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Article

Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway

  • Authors:
    • Dingqing Feng
    • Tingting Zhao
    • Keqin Yan
    • Haiyan Liang
    • Jing Liang
    • Ying Zhou
    • Weidong Zhao
    • Bin Ling
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, China-Japan Friendship Hospital, Beijing 100029, P.R. China, Department of Obstetrics, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214002, P.R. China, Department of Obstetrics and Gynecology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China
  • Pages: 1091-1098
    |
    Published online on: July 3, 2017
       https://doi.org/10.3892/or.2017.5784
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Abstract

It is generally accepted that ovarian cancer is associated with local elevation of gonadotropins (FSH and LH), with repeated ovulation and accompanying expression of inducible cyclooxygenase 2 (COX2). However, the roles of gonadotropins and the concomitant elevation of COX2 in the development of ovarian cancer have not been fully characterized. Herein, we report that excessive FSH/LH exposure did not induce proliferation in ovarian cancer cell lines but significantly promoted cell migration and invasion. Moreover, FSH/LH treatment rapidly upregulated COX2 expression within 24 h, whereas COX1 expression remained unchanged. Further results showed that enhancement of epithelial-mesenchymal transition (EMT) and upregulation of matrix metalloproteinase (MMP)2 and MMP9 contributed to the stimulatory effect of gonadotropins on cell migration and invasion; these effects were sufficiently blocked by a selective COX2 inhibitor. In conclusion, the present study suggests that gonadotropin-induced migration and invasion in ovarian cancer may be caused by EMT and MMP upregulation via a COX2-dependent pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Feng D, Zhao T, Yan K, Liang H, Liang J, Zhou Y, Zhao W and Ling B: Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway. Oncol Rep 38: 1091-1098, 2017.
APA
Feng, D., Zhao, T., Yan, K., Liang, H., Liang, J., Zhou, Y. ... Ling, B. (2017). Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway. Oncology Reports, 38, 1091-1098. https://doi.org/10.3892/or.2017.5784
MLA
Feng, D., Zhao, T., Yan, K., Liang, H., Liang, J., Zhou, Y., Zhao, W., Ling, B."Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway". Oncology Reports 38.2 (2017): 1091-1098.
Chicago
Feng, D., Zhao, T., Yan, K., Liang, H., Liang, J., Zhou, Y., Zhao, W., Ling, B."Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway". Oncology Reports 38, no. 2 (2017): 1091-1098. https://doi.org/10.3892/or.2017.5784
Copy and paste a formatted citation
x
Spandidos Publications style
Feng D, Zhao T, Yan K, Liang H, Liang J, Zhou Y, Zhao W and Ling B: Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway. Oncol Rep 38: 1091-1098, 2017.
APA
Feng, D., Zhao, T., Yan, K., Liang, H., Liang, J., Zhou, Y. ... Ling, B. (2017). Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway. Oncology Reports, 38, 1091-1098. https://doi.org/10.3892/or.2017.5784
MLA
Feng, D., Zhao, T., Yan, K., Liang, H., Liang, J., Zhou, Y., Zhao, W., Ling, B."Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway". Oncology Reports 38.2 (2017): 1091-1098.
Chicago
Feng, D., Zhao, T., Yan, K., Liang, H., Liang, J., Zhou, Y., Zhao, W., Ling, B."Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway". Oncology Reports 38, no. 2 (2017): 1091-1098. https://doi.org/10.3892/or.2017.5784
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