Inhibition of the growth of hepatocellular carcinoma cells through fibroblast growth factor 18 suppressed by miR-139

  • Authors:
    • Li Yang
    • Dian Yin
    • Yilang Wang
    • Lili Cao
  • View Affiliations

  • Published online on: August 2, 2017     https://doi.org/10.3892/or.2017.5869
  • Pages: 2565-2571
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Abstract

Hepatocellular carcinoma (HCC) is a highly malignant tumor and one of the most common causes for human cancer-related deaths. Fibroblast growth factor 18 (FGF18) is overexpressed in many types of cancer, and is associated with cell proliferation, invasion and angiogenesis. miR-139 has recently been reported as a tumor suppressor in various types of cancer and it can regulate many tumor-related genes, however its association with FGF18 expression in HCC has not been reported and thus remains unknown. In the present study, to explore the potential regulation mechanism of miR-139 with FGF18 in HCC, HCC tissues and cell lines were used. The results revealed that FGF18 was highly expressed in HCC tissues and cells, however miR-139 was lowly expressed. FGF18 was demonstrated to be a direct target of miR-139. Furthermore, the suppressive effect of miR-139 on FGF18 and in turn on proliferation, apoptosis, invasion, migration and tumor-induced angiogenesis of HCC cells was investigated. FGF18 was suggested as a prognostic biomarker and therapeutic target in HCC patients and miR-139 may be a promising strategy used in HCC treatment via the suppression of FGF18.

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October 2017
Volume 38 Issue 4

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APA
Yang, L., Yin, D., Wang , Y., & Cao, L. (2017). Inhibition of the growth of hepatocellular carcinoma cells through fibroblast growth factor 18 suppressed by miR-139. Oncology Reports, 38, 2565-2571. https://doi.org/10.3892/or.2017.5869
MLA
Yang, L., Yin, D., Wang , Y., Cao, L."Inhibition of the growth of hepatocellular carcinoma cells through fibroblast growth factor 18 suppressed by miR-139". Oncology Reports 38.4 (2017): 2565-2571.
Chicago
Yang, L., Yin, D., Wang , Y., Cao, L."Inhibition of the growth of hepatocellular carcinoma cells through fibroblast growth factor 18 suppressed by miR-139". Oncology Reports 38, no. 4 (2017): 2565-2571. https://doi.org/10.3892/or.2017.5869