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Article

Iodine-131 induces apoptosis in human cardiac muscle cells through the p53/Bax/caspase-3 and PIDD/caspase-2/ t‑BID/cytochrome c/caspase-3 signaling pathway

  • Authors:
    • Yansheng Wang
    • Changqing Liu
    • Jianchun Wang
    • Yang Zhang
    • Linlin Chen
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Central Hospital of Cangzhou, Cangzhou, Hebei 061001, P.R. China, Department of Nuclear Medicine, People's Hospital of Weifang, Weifang, Shandong 261041, P.R. China, Department of Anesthesiology, Central Hospital of Cangzhou, Cangzhou, Hebei 061001, P.R. China
  • Pages: 1579-1586
    |
    Published online on: July 13, 2017
       https://doi.org/10.3892/or.2017.5813
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Abstract

The aim of this study was to elucidate the effects of iodine-131 on the induction of apoptosis in human cardiac muscle cells and the underlying molecular mechanisms. We found that iodine-131 reduced cell proliferation, induced apoptosis, induced p53, PIDD, t-BID (mitochondria) protein expression, suppressed cytochrome c (mitochondria) protein expression, and increased Bax protein expression, and promoted caspase-2, -3 and -9 expression levels in human cardiac muscle cells. Meanwhile, si-p53 inhibited the effects of iodine-131 on the reduction in cell proliferation and induction of apoptosis in human cardiac muscle cells through regulation of Bax/cytochrome c/caspase-3 and PIDD/caspase‑2/t-BID/cytochrome c/caspase-3 signaling pathway. After si-Bax reduced the effects of iodine-131, it reduced cell proliferation and induced apoptosis in human cardiac muscle cells through the cytochrome c/caspase-3 signaling pathway. However, si-caspase-2 also reduced the effects of iodine-131 on the reduction of cell proliferation and induction of apoptosis in human cardiac muscle cells through the t-BID/cytochrome c/caspase-3 signaling pathway. These findings demonstrated that iodine-131 induces apoptosis in human cardiac muscle cells through the p53/Bax/caspase-3 and PIDD/caspase-2/t-BID/cytochrome c/caspase-3 signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Liu C, Wang J, Zhang Y and Chen L: Iodine-131 induces apoptosis in human cardiac muscle cells through the p53/Bax/caspase-3 and PIDD/caspase-2/ t‑BID/cytochrome c/caspase-3 signaling pathway. Oncol Rep 38: 1579-1586, 2017.
APA
Wang, Y., Liu, C., Wang, J., Zhang, Y., & Chen, L. (2017). Iodine-131 induces apoptosis in human cardiac muscle cells through the p53/Bax/caspase-3 and PIDD/caspase-2/ t‑BID/cytochrome c/caspase-3 signaling pathway. Oncology Reports, 38, 1579-1586. https://doi.org/10.3892/or.2017.5813
MLA
Wang, Y., Liu, C., Wang, J., Zhang, Y., Chen, L."Iodine-131 induces apoptosis in human cardiac muscle cells through the p53/Bax/caspase-3 and PIDD/caspase-2/ t‑BID/cytochrome c/caspase-3 signaling pathway". Oncology Reports 38.3 (2017): 1579-1586.
Chicago
Wang, Y., Liu, C., Wang, J., Zhang, Y., Chen, L."Iodine-131 induces apoptosis in human cardiac muscle cells through the p53/Bax/caspase-3 and PIDD/caspase-2/ t‑BID/cytochrome c/caspase-3 signaling pathway". Oncology Reports 38, no. 3 (2017): 1579-1586. https://doi.org/10.3892/or.2017.5813
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Liu C, Wang J, Zhang Y and Chen L: Iodine-131 induces apoptosis in human cardiac muscle cells through the p53/Bax/caspase-3 and PIDD/caspase-2/ t‑BID/cytochrome c/caspase-3 signaling pathway. Oncol Rep 38: 1579-1586, 2017.
APA
Wang, Y., Liu, C., Wang, J., Zhang, Y., & Chen, L. (2017). Iodine-131 induces apoptosis in human cardiac muscle cells through the p53/Bax/caspase-3 and PIDD/caspase-2/ t‑BID/cytochrome c/caspase-3 signaling pathway. Oncology Reports, 38, 1579-1586. https://doi.org/10.3892/or.2017.5813
MLA
Wang, Y., Liu, C., Wang, J., Zhang, Y., Chen, L."Iodine-131 induces apoptosis in human cardiac muscle cells through the p53/Bax/caspase-3 and PIDD/caspase-2/ t‑BID/cytochrome c/caspase-3 signaling pathway". Oncology Reports 38.3 (2017): 1579-1586.
Chicago
Wang, Y., Liu, C., Wang, J., Zhang, Y., Chen, L."Iodine-131 induces apoptosis in human cardiac muscle cells through the p53/Bax/caspase-3 and PIDD/caspase-2/ t‑BID/cytochrome c/caspase-3 signaling pathway". Oncology Reports 38, no. 3 (2017): 1579-1586. https://doi.org/10.3892/or.2017.5813
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