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Article

Salivary miR-93 and miR-200a as post-radiotherapy biomarkers in head and neck squamous cell carcinoma

  • Authors:
    • Thomas Greither
    • Freya Vorwerk
    • Matthias Kappler
    • Matthias Bache
    • Helge Taubert
    • Thomas Kuhnt
    • Jeremias Hey
    • Alexander W. Eckert
  • View Affiliations / Copyright

    Affiliations: Center for Reproductive Medicine and Andrology, Martin Luther University Halle-Wittenberg, Germany, Department of Prosthetic Dentistry, University School of Dental Medicine, Martin Luther University Halle-Wittenberg, Germany, Department of Oral and Maxillofacial Plastic Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany, Department of Radiotherapy, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany, Department of Urology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany, Department of Imaging and Radiation Medicine, University Clinic of Radiotherapy Leipzig, Leipzig, Germany
  • Pages: 1268-1275
    |
    Published online on: June 28, 2017
       https://doi.org/10.3892/or.2017.5764
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Abstract

Head and neck squamous cell carcinoma is the 6th most malignant tumor entity worldwide and has exhibited a 5-year mortality of approximately 50% for the last fifty years. For the therapy monitoring and successful management of this tumor entity new and easily accessible biomarkers are greatly needed. The aim of the study was to determine whether and to what extent microRNAs, a class of small regulatory RNAs, are detectable in saliva post-radiation therapy. The expression and feasibility as therapy monitoring marker of the microRNAs were analyzed by RT-qPCR in 83 saliva samples from 33 patients collected at several time points pre-, during and post-radiotherapy treatment. Ten head and neck squamous cell carcinoma- or radiation-associated microRNAs (miR-93, miR-125a, miR-142-3p, miR-200a, miR-203, miR-213, let-7a, let-7b, let-7g and let-7i) were analyzed. All were detectable to a different extent in the saliva of the patients. miR-93 and miR-200a were significantly higher expressed 12 months post-radiotherapy than at baseline (p=0.047 and p=0.036). These results point towards miR-93 and miR-200a as biomarkers for the treatment monitoring post-radiation of head and neck squamous cell carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Greither T, Vorwerk F, Kappler M, Bache M, Taubert H, Kuhnt T, Hey J and Eckert AW: Salivary miR-93 and miR-200a as post-radiotherapy biomarkers in head and neck squamous cell carcinoma. Oncol Rep 38: 1268-1275, 2017.
APA
Greither, T., Vorwerk, F., Kappler, M., Bache, M., Taubert, H., Kuhnt, T. ... Eckert, A.W. (2017). Salivary miR-93 and miR-200a as post-radiotherapy biomarkers in head and neck squamous cell carcinoma. Oncology Reports, 38, 1268-1275. https://doi.org/10.3892/or.2017.5764
MLA
Greither, T., Vorwerk, F., Kappler, M., Bache, M., Taubert, H., Kuhnt, T., Hey, J., Eckert, A. W."Salivary miR-93 and miR-200a as post-radiotherapy biomarkers in head and neck squamous cell carcinoma". Oncology Reports 38.2 (2017): 1268-1275.
Chicago
Greither, T., Vorwerk, F., Kappler, M., Bache, M., Taubert, H., Kuhnt, T., Hey, J., Eckert, A. W."Salivary miR-93 and miR-200a as post-radiotherapy biomarkers in head and neck squamous cell carcinoma". Oncology Reports 38, no. 2 (2017): 1268-1275. https://doi.org/10.3892/or.2017.5764
Copy and paste a formatted citation
x
Spandidos Publications style
Greither T, Vorwerk F, Kappler M, Bache M, Taubert H, Kuhnt T, Hey J and Eckert AW: Salivary miR-93 and miR-200a as post-radiotherapy biomarkers in head and neck squamous cell carcinoma. Oncol Rep 38: 1268-1275, 2017.
APA
Greither, T., Vorwerk, F., Kappler, M., Bache, M., Taubert, H., Kuhnt, T. ... Eckert, A.W. (2017). Salivary miR-93 and miR-200a as post-radiotherapy biomarkers in head and neck squamous cell carcinoma. Oncology Reports, 38, 1268-1275. https://doi.org/10.3892/or.2017.5764
MLA
Greither, T., Vorwerk, F., Kappler, M., Bache, M., Taubert, H., Kuhnt, T., Hey, J., Eckert, A. W."Salivary miR-93 and miR-200a as post-radiotherapy biomarkers in head and neck squamous cell carcinoma". Oncology Reports 38.2 (2017): 1268-1275.
Chicago
Greither, T., Vorwerk, F., Kappler, M., Bache, M., Taubert, H., Kuhnt, T., Hey, J., Eckert, A. W."Salivary miR-93 and miR-200a as post-radiotherapy biomarkers in head and neck squamous cell carcinoma". Oncology Reports 38, no. 2 (2017): 1268-1275. https://doi.org/10.3892/or.2017.5764
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