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Article

MACC1 induces autophagy to regulate proliferation, apoptosis, migration and invasion of squamous cell carcinoma

  • Authors:
    • Jian Wu
    • Dawei Zhang
    • Jun Li
    • Xin Deng
    • Guannan Liang
    • Yang Long
    • Xuemei He
    • Tianyang Dai
    • Delian Ren
  • View Affiliations / Copyright

    Affiliations: Department of Cardio-Thoracic Surgery, The Affiliated Hospital of South West Medical University, Luzhou, Sichuan, P.R. China, Drug Discovery Research Center, Southwest Medical University, Luzhou, Sichuan, P.R. China, Department of Immunology, Basic Medicine College, South West Medical University, Luzhou, Sichuan, P.R. China
  • Pages: 2369-2377
    |
    Published online on: August 8, 2017
       https://doi.org/10.3892/or.2017.5889
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Abstract

Metastasis-associated colon cancer-1 (MACC1) plays an important role in cancer development, but the role and mechansim of MACC1 in squamous cell carcinoma (ESCC) remain unclear. In this study, we found that MACC1 expression was increased in ESCC, and correlated with lymph node metastasis. MACC1 knockdown suppresed ESCC cell proliferation, metastasis and enchanced cell apoptosis. Moreover, MACC1 knockdown inhibited ESCC cell autophagy, and 3-methyladenine was able to rescue MACC1-induced malignant phenotype of ESCC cells. Furthermore, MACC1 knockdown inactivated AMPK-ULK1 signaling pathway, and metformin could rescue MACC1-induced autophagy in ESCC cells. Collectively, this study found that upregulation of MACC1 in ESCC was associated with lymph node metastasis of patients, and MACC1 regulated ESCC cell proliferation, apoptosis, migration and invasion mainly through AMPK-ULK1 induced autophagy.
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Copy and paste a formatted citation
Spandidos Publications style
Wu J, Zhang D, Li J, Deng X, Liang G, Long Y, He X, Dai T and Ren D: MACC1 induces autophagy to regulate proliferation, apoptosis, migration and invasion of squamous cell carcinoma. Oncol Rep 38: 2369-2377, 2017.
APA
Wu, J., Zhang, D., Li, J., Deng, X., Liang, G., Long, Y. ... Ren, D. (2017). MACC1 induces autophagy to regulate proliferation, apoptosis, migration and invasion of squamous cell carcinoma. Oncology Reports, 38, 2369-2377. https://doi.org/10.3892/or.2017.5889
MLA
Wu, J., Zhang, D., Li, J., Deng, X., Liang, G., Long, Y., He, X., Dai, T., Ren, D."MACC1 induces autophagy to regulate proliferation, apoptosis, migration and invasion of squamous cell carcinoma". Oncology Reports 38.4 (2017): 2369-2377.
Chicago
Wu, J., Zhang, D., Li, J., Deng, X., Liang, G., Long, Y., He, X., Dai, T., Ren, D."MACC1 induces autophagy to regulate proliferation, apoptosis, migration and invasion of squamous cell carcinoma". Oncology Reports 38, no. 4 (2017): 2369-2377. https://doi.org/10.3892/or.2017.5889
Copy and paste a formatted citation
x
Spandidos Publications style
Wu J, Zhang D, Li J, Deng X, Liang G, Long Y, He X, Dai T and Ren D: MACC1 induces autophagy to regulate proliferation, apoptosis, migration and invasion of squamous cell carcinoma. Oncol Rep 38: 2369-2377, 2017.
APA
Wu, J., Zhang, D., Li, J., Deng, X., Liang, G., Long, Y. ... Ren, D. (2017). MACC1 induces autophagy to regulate proliferation, apoptosis, migration and invasion of squamous cell carcinoma. Oncology Reports, 38, 2369-2377. https://doi.org/10.3892/or.2017.5889
MLA
Wu, J., Zhang, D., Li, J., Deng, X., Liang, G., Long, Y., He, X., Dai, T., Ren, D."MACC1 induces autophagy to regulate proliferation, apoptosis, migration and invasion of squamous cell carcinoma". Oncology Reports 38.4 (2017): 2369-2377.
Chicago
Wu, J., Zhang, D., Li, J., Deng, X., Liang, G., Long, Y., He, X., Dai, T., Ren, D."MACC1 induces autophagy to regulate proliferation, apoptosis, migration and invasion of squamous cell carcinoma". Oncology Reports 38, no. 4 (2017): 2369-2377. https://doi.org/10.3892/or.2017.5889
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