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Article

Radioiodine-labeled anti-epidermal growth factor receptor binding bovine serum albumin-polycaprolactone for targeting imaging of glioblastoma

  • Authors:
    • Chengxia Li
    • Jian Tan
    • Jin Chang
    • Wei Li
    • Zhongyun Liu
    • Ning Li
    • Yanhui Ji
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Heping, Tianjin 300052, P.R. China, Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin Key Laboratory of Composites and Functional Materials, Tianjin University, Tianjin 300072, P.R. China
  • Pages: 2919-2926
    |
    Published online on: September 4, 2017
       https://doi.org/10.3892/or.2017.5937
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Abstract

The aim of this study was to look for a new medicine in diagnosing and treating of glioblastoma. Radioiodine-labeled anti-epidermal growth factor receptor (EGFR) binding nanoparticles were constructed. In vitro cell-binding assays were confirmed by confocal microscopy and flow cytometry. Cell cytotoxicity assays were evaluated by MTT assay; radionuclide uptake assays were performed by γ-counter. Radioiodine-imaging studies were conducted using a xenograft nude mouse model in vivo. The results showed that EGFR significantly enhanced the uptake and accumulation of BSA-PCL in the experimental model of xenografts in nude mice, suggesting improved specific nanoparticle-based delivery. In conclusion, the data showed 131I-EGFR-BSA-PCL leading radioiodine therapy for U251 and U87 cells had a good effect in vitro and in vivo. Thus, 131I-EGFR-BSA-PCL may provide a new method for glioblastoma treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Li C, Tan J, Chang J, Li W, Liu Z, Li N and Ji Y: Radioiodine-labeled anti-epidermal growth factor receptor binding bovine serum albumin-polycaprolactone for targeting imaging of glioblastoma. Oncol Rep 38: 2919-2926, 2017.
APA
Li, C., Tan, J., Chang, J., Li, W., Liu, Z., Li, N., & Ji, Y. (2017). Radioiodine-labeled anti-epidermal growth factor receptor binding bovine serum albumin-polycaprolactone for targeting imaging of glioblastoma. Oncology Reports, 38, 2919-2926. https://doi.org/10.3892/or.2017.5937
MLA
Li, C., Tan, J., Chang, J., Li, W., Liu, Z., Li, N., Ji, Y."Radioiodine-labeled anti-epidermal growth factor receptor binding bovine serum albumin-polycaprolactone for targeting imaging of glioblastoma". Oncology Reports 38.5 (2017): 2919-2926.
Chicago
Li, C., Tan, J., Chang, J., Li, W., Liu, Z., Li, N., Ji, Y."Radioiodine-labeled anti-epidermal growth factor receptor binding bovine serum albumin-polycaprolactone for targeting imaging of glioblastoma". Oncology Reports 38, no. 5 (2017): 2919-2926. https://doi.org/10.3892/or.2017.5937
Copy and paste a formatted citation
x
Spandidos Publications style
Li C, Tan J, Chang J, Li W, Liu Z, Li N and Ji Y: Radioiodine-labeled anti-epidermal growth factor receptor binding bovine serum albumin-polycaprolactone for targeting imaging of glioblastoma. Oncol Rep 38: 2919-2926, 2017.
APA
Li, C., Tan, J., Chang, J., Li, W., Liu, Z., Li, N., & Ji, Y. (2017). Radioiodine-labeled anti-epidermal growth factor receptor binding bovine serum albumin-polycaprolactone for targeting imaging of glioblastoma. Oncology Reports, 38, 2919-2926. https://doi.org/10.3892/or.2017.5937
MLA
Li, C., Tan, J., Chang, J., Li, W., Liu, Z., Li, N., Ji, Y."Radioiodine-labeled anti-epidermal growth factor receptor binding bovine serum albumin-polycaprolactone for targeting imaging of glioblastoma". Oncology Reports 38.5 (2017): 2919-2926.
Chicago
Li, C., Tan, J., Chang, J., Li, W., Liu, Z., Li, N., Ji, Y."Radioiodine-labeled anti-epidermal growth factor receptor binding bovine serum albumin-polycaprolactone for targeting imaging of glioblastoma". Oncology Reports 38, no. 5 (2017): 2919-2926. https://doi.org/10.3892/or.2017.5937
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