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Article

Snail maintains metastatic potential, cancer stem-like properties, and chemoresistance in mesenchymal mouse breast cancer TUBO‑P2J cells

  • Authors:
    • Sun Young Ma
    • Jin-Hee Park
    • Hana Jung
    • Sung-Min Ha
    • Yeonye Kim
    • Dong Hyen Park
    • Deuk Hee Lee
    • Sooyong Lee
    • In-Ho Chu
    • So Young Jung
    • Il-Hwan Kim
    • Il-Whan Choi
    • Chang Soo Choi
    • Saegwang Park
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Kosin University College of Medicine, Busan 49267, Republic of Korea, Department of Microbiology and Immunology, INJE University College of Medicine, Busan 47392, Republic of Korea, Department of Radiation Oncology, Busan-Paik Hospital, INJE University College of Medicine, Busan 47392, Republic of Korea, Department of Surgery, INJE University College of Medicine, Busan 47392, Republic of Korea, Department of Dermatology, Haeundae Paik Hospital, INJE University College of Medicine, Busan 47392, Republic of Korea, Department of Internal Medicine Division of Hemato-Oncology, Heaundea Paik Hospital, INJE University College of Medicine, Busan 48108, Republic of Korea
  • Pages: 1867-1876
    |
    Published online on: July 18, 2017
       https://doi.org/10.3892/or.2017.5834
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Abstract

Snail, a zinc-finger transcriptional repressor of E-cadherin expression, is one of the key inducers of epithelial-mesenchymal transition (EMT) in epithelial cancer. In breast cancer, EMT has been associated with malignancies, including metastasis, cancer stem-like properties, and resistance to chemotherapy and radiotherapy. In this study, we analysed the role of Snail in the highly metastatic mesenchymal TUBO‑P2J mouse breast cancer cells, by loss of function using short hairpin RNA. Though silencing Snail did not restore the E-cadherin expression or induce morphological changes, Snail silencing significantly ablated in vitro and in vivo metastatic potentials. In addition, Snail silencing also reduced resistance to chemotherapy drugs and cancer stem-like properties, such as CD44 expression, aldehyde dehydrogenase (ALDH) activity, colony formation, and in vivo tumour formation and growth. However, radioresistance was not decreased by silencing Snail. Collectively, this study suggested that Snail is a main regulator of the maintenance of malignancy potentials and is a good target to prevent cancer metastasis and to increase chemotherapy susceptibility.
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Copy and paste a formatted citation
Spandidos Publications style
Ma SY, Park J, Jung H, Ha S, Kim Y, Park DH, Lee DH, Lee S, Chu I, Jung SY, Jung SY, et al: Snail maintains metastatic potential, cancer stem-like properties, and chemoresistance in mesenchymal mouse breast cancer TUBO‑P2J cells. Oncol Rep 38: 1867-1876, 2017.
APA
Ma, S.Y., Park, J., Jung, H., Ha, S., Kim, Y., Park, D.H. ... Park, S. (2017). Snail maintains metastatic potential, cancer stem-like properties, and chemoresistance in mesenchymal mouse breast cancer TUBO‑P2J cells. Oncology Reports, 38, 1867-1876. https://doi.org/10.3892/or.2017.5834
MLA
Ma, S. Y., Park, J., Jung, H., Ha, S., Kim, Y., Park, D. H., Lee, D. H., Lee, S., Chu, I., Jung, S. Y., Kim, I., Choi, I., Choi, C. S., Park, S."Snail maintains metastatic potential, cancer stem-like properties, and chemoresistance in mesenchymal mouse breast cancer TUBO‑P2J cells". Oncology Reports 38.3 (2017): 1867-1876.
Chicago
Ma, S. Y., Park, J., Jung, H., Ha, S., Kim, Y., Park, D. H., Lee, D. H., Lee, S., Chu, I., Jung, S. Y., Kim, I., Choi, I., Choi, C. S., Park, S."Snail maintains metastatic potential, cancer stem-like properties, and chemoresistance in mesenchymal mouse breast cancer TUBO‑P2J cells". Oncology Reports 38, no. 3 (2017): 1867-1876. https://doi.org/10.3892/or.2017.5834
Copy and paste a formatted citation
x
Spandidos Publications style
Ma SY, Park J, Jung H, Ha S, Kim Y, Park DH, Lee DH, Lee S, Chu I, Jung SY, Jung SY, et al: Snail maintains metastatic potential, cancer stem-like properties, and chemoresistance in mesenchymal mouse breast cancer TUBO‑P2J cells. Oncol Rep 38: 1867-1876, 2017.
APA
Ma, S.Y., Park, J., Jung, H., Ha, S., Kim, Y., Park, D.H. ... Park, S. (2017). Snail maintains metastatic potential, cancer stem-like properties, and chemoresistance in mesenchymal mouse breast cancer TUBO‑P2J cells. Oncology Reports, 38, 1867-1876. https://doi.org/10.3892/or.2017.5834
MLA
Ma, S. Y., Park, J., Jung, H., Ha, S., Kim, Y., Park, D. H., Lee, D. H., Lee, S., Chu, I., Jung, S. Y., Kim, I., Choi, I., Choi, C. S., Park, S."Snail maintains metastatic potential, cancer stem-like properties, and chemoresistance in mesenchymal mouse breast cancer TUBO‑P2J cells". Oncology Reports 38.3 (2017): 1867-1876.
Chicago
Ma, S. Y., Park, J., Jung, H., Ha, S., Kim, Y., Park, D. H., Lee, D. H., Lee, S., Chu, I., Jung, S. Y., Kim, I., Choi, I., Choi, C. S., Park, S."Snail maintains metastatic potential, cancer stem-like properties, and chemoresistance in mesenchymal mouse breast cancer TUBO‑P2J cells". Oncology Reports 38, no. 3 (2017): 1867-1876. https://doi.org/10.3892/or.2017.5834
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