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MicroRNA-345 inhibits metastasis and epithelial-mesenchymal transition of gastric cancer by targeting FOXQ1

  • Authors:
    • Aiwen Feng
    • Xiaoming Yuan
    • Xiangwei Li
  • View Affiliations / Copyright

    Affiliations: Department of Enterochirurgia, Huaian First People's Hospital, Huaian, Jiangsu 223300, P.R. China, Department of Gastroenterological Surgery, Huaian First People's Hospital, Huaian, Jiangsu 223300, P.R. China
    Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2752-2760
    |
    Published online on: September 26, 2017
       https://doi.org/10.3892/or.2017.6001
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Abstract

MicroRNAs (miRNAs) are a group of critical players in gastric cancer (GC). Among numerous cancer-related miRNAs, the expression level and functional role of miR-345 in GC has not been investigated. This study showed that miR-345 expression was decreased in GC. Decreased expression level of miR-345 was associated with occurrence of lymph metastasis and advanced TNM stage of GC patients. Patients with low expression level of miR-345 had reduced overall survival (OS) and disease-free survival (DFS). In vitro experiments showed that miR-345 could inhibit the migration and invasion of GC cells. In vivo experiments showed that miR-345 knockdown could promote lung metastasis of GC cells in nude mice. miR-345 was found to prevent the metastasis by inhibiting epithelial-mesenchymal transition (EMT) of GC cells. Furthermore, FOXQ1 was confirmed to be the downstream target of miR-345 in GC cells. Forced expression of FOXQ1 could reverse the inhibitory effects of miR-345 on GC metastasis, while knockdown of FOXQ1 prevented the promoting effects of miR-345 knockdown on GC metastasis. In summary, this study demonstrates miR-345 is a promising biomarker and therapeutic target in GC.
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View References

1 

Ha M and Kim VN: Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol. 15:509–524. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Alvarez-Garcia I and Miska EA: MicroRNA functions in animal development and human disease. Development. 132:4653–4662. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Gregory RI and Shiekhattar R: MicroRNA biogenesis and cancer. Cancer Res. 65:3509–3512. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Bartels CL and Tsongalis GJ: MicroRNAs: Novel biomarkers for human cancer. Clin Chem. 55:623–631. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Ueda T, Volinia S, Okumura H, Shimizu M, Taccioli C, Rossi S, Alder H, Liu CG, Oue N, Yasui W, et al: Relation between microRNA expression and progression and prognosis of gastric cancer: A microRNA expression analysis. Lancet Oncol. 11:136–146. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Volinia S, Calin GA, Liu C-G, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, et al: A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA. 103:pp. 2257–2261. 2006; View Article : Google Scholar : PubMed/NCBI

7 

Wu WK, Lee CW, Cho CH, Fan D, Wu K, Yu J and Sung JJ: MicroRNA dysregulation in gastric cancer: A new player enters the game. Oncogene. 29:5761–5771. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Chen L, Li X and Chen X: Prognostic significance of tissue miR-345 downregulation in non-small cell lung cancer. Int J Clin Exp Med. 8:20971–20976. 2015.PubMed/NCBI

9 

Srivastava SK, Bhardwaj A, Arora S, Tyagi N, Singh S, Andrews J, McClellan S, Wang B and Singh AP: MicroRNA-345 induces apoptosis in pancreatic cancer cells through potentiation of caspase-dependent and -independent pathways. Br J Cancer. 113:660–668. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Chen QG, Zhou W, Han T, Du SQ, Li ZH, Zhang Z, Shan GY and Kong CZ: MiR-345 suppresses proliferation, migration and invasion by targeting Smad1 in human prostate cancer. J Cancer Res Clin Oncol. 142:213–224. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Yu J, Li N, Wang X, Ren H, Wang W, Wang S, Song Y, Liu Y, Li Y, Zhou X, et al: Circulating serum microRNA-345 correlates with unfavorable pathological response to preoperative chemoradiotherapy in locally advanced rectal cancer. Oncotarget. 7:64233–64243. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Liang S-H, Yan X-Z, Wang B-L, Jin HF, Yao LP, Li YN, Chen M, Nie YZ, Wang X, Guo XG, et al: Increased expression of FOXQ1 is a prognostic marker for patients with gastric cancer. Tumour Biol. 34:2605–2609. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Zhang J, Liu Y, Zhang J, Cui X, Li G, Wang J, Ren H and Zhang Y: FOXQ1 promotes gastric cancer metastasis through upregulation of Snail. Oncol Rep. 35:3607–3613. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Yilmaz M and Christofori G: EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev. 28:15–33. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Carcas LP: Gastric cancer review. J Carcinog. 13:142014. View Article : Google Scholar : PubMed/NCBI

16 

Yasui W, Oue N, Aung PP, Matsumura S, Shutoh M and Nakayama H: Molecular-pathological prognostic factors of gastric cancer: A review. Gastric Cancer. 8:86–94. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Tsugane S and Sasazuki S: Diet and the risk of gastric cancer: Review of epidemiological evidence. Gastric Cancer. 10:75–83. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Crew KD and Neugut AI: Epidemiology of gastric cancer. World J Gastroenterol. 12:354–362. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Hampton T: MicroRNA and Metastasis. JAMA. 298(1998)2007.http://jamanetwork.com/journals/jama/article-abstract/209330

20 

Yates LA, Norbury CJ and Gilbert RJ: The long and short of microRNA. Cell. 153:516–519. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Qiao Y, Jiang X, Lee ST, Karuturi RK, Hooi SC and Yu Q: FOXQ1 regulates epithelial-mesenchymal transition in human cancers. Cancer Res. 71:3076–3086. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Xiang X-J, Deng J, Liu Y-W, Wan LY, Feng M, Chen J and Xiong JP: MiR-1271 inhibits cell proliferation, invasion and EMT in gastric cancer by targeting FOXQ1. Cell Physiol Biochem. 36:1382–1394. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Feng A, Yuan X and Li X: MicroRNA-345 inhibits metastasis and epithelial-mesenchymal transition of gastric cancer by targeting FOXQ1. Oncol Rep 38: 2752-2760, 2017.
APA
Feng, A., Yuan, X., & Li, X. (2017). MicroRNA-345 inhibits metastasis and epithelial-mesenchymal transition of gastric cancer by targeting FOXQ1. Oncology Reports, 38, 2752-2760. https://doi.org/10.3892/or.2017.6001
MLA
Feng, A., Yuan, X., Li, X."MicroRNA-345 inhibits metastasis and epithelial-mesenchymal transition of gastric cancer by targeting FOXQ1". Oncology Reports 38.5 (2017): 2752-2760.
Chicago
Feng, A., Yuan, X., Li, X."MicroRNA-345 inhibits metastasis and epithelial-mesenchymal transition of gastric cancer by targeting FOXQ1". Oncology Reports 38, no. 5 (2017): 2752-2760. https://doi.org/10.3892/or.2017.6001
Copy and paste a formatted citation
x
Spandidos Publications style
Feng A, Yuan X and Li X: MicroRNA-345 inhibits metastasis and epithelial-mesenchymal transition of gastric cancer by targeting FOXQ1. Oncol Rep 38: 2752-2760, 2017.
APA
Feng, A., Yuan, X., & Li, X. (2017). MicroRNA-345 inhibits metastasis and epithelial-mesenchymal transition of gastric cancer by targeting FOXQ1. Oncology Reports, 38, 2752-2760. https://doi.org/10.3892/or.2017.6001
MLA
Feng, A., Yuan, X., Li, X."MicroRNA-345 inhibits metastasis and epithelial-mesenchymal transition of gastric cancer by targeting FOXQ1". Oncology Reports 38.5 (2017): 2752-2760.
Chicago
Feng, A., Yuan, X., Li, X."MicroRNA-345 inhibits metastasis and epithelial-mesenchymal transition of gastric cancer by targeting FOXQ1". Oncology Reports 38, no. 5 (2017): 2752-2760. https://doi.org/10.3892/or.2017.6001
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