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Article Open Access

SP1 promotes tumor angiogenesis and invasion by activating VEGF expression in an acquired trastuzumab‑resistant ovarian cancer model

  • Authors:
    • Feng Su
    • Jing Geng
    • Xinying Li
    • Chuan Qiao
    • Longlong Luo
    • Jiannan Feng
    • Xinjun Dong
    • Ming Lv
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Immunology, Institute of Basic Medical Science, Academy of Military Medical Sciences, Haidian, Beijing 100850, P.R. China
    Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2677-2684
    |
    Published online on: September 25, 2017
       https://doi.org/10.3892/or.2017.5998
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Abstract

Ovarian cancer is one of the most common gynecologic cancers and the leading cause of mortality in women worldwide. HER2/neu is overexpressed in various types of cancers and is most commonly associated with decreased survival. Trastuzumab is a humanized anti-HER2 monoclonal antibody for the treatment of HER2-positive breast cancers. However, primary and/or acquired resistance occurs in up to 62% patients during the first year of treatment. Vascular endothelial growth factor (VEGF) is a well‑known angiogenesis factor involved in many physiological and pathological processes. Its significance has been implicated in promoting tumor growth and metastasis via angiogenesis. In the present study, we demonstrated that the upregulation of SP1 enhanced expression of VEGF promoting the angiogenesis and migration of trastuzumab-resistant ovarian cancer cell line SKOV3-T. Our in vitro and in vivo results both gave evidence that the SP1-VEGF axis was responsible for the enhanced malignancy, angiogenesis and migration in the acquired trastuzumab-resistant ovarian cancer cell model.
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1 

Esteva FJ, Yu D, Hung MC and Hortobagyi GN: Molecular predictors of response to trastuzumab and lapatinib in breast cancer. Nat Rev Clin Oncol. 7:98–107. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Madrid-Paredes A, Cañadas-Garre M, Sánchez-Pozo A and Calleja-Hernández MA: Non-HER2 signaling pathways activated in resistance to anti-HER2 therapy in breast cancer. Breast Cancer Res Treat. 153:493–505. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Madrid-Paredes A, Cañadas-Garre M, Sánchez-Pozo A and Calleja-Hernández MA: De novo resistance biomarkers to anti-HER2 therapies in HER2-positive breast cancer. Pharmacogenomics. 16:1411–1426. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Kruser TJ and Wheeler DL: Mechanisms of resistance to HER family targeting antibodies. Exp Cell Res. 316:1083–1100. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Fiszman GL and Jasnis MA: Molecular mechanisms of trastuzumab resistance in HER2 overexpressing breast cancer. Int J Breast Cancer. 2011:3521822011. View Article : Google Scholar : PubMed/NCBI

6 

Köninki K, Barok M, Tanner M, Staff S, Pitkänen J, Hemmilä P, Ilvesaro J and Isola J: Multiple molecular mechanisms underlying trastuzumab and lapatinib resistance in JIMT-1 breast cancer cells. Cancer Lett. 294:211–219. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Nahta R and Esteva FJ: HER2 therapy: Molecular mechanisms of trastuzumab resistance. Breast Cancer Res. 8:2152006. View Article : Google Scholar : PubMed/NCBI

8 

Ferrara N, Gerber HP and LeCouter J: The biology of VEGF and its receptors. Nat Med. 9:669–676. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Jia Y, Zhang Y, Qiao C, Liu G, Zhao Q, Zhou T, Chen G, Li Y, Feng J, Li Y, et al: IGF-1R and ErbB3/HER3 contribute to enhanced proliferation and carcinogenesis in trastuzumab-resistant ovarian cancer model. Biochem Biophys Res Commun. 436:740–745. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Yang J, Wang Q, Qiao C, Lin Z, Li X, Huang Y, Zhou T, Li Y, Shen B, Lv M, et al: Potent anti-angiogenesis and anti-tumor activity of a novel human anti-VEGF antibody, MIL60. Cell Mol Immunol. 11:285–293. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Nusrat O, Belotte J, Fletcher NM, Memaj I, Saed MG, Diamond MP and Saed GM: The role of angiogenesis in the persistence of chemoresistance in epithelial ovarian cancer. Reprod Sci. 23:1484–1492. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Thibault B, Castells M, Delord JP and Couderc B: Ovarian cancer microenvironment: Implications for cancer dissemination and chemoresistance acquisition. Cancer Metastasis Rev. 33:17–39. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Bookman MA, Darcy KM, Clarke-Pearson D, Boothby RA and Horowitz IR: Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: A phase II trial of the Gynecologic Oncology Group. J Clin Oncol. 21:283–290. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Wang W, Zhang Y, Lv M, Feng J, Peng H, Geng J, Lin Z, Zhou T, Li X, Shen B, et al: Anti-IGF-1R monoclonal antibody inhibits the carcinogenicity activity of acquired trastuzumab-resistant SKOV3. J Ovarian Res. 7:1032014. View Article : Google Scholar : PubMed/NCBI

15 

Ramakrishnan S, Subramanian IV, Yokoyama Y and Geller M: Angiogenesis in normal and neoplastic ovaries. Angiogenesis. 8:169–182. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Folkman J: Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med. 1:27–31. 1995. View Article : Google Scholar : PubMed/NCBI

17 

Bergers G and Benjamin LE: Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 3:401–410. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Chen Y, Huang Y, Huang Y, Xia X, Zhang J, Zhou Y, Tan Y, He S, Qiang F, Li A, et al: JWA suppresses tumor angiogenesis via Sp1-activated matrix metalloproteinase-2 and its prognostic significance in human gastric cancer. Carcinogenesis. 35:442–451. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Hsu TI, Wang MC, Chen SY, Yeh YM, Su WC, Chang WC and Hung JJ: Sp1 expression regulates lung tumor progression. Oncogene. 31:3973–3988. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Jungert K, Buck A, von Wichert G, Adler G, König A, Buchholz M, Gress TM and Ellenrieder V: Sp1 is required for transforming growth factor-beta-induced mesenchymal transition and migration in pancreatic cancer cells. Cancer Res. 67:1563–1570. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Vizcaíno C, Mansilla S and Portugal J: Sp1 transcription factor: A long-standing target in cancer chemotherapy. Pharmacol Ther. 152:111–124. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Liang X, Li ZL, Jiang LL, Guo QQ, Liu MJ and Nan KJ: Suppression of lung cancer cell invasion by LKB1 is due to the downregulation of tissue factor and vascular endothelial growth factor, partly dependent on SP1. Int J Oncol. 44:1989–1997. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Hirose T and Horvitz HR: An Sp1 transcription factor coordinates caspase-dependent and -independent apoptotic pathways. Nature. 500:354–358. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Zhao Y, Zhang W, Guo Z, Ma F, Wu Y, Bai Y, Gong W, Chen Y, Cheng T, Zhi F, et al: Inhibition of the transcription factor Sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts. Oncol Rep. 30:1782–1792. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Su F, Geng J, Li X, Qiao C, Luo L, Feng J, Dong X and Lv M: SP1 promotes tumor angiogenesis and invasion by activating VEGF expression in an acquired trastuzumab‑resistant ovarian cancer model. Oncol Rep 38: 2677-2684, 2017.
APA
Su, F., Geng, J., Li, X., Qiao, C., Luo, L., Feng, J. ... Lv, M. (2017). SP1 promotes tumor angiogenesis and invasion by activating VEGF expression in an acquired trastuzumab‑resistant ovarian cancer model. Oncology Reports, 38, 2677-2684. https://doi.org/10.3892/or.2017.5998
MLA
Su, F., Geng, J., Li, X., Qiao, C., Luo, L., Feng, J., Dong, X., Lv, M."SP1 promotes tumor angiogenesis and invasion by activating VEGF expression in an acquired trastuzumab‑resistant ovarian cancer model". Oncology Reports 38.5 (2017): 2677-2684.
Chicago
Su, F., Geng, J., Li, X., Qiao, C., Luo, L., Feng, J., Dong, X., Lv, M."SP1 promotes tumor angiogenesis and invasion by activating VEGF expression in an acquired trastuzumab‑resistant ovarian cancer model". Oncology Reports 38, no. 5 (2017): 2677-2684. https://doi.org/10.3892/or.2017.5998
Copy and paste a formatted citation
x
Spandidos Publications style
Su F, Geng J, Li X, Qiao C, Luo L, Feng J, Dong X and Lv M: SP1 promotes tumor angiogenesis and invasion by activating VEGF expression in an acquired trastuzumab‑resistant ovarian cancer model. Oncol Rep 38: 2677-2684, 2017.
APA
Su, F., Geng, J., Li, X., Qiao, C., Luo, L., Feng, J. ... Lv, M. (2017). SP1 promotes tumor angiogenesis and invasion by activating VEGF expression in an acquired trastuzumab‑resistant ovarian cancer model. Oncology Reports, 38, 2677-2684. https://doi.org/10.3892/or.2017.5998
MLA
Su, F., Geng, J., Li, X., Qiao, C., Luo, L., Feng, J., Dong, X., Lv, M."SP1 promotes tumor angiogenesis and invasion by activating VEGF expression in an acquired trastuzumab‑resistant ovarian cancer model". Oncology Reports 38.5 (2017): 2677-2684.
Chicago
Su, F., Geng, J., Li, X., Qiao, C., Luo, L., Feng, J., Dong, X., Lv, M."SP1 promotes tumor angiogenesis and invasion by activating VEGF expression in an acquired trastuzumab‑resistant ovarian cancer model". Oncology Reports 38, no. 5 (2017): 2677-2684. https://doi.org/10.3892/or.2017.5998
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