SNHG15 affects the growth of glioma microvascular endothelial cells by negatively regulating miR-153

Corrigendum in: /10.3892/or.2022.8267

  • Authors:
    • Yawen Ma
    • Yixue Xue
    • Xiaobai Liu
    • Chengbin Qu
    • Heng Cai
    • Ping Wang
    • Zhiqing Li
    • Zhen Li
    • Yunhui Liu
  • View Affiliations

  • Published online on: September 21, 2017     https://doi.org/10.3892/or.2017.5985
  • Pages: 3265-3277
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Abstract

Malignant glioma, the most common intracranial primary tumor, is characterized by increased angiogenesis. Accumulating evidence has shown that long non-coding RNAs (lncRNAs) play an important role in a variety of biological behaviors of tumors. However, the role of lncRNAs in the regulation of glioma vascular endothelial cell function remains to be investigated. To simulate the glioma microenvironment, we applied glioma conditioned medium (GCM) to human cerebral microvascular endothelial cells (hCMECs). In the present study, the lncRNA SNHG15 was found to be highly expressed in glioma vascular endothelial cells. Cell Counting Kit-8 (CCK-8), migration and tube formation assays demonstrated that knockdown of SNHG15 inhibited glioma vascular endothelial cell proliferation, migration and tube formation in vitro. Furthermore, knockdown of SNHG15 downregulated the expression of VEGFA and Cdc42, which are known to promote angiogenesis. Bioinformatics software and dual-luciferase system analysis confirmed that SNHG15 affected endothelial cell function by targeting miR-153. Additionally, the present study showed that miR-153 targeted the 3'‑untranslated region of VEGFA and Cdc42 and downregulated their expression. In conclusion, knockdown of SNHG15 downregulated the expression of VEGFA and Cdc42 by targeting miR-153, consequently suppressing glioma vascular endothelial cell proliferation, migration and tube formation. Therefore, SNHG15 and miR-153 are new potential therapeutic targets for anti-angiogenesis treatment of glioma.
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November-2017
Volume 38 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ma Y, Xue Y, Liu X, Qu C, Cai H, Wang P, Li Z, Li Z and Liu Y: SNHG15 affects the growth of glioma microvascular endothelial cells by negatively regulating miR-153 Corrigendum in /10.3892/or.2022.8267. Oncol Rep 38: 3265-3277, 2017
APA
Ma, Y., Xue, Y., Liu, X., Qu, C., Cai, H., Wang, P. ... Liu, Y. (2017). SNHG15 affects the growth of glioma microvascular endothelial cells by negatively regulating miR-153 Corrigendum in /10.3892/or.2022.8267. Oncology Reports, 38, 3265-3277. https://doi.org/10.3892/or.2017.5985
MLA
Ma, Y., Xue, Y., Liu, X., Qu, C., Cai, H., Wang, P., Li, Z., Li, Z., Liu, Y."SNHG15 affects the growth of glioma microvascular endothelial cells by negatively regulating miR-153 Corrigendum in /10.3892/or.2022.8267". Oncology Reports 38.5 (2017): 3265-3277.
Chicago
Ma, Y., Xue, Y., Liu, X., Qu, C., Cai, H., Wang, P., Li, Z., Li, Z., Liu, Y."SNHG15 affects the growth of glioma microvascular endothelial cells by negatively regulating miR-153 Corrigendum in /10.3892/or.2022.8267". Oncology Reports 38, no. 5 (2017): 3265-3277. https://doi.org/10.3892/or.2017.5985