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Article

Screening and identification of potential biomarkers in triple-negative breast cancer by integrated analysis

  • Authors:
    • Jilong Guo
    • Guohua Gong
    • Bin Zhang
  • View Affiliations / Copyright

    Affiliations: Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia 028000, P.R. China
  • Pages: 2219-2228
    |
    Published online on: August 21, 2017
       https://doi.org/10.3892/or.2017.5911
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Abstract

Triple-negative breast cancer (TNBC) has attracted great attention due to its unique biology, poor prognosis, and aggressiveness. TNBC patients are more likely to suffer from metastasis. We screened and identified the TNBC-specific genes as potential biomarkers. A total of 167 breast cancer samples (45 TNBC and 122 non-TNBC) were used in the integrated analysis. Gene expression microarrays were used to screen the differentially expressed genes. We identified 65 core DEGs. According to the GO and KEGG analysis, the gene function enrichment in TNBC was revealed, such as basal cell carcinoma, prostate cancer, oocyte meiosis and choline metabolism in cancer pathways. Moreover, the PPI network reconstruction would benefit the screening of hubs. A RFS analysis of TNBC-specific genes was also conducted. RT-PCR was used to validate the expression pattern of hubs in TNBC. Finally, nine genes were identified and all of them were novel, specific and higher dysregulation expressed genes in TNBC. Such that, these genes will serve as potential biomarkers in TNBC and benefit further research in TNBC.
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Copy and paste a formatted citation
Spandidos Publications style
Guo J, Gong G and Zhang B: Screening and identification of potential biomarkers in triple-negative breast cancer by integrated analysis. Oncol Rep 38: 2219-2228, 2017.
APA
Guo, J., Gong, G., & Zhang, B. (2017). Screening and identification of potential biomarkers in triple-negative breast cancer by integrated analysis. Oncology Reports, 38, 2219-2228. https://doi.org/10.3892/or.2017.5911
MLA
Guo, J., Gong, G., Zhang, B."Screening and identification of potential biomarkers in triple-negative breast cancer by integrated analysis". Oncology Reports 38.4 (2017): 2219-2228.
Chicago
Guo, J., Gong, G., Zhang, B."Screening and identification of potential biomarkers in triple-negative breast cancer by integrated analysis". Oncology Reports 38, no. 4 (2017): 2219-2228. https://doi.org/10.3892/or.2017.5911
Copy and paste a formatted citation
x
Spandidos Publications style
Guo J, Gong G and Zhang B: Screening and identification of potential biomarkers in triple-negative breast cancer by integrated analysis. Oncol Rep 38: 2219-2228, 2017.
APA
Guo, J., Gong, G., & Zhang, B. (2017). Screening and identification of potential biomarkers in triple-negative breast cancer by integrated analysis. Oncology Reports, 38, 2219-2228. https://doi.org/10.3892/or.2017.5911
MLA
Guo, J., Gong, G., Zhang, B."Screening and identification of potential biomarkers in triple-negative breast cancer by integrated analysis". Oncology Reports 38.4 (2017): 2219-2228.
Chicago
Guo, J., Gong, G., Zhang, B."Screening and identification of potential biomarkers in triple-negative breast cancer by integrated analysis". Oncology Reports 38, no. 4 (2017): 2219-2228. https://doi.org/10.3892/or.2017.5911
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