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Article

miR-25 promotes metastasis via targeting FBXW7 in esophageal squamous cell carcinoma

Retraction in: /10.3892/or.2023.8644
  • Authors:
    • Ye Hua
    • Kai Zhao
    • Gang Tao
    • Chunhua Dai
    • Yuting Su
  • View Affiliations / Copyright

    Affiliations: Institute of Oncology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China, Department of Gastroenterology, Changzhou Jintan People's Hospital, Changzhou, Jiangsu 213200, P.R. China, Department of Gastroenterology, Zhenjiang Hospital of Traditional Chinese and Western Medicine, Zhenjiang, Jiangsu 212001, P.R. China
  • Pages: 3030-3038
    |
    Published online on: September 25, 2017
       https://doi.org/10.3892/or.2017.5995
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Abstract

Increasing evidence suggests that miR-25 can function as an oncogene in different types of human malignancies, whereas little is known concerning the role of miR-25 in esophageal squamous cell carcinoma (ESCC). The aim of the present study was to investigate the role of miR-25 in ESCC and to determine the molecular mechanisms underlying its function. The expression level of miR-25 was detected in primary ESCC tissues and cell lines by real-time quantitative PCR. We also assessed whether knockdown of miR-25 influences in vitro cell invasion and migration. Western blot analysis was used to detect the influence of miR-25 on a target gene, and Pearson analysis was used to calculate the correlation between the expression of a target gene and miR-25 in ESCC tissues. The results revealed that the relative level of miR-25 expression was significantly upregulated in ESCC tissues and cell lines. Expression of miR-25 in ESCC tissues was positively associated with depth of tumor invasion and tumor stage. Moreover, high miR-25 expression conferred poorer overall survival (OS), and a multivariate analysis revealed that miR-25 was an independent risk factor for OS. In addition, knockdown of miR-25 in ESCC cells significantly suppressed cell migration and invasion. Furthermore, we identified F-box and WD repeat domain-containing 7 (FBXW7) protein as a direct functional target of miR-25 in ESCC. In conclusion, the present study supports the potential of miR-25 as a prognostic predictor with its high expression in cancer tissues and its association with tumor progression by targeting FBXW7 in ESCC.
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Copy and paste a formatted citation
Spandidos Publications style
Hua Y, Zhao K, Tao G, Dai C and Su Y: miR-25 promotes metastasis via targeting FBXW7 in esophageal squamous cell carcinoma Retraction in /10.3892/or.2023.8644. Oncol Rep 38: 3030-3038, 2017.
APA
Hua, Y., Zhao, K., Tao, G., Dai, C., & Su, Y. (2017). miR-25 promotes metastasis via targeting FBXW7 in esophageal squamous cell carcinoma Retraction in /10.3892/or.2023.8644. Oncology Reports, 38, 3030-3038. https://doi.org/10.3892/or.2017.5995
MLA
Hua, Y., Zhao, K., Tao, G., Dai, C., Su, Y."miR-25 promotes metastasis via targeting FBXW7 in esophageal squamous cell carcinoma Retraction in /10.3892/or.2023.8644". Oncology Reports 38.5 (2017): 3030-3038.
Chicago
Hua, Y., Zhao, K., Tao, G., Dai, C., Su, Y."miR-25 promotes metastasis via targeting FBXW7 in esophageal squamous cell carcinoma Retraction in /10.3892/or.2023.8644". Oncology Reports 38, no. 5 (2017): 3030-3038. https://doi.org/10.3892/or.2017.5995
Copy and paste a formatted citation
x
Spandidos Publications style
Hua Y, Zhao K, Tao G, Dai C and Su Y: miR-25 promotes metastasis via targeting FBXW7 in esophageal squamous cell carcinoma Retraction in /10.3892/or.2023.8644. Oncol Rep 38: 3030-3038, 2017.
APA
Hua, Y., Zhao, K., Tao, G., Dai, C., & Su, Y. (2017). miR-25 promotes metastasis via targeting FBXW7 in esophageal squamous cell carcinoma Retraction in /10.3892/or.2023.8644. Oncology Reports, 38, 3030-3038. https://doi.org/10.3892/or.2017.5995
MLA
Hua, Y., Zhao, K., Tao, G., Dai, C., Su, Y."miR-25 promotes metastasis via targeting FBXW7 in esophageal squamous cell carcinoma Retraction in /10.3892/or.2023.8644". Oncology Reports 38.5 (2017): 3030-3038.
Chicago
Hua, Y., Zhao, K., Tao, G., Dai, C., Su, Y."miR-25 promotes metastasis via targeting FBXW7 in esophageal squamous cell carcinoma Retraction in /10.3892/or.2023.8644". Oncology Reports 38, no. 5 (2017): 3030-3038. https://doi.org/10.3892/or.2017.5995
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