|
1
|
Brabletz T: EMT and MET in metastasis:
Where are the cancer stem cells? Cancer Cell. 22:699–701. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Franco-Chuaire ML, Carolina Magda SC and
Chuaire-Noack L: Epithelial-mesenchymal transition (EMT):
Principles and clinical impact in cancer therapy. Invest Clin.
54:186–205. 2013.PubMed/NCBI
|
|
3
|
Fantozzi A, Gruber DC, Pisarsky L, Heck C,
Kunita A, Yilmaz M, Meyer-Schaller N, Cornille K, Hopfer U,
Bentires-Alj M, et al: VEGF-mediated angiogenesis links EMT-induced
cancer stemness to tumor initiation. Cancer Res. 74:1566–1575.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
No authors listed: An oncogenic splice
variant drives EMT and metastasis in breast cancer. Cancer Discov.
3:OF162013. View Article : Google Scholar
|
|
5
|
Chang RM, Xu JF, Fang F, Yang H and Yang
LY: MicroRNA-130b promotes proliferation and EMT-induced metastasis
via PTEN/p-AKT/HIF-1α signaling. Tumour Biol. 37:10609–10619. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Sannino G, Armbruster N, Bodenhöfer M,
Haerle U, Behrens D, Buchholz M, Rothbauer U, Sipos B and Schmees
C: Role of BCL9L in transforming growth factor-β (TGF-β)-induced
epithelial-to-mesenchymal-transition (EMT) and metastasis of
pancreatic cancer. Oncotarget. 7:73725–73738. 2016.PubMed/NCBI
|
|
7
|
Gao D, Vahdat LT, Wong S, Chang JC and
Mittal V: Microenvironmental regulation of epithelial-mesenchymal
transitions in cancer. Cancer Res. 72:4883–4889. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Goswami S, Sahai E, Wyckoff JB, Cammer M,
Cox D, Pixley FJ, Stanley ER, Segall JE and Condeelis JS:
Macrophages promote the invasion of breast carcinoma cells via a
colony-stimulating factor-1/epidermal growth factor paracrine loop.
Cancer Res. 65:5278–5283. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Luo BH, Xiong F, Wang JP, Li JH, Zhong M,
Liu QL, Luo GQ, Yang XJ, Xiao N, Xie B, et al: Epidermal growth
factor-like domain-containing protein 7 (EGFL7) enhances EGF
receptor-AKT signaling, epithelial-mesenchymal transition, and
metastasis of gastric cancer cells. PLoS One. 9:e999222014.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Muthusami S, Prabakaran DS, Yu JR and Park
WY: EGF-induced expression of Fused Toes Homolog (FTS) facilitates
epithelial-mesenchymal transition and promotes cell migration in
ME180 cervical cancer cells. Cancer Lett. 351:252–259. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Henic E, Noskova V, Høyer-Hansen G,
Hansson S and Casslén B: Estradiol attenuates EGF-induced rapid
uPAR mobilization and cell migration via the G-protein-coupled
receptor 30 in ovarian cancer cells. Int J Gynecol Cancer.
19:214–222. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Hu J, Jo M, Cavenee WK, Furnari F,
VandenBerg SR and Gonias SL: Crosstalk between the urokinase-type
plasminogen activator receptor and EGF receptor variant III
supports survival and growth of glioblastoma cells. Proc Natl Acad
Sci USA. 108:15984–15989. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Hu J, Muller KA, Furnari FB, Cavenee WK,
VandenBerg SR and Gonias SL: Neutralizing the EGF receptor in
glioblastoma cells stimulates cell migration by activating
uPAR-initiated cell signaling. Oncogene. 34:4078–4088. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Gupta R, Chetty C, Bhoopathi P, Lakka S,
Mohanam S, Rao JS and Dinh DE: Downregulation of uPA/uPAR inhibits
intermittent hypoxia-induced epithelial-mesenchymal transition
(EMT) in DAOY and D283 medulloblastoma cells. Int J Oncol.
38:733–744. 2011.PubMed/NCBI
|
|
15
|
Ashour AA, Gurbuz N, Alpay SN, Abdel-Aziz
AA, Mansour AM, Huo L and Ozpolat B: Elongation factor-2 kinase
regulates TG2/β1 integrin/Src/uPAR pathway and
epithelial-mesenchymal transition mediating pancreatic cancer cells
invasion. J Cell Mol Med. 18:2235–2251. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Baek MK, Kim MH, Jang HJ, Park JS, Chung
IJ, Shin BA, Ahn BW and Jung YD: EGF stimulates uPAR expression and
cell invasiveness through ERK, AP-1, and NF-κB signaling in human
gastric carcinoma cells. Oncol Rep. 20:1569–1575. 2008.PubMed/NCBI
|
|
17
|
Smith HW and Marshall CJ: Regulation of
cell signalling by uPAR. Nat Rev Mol Cell Biol. 11:23–36. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Bessard A, Frémin C, Ezan F, Coutant A and
Baffet G: MEK/ERK-dependent uPAR expression is required for
motility via phosphorylation of P70S6K in human hepatocarcinoma
cells. J Cell Physiol. 212:526–536. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Hu Z, Xu R, Liu J, Zhang Y, Du J, Li W,
Zhang W, Li Y, Zhu Y and Gu L: GEP100 regulates epidermal growth
factor-induced MDA-MB-231 breast cancer cell invasion through the
activation of Arf6/ERK/uPAR signaling pathway. Exp Cell Res.
319:1932–1941. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Tushir JS and D'Souza-Schorey C:
ARF6-dependent activation of ERK and Rac1 modulates epithelial
tubule development. EMBO J. 26:1806–1819. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Li J, Shan F, Xiong G, Chen X, Guan X,
Wang JM, Wang WL, Xu X and Bai Y: EGF-induced C/EBPβ participates
in EMT by decreasing the expression of miR-203 in esophageal
squamous cell carcinoma cells. J Cell Sci. 127:3735–3744. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Wang Y, Lin Z, Sun L, Fan S, Huang Z,
Zhang D, Yang Z, Li J and Chen W: Akt/Ezrin Tyr353/NF-κB pathway
regulates EGF-induced EMT and metastasis in tongue squamous cell
carcinoma. Br J Cancer. 110:695–705. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Cordonnier T, Bishop JL, Shiota M, Nip KM,
Thaper D, Vahid S, Heroux D, Gleave M and Zoubeidi A: Hsp27
regulates EGF/β-catenin mediated epithelial to mesenchymal
transition in prostate cancer. Int J Cancer. 136:E496–E507. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Savagner P: Epithelial-mesenchymal
transitions: From cell plasticity to concept elasticity. Curr Top
Dev Biol. 112:273–300. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Ha GH, Park JS and Breuer EK: TACC3
promotes epithelial-mesenchymal transition (EMT) through the
activation of PI3K/Akt and ERK signaling pathways. Cancer Lett.
332:63–73. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Chen B, Zeng X, He Y, Wang X, Liang Z, Liu
J, Zhang P, Zhu H, Xu N and Liang S: STC2 promotes the
epithelial-mesenchymal transition of colorectal cancer cells
through AKT-ERK signaling pathways. Oncotarget. 7:71400–71416.
2016.PubMed/NCBI
|
|
27
|
Wang Z, Qu L, Deng B, Sun X, Wu S, Liao J,
Fan J and Peng Z: STYK1 promotes epithelial-mesenchymal transition
and tumor metastasis in human hepatocellular carcinoma through
MEK/ERK and PI3K/AKT signaling. Sci Rep. 6:332052016. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Zhang Y, Du J, Zheng J, Liu J, Xu R, Shen
T, Zhu Y, Chang J, Wang H, Zhang Z, et al: EGF-reduced Wnt5a
transcription induces epithelial-mesenchymal transition via
Arf6-ERK signaling in gastric cancer cells. Oncotarget.
6:7244–7261. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Laurenzana A, Biagioni A, Bianchini F,
Peppicelli S, Chillà A, Margheri F, Luciani C, Pimpinelli N, Del
Rosso M, Calorini L, et al: Inhibition of uPAR-TGFβ crosstalk
blocks MSC-dependent EMT in melanoma cells. J Mol Med. 93:783–794.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Clapéron A, Mergey M, Nguyen Ho-Bouldoires
TH, Vignjevic D, Wendum D, Chrétien Y, Merabtene F, Frazao A,
Paradis V, Housset C, et al: EGF/EGFR axis contributes to the
progression of cholangiocarcinoma through the induction of an
epithelial-mesenchymal transition. J Hepatol. 61:325–332. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Grassi ML, Palma CS, Thomé CH, Lanfredi
GP, Poersch A and Faça VM: Proteomic analysis of ovarian cancer
cells during epithelial-mesenchymal transition (EMT) induced by
epidermal growth factor (EGF) reveals mechanisms of cell cycle
control. J Proteomics. 151:2–11. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Xu Q, Zhang Q, Ishida Y, Hajjar S, Tang X,
Shi H, Dang CV and Le AD: EGF induces epithelial-mesenchymal
transition and cancer stem-like cell properties in human oral
cancer cells via promoting Warburg effect. Oncotarget. 8:9557–9571.
2017.PubMed/NCBI
|
|
33
|
Han J, Xie Y, Lan F, Yu Y, Liu W, Chen J,
Zheng F, Ouyang X, Lin X, Lin Y, et al: Additive effects of EGF and
IL-1β regulate tumor cell migration and invasion in gastric
adenocarcinoma via activation of ERK1/2. Int J Oncol. 45:291–301.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
da Rosa MR, Falcão AS, Fuzii HT, da Silva
Kataoka MS, Ribeiro AL, Boccardo E, de Siqueira AS, Jaeger RG, de
Jesus Viana Pinheiro J and de Melo Alves Júnior S: EGFR signaling
downstream of EGF regulates migration, invasion, and MMP secretion
of immortalized cells derived from human ameloblastoma. Tumour
Biol. 35:11107–11120. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Guo B, Gao J, Zhan J and Zhang H:
Kindlin-2 interacts with and stabilizes EGFR and is required for
EGF-induced breast cancer cell migration. Cancer Lett. 361:271–281.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Yu XX, Hu Z, Shen X, Dong LY, Zhou WZ and
Hu WH: IL-33 promotes gastric cancer cell invasion and migration
via ST2-ERK1/2 pathway. Dig Dis Sci. 60:1265–1272. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Hong H, Jiang L, Lin Y, He C, Zhu G, Du Q,
Wang X, She F and Chen Y: TNF-alpha promotes lymphangiogenesis and
lymphatic metastasis of gallbladder cancer through the
ERK1/2/AP-1/VEGF-D pathway. BMC Cancer. 16:2402016. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Kong B, Michalski CW, Hong X, Valkovskaya
N, Rieder S, Abiatari I, Streit S, Erkan M, Esposito I, Friess H,
et al: AZGP1 is a tumor suppressor in pancreatic cancer inducing
mesenchymal-to-epithelial transdifferentiation by inhibiting
TGF-β-mediated ERK signaling. Oncogene. 29:5146–5158. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Shirakihara T, Horiguchi K, Miyazawa K,
Ehata S, Shibata T, Morita I, Miyazono K and Saitoh M: TGF-β
regulates isoform switching of FGF receptors and
epithelial-mesenchymal transition. EMBO J. 30:783–795. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Li Y, Shen Y, Miao Y, Luan Y, Sun B and
Qiu X: Co-expression of uPAR and CXCR4 promotes tumor growth and
metastasis in small cell lung cancer. Int J Clin Exp Pathol.
7:3771–3780. 2014.PubMed/NCBI
|
|
41
|
Pavón MA, Arroyo-Solera I, Céspedes MV,
Casanova I, León X and Mangues R: uPA/uPAR and SERPINE1 in head and
neck cancer: Role in tumor resistance, metastasis, prognosis and
therapy. Oncotarget. 7:57351–57366. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
LaRusch GA, Mahdi F, Shariat-Madar Z,
Adams G, Sitrin RG, Zhang WM, McCrae KR and Schmaier AH: Factor XII
stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to
initiate angiogenesis. Blood. 115:5111–5120. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Zheng D, Hu Z, He F, Gao C, Xu L, Zou H,
Wu Z, Jiang X and Wang J: Downregulation of galectin-3 causes a
decrease in uPAR levels and inhibits the proliferation, migration
and invasion of hepatocellular carcinoma cells. Oncol Rep.
32:411–418. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Ahmed N, Oliva K, Wang Y, Quinn M and Rice
G: Downregulation of urokinase plasminogen activator receptor
expression inhibits Erk signalling with concomitant suppression of
invasiveness due to loss of uPAR-beta1 integrin complex in colon
cancer cells. Br J Cancer. 89:374–384. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Raghu H, Gondi CS, Dinh DH, Gujrati M and
Rao JS: Specific knockdown of uPA/uPAR attenuates invasion in
glioblastoma cells and xenografts by inhibition of cleavage and
trafficking of Notch-1 receptor. Mol Cancer. 10:1302011. View Article : Google Scholar : PubMed/NCBI
|
