, Wang Q, Gao Y and Sun H: MicroRNA-25 promotes gastric cancer proliferation, invasion, and migration by directly targeting F-box and WD-40 Domain Protein 7, FBXW7. Tumour Biol. 36:7831–7840. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Ren H, Koo J, Guan B, Yue P, Deng X, Chen M, Khuri FR and Sun SY: The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis. Mol Cancer. 12:1462013. View Article : Google Scholar : PubMed/NCBI

14 

Sun X, Tang SC, Xu C, Wang C, Qin S, Du N, Liu J, Zhang Y, Li X, Luo G, et al: DICER1 regulated let-7 expression levels in p53-induced cancer repression requires cyclin D1. J Cell Mol Med. 19:1357–1365. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Qiang BU and Jiang H: Chemosensitivity testing for human prostatic cancer with primary culture cells and purified culture cells using the CCK-8 assay. Pharmaceutical and Clinical Research. 2013.

16 

Wang GC, He QY, Tong DK, Wang CF, Liu K, Ding C, Ji F and Zhang H: MiR-367 negatively regulates apoptosis induced by adriamycin in osteosarcoma cells by targeting KLF4. J Bone Oncol. 5:51–56. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Guan Y, Chen L, Bao Y, Qiu B, Pang C, Cui R and Wang Y: High miR-196a and low miR-367 cooperatively correlate with unfavorable prognosis of high-grade glioma. Int J Clin Exp Pathol. 8:6576–6588. 2015.PubMed/NCBI

18 

Zhang L, Liu Y, Song F, Zheng H, Hu L, Lu H, Liu P, Hao X, Zhang W and Chen K: Functional SNP in the microRNA-367 binding site in the 3′UTR of the calcium channel ryanodine receptor gene 3 (RYR3) affects breast cancer risk and calcification. Proc Natl Acad Sci USA. 108:13653–13658. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Sun J, Song K, Feng X and Gao S: MicroRNA-367 is a potential diagnostic biomarker for patients with esophageal squamous cell carcinoma. Biochem Biophys Res Commun. 473:363–369. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Hanahan D and Awada A: The Hallmarks of Cancer Review. Ann Oncol. 100:57–70. 2012.

21 

Yang W, Dou C, Wang Y, Jia Y, Li C, Zheng X and Tu K: MicroRNA-92a contributes to tumor growth of human hepatocellular carcinoma by targeting FBXW7. Oncol Rep. 34:2576–2584. 2015.PubMed/NCBI

22 

Guo Z, Zhou Y, Evers BM and Wang Q: Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells. Biochem Biophys Res Commun. 418:426–432. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Fu Y, Lin Y, Yang Z, Yang G, Li G, Liu Y, Tan X, Huang Y, Wu X, Wang Y, et al: FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis. Med Oncol. 32:2152015. View Article : Google Scholar : PubMed/NCBI

24 

Chen J: Mechanism of molecular regulation of cyclin E-CDK2. Journal of Medical Molecular Biology. 2006.

25 

Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R and Brenner DA: c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology. 37:824–832. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Anokye-Danso F, Trivedi CM, Juhr D, Gupta M, Cui Z, Tian Y, Zhang Y, Yang W, Gruber PJ, Epstein JA, et al: Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell. 8:376–388. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Lin SL, Chang DC, Lin CH, Ying SY, Leu D and Wu DT: Regulation of somatic cell reprogramming through inducible mir-302 expression. Nucleic Acids Res. 39:1054–1065. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Yang H, Lu X, Liu Z, Chen L, Xu Y, Wang Y, Wei G and Chen Y: FBXW7 suppresses epithelial-mesenchymal transition, stemness and metastatic potential of cholangiocarcinoma cells. Oncotarget. 6:6310–6325. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Wang Y, Liu Y, Lu J, Zhang P, Wang Y, Xu Y, Wang Z, Mao JH and Wei G: Rapamycin inhibits FBXW7 loss-induced epithelial-mesenchymal transition and cancer stem cell-like characteristics in colorectal cancer cells. Biochem Biophys Res Commun. 434:352–356. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xiao G, Gao X, Sun X, Yang C, Zhang B, Sun R, Huang G, Li X, Liu J, Du N, Du N, et al: miR-367 promotes tumor growth by inhibiting FBXW7 in NSCLC. Oncol Rep 38: 1190-1198, 2017.
APA
Xiao, G., Gao, X., Sun, X., Yang, C., Zhang, B., Sun, R. ... Qin, S. (2017). miR-367 promotes tumor growth by inhibiting FBXW7 in NSCLC. Oncology Reports, 38, 1190-1198. https://doi.org/10.3892/or.2017.5755
MLA
Xiao, G., Gao, X., Sun, X., Yang, C., Zhang, B., Sun, R., Huang, G., Li, X., Liu, J., Du, N., Liu, D., Liang, R., Ren, H., Qin, S."miR-367 promotes tumor growth by inhibiting FBXW7 in NSCLC". Oncology Reports 38.2 (2017): 1190-1198.
Chicago
Xiao, G., Gao, X., Sun, X., Yang, C., Zhang, B., Sun, R., Huang, G., Li, X., Liu, J., Du, N., Liu, D., Liang, R., Ren, H., Qin, S."miR-367 promotes tumor growth by inhibiting FBXW7 in NSCLC". Oncology Reports 38, no. 2 (2017): 1190-1198. https://doi.org/10.3892/or.2017.5755
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao G, Gao X, Sun X, Yang C, Zhang B, Sun R, Huang G, Li X, Liu J, Du N, Du N, et al: miR-367 promotes tumor growth by inhibiting FBXW7 in NSCLC. Oncol Rep 38: 1190-1198, 2017.
APA
Xiao, G., Gao, X., Sun, X., Yang, C., Zhang, B., Sun, R. ... Qin, S. (2017). miR-367 promotes tumor growth by inhibiting FBXW7 in NSCLC. Oncology Reports, 38, 1190-1198. https://doi.org/10.3892/or.2017.5755
MLA
Xiao, G., Gao, X., Sun, X., Yang, C., Zhang, B., Sun, R., Huang, G., Li, X., Liu, J., Du, N., Liu, D., Liang, R., Ren, H., Qin, S."miR-367 promotes tumor growth by inhibiting FBXW7 in NSCLC". Oncology Reports 38.2 (2017): 1190-1198.
Chicago
Xiao, G., Gao, X., Sun, X., Yang, C., Zhang, B., Sun, R., Huang, G., Li, X., Liu, J., Du, N., Liu, D., Liang, R., Ren, H., Qin, S."miR-367 promotes tumor growth by inhibiting FBXW7 in NSCLC". Oncology Reports 38, no. 2 (2017): 1190-1198. https://doi.org/10.3892/or.2017.5755
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