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Article

Comprehensive analysis of aberrantly expressed microRNA profiles reveals potential biomarkers of human lung adenocarcinoma progression

  • Authors:
    • Jing Sui
    • Ru-Song Yang
    • Si-Yi Xu
    • Yan-Qiu Zhang
    • Cheng-Yun Li
    • Sheng Yang
    • Li-Hong Yin
    • Yue-Pu Pu
    • Ge-Yu Liang
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, P.R. China, Department of Thoracic Surgery, Nanjing Chest Hospital, Nanjing, Jiangsu 210029, P.R. China
  • Pages: 2453-2463
    |
    Published online on: August 4, 2017
       https://doi.org/10.3892/or.2017.5880
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Abstract

Lung adenocarcinoma (LUAD) is a complex disease that poses challenges for diagnosis and treatment. The aim of the present study is to investigate LUAD-specific key microRNAs (miRNAs) from large-scale samples in The Cancer Genome Atlas (TCGA) database. We used an integrative computational method to identify LUAD-specific key miRNAs related to TNM stage and lymphatic metastasis from the TCGA database. Twenty-five LUAD-specific key miRNAs (fold change >2, p<0.05) from the TCGA database were investigated, and 15 were found to be aberrantly expressed with respect to clinical features. Three miRNAs were correlated with overall survival (log-rank p<0.05). Then, 5 miRNAs were randomly selected for verification of expression in 53 LUAD patient tissues using qRT-PCR. Diagnostic value of these above 5 miRNAs was determined by areas under receiver operating characteristic curves (ROC). Finally, the LUAD-related miRNA miR-30a-3p was selected for verification of biologic function in A549 cells. The results of tests for cell proliferation, apoptosis, and target genes suggested that miR-30a-3p decreases cell proliferation and promotes apoptosis through targeting AKT3. Therefore, miR-30a-3p may be a promising biomarker for the early screening of high-risk populations and early diagnosis of LUAD. Our studies provide insights into identifying novel potential biomarkers for diagnosis and prognosis of LUAD.
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View References

1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Meng W, Ye Z, Cui R, Perry J, Dedousi-Huebner V, Huebner A, Wang Y, Li B, Volinia S, Nakanishi H, et al: MicroRNA-31 predicts the presence of lymph node metastases and survival in patients with lung adenocarcinoma. Clin Cancer Res. 19:5423–5433. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Lagos-Quintana M, Rauhut R, Lendeckel W and Tuschl T: Identification of novel genes coding for small expressed RNAs. Science. 294:853–858. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Carthew RW and Sontheimer EJ: Origins and mechanisms of miRNAs and siRNAs. Cell. 136:642–655. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Li CY, Liang GY, Yao WZ, Sui J, Shen X, Zhang YQ, Peng H, Hong WW, Ye YC, Zhang ZY, et al: Identification and functional characterization of microRNAs reveal a potential role in gastric cancer progression. Clin Transl Oncol. 19:162–172. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Babu KR and Muckenthaler MU: miR-20a regulates expression of the iron exporter ferroportin in lung cancer. J Mol Med (Berl). 94:347–359. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Wu W, Dang S, Feng Q, Liang J, Wang Y and Fan N: MicroRNA-542-3p inhibits the growth of hepatocellular carcinoma cells by targeting FZD7/Wnt signaling pathway. Biochem Biophys Res Commun. 482:100–105. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Ren C, Chen H, Han C, Fu D, Wang D and Shen M: High expression of miR-16 and miR-451 predicating better prognosis in patients with gastric cancer. J Cancer Res Clin Oncol. 142:2489–2496. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Wang X, Li M, Wang Z, Han S, Tang X, Ge Y, Zhou L, Zhou C, Yuan Q and Yang M: Silencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells. J Biol Chem. 290:3925–3935. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Kent OA and Mendell JT: A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes. Oncogene. 25:6188–6196. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Borel C and Antonarakis SE: Functional genetic variation of human miRNAs and phenotypic consequences. Mamm Genome. 19:503–509. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, Harano T, Yatabe Y, Nagino M, Nimura Y, et al: Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res. 64:3753–3756. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Becker-Santos DD, Thu KL, English JC, Pikor LA, Martinez VD, Zhang M, Vucic EA, Luk MT, Carraro A, Korbelik J, et al: Developmental transcription factor NFIB is a putative target of oncofetal miRNAs and is associated with tumour aggressiveness in lung adenocarcinoma. J Pathol. 240:161–172. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Mou X and Liu S: MiR-485 inhibits metastasis and EMT of lung adenocarcinoma by targeting Flot2. Biochem Biophys Res Commun. 477:521–526. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Xie K, Wang C, Qin N, Yang J, Zhu M, Dai J, Jin G, Shen H, Ma H and Hu Z: Genetic variants in regulatory regions of microRNAs are associated with lung cancer risk. Oncotarget. 7:47966–47974. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Sui J, Li YH, Zhang YQ, Li CY, Shen X, Yao WZ, Peng H, Hong WW, Yin LH, Pu YP, et al: Integrated analysis of long non-coding RNA-associated ceRNA network reveals potential lncRNA biomarkers in human lung adenocarcinoma. Int J Oncol. 49:2023–2036. 2016.PubMed/NCBI

18 

Li CY, Liang GY, Yao WZ, Sui J, Shen X, Zhang YQ, Peng H, Hong WW, Ye YC, Zhang ZY, et al: Integrated analysis of long non-coding RNA competing interactions reveals the potential role in progression of human gastric cancer. Int J Oncol. 48:1965–1976. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Xie J and Liu C: Adjusted Kaplan-Meier estimator and log-rank test with inverse probability of treatment weighting for survival data. Stat Med. 24:3089–3110. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Branders S and Dupont P: A balanced hazard ratio for risk group evaluation from survival data. Stat Med. 34:2528–2543. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Sana J, Faltejskova P, Svoboda M and Slaby O: Novel classes of non-coding RNAs and cancer. J Transl Med. 10:1032012. View Article : Google Scholar : PubMed/NCBI

22 

Wang DY, Wu YN, Huang JQ, Wang W, Xu M, Jia JP, Han G, Mao BB and Bi WZ: Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance. Chin J Cancer. 35:472016. View Article : Google Scholar : PubMed/NCBI

23 

Mo X, Cao Q, Liang H, Liu J, Li H and Liu F: MicroRNA-610 suppresses the proliferation of human glioblastoma cells by repressing CCND2 and AKT3. Mol Med Rep. 13:1961–1966. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Kerr KM: Pulmonary adenocarcinomas: Classification and reporting. Histopathology. 54:12–27. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Yoshizawa A, Motoi N, Riely GJ, Sima CS, Gerald WL, Kris MG, Park BJ, Rusch VW, Travis WD, et al: Impact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases. Mod pathol. 24:653–664. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Ortea I, Rodríguez-Ariza A, Chicano-Gálvez E, Vacas Arenas MS and Jurado Gámez B: Discovery of potential protein biomarkers of lung adenocarcinoma in bronchoalveolar lavage fluid by SWATH MS data-independent acquisition and targeted data extraction. J Proteomics. 138:106–114. 2016. View Article : Google Scholar : PubMed/NCBI

27 

De Luca A, Maiello MR, DAlessio A, Pergameno M and Normanno N: The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: Role in cancer pathogenesis and implications for therapeutic approaches. Expert Opin Ther Targets. 16 Suppl 2:S17–S27. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Cardarella S and Johnson BE: The impact of genomic changes on treatment of lung cancer. Am J Respir Crit Care Med. 188:770–775. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, et al: MicroRNA expression profiles classify human cancers. Nature. 435:834–838. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Cai Y, Yu X, Hu S and Yu J: A brief review on the mechanisms of miRNA regulation. Genomics Proteomics Bioinformatics. 7:147–154. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Shi X, Xu Y, Zhang C, Feng L, Sun Z, Han J, Su F, Zhang Y, Li C and Li X: Subpathway-LNCE: Identify dysfunctional subpathways competitively regulated by lncRNAs through integrating lncRNA-mRNA expression profile and pathway topologies. Oncotarget. 7:69857–69870. 2016.PubMed/NCBI

32 

Wu C, Xu B, Zhou Y, Ji M, Zhang D, Jiang J and Wu C: Correlation between serum IL-1β and miR-144-3p as well as their prognostic values in LUAD and LUSC patients. Oncotarget. 7:85876–85887. 2016.PubMed/NCBI

33 

Ma Y, Zhang P, Yang J, Liu Z, Yang Z and Qin H: Candidate microRNA biomarkers in human colorectal cancer: Systematic review profiling studies and experimental validation. Int J Cancer. 130:2077–2087. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Pantaleo MA, Ravegnini G, Astolfi A, Simeon V, Nannini M, Saponara M, Urbini M, Gatto L, Indio V, Sammarini G, et al: Integrating miRNA and gene expression profiling analysis revealed regulatory networks in gastrointestinal stromal tumors. Epigenomics. 8:1347–1366. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Wei Y, He R, Wu Y, Gan B, Wu P, Qiu X, Lan A, Chen G, Wang Q, Lin X, et al: Comprehensive investigation of aberrant microRNA profiling in bladder cancer tissues. Tumour Biol. 37:12555–12569. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Pichler M, Stiegelbauer V, Vychytilova-Faltejskova P, Ivan C, Ling H, Winter E, Zhang X, Goblirsch M, Wulf-Goldenberg A, Ohtsuka M, et al: Genome-wide microRNA analysis identifies miR-188-3p as novel prognostic marker and molecular factor involved in colorectal carcinogenesis. Clin Cancer Res. 23:1323–1333. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Shao Y, Shen YQ, Li YL, Liang C, Zhang BJ, Lu SD, He YY, Wang P, Sun QL, Jin YX, et al: Direct repression of the oncogene CDK4 by the tumor suppressor miR-486-5p in non-small cell lung cancer. Oncotarget. 7:34011–34021. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Xiao P and Liu WL: MiR-142-3p functions as a potential tumor suppressor directly targeting HMGB1 in non-small-cell lung carcinoma. Int J Clin Exp Pathol. 8:10800–10807. 2015.PubMed/NCBI

39 

Chen Q, Hu H, Jiao D, Yan J, Xu W, Tang X, Chen J and Wang J: miR-126-3p and miR-451a correlate with clinicopathological features of lung adenocarcinoma: The underlying molecular mechanisms. Oncol Rep. 36:909–917. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Mathew LK, Lee SS, Skuli N, Rao S, Keith B, Nathanson KL, Lal P and Simon MC: Restricted expression of miR-30c-2-3p and miR-30a-3p in clear cell renal cell carcinomas enhances HIF2α activity. Cancer Discov. 4:53–60. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Rodríguez-González FG, Sieuwerts AM, Smid M, Look MP, Meijer-van Gelder ME, de Weerd V, Sleijfer S, Martens JW and Foekens JA: MicroRNA-30c expression level is an independent predictor of clinical benefit of endocrine therapy in advanced estrogen receptor positive breast cancer. Breast Cancer Res Treat. 127:43–51. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Shin K, Kim KH, Yoon MS, Suh DS, Lee JY, Kim A and Eo W: Expression of interactive genes associated with apoptosis and their prognostic value for ovarian serous adenocarcinoma. Adv Clin Exp Med. 25:513–521. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sui J, Yang R, Xu S, Zhang Y, Li C, Yang S, Yin L, Pu Y and Liang G: Comprehensive analysis of aberrantly expressed microRNA profiles reveals potential biomarkers of human lung adenocarcinoma progression. Oncol Rep 38: 2453-2463, 2017.
APA
Sui, J., Yang, R., Xu, S., Zhang, Y., Li, C., Yang, S. ... Liang, G. (2017). Comprehensive analysis of aberrantly expressed microRNA profiles reveals potential biomarkers of human lung adenocarcinoma progression. Oncology Reports, 38, 2453-2463. https://doi.org/10.3892/or.2017.5880
MLA
Sui, J., Yang, R., Xu, S., Zhang, Y., Li, C., Yang, S., Yin, L., Pu, Y., Liang, G."Comprehensive analysis of aberrantly expressed microRNA profiles reveals potential biomarkers of human lung adenocarcinoma progression". Oncology Reports 38.4 (2017): 2453-2463.
Chicago
Sui, J., Yang, R., Xu, S., Zhang, Y., Li, C., Yang, S., Yin, L., Pu, Y., Liang, G."Comprehensive analysis of aberrantly expressed microRNA profiles reveals potential biomarkers of human lung adenocarcinoma progression". Oncology Reports 38, no. 4 (2017): 2453-2463. https://doi.org/10.3892/or.2017.5880
Copy and paste a formatted citation
x
Spandidos Publications style
Sui J, Yang R, Xu S, Zhang Y, Li C, Yang S, Yin L, Pu Y and Liang G: Comprehensive analysis of aberrantly expressed microRNA profiles reveals potential biomarkers of human lung adenocarcinoma progression. Oncol Rep 38: 2453-2463, 2017.
APA
Sui, J., Yang, R., Xu, S., Zhang, Y., Li, C., Yang, S. ... Liang, G. (2017). Comprehensive analysis of aberrantly expressed microRNA profiles reveals potential biomarkers of human lung adenocarcinoma progression. Oncology Reports, 38, 2453-2463. https://doi.org/10.3892/or.2017.5880
MLA
Sui, J., Yang, R., Xu, S., Zhang, Y., Li, C., Yang, S., Yin, L., Pu, Y., Liang, G."Comprehensive analysis of aberrantly expressed microRNA profiles reveals potential biomarkers of human lung adenocarcinoma progression". Oncology Reports 38.4 (2017): 2453-2463.
Chicago
Sui, J., Yang, R., Xu, S., Zhang, Y., Li, C., Yang, S., Yin, L., Pu, Y., Liang, G."Comprehensive analysis of aberrantly expressed microRNA profiles reveals potential biomarkers of human lung adenocarcinoma progression". Oncology Reports 38, no. 4 (2017): 2453-2463. https://doi.org/10.3892/or.2017.5880
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