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Glioblastoma entities express subtle differences in molecular composition and response to treatment

  • Authors:
    • Joana Balça-Silva
    • Diana Matias
    • Anália Do Carmo
    • Luiz Gustavo Dubois
    • Ana Cristina Gonçalves
    • Henrique Girão
    • Nathalie Henriques Silva Canedo
    • Ana Helena Correia
    • Jorge Marcondes De Souza
    • Ana Bela Sarmento-Ribeiro
    • Maria Celeste Lopes
    • Vivaldo Moura-Neto
  • View Affiliations / Copyright

    Affiliations: Center for Neuroscience and Cell Biology and Institute for Biomedical Imaging and Life Sciences (CNC.IBILI), Coimbra, Portugal, Instituto Estadual do Cérebro Paulo Niemeyer (IECPN), Secretaria de Estado de Saúde, Rio de Janeiro, Brazil, Department of Pathology, Clementino Fraga Filho Hospital, Federal University of Rio de Janeiro, School of Medicine, Rio de Janeiro, Brazil, Department of Neurosurgery, Clementino Fraga Filho Hospital, Federal University of Rio de Janeiro, School of Medicine, Rio de Janeiro, Brazil
    Copyright: © Balça-Silva et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1341-1352
    |
    Published online on: July 7, 2017
       https://doi.org/10.3892/or.2017.5799
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Abstract

Glioblastoma (GBM) is a grade IV astrocytoma. GBM patients show resistance to chemotherapy such as temozolomide (TMZ), the gold standard treatment. In order to simulate the molecular mechanisms behind the different chemotherapeutic responses in GBM patients we compared the cellular heterogeneity and chemotherapeutic resistance mechanisms in different GBM cell lines. We isolated and characterized a human GBM cell line obtained from a GBM patient, named GBM11. We studied the GBM11 behaviour when treated with Tamoxifen (TMX) that, among other functions, is a protein kinase C (PKC) inhibitor, alone and in combination with TMZ in comparison with the responses of U87 and U118 human GBM cell lines. We evaluated the cell death, cell cycle arrest and cell proliferation, mainly through PKC expression, by flow cytometry and western blot analysis and, ultimately, cell migration capability and f-actin filament disorganization by fluorescence microscopy. We demonstrated that the constitutive activation of p-PKC seems to be one of the main metabolic implicated on GBM malignancy. Despite of its higher resistance, possibly due to the overexpression of P-glycoprotein and stem-like cell markers, GBM11 cells presented a subtle different chemotherapeutic response compared to U87 and U118 cells. The GBM11, U87, U118 cell lines show subtle molecular differences, which clearly indicate the characterization of GBM heterogeneity, one of the main reasons for tumor resistance. The adding of cellular heterogeneity in molecular behaviour constitutes a step closer in the understanding of resistant molecular mechanisms in GBM, and can circumvents the eventual impaired therapy.
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1 

Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P and Ellison DW: The 2016 World Health Organization Classification of Tumors of the Central Nervous System: A summary. Acta Neuropathol. 131:803–820. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Stupp R, Hegi ME, Gilbert MR and Chakravarti A: Chemoradiotherapy in malignant glioma: Standard of care and future directions. J Clin Oncol. 25:4127–4136. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, et al: European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 352:987–996. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Lima FRS, Kahn SA, Soletti RC, Biasoli D, Alves T, da Fonseca AC, Garcia C, Romão L, Brito J, Holanda-Afonso R, et al: Glioblastoma: Therapeutic challenges, what lies ahead. Biochim Biophys Acta. 1826:338–349. 2012.PubMed/NCBI

5 

Huse JT, Holland E and DeAngelis LM: Glioblastoma: Molecular analysis and clinical implications. Annu Rev Med. 64:59–70. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Balça-Silva J, Matias D, do Carmo A, Girão H, Moura-Neto V, Sarmento-Ribeiro AB and Lopes MC: Tamoxifen in combination with temozolomide induce a synergistic inhibition of PKC-pan in GBM cell lines. Biochim Biophys Acta. 1850:722–732. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Carmo A, Carvalheiro H, Crespo I, Nunes I and Lopes MC: Effect of temozolomide on the U-118 glioma cell line. Oncol Lett. 2:1165–1170. 2011.PubMed/NCBI

8 

do Carmo A, Patricio I, Cruz MT, Carvalheiro H, Oliveira CR and Lopes MC: CXCL12/CXCR4 promotes motility and proliferation of glioma cells. Cancer Biol Ther. 9:56–65. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Hattermann K and Mentlein R: An infernal trio: The chemokine CXCL12 and its receptors CXCR4 and CXCR7 in tumor biology. Ann Anat. 195:103–110. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Zhou J, Atsina KB, Himes BT, Strohbehn GW and Saltzman WM: Novel delivery strategies for glioblastoma. Cancer J. 18:89–99. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Safa AR, Saadatzadeh MR, Cohen-Gadol AA, Pollok KE and Bijangi-Vishehsaraei K: Glioblastoma stem cells (GSCs) epigenetic plasticity and interconversion between differentiated non-GSCs and GSCs. Genes Dis. 2:152–163. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, et al: European Organisation for Research and Treatment of Cancer Brain Tumour and Radiation Oncology Groups; National Cancer Institute of Canada Clinical Trials Group: Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 10:459–466. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Thirant C, Bessette B, Varlet P, Puget S, Cadusseau J, Tavares SR, Studler JM, Silvestre DC, Susini A, Villa C, et al: Clinical relevance of tumor cells with stem-like properties in pediatric brain tumors. PLoS One. 6:e163752011. View Article : Google Scholar : PubMed/NCBI

14 

Bogush T, Dudko E, Bogush E, Polotsky B, Tjulandin S and Davydov M: Tamoxifen non-estrogen receptor mediated molecular targets. Oncol Rev. 6:e152012. View Article : Google Scholar : PubMed/NCBI

15 

Kahn SA, Biasoli D, Garcia C, Geraldo LH, Pontes B, Sobrinho M, Frauches AC, Romão L, Soletti RC, Assunção FS, et al: Equinatoxin II potentiates temozolomide- and etoposide-induced glioblastoma cell death. Curr Top Med Chem. 12:2082–2093. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Faria J, Romão L, Martins S, Alves T, Mendes FA, de Faria GP, Hollanda R, Takiya C, Chimelli L, Morandi V, et al: Interactive properties of human glioblastoma cells with brain neurons in culture and neuronal modulation of glial laminin organization. Differentiation. 74:562–572. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Linn SC, Giaccone G, van Diest PJ, Blokhuis WM, van der Valk P, van Kalken CK, Kuiper CM, Pinedo HM and Baak JP: Prognostic relevance of P-glycoprotein expression in breast cancer. Ann Oncol. 6:679–685. 1995. View Article : Google Scholar : PubMed/NCBI

18 

Calatozzolo C, Gelati M, Ciusani E, Sciacca FL, Pollo B, Cajola L, Marras C, Silvani A, Vitellaro-Zuccarello L, Croci D, et al: Expression of drug resistance proteins Pgp, MRP1, MRP3, MRP5 and GST-π in human glioma. J Neurooncol. 74:113–121. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Gonçalves AC, Cortesão E, Oliveiros B, Alves V, Espadana AI, Rito L, Magalhães E, Lobão MJ, Pereira A, Costa JM Nascimento, et al: Oxidative stress and mitochondrial dysfunction play a role in myelodysplastic syndrome development, diagnosis, and prognosis: A pilot study. Free Radic Res. 49:1081–1094. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Towbin H, Staehelin T and Gordon J: Immunoblotting in the clinical laboratory. J Clin Chem Clin Biochem. 27:495–501. 1989.PubMed/NCBI

21 

Liang CC, Park AY and Guan JL: In vitro scratch assay: A convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc. 2:329–333. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Rittierodt M and Harada K: Repetitive doxorubicin treatment of glioblastoma enhances the PGP expression - a special role for endothelial cells. Exp Toxicol Pathol. 55:39–44. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Borowski E, Bontemps-Gracz MM and Piwkowska A: Strategies for overcoming ABC-transporters-mediated multidrug resistance (MDR) of tumor cells. Acta Biochim Pol. 52:609–627. 2005.PubMed/NCBI

24 

Qiu ZK, Shen D, Chen YS, Yang QY, Guo CC, Feng BH and Chen ZP: Enhanced MGMT expression contributes to temozolomide resistance in glioma stem-like cells. Chin J Cancer. 33:115–122. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Hegi ME, Diserens A-C, Gorlia T, Hamou MF, de Tribolet N, Weller M, Kros JM, Hainfellner JA, Mason W, Mariani L, et al: MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 352:997–1003. 2005. View Article : Google Scholar : PubMed/NCBI

26 

He W, Liu R, Yang SH and Yuan F: Chemotherapeutic effect of tamoxifen on temozolomide-resistant gliomas. Anticancer Drugs. 26:293–300. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Couldwell WT, Hinton DR, He S, Chen TC, Sebat I, Weiss MH and Law RE: Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines. FEBS Lett. 345:43–46. 1994. View Article : Google Scholar : PubMed/NCBI

28 

Zhang W, Couldwell WT, Song H, Takano T, Lin JH and Nedergaard M: Tamoxifen-induced enhancement of calcium signaling in glioma and MCF-7 breast cancer cells. Cancer Res. 60:5395–5400. 2000.PubMed/NCBI

29 

OBrian CA, Liskamp RM, Solomon DH and Weinstein IB: Inhibition of protein kinase C by tamoxifen. Cancer Res. 45:2462–2465. 1985.PubMed/NCBI

30 

Kamburoğlu G, Kiratli H, Söylemezoğlu F and Bilgiç S: Clinicopathological parameters and expression of P-glycoprotein and MRP-1 in retinoblastoma. Ophthalmic Res. 39:191–197. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Hui AM, Zhang W, Chen W, Xi D, Purow B, Friedman GC and Fine HA: Agents with selective estrogen receptor (ER) modulator activity induce apoptosis in vitro and in vivo in ER-negative glioma cells. Cancer Res. 64:9115–9123. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Deck JH, Eng LF, Bigbee J and Woodcock SM: The role of glial fibrillary acidic protein in the diagnosis of central nervous system tumors. Acta Neuropathol. 42:183–190. 1978. View Article : Google Scholar : PubMed/NCBI

33 

Altaner C and Altanerova V: Stem cell based glioblastoma gene therapy. Neoplasma. 59:756–760. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Jackson M, Hassiotou F and Nowak A: Glioblastoma stem-like cells: At the root of tumor recurrence and a therapeutic target. Carcinogenesis. 36:177–185. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Meacham CE and Morrison SJ: Tumour heterogeneity and cancer cell plasticity. Nature. 501:328–337. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Garcia C, Dubois LG, Xavier AL, Geraldo LH, da Fonseca AC, Correia AH, Meirelles F, Ventura G, Romão L, Canedo NH, et al: The orthotopic xenotransplant of human glioblastoma successfully recapitulates glioblastoma-microenvironment interactions in a non-immunosuppressed mouse model. BMC Cancer. 14:9232014. View Article : Google Scholar : PubMed/NCBI

37 

Tóth K, Vaughan MM, Peress NS, Slocum HK and Rustum YM: MDR1 P-glycoprotein is expressed by endothelial cells of newly formed capillaries in human gliomas but is not expressed in the neovasculature of other primary tumors. Am J Pathol. 149:853–858. 1996.PubMed/NCBI

38 

Sun H, Dai H, Shaik N and Elmquist WF: Drug efflux transporters in the CNS. Adv Drug Deliv Rev. 55:83–105. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Cordon-Cardo C, OBrien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed MR and Bertino JR: Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci USA. 86:695–698. 1989. View Article : Google Scholar : PubMed/NCBI

40 

Schaich M, Kestel L, Pfirrmann M, Robel K, Illmer T, Kramer M, Dill C, Ehninger G, Schackert G and Krex D: A MDR1 (ABCB1) gene single nucleotide polymorphism predicts outcome of temozolomide treatment in glioblastoma patients. Ann Oncol. 20:175–181. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Tomaszowski KH, Schirrmacher R and Kaina B: Multidrug efflux pumps attenuate the effect of MGMT inhibitors. Mol Pharm. 12:3924–3934. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, Henkelman RM, Cusimano MD and Dirks PB: Identification of human brain tumour initiating cells. Nature. 432:396–401. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Diaz A and Leon K: Therapeutic approaches to target cancer stem cells. Cancers (Basel). 3:3331–3352. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Ortensi B, Setti M, Osti D and Pelicci G: Cancer stem cell contribution to glioblastoma invasiveness. Stem Cell Res Ther. 4:182013. View Article : Google Scholar : PubMed/NCBI

45 

Seymour T, Nowak A and Kakulas F: Targeting aggressive cancer stem cells in glioblastoma. Front Oncol. 5:1592015. View Article : Google Scholar : PubMed/NCBI

46 

Cox JL, Wilder PJ, Desler M and Rizzino A: Elevating SOX2 levels deleteriously affects the growth of medulloblastoma and glioblastoma cells. PLoS One. 7:e440872012. View Article : Google Scholar : PubMed/NCBI

47 

Callaghan R and Higgins C: Interaction of tamoxifen with the multidrug resistance P-glycoprotein. Br J Cancer. 71:294–299. 1995. View Article : Google Scholar : PubMed/NCBI

48 

Di Cristofori A, Carrabba G, Lanfranchi G, Menghetti C, Rampini P and Caroli M: Continuous tamoxifen and dose-dense temozolomide in recurrent glioblastoma. Anticancer Res. 33:3383–3389. 2013.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Balça-Silva J, Matias D, Do Carmo A, Dubois LG, Gonçalves AC, Girão H, Canedo NS, Correia AH, De Souza JM, Sarmento-Ribeiro AB, Sarmento-Ribeiro AB, et al: Glioblastoma entities express subtle differences in molecular composition and response to treatment. Oncol Rep 38: 1341-1352, 2017.
APA
Balça-Silva, J., Matias, D., Do Carmo, A., Dubois, L.G., Gonçalves, A.C., Girão, H. ... Moura-Neto, V. (2017). Glioblastoma entities express subtle differences in molecular composition and response to treatment. Oncology Reports, 38, 1341-1352. https://doi.org/10.3892/or.2017.5799
MLA
Balça-Silva, J., Matias, D., Do Carmo, A., Dubois, L. G., Gonçalves, A. C., Girão, H., Canedo, N. S., Correia, A. H., De Souza, J. M., Sarmento-Ribeiro, A. B., Lopes, M. C., Moura-Neto, V."Glioblastoma entities express subtle differences in molecular composition and response to treatment". Oncology Reports 38.3 (2017): 1341-1352.
Chicago
Balça-Silva, J., Matias, D., Do Carmo, A., Dubois, L. G., Gonçalves, A. C., Girão, H., Canedo, N. S., Correia, A. H., De Souza, J. M., Sarmento-Ribeiro, A. B., Lopes, M. C., Moura-Neto, V."Glioblastoma entities express subtle differences in molecular composition and response to treatment". Oncology Reports 38, no. 3 (2017): 1341-1352. https://doi.org/10.3892/or.2017.5799
Copy and paste a formatted citation
x
Spandidos Publications style
Balça-Silva J, Matias D, Do Carmo A, Dubois LG, Gonçalves AC, Girão H, Canedo NS, Correia AH, De Souza JM, Sarmento-Ribeiro AB, Sarmento-Ribeiro AB, et al: Glioblastoma entities express subtle differences in molecular composition and response to treatment. Oncol Rep 38: 1341-1352, 2017.
APA
Balça-Silva, J., Matias, D., Do Carmo, A., Dubois, L.G., Gonçalves, A.C., Girão, H. ... Moura-Neto, V. (2017). Glioblastoma entities express subtle differences in molecular composition and response to treatment. Oncology Reports, 38, 1341-1352. https://doi.org/10.3892/or.2017.5799
MLA
Balça-Silva, J., Matias, D., Do Carmo, A., Dubois, L. G., Gonçalves, A. C., Girão, H., Canedo, N. S., Correia, A. H., De Souza, J. M., Sarmento-Ribeiro, A. B., Lopes, M. C., Moura-Neto, V."Glioblastoma entities express subtle differences in molecular composition and response to treatment". Oncology Reports 38.3 (2017): 1341-1352.
Chicago
Balça-Silva, J., Matias, D., Do Carmo, A., Dubois, L. G., Gonçalves, A. C., Girão, H., Canedo, N. S., Correia, A. H., De Souza, J. M., Sarmento-Ribeiro, A. B., Lopes, M. C., Moura-Neto, V."Glioblastoma entities express subtle differences in molecular composition and response to treatment". Oncology Reports 38, no. 3 (2017): 1341-1352. https://doi.org/10.3892/or.2017.5799
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