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Article

Involvement of mitochondrial dynamics in the antineoplastic activity of cisplatin in murine leukemia L1210 cells

  • Authors:
    • Xiao-Jian Han
    • Sheng-Lan Shi
    • Yong-Fang Wei
    • Li-Ping Jiang
    • Miao-Yu Guo
    • Hong-Li Wu
    • Yu-Ying Wan
  • View Affiliations / Copyright

    Affiliations: Department of Intra-Hospital Infection Management, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Research Institute of Ophthalmology and Visual Sciences, Affiliated Eye Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Pharmacology, School of Pharmaceutical Sciences, Nanchang University, Nanchang, Jiangxi 330006, P.R. China
  • Pages: 985-992
    |
    Published online on: June 28, 2017
       https://doi.org/10.3892/or.2017.5765
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Abstract

Leukemia is a type of hematopoietic stem cell malignant cloned disease with high mortality. Cisplatin-based chemotherapy is one of the most common treatments for leukemia. Similar to other chemotherapeutic agents, cisplatin resistance has become a serious issue in cancer therapy. In the present study, we investigated the role of mitochondrial dynamics in the antineoplastic activity of cisplatin in murine leukemia L1210 cells. Firstly, the L1210 cell line resistant to cisplatin (L1210/DDP) was established. Compared to its parental cell line, the IC50 value of cisplatin in the L1210/DDP cells was increased 10-fold. Mitofusins (Mfn1 and Mfn2), mitochondrial outer membrane fusion proteins, were markedly upregulated in the L1210/DDP cells, whereas the expression of fission protein Drp1 and inner membrane fusion protein OPA1 were not significantly altered. In addition, mitofusins were also upregulated in the parental L1210 cells subjected to cisplatin stress. To investigate the role of mitochondrial dynamics in the antineoplastic activity of cisplatin, the effect of mitochondrial division inhibitor (Mdivi)-1 on cisplatin‑induced cell death, caspase-3 cleavage and ROS production was examined in L1210 cells. We found that 5 µM of Mdivi-1 efficiently attenuated cisplatin-induced cell death, caspase activation and intracellular ROS increase in L1210 cells. Our data indicated that mitochondrial dynamics play an important role in the antineoplastic activity of cisplatin, and mitofusin-mediated mitochondrial fusion may be involved in the process of cisplatin resistance in leukemia cells. Therefore, the present study revealed that mitochondrial dynamics may be a potential target used to improve the antineoplastic activity of cisplatin in leukemia in the future.
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1 

Benton CB, Nazha A, Pemmaraju N and Garcia-Manero G: Chronic myelomonocytic leukemia: Forefront of the field in 2015. Crit Rev Oncol Hematol. 95:222–242. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Chavez-Gonzalez A, Bakhshinejad B, Pakravan K, Guzman ML and Babashah S: Novel strategies for targeting leukemia stem cells: sounding the death knell for blood cancer. Cell Oncol. 40:1–20. 2017. View Article : Google Scholar

3 

Calado RT and Young NS: Telomere maintenance and human bone marrow failure. Blood. 111:4446–4455. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Safe S, Jin UH, Hedrick E, Reeder A and Lee SO: Minireview: Role of orphan nuclear receptors in cancer and potential as drug targets. Mol Endocrinol. 28:157–172. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Chen BA, Huang ZH, Zhang XP, Ou-Yang J, Li JY, Zhai YP, Sun XM, Xu YL, Lu Q, Wang JM, et al: An epidemiological investigation of leukemia incidence between 2003 and 2007 in Nanjing, China. J Hematol Oncol. 3:212010. View Article : Google Scholar : PubMed/NCBI

6 

Welch HG and Larson EB: Cost effectiveness of bone marrow transplantation in acute nonlymphocytic leukemia. N Engl J Med. 321:807–812. 1989. View Article : Google Scholar : PubMed/NCBI

7 

Lenarsky C and Parkman R: Bone marrow transplantation for the treatment of immune deficiency states. Bone Marrow Transplant. 6:361–369. 1990.PubMed/NCBI

8 

Godder KT, Abhyankar SH, Lamb LS, Best RG, Geier SS, Pati AR, Gee AP and Henslee-Downey PJ: Donor leukocyte infusion for treatment of graft rejection post partially mismatched related donor bone marrow transplant. Bone Marrow Transplant. 22:111–113. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Kobayashi T, Yoshida J, Ishiyama J, Noda S, Kito A and Kida Y: Combination chemotherapy with cisplatin and etoposide for malignant intracranial germ-cell tumors. An experimental and clinical study. J Neurosurg. 70:676–681. 1989. View Article : Google Scholar : PubMed/NCBI

10 

Borst P, Rottenberg S and Jonkers J: How do real tumors become resistant to cisplatin? Cell Cycle. 7:1353–1359. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Wong E and Giandomenico CM: Current status of platinum-based antitumor drugs. Chem Rev. 99:2451–2466. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Milacic V, Fregona D and Dou QP: Gold complexes as prospective metal-based anticancer drugs. Histol Histopathol. 23:101–108. 2008.PubMed/NCBI

13 

Chen H, Hardy TM and Tollefsbol TO: Epigenomics of ovarian cancer and its chemoprevention. Front Genet. 2:672011. View Article : Google Scholar : PubMed/NCBI

14 

Wu Y, Bhattacharyya D, King CL, Baskerville-Abraham I, Huh SH, Boysen G, Swenberg JA, Temple B, Campbell SL and Chaney SG: Solution structures of a DNA dodecamer duplex with and without a cisplatin 1,2-d(GG) intrastrand cross-link: Comparison with the same DNA duplex containing an oxaliplatin 1,2-d(GG) intrastrand cross-link. Biochemistry. 46:6477–6487. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Podratz JL, Knight AM, Ta LE, Staff NP, Gass JM, Genelin K, Schlattau A, Lathroum L and Windebank AJ: Cisplatin induced mitochondrial DNA damage in dorsal root ganglion neurons. Neurobiol Dis. 41:661–668. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Oakes SA and Korsmeyer SJ: Untangling the web: Mitochondrial fission and apoptosis. Dev Cell. 7:460–462. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Szabadkai G, Simoni AM, Chami M, Wieckowski MR, Youle RJ and Rizzuto R: Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis. Mol Cell. 16:59–68. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Shaw JM and Nunnari J: Mitochondrial dynamics and division in budding yeast. Trends Cell Biol. 12:178–184. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Wan YY, Zhang JF, Yang ZJ, Jiang LP, Wei YF, Lai QN, Wang JB, Xin HB and Han XJ: Involvement of Drp1 in hypoxia-induced migration of human glioblastoma U251 cells. Oncol Rep. 32:619–626. 2014.PubMed/NCBI

20 

Chan DC: Mitochondrial fusion and fission in mammals. Annu Rev Cell Dev Biol. 22:79–99. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Santin G, Piccolini VM, Barni S, Veneroni P, Giansanti V, Dal Bo V, Bernocchi G and Bottone MG: Mitochondrial fusion: A mechanism of cisplatin-induced resistance in neuroblastoma cells? Neurotoxicology. 34:51–60. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Farrand L, Byun S, Kim JY, Im-Aram A, Lee J, Lim S, Lee KW, Suh JY, Lee HJ and Tsang BK: Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission. J Biol Chem. 288:23740–23750. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Kato S, Ideguchi H, Muta K, Nishimura J and Nawata H: Mechanisms involved in the development of adriamycin resistance in human leukemic cells. Leuk Res. 14:567–573. 1990. View Article : Google Scholar : PubMed/NCBI

24 

Zwelling LA, Michaels S, Schwartz H, Dobson PP and Kohn KW: DNA cross-linking as an indicator of sensitivity and resistance of mouse L1210 leukemia to cis-diamminedichloroplatinum(II) and L-phenylalanine mustard. Cancer Res. 41:640–649. 1981.PubMed/NCBI

25 

Horvathova K, Novotny L and Vachalkova A: The free radical scavenging activity of four flavonoids determined by the comet assay. Neoplasma. 50:291–295. 2003.PubMed/NCBI

26 

Choi YM, Kim HK, Shim W, Anwar MA, Kwon JW, Kwon HK, Kim HJ, Jeong H, Kim HM, Hwang D, et al: Mechanism of cisplatin-induced cytotoxicity is correlated to impaired metabolism due to mitochondrial ROS generation. PLoS One. 10:e01350832015. View Article : Google Scholar : PubMed/NCBI

27 

Kaushal GP, Kaushal V, Hong X and Shah SV: Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells. Kidney Int. 60:1726–1736. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Bai J, He A, Huang C, Yang J, Zhang W, Wang J, Yang Y, Zhang P, Zhang Y and Zhou F: Serum peptidome based biomarkers searching for monitoring minimal residual disease in adult acute lymphocytic leukemia. Proteome Sci. 12:492014. View Article : Google Scholar : PubMed/NCBI

29 

Muggia F: Platinum compounds 30 years after the introduction of cisplatin: Implications for the treatment of ovarian cancer. Gynecol Oncol. 112:275–281. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Prestayko AW, D'Aoust JC, Issell BF and Crooke ST: Cisplatin (cis-diamminedichloroplatinum II). Cancer Treat Rev. 6:17–39. 1979. View Article : Google Scholar : PubMed/NCBI

31 

Lebwohl D and Canetta R: Clinical development of platinum complexes in cancer therapy: An historical perspective and an update. Eur J Cancer. 34:1522–1534. 1998. View Article : Google Scholar : PubMed/NCBI

32 

Galanski M: Recent developments in the field of anticancer platinum complexes. Recent Patents Anticancer Drug Discov. 1:285–295. 2006. View Article : Google Scholar

33 

Chen H and Chan DC: Physiological functions of mitochondrial fusion. Ann NY Acad Sci. 1201:21–25. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Renault TT, Floros KV, Elkholi R, Corrigan KA, Kushnareva Y, Wieder SY, Lindtner C, Serasinghe MN, Asciolla JJ, Buettner C, et al: Mitochondrial shape governs BAX-induced membrane permeabilization and apoptosis. Mol Cell. 57:69–82. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Brooks C, Wei Q, Feng L, Dong G, Tao Y, Mei L, Xie ZJ and Dong Z: Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins. Proc Natl Acad Sci USA. 104:11649–11654. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Whelan RS, Konstantinidis K, Wei AC, Chen Y, Reyna DE, Jha S, Yang Y, Calvert JW, Lindsten T, Thompson CB, et al: Bax regulates primary necrosis through mitochondrial dynamics. Proc Natl Acad Sci USA. 109:6566–6571. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Wen S, Zhu D and Huang P: Targeting cancer cell mitochondria as a therapeutic approach. Future Med Chem. 5:53–67. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Tanaka A and Youle RJ: A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol Cell. 29:409–410. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Han XJ, Yang ZJ, Jiang LP, Wei YF, Liao MF, Qian Y, Li Y, Huang X, Wang JB, Xin HB, et al: Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells. Int J Oncol. 46:691–700. 2015.PubMed/NCBI

40 

Kim H, Lee JY, Park KJ, Kim WH and Roh GS: A mitochondrial division inhibitor, Mdivi-1, inhibits mitochondrial fragmentation and attenuates kainic acid-induced hippocampal cell death. BMC Neurosci. 17:332016. View Article : Google Scholar : PubMed/NCBI

41 

Akita M, Suzuki-Karasaki M, Fujiwara K, Nakagawa C, Soma M, Yoshida Y, Ochiai T, Tokuhashi Y and Suzuki-Karasaki Y: Mitochondrial division inhibitor-1 induces mitochondrial hyperfusion and sensitizes human cancer cells to TRAIL-induced apoptosis. Int J Oncol. 45:1901–1912. 2014.PubMed/NCBI

42 

Han XJ, Lu YF, Li SA, Kaitsuka T, Sato Y, Tomizawa K, Nairn AC, Takei K, Matsui H and Matsushita M: CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology. J Cell Biol. 182:573–585. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Han X, Shi S, Wei Y, Jiang L, Guo M, Wu H and Wan Y: Involvement of mitochondrial dynamics in the antineoplastic activity of cisplatin in murine leukemia L1210 cells. Oncol Rep 38: 985-992, 2017.
APA
Han, X., Shi, S., Wei, Y., Jiang, L., Guo, M., Wu, H., & Wan, Y. (2017). Involvement of mitochondrial dynamics in the antineoplastic activity of cisplatin in murine leukemia L1210 cells. Oncology Reports, 38, 985-992. https://doi.org/10.3892/or.2017.5765
MLA
Han, X., Shi, S., Wei, Y., Jiang, L., Guo, M., Wu, H., Wan, Y."Involvement of mitochondrial dynamics in the antineoplastic activity of cisplatin in murine leukemia L1210 cells". Oncology Reports 38.2 (2017): 985-992.
Chicago
Han, X., Shi, S., Wei, Y., Jiang, L., Guo, M., Wu, H., Wan, Y."Involvement of mitochondrial dynamics in the antineoplastic activity of cisplatin in murine leukemia L1210 cells". Oncology Reports 38, no. 2 (2017): 985-992. https://doi.org/10.3892/or.2017.5765
Copy and paste a formatted citation
x
Spandidos Publications style
Han X, Shi S, Wei Y, Jiang L, Guo M, Wu H and Wan Y: Involvement of mitochondrial dynamics in the antineoplastic activity of cisplatin in murine leukemia L1210 cells. Oncol Rep 38: 985-992, 2017.
APA
Han, X., Shi, S., Wei, Y., Jiang, L., Guo, M., Wu, H., & Wan, Y. (2017). Involvement of mitochondrial dynamics in the antineoplastic activity of cisplatin in murine leukemia L1210 cells. Oncology Reports, 38, 985-992. https://doi.org/10.3892/or.2017.5765
MLA
Han, X., Shi, S., Wei, Y., Jiang, L., Guo, M., Wu, H., Wan, Y."Involvement of mitochondrial dynamics in the antineoplastic activity of cisplatin in murine leukemia L1210 cells". Oncology Reports 38.2 (2017): 985-992.
Chicago
Han, X., Shi, S., Wei, Y., Jiang, L., Guo, M., Wu, H., Wan, Y."Involvement of mitochondrial dynamics in the antineoplastic activity of cisplatin in murine leukemia L1210 cells". Oncology Reports 38, no. 2 (2017): 985-992. https://doi.org/10.3892/or.2017.5765
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