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Upregulation of long non-coding RNA MALAT-1 confers poor prognosis and influences cell proliferation and apoptosis in acute monocytic leukemia

  • Authors:
    • Jin-Long Huang
    • Wei Liu
    • Li-Hong Tian
    • Ting-Ting Chai
    • Yang Liu
    • Feng Zhang
    • Hai-Ying Fu
    • Hua-Rong Zhou
    • Jian-Zhen Shen
  • View Affiliations / Copyright

    Affiliations: Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1353-1362
    |
    Published online on: July 10, 2017
       https://doi.org/10.3892/or.2017.5802
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Abstract

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), a long non-coding RNA, has been documented to be a new prognostic marker and gene regulator in several types of cancer, but its potential involvement in acute myeloid leukemia (AML) remains unclear. This study investigated the expression and functional role of MALAT-1 in AML. MALAT-1 expression was assessed by real-time quantitative PCR. After lentiviral-mediated MALAT-1 knockdown, the proliferation of AML cells was determined by CCK-8 and colony formation assays. Cell cycle progression and apoptosis were evaluated by flow cytometry and the expression of caspase-3, -8 and -9 was assessed by western blot analysis. We found that MALAT-1 expression in patients with acute monocytic leukemia (M5) was significantly increased when compared with that of healthy controls, and the overall survival of M5 patients with high MALAT-1 expression was markedly reduced when compared with the overall survival of patients with low MALAT-1 expression. The analysis of cellular experiments showed that MALAT-1 silencing decreased the proliferation of M5 cells (U-937 and THP-1), inhibited cell cycle progression and increased apoptosis. Taken together, these findings suggest that high MALAT-1 expression is closely associated with poor prognosis in M5 patients and may play a role in leukemia cell proliferation and apoptosis, and may serve as a promising theranostic marker.
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1 

Sana J, Faltejskova P, Svoboda M and Slaby O: Novel classes of non-coding RNAs and cancer. J Transl Med. 10:1032012. View Article : Google Scholar : PubMed/NCBI

2 

Ponting CP, Oliver PL and Reik W: Evolution and functions of long noncoding RNAs. Cell. 136:629–641. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Qiu MT, Hu JW, Yin R and Xu L: Long noncoding RNA: An emerging paradigm of cancer research. Tumour Biol. 34:613–620. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Ji P, Diederichs S, Wang W, Böing S, Metzger R, Schneider PM, Tidow N, Brandt B, Buerger H, Bulk E, et al: MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene. 22:8031–8041. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Shi X, Sun M, Liu H, Yao Y and Song Y: Long non-coding RNAs: A new frontier in the study of human diseases. Cancer Lett. 339:159–166. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Shen L, Chen L, Wang Y, Jiang X, Xia H and Zhuang Z: Long noncoding RNA MALAT1 promotes brain metastasis by inducing epithelial-mesenchymal transition in lung cancer. J Neurooncol. 121:101–108. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Lai MC, Yang Z, Zhou L, Zhu QQ, Xie HY, Zhang F, Wu LM, Chen LM and Zheng SS: Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation. Med Oncol. 29:1810–1816. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Okugawa Y, Toiyama Y, Hur K, Toden S, Saigusa S, Tanaka K, Inoue Y, Mohri Y, Kusunoki M, Boland CR, et al: Metastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis. Carcinogenesis. 35:2731–2739. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Ji Q, Zhang L, Liu X, Zhou L, Wang W, Han Z, Sui H, Tang Y, Wang Y, Liu N, et al: Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex. Br J Cancer. 111:736–748. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Han Y, Liu Y, Nie L, Gui Y and Cai Z: Inducing cell proliferation inhibition, apoptosis, and motility reduction by silencing long noncoding ribonucleic acid metastasis-associated lung adenocarcinoma transcript 1 in urothelial carcinoma of the bladder. Urology. 81:209.e1–209.e7. 2013. View Article : Google Scholar

11 

Tian X and Xu G: Clinical value of lncRNA MALAT1 as a prognostic marker in human cancer: Systematic review and meta-analysis. BMJ Open. 5:e0086532015. View Article : Google Scholar : PubMed/NCBI

12 

Lopez-Ayllon BD, Moncho-Amor V, Abarrategi A, de Ibañez Cáceres I, Castro-Carpeño J, Belda-Iniesta C, Perona R and Sastre L: Cancer stem cells and cisplatin-resistant cells isolated from non-small-lung cancer cell lines constitute related cell populations. Cancer Med. 3:1099–1111. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Dores GM, Devesa SS, Curtis RE, Linet MS and Morton LM: Acute leukemia incidence and patient survival among children and adults in the United States, 2001–2007. Blood. 119:34–43. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Löwenberg B, Downing JR and Burnett A: Acute myeloid leukemia. N Engl J Med. 341:1051–1062. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Farag SS, Ruppert AS, Mrózek K, Mayer RJ, Stone RM, Carroll AJ, Powell BL, Moore JO, Pettenati MJ, Koduru PR, et al: Outcome of induction and postremission therapy in younger adults with acute myeloid leukemia with normal karyotype: A cancer and leukemia group B study. J Clin Oncol. 23:482–493. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Mims A and Stuart RK: Developmental therapeutics in acute myelogenous leukemia: Are there any new effective cytotoxic chemotherapeutic agents out there? Curr Hematol Malig Rep. 8:156–162. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Shen JZ, Zhang YY, Fu HY, Wu DS and Zhou HR: Overexpression of microRNA-143 inhibits growth and induces apoptosis in human leukemia cells. Oncol Rep. 31:2035–2042. 2014.PubMed/NCBI

18 

Azoulay E, Fieux F, Moreau D, Thiery G, Rousselot P, Parrot A, Le Gall JR, Dombret H and Schlemmer B: Acute monocytic leukemia presenting as acute respiratory failure. Am J Respir Crit Care Med. 167:1329–1333. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Porcu P, Cripe LD, Ng EW, Bhatia S, Danielson CM, Orazi A and McCarthy LJ: Hyperleukocytic leukemias and leukostasis: A review of pathophysiology, clinical presentation and management. Leuk Lymphoma. 39:1–18. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Lane L, Argoud-Puy G, Britan A, Cusin I, Duek PD, Evalet O, Gateau A, Gaudet P, Gleizes A, Masselot A, et al: neXtProt: A knowledge platform for human proteins. Nucleic Acids Res. 40:(D1). D76–D83. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Wu C, Macleod I and Su AI: BioGPS and MyGene.info: Organizing online, gene-centric information. Nucleic Acids Res. 41:(D1). D561–D565. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Cho SF, Chang YC, Chang CS, Lin SF, Liu YC, Hsiao HH, Chang JG and Liu TC: MALAT1 long non-coding RNA is overexpressed in multiple myeloma and may serve as a marker to predict disease progression. BMC Cancer. 14:8092014. View Article : Google Scholar : PubMed/NCBI

23 

Isin M, Ozgur E, Cetin G, Erten N, Aktan M, Gezer U and Dalay N: Investigation of circulating lncRNAs in B-cell neoplasms. Clin Chim Acta. 431:255–259. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Moqadam F Akbari, Lange-Turenhout EA, Ariës IM, Pieters R and den Boer ML: miR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia. Leuk Res. 37:1315–1321. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Wu S, Zheng C, Chen S, Cai X, Shi Y, Lin B and Chen Y: Overexpression of long non-coding RNA HOTAIR predicts a poor prognosis in patients with acute myeloid leukemia. Oncol Lett. 10:2410–2414. 2015.PubMed/NCBI

26 

Zhang YY, Huang SH, Zhou HR, Chen CJ, Tian LH and Shen JZ: Role of HOTAIR in the diagnosis and prognosis of acute leukemia. Oncol Rep. 36:3113–3122. 2016.PubMed/NCBI

27 

Wang J, Su L, Chen X, Li P, Cai Q, Yu B, Liu B, Wu W and Zhu Z: MALAT1 promotes cell proliferation in gastric cancer by recruiting SF2/ASF. Biomed Pharmacother. 68:557–564. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Zhou Y, Xu X, Lv H, Wen Q, Li J, Tan L, Li J and Sheng X: The long noncoding RNA MALAT-1 is highly expressed in ovarian cancer and induces cell growth and migration. PLoS One. 11:e01552502016. View Article : Google Scholar : PubMed/NCBI

29 

Tripathi V, Shen Z, Chakraborty A, Giri S, Freier SM, Wu X, Zhang Y, Gorospe M, Prasanth SG, Lal A, et al: Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB. PLoS Genet. 9:e10033682013. View Article : Google Scholar : PubMed/NCBI

30 

Miura M: Apoptotic and nonapoptotic caspase functions in animal development. Cold Spring Harb Perspect Biol. 4:42012. View Article : Google Scholar

31 

Guo F, Li Y, Liu Y, Wang J, Li Y and Li G: Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion. Acta Biochim Biophys Sin (Shanghai). 42:224–229. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang J, Liu W, Tian L, Chai T, Liu Y, Zhang F, Fu H, Zhou H and Shen J: Upregulation of long non-coding RNA MALAT-1 confers poor prognosis and influences cell proliferation and apoptosis in acute monocytic leukemia. Oncol Rep 38: 1353-1362, 2017.
APA
Huang, J., Liu, W., Tian, L., Chai, T., Liu, Y., Zhang, F. ... Shen, J. (2017). Upregulation of long non-coding RNA MALAT-1 confers poor prognosis and influences cell proliferation and apoptosis in acute monocytic leukemia. Oncology Reports, 38, 1353-1362. https://doi.org/10.3892/or.2017.5802
MLA
Huang, J., Liu, W., Tian, L., Chai, T., Liu, Y., Zhang, F., Fu, H., Zhou, H., Shen, J."Upregulation of long non-coding RNA MALAT-1 confers poor prognosis and influences cell proliferation and apoptosis in acute monocytic leukemia". Oncology Reports 38.3 (2017): 1353-1362.
Chicago
Huang, J., Liu, W., Tian, L., Chai, T., Liu, Y., Zhang, F., Fu, H., Zhou, H., Shen, J."Upregulation of long non-coding RNA MALAT-1 confers poor prognosis and influences cell proliferation and apoptosis in acute monocytic leukemia". Oncology Reports 38, no. 3 (2017): 1353-1362. https://doi.org/10.3892/or.2017.5802
Copy and paste a formatted citation
x
Spandidos Publications style
Huang J, Liu W, Tian L, Chai T, Liu Y, Zhang F, Fu H, Zhou H and Shen J: Upregulation of long non-coding RNA MALAT-1 confers poor prognosis and influences cell proliferation and apoptosis in acute monocytic leukemia. Oncol Rep 38: 1353-1362, 2017.
APA
Huang, J., Liu, W., Tian, L., Chai, T., Liu, Y., Zhang, F. ... Shen, J. (2017). Upregulation of long non-coding RNA MALAT-1 confers poor prognosis and influences cell proliferation and apoptosis in acute monocytic leukemia. Oncology Reports, 38, 1353-1362. https://doi.org/10.3892/or.2017.5802
MLA
Huang, J., Liu, W., Tian, L., Chai, T., Liu, Y., Zhang, F., Fu, H., Zhou, H., Shen, J."Upregulation of long non-coding RNA MALAT-1 confers poor prognosis and influences cell proliferation and apoptosis in acute monocytic leukemia". Oncology Reports 38.3 (2017): 1353-1362.
Chicago
Huang, J., Liu, W., Tian, L., Chai, T., Liu, Y., Zhang, F., Fu, H., Zhou, H., Shen, J."Upregulation of long non-coding RNA MALAT-1 confers poor prognosis and influences cell proliferation and apoptosis in acute monocytic leukemia". Oncology Reports 38, no. 3 (2017): 1353-1362. https://doi.org/10.3892/or.2017.5802
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