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October-2017 Volume 38 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Zinc finger protein 307 functions as a tumor‑suppressor and inhibits cell proliferation by inducing apoptosis in hepatocellular carcinoma

  • Authors:
    • Yonghao Liang
    • Qisheng Li
    • Keli Chen
    • Wen Ni
    • Zetao Zhan
    • Feng Ye
    • Yiyi Li
    • Yuan Fang
    • Fengjiao Zhang
    • Longhua Chen
    • Yi Ding
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
  • Pages: 2229-2236
    |
    Published online on: August 1, 2017
       https://doi.org/10.3892/or.2017.5868
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Abstract

Zinc finger protein 307 (ZNF307) is a new Krüppel-associated box zinc-finger protein gene and a member of the zinc-finger family of transcriptional factors. Notably, the role of ZNF307 and its underlying mechanisms involved in hepatocarcinogenesis are poorly investigated. In the present study, we found that the expression of ZNF307 was significantly downregulated in hepatocellular carcinoma (HCC) tissues, compared with that in adjacent non-tumor tissues. In vitro studies further demonstrated that ectopic expression of ZNF307 in HCC cell lines Bel7402 and HCCLM3 significantly reduced cell proliferation, migration and invasive ability. Concordantly, knockdown of ZNF307 increased cell proliferation, migration and invasive ability of HCC cell lines MHCC97L and QGY7701. In vivo functional studies showed that upregulation of ZNF307 expression in Bel7402 cells led to a suppression of tumorigenicity in mice, while knockdown of ZNF307 in MHCC97L cells resulted in reverse. effects. Importantly, flow cytometric analysis showed that ZNF307 overexpression increased the incidence of apoptosis, while ZNF307 knockdown decreased the incidence of apoptosis. Consistently, key regulators in apoptosis, such as caspase-3, BAX and BCL-2 were also regulated by ZNF307. Therefore, our results indicate that ZNF307 may serve as a tumor suppressor and inhibits cell proliferation of HCC via inducing apoptosis.
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Copy and paste a formatted citation
Spandidos Publications style
Liang Y, Li Q, Chen K, Ni W, Zhan Z, Ye F, Li Y, Fang Y, Zhang F, Chen L, Chen L, et al: Zinc finger protein 307 functions as a tumor‑suppressor and inhibits cell proliferation by inducing apoptosis in hepatocellular carcinoma. Oncol Rep 38: 2229-2236, 2017.
APA
Liang, Y., Li, Q., Chen, K., Ni, W., Zhan, Z., Ye, F. ... Ding, Y. (2017). Zinc finger protein 307 functions as a tumor‑suppressor and inhibits cell proliferation by inducing apoptosis in hepatocellular carcinoma. Oncology Reports, 38, 2229-2236. https://doi.org/10.3892/or.2017.5868
MLA
Liang, Y., Li, Q., Chen, K., Ni, W., Zhan, Z., Ye, F., Li, Y., Fang, Y., Zhang, F., Chen, L., Ding, Y."Zinc finger protein 307 functions as a tumor‑suppressor and inhibits cell proliferation by inducing apoptosis in hepatocellular carcinoma". Oncology Reports 38.4 (2017): 2229-2236.
Chicago
Liang, Y., Li, Q., Chen, K., Ni, W., Zhan, Z., Ye, F., Li, Y., Fang, Y., Zhang, F., Chen, L., Ding, Y."Zinc finger protein 307 functions as a tumor‑suppressor and inhibits cell proliferation by inducing apoptosis in hepatocellular carcinoma". Oncology Reports 38, no. 4 (2017): 2229-2236. https://doi.org/10.3892/or.2017.5868
Copy and paste a formatted citation
x
Spandidos Publications style
Liang Y, Li Q, Chen K, Ni W, Zhan Z, Ye F, Li Y, Fang Y, Zhang F, Chen L, Chen L, et al: Zinc finger protein 307 functions as a tumor‑suppressor and inhibits cell proliferation by inducing apoptosis in hepatocellular carcinoma. Oncol Rep 38: 2229-2236, 2017.
APA
Liang, Y., Li, Q., Chen, K., Ni, W., Zhan, Z., Ye, F. ... Ding, Y. (2017). Zinc finger protein 307 functions as a tumor‑suppressor and inhibits cell proliferation by inducing apoptosis in hepatocellular carcinoma. Oncology Reports, 38, 2229-2236. https://doi.org/10.3892/or.2017.5868
MLA
Liang, Y., Li, Q., Chen, K., Ni, W., Zhan, Z., Ye, F., Li, Y., Fang, Y., Zhang, F., Chen, L., Ding, Y."Zinc finger protein 307 functions as a tumor‑suppressor and inhibits cell proliferation by inducing apoptosis in hepatocellular carcinoma". Oncology Reports 38.4 (2017): 2229-2236.
Chicago
Liang, Y., Li, Q., Chen, K., Ni, W., Zhan, Z., Ye, F., Li, Y., Fang, Y., Zhang, F., Chen, L., Ding, Y."Zinc finger protein 307 functions as a tumor‑suppressor and inhibits cell proliferation by inducing apoptosis in hepatocellular carcinoma". Oncology Reports 38, no. 4 (2017): 2229-2236. https://doi.org/10.3892/or.2017.5868
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