Radioiodine-labeled anti-epidermal growth factor receptor binding bovine serum albumin-polycaprolactone for targeting imaging of glioblastoma

  • Authors:
    • Chengxia Li
    • Jian Tan
    • Jin Chang
    • Wei Li
    • Zhongyun Liu
    • Ning Li
    • Yanhui Ji
  • View Affiliations

  • Published online on: September 4, 2017     https://doi.org/10.3892/or.2017.5937
  • Pages: 2919-2926
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Abstract

The aim of this study was to look for a new medicine in diagnosing and treating of glioblastoma. Radioiodine-labeled anti-epidermal growth factor receptor (EGFR) binding nanoparticles were constructed. In vitro cell-binding assays were confirmed by confocal microscopy and flow cytometry. Cell cytotoxicity assays were evaluated by MTT assay; radionuclide uptake assays were performed by γ-counter. Radioiodine-imaging studies were conducted using a xenograft nude mouse model in vivo. The results showed that EGFR significantly enhanced the uptake and accumulation of BSA-PCL in the experimental model of xenografts in nude mice, suggesting improved specific nanoparticle-based delivery. In conclusion, the data showed 131I-EGFR-BSA-PCL leading radioiodine therapy for U251 and U87 cells had a good effect in vitro and in vivo. Thus, 131I-EGFR-BSA-PCL may provide a new method for glioblastoma treatment.
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November-2017
Volume 38 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Li C, Tan J, Chang J, Li W, Liu Z, Li N and Ji Y: Radioiodine-labeled anti-epidermal growth factor receptor binding bovine serum albumin-polycaprolactone for targeting imaging of glioblastoma. Oncol Rep 38: 2919-2926, 2017
APA
Li, C., Tan, J., Chang, J., Li, W., Liu, Z., Li, N., & Ji, Y. (2017). Radioiodine-labeled anti-epidermal growth factor receptor binding bovine serum albumin-polycaprolactone for targeting imaging of glioblastoma. Oncology Reports, 38, 2919-2926. https://doi.org/10.3892/or.2017.5937
MLA
Li, C., Tan, J., Chang, J., Li, W., Liu, Z., Li, N., Ji, Y."Radioiodine-labeled anti-epidermal growth factor receptor binding bovine serum albumin-polycaprolactone for targeting imaging of glioblastoma". Oncology Reports 38.5 (2017): 2919-2926.
Chicago
Li, C., Tan, J., Chang, J., Li, W., Liu, Z., Li, N., Ji, Y."Radioiodine-labeled anti-epidermal growth factor receptor binding bovine serum albumin-polycaprolactone for targeting imaging of glioblastoma". Oncology Reports 38, no. 5 (2017): 2919-2926. https://doi.org/10.3892/or.2017.5937