miR-25 promotes metastasis via targeting FBXW7 in esophageal squamous cell carcinoma

Retraction in: /10.3892/or.2023.8644

  • Authors:
    • Ye Hua
    • Kai Zhao
    • Gang Tao
    • Chunhua Dai
    • Yuting Su
  • View Affiliations

  • Published online on: September 25, 2017     https://doi.org/10.3892/or.2017.5995
  • Pages: 3030-3038
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Abstract

Increasing evidence suggests that miR-25 can function as an oncogene in different types of human malignancies, whereas little is known concerning the role of miR-25 in esophageal squamous cell carcinoma (ESCC). The aim of the present study was to investigate the role of miR-25 in ESCC and to determine the molecular mechanisms underlying its function. The expression level of miR-25 was detected in primary ESCC tissues and cell lines by real-time quantitative PCR. We also assessed whether knockdown of miR-25 influences in vitro cell invasion and migration. Western blot analysis was used to detect the influence of miR-25 on a target gene, and Pearson analysis was used to calculate the correlation between the expression of a target gene and miR-25 in ESCC tissues. The results revealed that the relative level of miR-25 expression was significantly upregulated in ESCC tissues and cell lines. Expression of miR-25 in ESCC tissues was positively associated with depth of tumor invasion and tumor stage. Moreover, high miR-25 expression conferred poorer overall survival (OS), and a multivariate analysis revealed that miR-25 was an independent risk factor for OS. In addition, knockdown of miR-25 in ESCC cells significantly suppressed cell migration and invasion. Furthermore, we identified F-box and WD repeat domain-containing 7 (FBXW7) protein as a direct functional target of miR-25 in ESCC. In conclusion, the present study supports the potential of miR-25 as a prognostic predictor with its high expression in cancer tissues and its association with tumor progression by targeting FBXW7 in ESCC.
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November-2017
Volume 38 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hua Y, Zhao K, Tao G, Dai C and Su Y: miR-25 promotes metastasis via targeting FBXW7 in esophageal squamous cell carcinoma Retraction in /10.3892/or.2023.8644. Oncol Rep 38: 3030-3038, 2017
APA
Hua, Y., Zhao, K., Tao, G., Dai, C., & Su, Y. (2017). miR-25 promotes metastasis via targeting FBXW7 in esophageal squamous cell carcinoma Retraction in /10.3892/or.2023.8644. Oncology Reports, 38, 3030-3038. https://doi.org/10.3892/or.2017.5995
MLA
Hua, Y., Zhao, K., Tao, G., Dai, C., Su, Y."miR-25 promotes metastasis via targeting FBXW7 in esophageal squamous cell carcinoma Retraction in /10.3892/or.2023.8644". Oncology Reports 38.5 (2017): 3030-3038.
Chicago
Hua, Y., Zhao, K., Tao, G., Dai, C., Su, Y."miR-25 promotes metastasis via targeting FBXW7 in esophageal squamous cell carcinoma Retraction in /10.3892/or.2023.8644". Oncology Reports 38, no. 5 (2017): 3030-3038. https://doi.org/10.3892/or.2017.5995