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Article Open Access

MicroRNA-345 inhibits hepatocellular carcinoma metastasis by inhibiting YAP1

Retraction in: /10.3892/or.2025.8913
  • Authors:
    • Hui Zhang
    • Hui Liu
    • Huaqiang Bi
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Southwest Hospital, The Third Military Medical University, Chongqing 400038, P.R. China, Department of Hepatobiliary Surgery, Southwest Hospital, The Third Military Medical University, Chongqing 400038, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 843-849
    |
    Published online on: June 30, 2017
       https://doi.org/10.3892/or.2017.5772
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Abstract

MicroRNAs (miRNAs) play critical roles in hepatocellular carcinoma (HCC). However, the expression and biological function of miR-345 in HCC remain unknown. The present study demonstrated that miR-345 expression was reduced in HCC tissues and cell lines. Decreased miR-345 expression was associated with unfavorable clinical features and poor prognosis. In vitro functional assays showed that miR-345 overexpression inhibited the migration and invasion of MHCC-97H cells while miR-345 knockdown promoted metastatic behavior of Hep3B cells. In vivo experiments showed that miR-345 overexpression inhibited while miR-345 knockdown promoted lung metastasis of HCC cells in nude mice. Mechanically, YAP1 was identified to be the downstream target of miR-345 in HCC cells. YAP1 overexpression reversed the inhibitory effects of miR-345 on MHCC-97H migration and invasion, while YAP1 knockdown reduced the promoting effects of miR-345 knockdown on the metastatic behavior of Hep3B cells.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Liu H and Bi H: MicroRNA-345 inhibits hepatocellular carcinoma metastasis by inhibiting YAP1 Retraction in /10.3892/or.2025.8913. Oncol Rep 38: 843-849, 2017.
APA
Zhang, H., Liu, H., & Bi, H. (2017). MicroRNA-345 inhibits hepatocellular carcinoma metastasis by inhibiting YAP1 Retraction in /10.3892/or.2025.8913. Oncology Reports, 38, 843-849. https://doi.org/10.3892/or.2017.5772
MLA
Zhang, H., Liu, H., Bi, H."MicroRNA-345 inhibits hepatocellular carcinoma metastasis by inhibiting YAP1 Retraction in /10.3892/or.2025.8913". Oncology Reports 38.2 (2017): 843-849.
Chicago
Zhang, H., Liu, H., Bi, H."MicroRNA-345 inhibits hepatocellular carcinoma metastasis by inhibiting YAP1 Retraction in /10.3892/or.2025.8913". Oncology Reports 38, no. 2 (2017): 843-849. https://doi.org/10.3892/or.2017.5772
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang H, Liu H and Bi H: MicroRNA-345 inhibits hepatocellular carcinoma metastasis by inhibiting YAP1 Retraction in /10.3892/or.2025.8913. Oncol Rep 38: 843-849, 2017.
APA
Zhang, H., Liu, H., & Bi, H. (2017). MicroRNA-345 inhibits hepatocellular carcinoma metastasis by inhibiting YAP1 Retraction in /10.3892/or.2025.8913. Oncology Reports, 38, 843-849. https://doi.org/10.3892/or.2017.5772
MLA
Zhang, H., Liu, H., Bi, H."MicroRNA-345 inhibits hepatocellular carcinoma metastasis by inhibiting YAP1 Retraction in /10.3892/or.2025.8913". Oncology Reports 38.2 (2017): 843-849.
Chicago
Zhang, H., Liu, H., Bi, H."MicroRNA-345 inhibits hepatocellular carcinoma metastasis by inhibiting YAP1 Retraction in /10.3892/or.2025.8913". Oncology Reports 38, no. 2 (2017): 843-849. https://doi.org/10.3892/or.2017.5772
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