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Article

Baicalein inhibits tumor progression by inhibiting tumor cell growth and tumor angiogenesis

  • Authors:
    • Yang-Gyu Park
    • Jawun Choi
    • Hye-Kang Jung
    • Bumseok Kim
    • Chan Kim
    • Sang-Youel Park
    • Jae-Won Seol
  • View Affiliations / Copyright

    Affiliations: Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University, Iksana, Republic of Korea, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea
  • Pages: 3011-3018
    |
    Published online on: September 26, 2017
       https://doi.org/10.3892/or.2017.6007
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Abstract

Baicalein, a herbal medicine, is a natural flavonoid isolated from the roots of Scutellaria baicalensis Georgi. It is known for its anticancer, anti-inflammatory and neuroprotective properties. Despite these well-known properties, it is not yet clear what effect baicalein has on tumor progression. Therefore, in the present study, we used B16F10 cells, Lewis lung carcinoma (LLC) cells, and human umbilical vein endothelial cells (HUVECs) to investigate the effect of baicalein on cell proliferation and viability, migration and tube formation in vitro. In addition, an experimental animal model was used to observe the growth rate and metastasis of tumors and tumor vessel formation in vivo. Our results showed that baicalein decreased the proliferation and migration and induced tumor cell death via caspase-3 activation in the B16F10 and LLC cells, and strongly inhibited tube formation and cell migration in HUVECs. Furthermore, mouse models showed that baicalein reduced the tumor volume and greatly reduced the tumor growth rate in the early stages of tumor progression, and the baicalein-treated groups had significantly reduced expression of CD31 (endothelial cell marker) and α-SMA (mural cell marker) in the tumors, indicating that baicalein inhibits tumor angiogenesis by disrupting tumor vasculature development. Comparison of the lymph node and lung samples collected from the baicalein-treated group, and the untreated group showed that baicalein reduced metastasis of the tumor to these tissues. In summary, baicalein reduced tumor progression and metastasis, directly induced tumor cell death, and inhibited tumor angiogenesis. Our results strongly demonstrate that baicalein is a potential chemotherapeutic agent.
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View References

1 

O'Neill AC, Jagannathan JP and Ramaiya NH: Evolving cancer classification in the era of personalized medicine: A primer for radiologists. Korean J Radiol. 18:6–17. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Lechner MG, Karimi SS, Barry-Holson K, Angell TE, Murphy KA, Church CH, Ohlfest JR, Hu P and Epstein AL: Immunogenicity of murine solid tumor models as a defining feature of in vivo behavior and response to immunotherapy. J Immunother. 36:477–489. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, Stein KD, Alteri R and Jemal A: Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 66:271–289. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Rolston KVI: Infections in cancer patients with solid tumors: A review. Infect Dis Ther. 6:69–83. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Liu H, Dong Y, Gao Y, Du Z, Wang Y, Cheng P, Chen A and Huang H: The fascinating effects of baicalein on cancer: A review. Int J Mol Sci. 17:172016. View Article : Google Scholar

6 

Lee W, Ku SK and Bae JS: Anti-inflammatory effects of baicalin, baicalein, and wogonin in vitro and in vivo. Inflammation. 38:110–125. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Zhang Y, Song L, Cai L, Wei R, Hu H and Jin W: Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. Food Chem Toxicol. 53:325–333. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Chen YJ, Wu CS, Shieh JJ, Wu JH, Chen HY, Chung TW, Chen YK and Lin CC: Baicalein triggers mitochondria-mediated apoptosis and enhances the antileukemic effect of vincristine in childhood acute lymphoblastic leukemia CCRF-CEM cells. Evid Based Complement Alternat Med. 2013:1247472013.PubMed/NCBI

9 

Wang Z, Jiang C, Chen W, Zhang G, Luo D, Cao Y, Wu J, Ding Y and Liu B: Baicalein induces apoptosis and autophagy via endoplasmic reticulum stress in hepatocellular carcinoma cells. Biomed Res Int. 2014:7325162014.PubMed/NCBI

10 

Wang YF, Li T, Tang ZH, Chang LL, Zhu H, Chen XP, Wang YT and Lu JJ: Baicalein triggers autophagy and inhibits the protein kinase B/mammalian target of rapamycin pathway in hepatocellular carcinoma HepG2 cells. Phytother Res. 29:674–679. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Chen K, Zhang S, Ji Y, Li J, An P, Ren H, Liang R, Yang J and Li Z: Baicalein inhibits the invasion and metastatic capabilities of hepatocellular carcinoma cells via down-regulation of the ERK pathway. PLoS One. 8:e729272013. View Article : Google Scholar : PubMed/NCBI

12 

Kim C, Yang H, Fukushima Y, Saw PE, Lee J, Park JS, Park I, Jung J, Kataoka H, Lee D, et al: Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption. Cancer Cell. 25:102–117. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Sundar SS and Ganesan TS: Role of lymphangiogenesis in cancer. J Clin Oncol. 25:4298–4307. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Gomes FG, Nedel F, Alves AM, Nör JE and Tarquinio SB: Tumor angiogenesis and lymphangiogenesis: Tumor/endothelial crosstalk and cellular/microenvironmental signaling mechanisms. Life Sci. 92:101–107. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Foubert P and Varner JA: Integrins in tumor angiogenesis and lymphangiogenesis. Methods Mol Biol. 757:471–486. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Dong LH, Wen JK, Miao SB, Jia Z, Hu HJ, Sun RH, Wu Y and Han M: Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFR beta-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia. Cell Res. 21:1276. 2011. View Article : Google Scholar :

18 

Ling Y, Chen Y, Chen P, Hui H, Song X, Lu Z, Li C, Lu N and Guo Q: Baicalein potently suppresses angiogenesis induced by vascular endothelial growth factor through the p53/Rb signaling pathway leading to G1/S cell cycle arrest. Exp Biol Med. 236:851–858. 2011. View Article : Google Scholar

19 

Huang Y, Miao Z, Hu Y, Yuan Y, Zhou Y, Wei L, Zhao K, Guo Q and Lu N: Baicalein reduces angiogenesis in the inflammatory microenvironment via inhibiting the expression of AP-1. Oncotarget. 8:883–899. 2017.PubMed/NCBI

20 

Cathcart MC, Useckaite Z, Drakeford C, Semik V, Lysaght J, Gately K, O'Byrne KJ and Pidgeon GP: Anti-cancer effects of baicalein in non-small cell lung cancer in-vitro and in-vivo. BMC Cancer. 16:7072016. View Article : Google Scholar : PubMed/NCBI

21 

Trédan O, Galmarini CM, Patel K and Tannock IF: Drug resistance and the solid tumor microenvironment. J Natl Cancer Inst. 99:1441–1454. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Yamashita S, Baba K, Makio A, Kumazoe M, Huang Y, Lin IC, Bae J, Murata M, Yamada S and Tachibana H: γ-Tocotrienol upregulates aryl hydrocarbon receptor expression and enhances the anticancer effect of baicalein. Biochem Biophys Res Commun. 473:801–807. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Liu TY, Gong W, Tan ZJ, Lu W, Wu XS, Weng H, Ding Q, Shu YJ, Bao RF, Cao Y, et al: Baicalein inhibits progression of gallbladder cancer cells by downregulating ZFX. PLoS One. 10:e01148512015. View Article : Google Scholar : PubMed/NCBI

24 

Dong LH, Wen JK, Miao SB, Jia Z, Hu HJ, Sun RH, Wu Y and Han M: Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRβ-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia. Cell Res. 20:1252–1262. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Cébe-Suarez S, Zehnder-Fjällman A and Ballmer-Hofer K: The role of VEGF receptors in angiogenesis; complex partnerships. Cell Mol Life Sci. 63:601–615. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Appelmann I, Liersch R, Kessler T, Mesters RM and Berdel WE: Angiogenesis inhibition in cancer therapy: platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors: biological functions and role in malignancy. Recent Results Cancer Res. 180:51–81. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Park Y, Choi J, Jung H, Kim B, Kim C, Park S and Seol J: Baicalein inhibits tumor progression by inhibiting tumor cell growth and tumor angiogenesis. Oncol Rep 38: 3011-3018, 2017.
APA
Park, Y., Choi, J., Jung, H., Kim, B., Kim, C., Park, S., & Seol, J. (2017). Baicalein inhibits tumor progression by inhibiting tumor cell growth and tumor angiogenesis. Oncology Reports, 38, 3011-3018. https://doi.org/10.3892/or.2017.6007
MLA
Park, Y., Choi, J., Jung, H., Kim, B., Kim, C., Park, S., Seol, J."Baicalein inhibits tumor progression by inhibiting tumor cell growth and tumor angiogenesis". Oncology Reports 38.5 (2017): 3011-3018.
Chicago
Park, Y., Choi, J., Jung, H., Kim, B., Kim, C., Park, S., Seol, J."Baicalein inhibits tumor progression by inhibiting tumor cell growth and tumor angiogenesis". Oncology Reports 38, no. 5 (2017): 3011-3018. https://doi.org/10.3892/or.2017.6007
Copy and paste a formatted citation
x
Spandidos Publications style
Park Y, Choi J, Jung H, Kim B, Kim C, Park S and Seol J: Baicalein inhibits tumor progression by inhibiting tumor cell growth and tumor angiogenesis. Oncol Rep 38: 3011-3018, 2017.
APA
Park, Y., Choi, J., Jung, H., Kim, B., Kim, C., Park, S., & Seol, J. (2017). Baicalein inhibits tumor progression by inhibiting tumor cell growth and tumor angiogenesis. Oncology Reports, 38, 3011-3018. https://doi.org/10.3892/or.2017.6007
MLA
Park, Y., Choi, J., Jung, H., Kim, B., Kim, C., Park, S., Seol, J."Baicalein inhibits tumor progression by inhibiting tumor cell growth and tumor angiogenesis". Oncology Reports 38.5 (2017): 3011-3018.
Chicago
Park, Y., Choi, J., Jung, H., Kim, B., Kim, C., Park, S., Seol, J."Baicalein inhibits tumor progression by inhibiting tumor cell growth and tumor angiogenesis". Oncology Reports 38, no. 5 (2017): 3011-3018. https://doi.org/10.3892/or.2017.6007
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