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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
September-2017 Volume 38 Issue 3

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Neuroendocrine factors: The missing link in non‑melanoma skin cancer (Review)

Mihai Lupu, Ana Caruntu, Constantin Caruntu, Laura Maria Lucia Papagheorghe, Mihaela Adriana Ilie, Vlad Voiculescu, Daniel Boda, Carolina Constantin, Cristiana Tanase, Maria Sifaki, Nikolaos Drakoulis, Charalampos Mamoulakis, George Tzanakakis, Monica Neagu, Demetrios A. Spandidos, Boris N. Izotov, Aristides M. Tsatsakis
Pages: 1327-1340
Published online on: 13 July 2017

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Article Open Access

Glioblastoma entities express subtle differences in molecular composition and response to treatment

Joana Balça-Silva, Diana Matias, Anália Do Carmo, Luiz Gustavo Dubois, Ana Cristina Gonçalves, Henrique Girão, Nathalie Henriques Silva Canedo, Ana Helena Correia, Jorge Marcondes De Souza, Ana Bela Sarmento-Ribeiro, Maria Celeste Lopes, Vivaldo Moura-Neto
Pages: 1341-1352
Published online on: 07 July 2017

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Article Open Access

Upregulation of long non-coding RNA MALAT-1 confers poor prognosis and influences cell proliferation and apoptosis in acute monocytic leukemia

Jin-Long Huang, Wei Liu, Li-Hong Tian, Ting-Ting Chai, Yang Liu, Feng Zhang, Hai-Ying Fu, Hua-Rong Zhou, Jian-Zhen Shen
Pages: 1353-1362
Published online on: 10 July 2017

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Article Open Access

Microarray expression profiles of long non-coding RNAs in germinal center-like diffuse large B-cell lymphoma

Hong-Yu Gao, Bin Wu, Wei Yan, Zi-Mu Gong, Qi Sun, Hui-Han Wang, Wei Yang
Pages: 1363-1372
Published online on: 14 July 2017

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Article Open Access

Anacardic acid induces cell apoptosis of prostatic cancer through autophagy by ER stress/DAPK3/Akt signaling pathway

Jing Tan, Xianzhen Jiang, Guangming Yin, Leye He, Jianye Liu, Zhi Long, Zhiqiang Jiang, Kun Yao
Pages: 1373-1382
Published online on: 20 July 2017

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Article Open Access

MEG3 is a prognostic factor for CRC and promotes chemosensitivity by enhancing oxaliplatin-induced cell apoptosis

Lixia Li, Jian Shang, Yupeng Zhang, Shi Liu, Yanan Peng, Zhou Zhou, Huaqing Pan, Xiaobing Wang, Lipng Chen, Qiu Zhao
Pages: 1383-1392
Published online on: 17 July 2017

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Article Open Access

CCL28 promotes breast cancer growth and metastasis through MAPK-mediated cellular anti-apoptosis and pro-metastasis

Xiao Li Yang, Kai Yi Liu, Feng Juan Lin, Hui Min Shi, Zhou Luo Ou
Pages: 1393-1401
Published online on: 07 July 2017

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Article Open Access

The long non-coding RNA SNHG3 functions as a competing endogenous RNA to promote malignant development of colorectal cancer

Weizhen Huang, Yunming Tian, Shaoting Dong, Yinlian Cha, Jun Li, Xiaohong Guo, Xia Yuan
Pages: 1402-1410
Published online on: 18 July 2017

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Article Open Access

The biological functions and mechanism of miR‑212 in prostate cancer proliferation, migration and invasion via targeting Engrailed-2

Yi Zhou, Zhigang Ji, Weigang Yan, Zhien Zhou, Hanzhong Li
Pages: 1411-1419
Published online on: 12 July 2017

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Article Open Access

Bufalin reverses acquired drug resistance by inhibiting stemness in colorectal cancer cells

Jian Sun, Ke Xu, Yanyan Qiu, Hong Gao, Jianhua Xu, Qingfeng Tang, Peihao Yin
Pages: 1420-1430
Published online on: 17 July 2017

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Article Open Access

Mangiferin induces apoptosis in human ovarian adenocarcinoma OVCAR3 cells via the regulation of Notch3

Bingyu Zou, Hailian Wang, Yilong Liu, Ping Qi, Tiantian Lei, Minghan Sun, Yi Wang
Pages: 1431-1441
Published online on: 13 July 2017

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Article Open Access

Active targeting co-delivery system based on hollow mesoporous silica nanoparticles for antitumor therapy in ovarian cancer stem-like cells

Xin Guo, Nan Guo, Jianwen Zhao, Yunlang Cai
Pages: 1442-1450
Published online on: 18 July 2017

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Article Open Access

ALDH1L1 variant rs2276724 and mRNA expression predict post-operative clinical outcomes and are associated with TP53 expression in HBV-related hepatocellular carcinoma

Guangzhi Zhu, Xiwen Liao, Chuangye Han, Xiaoguang Liu, Long Yu, Wei Qin, Sicong Lu, Hao Su, Zhiwei Chen, Zhengtao Liu, Yu Liang, Jianlu Huang, Tingdong Yu, Chengkun Yang, Ketuan Huang, Liming Shang, Xinping Ye, Lequn Li, Xue Qin, Kaiyin Xiao, Minhao Peng, Tao Peng
Pages: 1451-1463
Published online on: 14 July 2017

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Article Open Access

Human chorionic gonadotropin β regulates epithelial-mesenchymal transition and metastasis in human ovarian cancer Corrigendum in /10.3892/or.2025.8948

Na Liu, Shu-Min Peng, Guang-Xi Zhan, Jing Yu, Wei-Min Wu, Hao Gao, Xiao-Feng Li, Xiao-Qing Guo
Pages: 1464-1472
Published online on: 14 July 2017

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Article Open Access

miR-374 mediates the malignant transformation of gastric cancer-associated mesenchymal stem cells in an experimental rat model

Runbi Ji, Xu Zhang, Hui Qian, Hongbing Gu, Zixun Sun, Fei Mao, Yongmin Yan, Jingyan Chen, Zhaofeng Liang, Wenrong Xu
Pages: 1473-1481
Published online on: 18 July 2017

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Article Open Access

LHX3 is an early stage and radiosensitivity prognostic biomarker in lung adenocarcinoma

Xin Lin, Yan Li, Jin Wang, Fei Han, Shuang Lu, Yu Wang, Wenjian Luo, Mingqian Zhang
Pages: 1482-1490
Published online on: 18 July 2017

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Article Open Access

Cytotoxic and chemosensitization effects of Scutellarin from traditional Chinese herb Scutellaria altissima L. in human prostate cancer cells

Chen Gao, Yinglu Zhou, Zhongling Jiang, Yuan Zhao, Dongjun Zhang, Xia Cong, Rongfeng Cao, Huatao Li, Wenru Tian
Pages: 1491-1499
Published online on: 24 July 2017

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Article

Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70

Toru Yanoma, Kyoichi Ogata, Takehiko Yokobori, Munenori Ide, Erito Mochiki, Yoshitaka Toyomasu, Mitsuhiro Yanai, Norimichi Kogure, Akiharu Kimura, Masaki Suzuki, Nobuhiro Nakazawa, Tuya Bai, Tetsunari Oyama, Takayuki Asao, Ken Shirabe, Hiroyuki Kuwano
Pages: 1500-1506
Published online on: 21 July 2017

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Article

Immunocytochemical stem cell markers can predict clinical stage of breast cancer

Pedro J. Gutiérrez Diez, Yanrong Su, Jose Russo
Pages: 1507-1516
Published online on: 14 July 2017

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Article

Hsp90 inhibitor induces KG-1a cell differentiation and apoptosis via Akt/NF-κB signaling

Jin-Hong Qin, Kun Wang, Xin-Lu Fu, Peng-Jun Zhou, Zhong Liu, Dan-Dan Xu, Yi-Fei Wang, De-Po Yang, Qiu-Ling Xie, Qiu-Ying Liu
Pages: 1517-1524
Published online on: 07 July 2017

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Article

Long non-coding RNA LINK-A promotes glioma cell growth and invasion via lactate dehydrogenase A

Dejun Wu, Bing Zhao, Xiaoyu Cao, Jinghai Wan
Pages: 1525-1532
Published online on: 12 July 2017

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Article

SYPL1 overexpression predicts poor prognosis of hepatocellular carcinoma and associates with epithelial-mesenchymal transition

Dong-Han Chen, Qiu-Wan Wu, Xiu-Dong Li, Shuang-Jia Wang, Zhi-Ming Zhang
Pages: 1533-1542
Published online on: 21 July 2017

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Article

miR-142 inhibits the migration and invasion of glioma by targeting Rac1

Wenyi Qin, Xiaofeng Rong, Jiangchuan Dong, Chao Yu, Juan Yang
Pages: 1543-1550
Published online on: 13 July 2017

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Article

Kindlin‑2 promotes clear cell renal cell carcinoma progression through the Wnt signaling pathway

Muhan Li, Xuelian Pei, Guoliang Wang, Jun Zhan, Juan Du, Hao Jiang, Yan Tang, Hongquan Zhang, Huiying He
Pages: 1551-1560
Published online on: 04 July 2017

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Article

Lactobacilli inhibit cervical cancer cell migration in vitro and reduce tumor burden in vivo through upregulation of E-cadherin

Xiaoxi Li, Hong Wang, Xingxing Du, Wenna Yu, Jingwen Jiang, Yanhong Geng, Xiaobing Guo, Xiuhua Fan, Cuiqing Ma
Pages: 1561-1568
Published online on: 05 July 2017

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Article

MicroRNA-326 inhibits cell proliferation and invasion, activating apoptosis in hepatocellular carcinoma by directly targeting LIM and SH3 protein 1 Retraction in /10.3892/or.2023.8524

Shiping Hu, Yun Ran, Wenlin Chen, Yuncheng Zhang, Yongjian Xu
Pages: 1569-1578
Published online on: 12 July 2017

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Article

Iodine-131 induces apoptosis in human cardiac muscle cells through the p53/Bax/caspase-3 and PIDD/caspase-2/ t‑BID/cytochrome c/caspase-3 signaling pathway

Yansheng Wang, Changqing Liu, Jianchun Wang, Yang Zhang, Linlin Chen
Pages: 1579-1586
Published online on: 13 July 2017

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Article

Trichostatin A induces bladder cancer cell death via intrinsic apoptosis at the early phase and Sp1‑survivin downregulation at the late phase of treatment

Shou-Chieh Wang, Shou-Tsung Wang, Hung-Te Liu, Xiang-Yu Wang, She-Ching Wu, Lei-Chin Chen, Yi-Wen Liu
Pages: 1587-1596
Published online on: 06 July 2017

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Article

Enhanced anticancer effects of a mixture of low-dose mushrooms and Panax ginseng root extracts in human colorectal cancer cells

Mi So Lee, Mi-Sook Kim, Jae Kuk Yoo, Ji Young Lee, Jae Eun Ju, Youn Kyoung Jeong
Pages: 1597-1604
Published online on: 07 July 2017

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Article

ANP32A modulates cell growth by regulating p38 and Akt activity in colorectal cancer

Wei Yan, Zhun Bai, Juan Wang, Xumei Li, Bixia Chi, Xu Chen
Pages: 1605-1612
Published online on: 21 July 2017

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Article

The differential regulation of microRNAs is associated with oral cancer

Shih-Chang Tsai, Sheng-Fong Huang, Jo-Hua Chiang, Yen-Fu Chen, Chia-Chang Huang, Ming-Hsui Tsai, Fuu-Jen Tsai, Ming-Ching Kao, Jai-Sing Yang
Pages: 1613-1620
Published online on: 12 July 2017

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Article

miR-361-5p modulates metabolism and autophagy via the Sp1-mediated regulation of PKM2 in prostate cancer

Zhixin Ling, Dachuang Liu, Guangyuan Zhang, Qing Liang, Ping Xiang, Yan Xu, Conghui Han, Tao Tao
Pages: 1621-1628
Published online on: 25 July 2017

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Article

Carboxy-terminus Hsc70 interacting protein exerts a tumor inhibition function in head and neck cancer

Meng Xiao, Ming Yan, Jianjun Zhang, Qin Xu, Wantao Chen
Pages: 1629-1636
Published online on: 17 July 2017

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Article

Combination of rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cell apoptosis and suppresses tumor growth in xenograft nude mice through autophagy/p62/Nrf2 pathway

Siying Li, Guang Yang, Xiaosong Zhu, Lin Cheng, Yueyue Sun, Zhongxi Zhao
Pages: 1637-1644
Published online on: 24 July 2017

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Article

High expression of TRIM29 (ATDC) contributes to poor prognosis and tumor metastasis by inducing epithelial‑mesenchymal transition in osteosarcoma

Si-Xiang Zeng, Qing-Chun Cai, Chi-Hua Guo, Li-Qiang Zhi, Xing Dai, Dang-Feng Zhang, Wei Ma
Pages: 1645-1654
Published online on: 21 July 2017

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Article

Clinical significance of miR-138 in patients with malignant melanoma through targeting of PDK1 in the PI3K/AKT autophagy signaling pathway

Fanjun Meng, Yuxia Zhang, Xing Li, Juan Wang, Zhiyu Wang
Pages: 1655-1662
Published online on: 19 July 2017

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Article

In vivo and in vitro inhibition of human gastric cancer progress by upregulating Kank1 gene

Tao Chen, Kun Wang, Xianzhou Tong
Pages: 1663-1669
Published online on: 17 July 2017

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Article

MicroRNA-202 inhibits cell proliferation, migration and invasion of glioma by directly targeting metadherin Retraction in /10.3892/or.2022.8344

Jinsheng Yang, Bo Fan, Yachao Zhao, Junchao Fang
Pages: 1670-1678
Published online on: 13 July 2017

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Article

Downregulation of miRNA-26b inhibits cancer proliferation of laryngeal carcinoma through autophagy by targeting ULK2 and inactivation of the PTEN/AKT pathway

Shujing Wang, Dandan Guo, Congying Li
Pages: 1679-1687
Published online on: 11 July 2017

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Article

miR‑206 inhibits cancer initiating cells by targeting EHF in gastric cancer Retraction in /10.3892/or.2023.8634

Yan-Cui Gong, Guo-Liang Ren, Bo Liu, Feng Li, Hong-Peng Zhao, Jing-Bo Chen, Yu-Peng Li, Hai-Hua Yu
Pages: 1688-1694
Published online on: 06 July 2017

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Article

Expression of epithelial-mesenchymal transition and cancer stem cell markers in colorectal adenocarcinoma: Clinicopathological significance

Ji Eun Choi, Jun Sang Bae, Myoung Jae Kang, Myoung Ja Chung, Kyu Yun Jang, Ho Sung Park, Woo Sung Moon
Pages: 1695-1705
Published online on: 05 July 2017

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Article

Upregulation of Wnt signaling under hypoxia promotes lung cancer progression

Chun-Fu Hong, Wei-You Chen, Cheng-Wen Wu
Pages: 1706-1714
Published online on: 12 July 2017

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Article

miRNA-125b regulates apoptosis of human non-small cell lung cancer via the PI3K/Akt/GSK3β signaling pathway

Yingyi Wang, Ming Zhao, Jieying Liu, Zhao Sun, Jianjiao Ni, Hongsheng Liu
Pages: 1715-1723
Published online on: 12 July 2017

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Article

Musashi1, a potential prognostic marker in esophageal squamous cell carcinoma

Guohui Qin, Jingyao Lian, Dongli Yue, Xinfeng Chen, Shufeng Nan, Yu Qi, Bing Li, Guanghui Cui, Xiangnan Li, Song Zhao, Yi Zhang
Pages: 1724-1732
Published online on: 12 July 2017

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Article

Overexpression of SET oncoprotein is associated with tumor progression and poor prognosis in human gastric cancer Corrigendum in /10.3892/or.2025.8976

Xiaoning Yuan, Te Zhang, Xin Zheng, Yunfei Zhang, Tingting Feng, Pengfei Liu, Zhiting Sun, Shanshan Qin, Xuewen Liu, Liang Zhang, Jie Song, Ying Liu
Pages: 1733-1741
Published online on: 04 July 2017

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Article

Phosphorylation of Bcl-2 plays an important role in glycochenodeoxycholate-induced survival and chemoresistance in HCC

Maojun Zhou, Qi Zhang, Jinfeng Zhao, Mingmei Liao, Sailan Wen, Manyi Yang
Pages: 1742-1750
Published online on: 18 July 2017

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Article

miR-216b inhibits glioma cell migration and invasion through suppression of FoxM1 Retraction in /10.3892/or.2023.8663

Tingting Zhang, Guangtao Ma, Yan Zhang, Hongda Huo, Yuqian Zhao
Pages: 1751-1759
Published online on: 17 July 2017

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Article

Overexpression of Derlin 3 is associated with malignant phenotype of breast cancer cells

Masahiro Shibata, Mitsuro Kanda, Haruyoshi Tanaka, Shinichi Umeda, Takashi Miwa, Dai Shimizu, Masamichi Hayashi, Takahiro Inaishi, Noriyuki Miyajima, Yayoi Adachi, Yuko Takano, Kenichi Nakanishi, Dai Takeuchi, Sumiyo Noda, Yasuhiro Kodera, Toyone Kikumori
Pages: 1760-1766
Published online on: 10 July 2017

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Article

Inhibition of NAMPT decreases cell growth and enhances susceptibility to oxidative stress

Renhua Xu, Zhenwei Yuan, Lijuan Yang, Lele Li, Dan Li, Changjun Lv
Pages: 1767-1773
Published online on: 06 July 2017

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Article

MicroRNA-106a promotes cell migration and invasion by targeting tissue inhibitor of matrix metalloproteinase 2 in cervical cancer

Xia Li, Qi Zhou, Ling Tao, Chunxia Yu
Pages: 1774-1782
Published online on: 18 July 2017

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Article

MHY451 induces cell cycle arrest and apoptosis by ROS generation in HCT116 human colorectal cancer cells

Na Lam Hwang, Yong Jung Kang, Bokyung Sung, Seong Yeon Hwang, Jung Yoon Jang, Hye Jin Oh, Yu Ra Ahn, Do Hyun Kim, Su Jeong Kim, Sultan Ullah, Mohammad Akbar Hossain, Hyung Ryong Moon, Hae Young Chung, Nam Deuk Kim
Pages: 1783-1789
Published online on: 18 July 2017

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Article

miR-125a-5p upregulation suppresses the proliferation and induces the cell apoptosis of lung adenocarcinoma by targeting NEDD9 Retraction in /10.3892/or.2022.8466

Hong Zheng, Jianbo Wu, Jiachen Shi, Chunya Lu, Yuanyuan Wang, Qianqian Sun, Guojun Zhang, Guoqiang Zhao
Pages: 1790-1796
Published online on: 13 July 2017

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Article

Truncated apolipoprotein C-I induces apoptosis in neuroblastoma by activating caspases in the extrinsic and intrinsic pathways

Fei Guo, Wei Zhao, Lin Yang, Yang Yang, Saiqi Wang, Yingjun Wang, Zhaoming Li, Jiaxiang Wang
Pages: 1797-1805
Published online on: 14 July 2017

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Article

SMURF1 promotes the proliferation, migration and invasion of gastric cancer cells

Youmao Tao, Caixia Sun, Tao Zhang, Yan Song
Pages: 1806-1814
Published online on: 17 July 2017

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Article

TAZ inhibition restores sensitivity of cisplatin via AKT/mTOR signaling in lung adenocarcinoma

Wei Xu, Yunyan Wei, Yue Li, Yuan Yin, Weiwei Yuan, Yan Yang, Weihong Zhao, Jianqing Wu
Pages: 1815-1821
Published online on: 24 July 2017

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Article

Role of triosephosphate isomerase and downstream functional genes on gastric cancer

Tingting Chen, Zhigang Huang, Yunxiao Tian, Haiwei Wang, Ping Ouyang, Haoqin Chen, Lili Wu, Bode Lin, Rongwei He
Pages: 1822-1832
Published online on: 24 July 2017

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Article

Royal jelly lipophilic fraction induces antiproliferative effects on SH-SY5Y human neuroblastoma cells

Angelo Gismondi, Eleonora Trionfera, Lorena Canuti, Gabriele Di Marco, Antonella Canini
Pages: 1833-1844
Published online on: 24 July 2017

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Article

Inhibitory effects of 1,25(OH)2D3 on the proliferation of hepatocellular carcinoma cells through the downregulation of HDAC2

Jian Huang, Guozhen Yang, Yunzhu Huang, Shu Zhang
Pages: 1845-1850
Published online on: 24 July 2017

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Let-7c-5p inhibits cell proliferation and induces cell apoptosis by targeting ERCC6 in breast cancer

Xiaonan Fu, Xuan Mao, Yuxiang Wang, Xianfeng Ding, Yongfeng Li
Pages: 1851-1856
Published online on: 19 July 2017

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MicroRNA-379 acts as a tumor suppressor in non-small cell lung cancer by targeting the IGF‑1R-mediated AKT and ERK pathways Retraction in /10.3892/or.2022.8339

Fangzheng Zhou, Long Nie, Dali Feng, Siyan Guo, Ren'na Luo
Pages: 1857-1866
Published online on: 18 July 2017

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Snail maintains metastatic potential, cancer stem-like properties, and chemoresistance in mesenchymal mouse breast cancer TUBO‑P2J cells

Sun Young Ma, Jin-Hee Park, Hana Jung, Sung-Min Ha, Yeonye Kim, Dong Hyen Park, Deuk Hee Lee, Sooyong Lee, In-Ho Chu, So Young Jung, Il-Hwan Kim, Il-Whan Choi, Chang Soo Choi, Saegwang Park
Pages: 1867-1876
Published online on: 18 July 2017

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Article

Targeting VEGFR and FGFR in head and neck squamous cell carcinoma in vitro

Roman C. Brands, Luise M. Knierim, Francesco De Donno, Valentin Steinacker, Stefan Hartmann, Axel Seher, Alexander C. Kübler, Urs D.A. Müller-Richter
Pages: 1877-1885
Published online on: 10 July 2017

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Article

Circulating levels of angiogenesis-related growth factors in breast cancer: A study to profile proteins responsible for tubule formation

Gemma A. Barron, Marie Goua, Klaus W.J. Wahle, Giovanna Bermano
Pages: 1886-1894
Published online on: 11 July 2017

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Article

Spica Prunellae extract suppresses the growth of human colon carcinoma cells by targeting multiple oncogenes via activating miR-34a

Yi Fang, Ling Zhang, Jianyu Feng, Wei Lin, Qiaoyan Cai, Jun Peng
Pages: 1895-1901
Published online on: 06 July 2017

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Article

Promotion of glycolysis by HOTAIR through GLUT1 upregulation via mTOR signaling

Shibo Wei, Qing Fan, Liang Yang, Xiaodong Zhang, Yingbo Ma, Zhihong Zong, Xiangdong Hua, Dongming Su, Hongzhi Sun, Hangyu Li, Zhen Liu
Pages: 1902-1908
Published online on: 20 July 2017

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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Article Open Access

S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Correction Open Access

[Corrigendum] Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR‑30c in breast cancer

Meng-Chi Yen, Ying-Chu Shih, Ya-Ling Hsu, En-Shyh Lin, Yi-Shiuan Lin, Eing-Mei Tsai, Ya-Wen Ho, Ming-Feng Hou, Po-Lin Kuo
Article Number: 36
Published online on: 22 December 2025

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Article Open Access

Hypoxia‑mediated Krebs von den Lungen‑6 expression in breast cancer: Implications for tumor invasion and metastasis

Taisei Ichihara, Yoshihiro Hayashi, Takuya Sato, Mitsuko Iguchi, Makoto Toi, Hironaga Satake, Ichiro Murakami
Article Number: 35
Published online on: 19 December 2025

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Retraction Open Access

[Retracted] β‑elemene decreases cell invasion by upregulating E‑cadherin expression in MCF‑7 human breast cancer cells

Xian Zhang, Yang Zhang, Yinghua Li
Article Number: 34
Published online on: 18 December 2025

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Review Open Access

Research progress on the regulation of ferroptosis in NPC (Review)

Shuai Bai, Yanjie Guo, Jingling Qiang, Qiangfang Dai, Yanling Yang
Article Number: 33
Published online on: 18 December 2025

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Retraction Open Access

[Retracted] Platelet‑derived growth factor BB mediates the glioma‑induced migration of bone marrow‑derived mesenchymal stem cells by promoting the expression of vascular cell adhesion molecule‑1 through the PI3K, P38 MAPK and NF‑κB pathways

Yi Hu, Peng Cheng, Jiang-Chun Ma, Yi-Xue Xue, Yun-Hui Liu
Article Number: 32
Published online on: 08 December 2025

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Review Open Access

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review)

Wenpu Zhu, Zikun Wu, Chai Luv, Banghe Bao, Weijie Zhao, Guanglong Chen, Hang Yang, Huihan Ai, Faqiang Liu, Zhi Li
Article Number: 31
Published online on: 05 December 2025

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Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Article Open Access

Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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