miR-216b inhibits glioma cell migration and invasion through suppression of FoxM1

Retraction in: /10.3892/or.2023.8663

  • Authors:
    • Tingting Zhang
    • Guangtao Ma
    • Yan Zhang
    • Hongda Huo
    • Yuqian Zhao
  • View Affiliations

  • Published online on: July 17, 2017     https://doi.org/10.3892/or.2017.5824
  • Pages: 1751-1759
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Abstract

MicroRNAs (miRNAs) play a vital role in tumour biological and pathologic processes. In the present study, we aimed to detect the expression and biological role of miR-216b in glioma. Our data showed that miR-216b was significantly downregulated in human glioma tissues and cells. Ectopic expression of miR-216b inhibited the proliferation and invasion of U87 and U251 cells and suppressed the growth of xenograft tumours in vivo. Bioinformatic and luciferase reporter analyses identified Forkhead box protein M1 (FoxM1) as a direct target of miR-216b. Overexpression of miR-216b inhibited the expression of FoxM1 in glioma cells. Rescue experiments demonstrated that co-transfection of FoxM1 lacking the 3'-untranslated region partially prevented miR‑216b-induced inhibition of glioma cell growth and invasion. In vivo studies indicated that ectopic expression of miR-216b impeded the proliferation of glioma xenograft tumours in nude mice, coupled with a decreased in FoxM1 protein expression and the percentage of Ki-67-positive tumour cells. Taken together, our results provide evidence of the suppressive activity of miR‑216b in glioma, which is largely ascribed to downregulation of FoxM1. Restoration of miR-216b may provide a novel potential therapeutic agent for glioma.
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September-2017
Volume 38 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhang T, Ma G, Zhang Y, Huo H and Zhao Y: miR-216b inhibits glioma cell migration and invasion through suppression of FoxM1 Retraction in /10.3892/or.2023.8663. Oncol Rep 38: 1751-1759, 2017
APA
Zhang, T., Ma, G., Zhang, Y., Huo, H., & Zhao, Y. (2017). miR-216b inhibits glioma cell migration and invasion through suppression of FoxM1 Retraction in /10.3892/or.2023.8663. Oncology Reports, 38, 1751-1759. https://doi.org/10.3892/or.2017.5824
MLA
Zhang, T., Ma, G., Zhang, Y., Huo, H., Zhao, Y."miR-216b inhibits glioma cell migration and invasion through suppression of FoxM1 Retraction in /10.3892/or.2023.8663". Oncology Reports 38.3 (2017): 1751-1759.
Chicago
Zhang, T., Ma, G., Zhang, Y., Huo, H., Zhao, Y."miR-216b inhibits glioma cell migration and invasion through suppression of FoxM1 Retraction in /10.3892/or.2023.8663". Oncology Reports 38, no. 3 (2017): 1751-1759. https://doi.org/10.3892/or.2017.5824