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Article Open Access

Tetramethylpyrazine inhibits prostate cancer progression by downregulation of forkhead box M1

Retraction in: /10.3892/or.2024.8811
  • Authors:
    • Yi Zhou
    • Zhigang Ji
    • Weigang Yan
    • Zhien Zhou
    • Hanzhong Li
    • Yu Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100000, P.R. China, Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100000, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 837-842
    |
    Published online on: June 29, 2017
       https://doi.org/10.3892/or.2017.5768
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Abstract

Tetramethylpyrazine (TMP) has exhibited various anticancer effects. However, its ability to inhibit proliferation, migration, and invasion of prostate cancer (PCa) PC-3 cells is still unclear. In the present study, different concentrations of TMP were co-incubated with PC-3 cells. The pcDNA-FOXM1 plasmid was transfected into cells before treatment with 500 µg/l TMP. The proliferative, migratory and invasive abilities of PC-3 cells were tested by MTT assay, wound healing assay and colony formation assay. Western blotting was used to investigate the expression of FOXM1. We found that, compared with the control, the proliferative, migratory and invasive abilities of PC-3 cells were decreased after incubation with different concentrations of TMP (P<0.01). The expression of FOXM1 was decreased in TMP-treated PC-3 cells (P<0.01). In addition, overexpression of FOXM1 reversed TMP-mediated inhibition of proliferation, migration and invasion of PC-3 cells. We also found that TMP inhibited PCa growth in vivo in a dose-dependent manner. These results suggest that TMP inhibits PC-3 cell proliferation, migration and invasion by downregulation of FOXM1.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou Y, Ji Z, Yan W, Zhou Z, Li H and Xiao Y: Tetramethylpyrazine inhibits prostate cancer progression by downregulation of forkhead box M1 Retraction in /10.3892/or.2024.8811. Oncol Rep 38: 837-842, 2017.
APA
Zhou, Y., Ji, Z., Yan, W., Zhou, Z., Li, H., & Xiao, Y. (2017). Tetramethylpyrazine inhibits prostate cancer progression by downregulation of forkhead box M1 Retraction in /10.3892/or.2024.8811. Oncology Reports, 38, 837-842. https://doi.org/10.3892/or.2017.5768
MLA
Zhou, Y., Ji, Z., Yan, W., Zhou, Z., Li, H., Xiao, Y."Tetramethylpyrazine inhibits prostate cancer progression by downregulation of forkhead box M1 Retraction in /10.3892/or.2024.8811". Oncology Reports 38.2 (2017): 837-842.
Chicago
Zhou, Y., Ji, Z., Yan, W., Zhou, Z., Li, H., Xiao, Y."Tetramethylpyrazine inhibits prostate cancer progression by downregulation of forkhead box M1 Retraction in /10.3892/or.2024.8811". Oncology Reports 38, no. 2 (2017): 837-842. https://doi.org/10.3892/or.2017.5768
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou Y, Ji Z, Yan W, Zhou Z, Li H and Xiao Y: Tetramethylpyrazine inhibits prostate cancer progression by downregulation of forkhead box M1 Retraction in /10.3892/or.2024.8811. Oncol Rep 38: 837-842, 2017.
APA
Zhou, Y., Ji, Z., Yan, W., Zhou, Z., Li, H., & Xiao, Y. (2017). Tetramethylpyrazine inhibits prostate cancer progression by downregulation of forkhead box M1 Retraction in /10.3892/or.2024.8811. Oncology Reports, 38, 837-842. https://doi.org/10.3892/or.2017.5768
MLA
Zhou, Y., Ji, Z., Yan, W., Zhou, Z., Li, H., Xiao, Y."Tetramethylpyrazine inhibits prostate cancer progression by downregulation of forkhead box M1 Retraction in /10.3892/or.2024.8811". Oncology Reports 38.2 (2017): 837-842.
Chicago
Zhou, Y., Ji, Z., Yan, W., Zhou, Z., Li, H., Xiao, Y."Tetramethylpyrazine inhibits prostate cancer progression by downregulation of forkhead box M1 Retraction in /10.3892/or.2024.8811". Oncology Reports 38, no. 2 (2017): 837-842. https://doi.org/10.3892/or.2017.5768
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