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The long non-coding RNA SNHG3 functions as a competing endogenous RNA to promote malignant development of colorectal cancer

  • Authors:
    • Weizhen Huang
    • Yunming Tian
    • Shaoting Dong
    • Yinlian Cha
    • Jun Li
    • Xiaohong Guo
    • Xia Yuan
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Huizhou Municipal Central Hospital of Guangdong Province, Huizhou, Guangdong 516000, P.R. China, Department of Radiation Oncology, Huizhou Municipal Central Hospital of Guangdong Province, Huizhou, Guangdong 516000, P.R. China, Department of Oncology, Huizhou Municipal Central Hospital of Guangdong Province, Huizhou, Guangdong 516000, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1402-1410
    |
    Published online on: July 18, 2017
       https://doi.org/10.3892/or.2017.5837
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Abstract

Accumulating evidence has revealed that aberrantly expressed long non-coding transcripts are involved in the development and progression of colorectal cancer (CRC). Small nucleolar RNA host gene 3 (SNHG3) is a newly identified lncRNA, and little is known about its clinical significance and biological functions in the development of CRC. In the present study, we found that the expression of SNHG3 was significantly upregulated in CRC, and upregulation of SNHG3 predicted poor prognosis for patients with CRC as determined through analysis of the data obtained from TCGA database. Gain-of function and loss-of function assays revealed that SNHG3 markedly promoted cellular proliferation of CRC cells. Gene Set Enrichment Analysis (GSEA) suggested that high expression of SNHG3 was positively associated with c-Myc and its targets genes. Furthermore, ectopic overexpression of SNHG3 increased the expression of c-Myc and its target genes, whereas inhibition of SNHG3 had opposite effect on the expression of c-Myc and its targets. Mechanistic investigations demonstrated that SNHG3 functioned as a competing endogenous RNA (ceRNA) to ʻspongeʼ miR-182-5p, thus leading to the release of c-Myc from miR-182-5p and modulating the expression of c-Myc. In conclusion, SNHG3 promoted CRC progression via sponging miR-182-5p and upregulating c-Myc and its target genes.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, Stein KD, Alteri R and Jemal A: Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 66:271–289. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Schmoll HJ, Van Cutsem E, Stein A, Valentini V, Glimelius B, Haustermans K, Nordlinger B, van de Velde CJ, Balmana J, Regula J, et al: ESMO Consensus Guidelines for management of patients with colon and rectal cancer. a personalized approach to clinical decision making. Ann Oncol. 23:2479–2516. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Cao D, Ding Q, Yu W, Gao M and Wang Y: Long noncoding RNA SPRY4-IT1 promotes malignant development of colorectal cancer by targeting epithelial-mesenchymal transition. Onco Targets Ther. 9:5417–5425. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Yang G, Lu X and Yuan L: LncRNA: A link between RNA and cancer. Biochim Biophys Acta. 1839:1097–1109. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Yang X, Xie X, Xiao YF, Xie R, Hu CJ, Tang B, Li BS and Yang SM: The emergence of long non-coding RNAs in the tumorigenesis of hepatocellular carcinoma. Cancer Lett. 360:119–124. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Quinn JJ and Chang HY: Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet. 17:47–62. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Khorkova O, Hsiao J and Wahlestedt C: Basic biology and therapeutic implications of lncRNA. Adv Drug Deliv Rev. 87:15–24. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Ballantyne MD, Pinel K, Dakin R, Vesey AT, Diver L, Mackenzie R, Garcia R, Welsh P, Sattar N, Hamilton G, et al: Smooth muscle enriched long noncoding RNA (SMILR) regulates cell proliferation. Circulation. 133:2050–2065. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Sun T and Wong N: Transforming growth factor-β-induced long noncoding RNA promotes liver cancer metastasis via RNA-RNA crosstalk. Hepatology. 61:722–724. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Ranzani V, Arrigoni A, Rossetti G, Panzeri I, Abrignani S, Bonnal RJ and Pagani M: Next-generation sequencing analysis of long noncoding RNAs in CD4+ T cell differentiation. Methods Mol Biol. 1514:173–185. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Padua D, Mahurkar-Joshi S, Law IK, Polytarchou C, Vu JP, Pisegna JR, Shih D, Iliopoulos D and Pothoulakis C: A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammation. Am J Physiol Gastrointest Liver Physiol. 311:G446–G457. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Jia P, Cai H, Liu X, Chen J, Ma J, Wang P, Liu Y, Zheng J and Xue Y: Long non-coding RNA H19 regulates glioma angiogenesis and the biological behavior of glioma-associated endothelial cells by inhibiting microRNA-29a. Cancer Lett. 381:359–369. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Yang F, Zhang H, Mei Y and Wu M: Reciprocal regulation of HIF-1α and lincRNA-p21 modulates the Warburg effect. Mol Cell. 53:88–100. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Niknafs YS, Han S, Ma T, Speers C, Zhang C, Wilder-Romans K, Iyer MK, Pitchiaya S, Malik R, Hosono Y, et al: The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression. Nat Commun. 7:127912016. View Article : Google Scholar : PubMed/NCBI

16 

Chen ZZ, Huang L, Wu YH, Zhai WJ, Zhu PP and Gao YF: LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression. Nat Commun. 7:125982016. View Article : Google Scholar : PubMed/NCBI

17 

Zhang D, Cao C, Liu L and Wu D: Up-regulation of lncRNA SNHG20 predicts poor prognosis in hepatocellular carcinoma. J Cancer. 7:608–617. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Zheng J, Huang X, Tan W, Yu D, Du Z, Chang J, Wei L, Han Y, Wang C, Che X, et al: Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation. Nat Genet. 48:747–757. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Zhang T, Cao C, Wu D and Liu L: SNHG3 correlates with malignant status and poor prognosis in hepatocellular carcinoma. Tumour Biol. 37:2379–2385. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Huang W, Li J, Guo X, Zhao Y and Yuan X: miR-663a inhibits hepatocellular carcinoma cell proliferation and invasion by targeting HMGA2. Biomed Pharmacother. 81:431–438. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, et al: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 102:15545–15550. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C, Xia P, et al: The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. Cell Stem Cell. 16:413–425. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Tichon A, Gil N, Lubelsky Y, Solomon T Havkin, Lemze D, Itzkovitz S, Stern-Ginossar N and Ulitsky I: A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells. Nat Commun. 7:122092016. View Article : Google Scholar : PubMed/NCBI

24 

Yuan JH, Yang F, Wang F, Ma JZ, Guo YJ, Tao QF, Liu F, Pan W, Wang TT, Zhou CC, et al: A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma. Cancer Cell. 25:666–681. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Tay Y, Rinn J and Pandolfi PP: The multilayered complexity of ceRNA crosstalk and competition. Nature. 505:344–352. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Lv J, Fan HX, Zhao XP, Lv P, Fan JY, Zhang Y, Liu M and Tang H: Long non-coding RNA Unigene56159 promotes epithelial-mesenchymal transition by acting as a ceRNA of miR-140-5p in hepatocellular carcinoma cells. Cancer Lett. 382:166–175. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Wang SH, Zhang WJ, Wu XC, Zhang MD, Weng MZ, Zhou D, Wang JD and Quan ZW: Long non-coding RNA Malat1 promotes gallbladder cancer development by acting as a molecular sponge to regulate miR-206. Oncotarget. 7:37857–37867. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Sipos F, Firneisz G and Műzes G: Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseases. World J Gastroenterol. 22:7938–7950. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Pazos E, Garcia-Algar M, Penas C, Nazarenus M, Torruella A, Pazos-Perez N, Guerrini L, Vázquez ME, Garcia-Rico E, Mascareñas JL, et al: Surface-enhanced raman scattering surface selection rules for the proteomic liquid biopsy in real samples: Efficient detection of the oncoprotein c-MYC. J Am Chem Soc. 138:14206–14209. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Feng XH, Liang YY, Liang M, Zhai W and Lin X: Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-β-mediated induction of the CDK inhibitor p15(Ink4B). Mol Cell. 63:10892016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang W, Tian Y, Dong S, Cha Y, Li J, Guo X and Yuan X: The long non-coding RNA SNHG3 functions as a competing endogenous RNA to promote malignant development of colorectal cancer. Oncol Rep 38: 1402-1410, 2017.
APA
Huang, W., Tian, Y., Dong, S., Cha, Y., Li, J., Guo, X., & Yuan, X. (2017). The long non-coding RNA SNHG3 functions as a competing endogenous RNA to promote malignant development of colorectal cancer. Oncology Reports, 38, 1402-1410. https://doi.org/10.3892/or.2017.5837
MLA
Huang, W., Tian, Y., Dong, S., Cha, Y., Li, J., Guo, X., Yuan, X."The long non-coding RNA SNHG3 functions as a competing endogenous RNA to promote malignant development of colorectal cancer". Oncology Reports 38.3 (2017): 1402-1410.
Chicago
Huang, W., Tian, Y., Dong, S., Cha, Y., Li, J., Guo, X., Yuan, X."The long non-coding RNA SNHG3 functions as a competing endogenous RNA to promote malignant development of colorectal cancer". Oncology Reports 38, no. 3 (2017): 1402-1410. https://doi.org/10.3892/or.2017.5837
Copy and paste a formatted citation
x
Spandidos Publications style
Huang W, Tian Y, Dong S, Cha Y, Li J, Guo X and Yuan X: The long non-coding RNA SNHG3 functions as a competing endogenous RNA to promote malignant development of colorectal cancer. Oncol Rep 38: 1402-1410, 2017.
APA
Huang, W., Tian, Y., Dong, S., Cha, Y., Li, J., Guo, X., & Yuan, X. (2017). The long non-coding RNA SNHG3 functions as a competing endogenous RNA to promote malignant development of colorectal cancer. Oncology Reports, 38, 1402-1410. https://doi.org/10.3892/or.2017.5837
MLA
Huang, W., Tian, Y., Dong, S., Cha, Y., Li, J., Guo, X., Yuan, X."The long non-coding RNA SNHG3 functions as a competing endogenous RNA to promote malignant development of colorectal cancer". Oncology Reports 38.3 (2017): 1402-1410.
Chicago
Huang, W., Tian, Y., Dong, S., Cha, Y., Li, J., Guo, X., Yuan, X."The long non-coding RNA SNHG3 functions as a competing endogenous RNA to promote malignant development of colorectal cancer". Oncology Reports 38, no. 3 (2017): 1402-1410. https://doi.org/10.3892/or.2017.5837
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