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Article

miR-142 inhibits the migration and invasion of glioma by targeting Rac1

  • Authors:
    • Wenyi Qin
    • Xiaofeng Rong
    • Jiangchuan Dong
    • Chao Yu
    • Juan Yang
  • View Affiliations / Copyright

    Affiliations: Department of Integrated Chinese and Western Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China, Department of Emergency, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China, Department of Emergency, Chongqing JiangBei Hospital of Traditional Chinese Medicine, Chongqing 400020, P.R. China
  • Pages: 1543-1550
    |
    Published online on: July 13, 2017
       https://doi.org/10.3892/or.2017.5816
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Abstract

Increasing evidence has shown that aberrant microRNAs (miRNAs) are implicated in tumorigenesis and tumor progression by regulating oncogenes or tumor suppressors. Dysregulation of miR-142 has been reported in multiple tumors. However, its clinical roles and underlying mechanism in glioma remain to be elucidated. In the present study, we found that the expression of miR-142 was significantly downregulated in both glioma tissues and cell lines by qRT-PCR. Clinical analysis revealed that decreased miR-142 was markedly associated with advanced World Health Organization (WHO) grade. Moreover, we disclosed that miR-142 was a novel independent prognostic marker in the prediction of the 5-year survival of glioma patients. The ectopic overexpression of miR-142 inhibited cell migration, invasion and invasion‑related gene expression. Notably, miR-142 modulated Rac1 by directly binding to its 3'-untranslated (3'-UTR) region, leading to the suppression of the expression of matrix metalloproteinases (MMPs). In glioma clinical samples, miR-142 was inversely correlated with Rac1 expression, and played positive roles in glioma migration and invasion. Alteration of Rac1 expression at least partially abolished the migration, invasion and MMP expression of miR-142 in glioma cells. In the present study, we identified Rac1 as a functional target of miR-142 in glioma. In conclusion, our data indicated that miR-142 inhibited the migration, invasion and MMP expression of glioma by targeting Rac1, and may represent a novel potential therapeutic target and prognostic marker for glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Qin W, Rong X, Dong J, Yu C and Yang J: miR-142 inhibits the migration and invasion of glioma by targeting Rac1. Oncol Rep 38: 1543-1550, 2017.
APA
Qin, W., Rong, X., Dong, J., Yu, C., & Yang, J. (2017). miR-142 inhibits the migration and invasion of glioma by targeting Rac1. Oncology Reports, 38, 1543-1550. https://doi.org/10.3892/or.2017.5816
MLA
Qin, W., Rong, X., Dong, J., Yu, C., Yang, J."miR-142 inhibits the migration and invasion of glioma by targeting Rac1". Oncology Reports 38.3 (2017): 1543-1550.
Chicago
Qin, W., Rong, X., Dong, J., Yu, C., Yang, J."miR-142 inhibits the migration and invasion of glioma by targeting Rac1". Oncology Reports 38, no. 3 (2017): 1543-1550. https://doi.org/10.3892/or.2017.5816
Copy and paste a formatted citation
x
Spandidos Publications style
Qin W, Rong X, Dong J, Yu C and Yang J: miR-142 inhibits the migration and invasion of glioma by targeting Rac1. Oncol Rep 38: 1543-1550, 2017.
APA
Qin, W., Rong, X., Dong, J., Yu, C., & Yang, J. (2017). miR-142 inhibits the migration and invasion of glioma by targeting Rac1. Oncology Reports, 38, 1543-1550. https://doi.org/10.3892/or.2017.5816
MLA
Qin, W., Rong, X., Dong, J., Yu, C., Yang, J."miR-142 inhibits the migration and invasion of glioma by targeting Rac1". Oncology Reports 38.3 (2017): 1543-1550.
Chicago
Qin, W., Rong, X., Dong, J., Yu, C., Yang, J."miR-142 inhibits the migration and invasion of glioma by targeting Rac1". Oncology Reports 38, no. 3 (2017): 1543-1550. https://doi.org/10.3892/or.2017.5816
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