Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway

  • Authors:
    • Xiaoling Wu
    • Jie Zhou
    • Dongge Cai
    • Mu Li
  • View Affiliations

  • Published online on: July 3, 2017     https://doi.org/10.3892/or.2017.5787
  • Pages: 1312-1320
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Abstract

Matrine is a traditional Chinese herbal medicine that shows antitumor efficacy for many types of cancer. The present study evaluated the antitumor efficacy of matrine on cervical cancer and to investigate the underlying mechanisms. We performed MTT assays, and in vitro invasion and migration assays, and P1 L6 found that matrine significantly inhibited cervical cancer cell growth by inducing apoptosis, and suppressed the invasion and migration ability of cervical cancer cells in vitro in a concentration-dependent manner. Mechanistically, we found that matrine decreased the expression and activity of the extracellular matrix factors, matrix metalloproteinases-2 (MMP-2) and MMP-9 via the suppression of p38 signaling pathway. In addition, when cervical cancer cells were grown as xenografts in nude mice, intraperitoneal (i.p.) injection of matrine induced a significant dose-dependent decrease in tumor growth. Taken together, these findings suggest that a potential mechanism by which matrine inhibits the growth and metastasis of cervical cancer through downregulating the p38 signaling pathway.
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August-2017
Volume 38 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wu X, Zhou J, Cai D and Li M: Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway. Oncol Rep 38: 1312-1320, 2017
APA
Wu, X., Zhou, J., Cai, D., & Li, M. (2017). Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway. Oncology Reports, 38, 1312-1320. https://doi.org/10.3892/or.2017.5787
MLA
Wu, X., Zhou, J., Cai, D., Li, M."Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway". Oncology Reports 38.2 (2017): 1312-1320.
Chicago
Wu, X., Zhou, J., Cai, D., Li, M."Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway". Oncology Reports 38, no. 2 (2017): 1312-1320. https://doi.org/10.3892/or.2017.5787