1
|
Seufferlein T, Bachet JB, Van Cutsem E and
Rougier P: ESMO Guidelines Working Group: Pancreatic
adenocarcinoma: ESMO-ESDO Clinical Practice Guidelines for
diagnosis, treatment and follow-up. Ann Oncol. 23 Suppl
7:vii33–vii40. 2012. View Article : Google Scholar : PubMed/NCBI
|
2
|
Fokas E, O'Neill E, Gordon-Weeks A,
Mukherjee S, McKenna WG and Muschel RJ: Pancreatic ductal
adenocarcinoma: From genetics to biology to radiobiology to
oncoimmunology and all the way back to the clinic. Biochim Biophys
Acta. 1855:61–82. 2015.PubMed/NCBI
|
3
|
Derynck R and Zhang YE: Smad-dependent and
Smad-independent pathways in TGF-β family signalling. Nature.
425:577–584. 2003. View Article : Google Scholar : PubMed/NCBI
|
4
|
Jiang Z, Seo JY, Ha H, Lee EA, Kim YS, Han
DC, Uh ST, Park CS and Lee HB: Reactive oxygen species mediate
TGF-β1-induced plasminogen activator inhibitor-1 upregulation in
mesangial cells. Biochem Biophys Res Commun. 309:961–966. 2003.
View Article : Google Scholar : PubMed/NCBI
|
5
|
Li WQ, Qureshi HY, Liacini A, Dehnade F
and Zafarullah M: Transforming growth factor Beta1 induction of
tissue inhibitor of metalloproteinases 3 in articular chondrocytes
is mediated by reactive oxygen species. Free Radic Biol Med.
37:196–207. 2004. View Article : Google Scholar : PubMed/NCBI
|
6
|
Mu Y, Gudey SK and Landström M: Non-Smad
signaling pathways. Cell Tissue Res. 347:11–20. 2012. View Article : Google Scholar : PubMed/NCBI
|
7
|
Díaz B and Courtneidge SA: Redox signaling
at invasive microdomains in cancer cells. Free Radic Biol Med.
52:247–256. 2012. View Article : Google Scholar : PubMed/NCBI
|
8
|
Chiera F, Meccia E, Degan P, Aquilina G,
Pietraforte D, Minetti M, Lambeth D and Bignami M: Overexpression
of human NOX1 complex induces genome instability in mammalian
cells. Free Radic Biol Med. 44:332–342. 2008. View Article : Google Scholar : PubMed/NCBI
|
9
|
Yu JH and Kim H: Oxidative stress and
cytokines in the pathogenesis of pancreatic cancer. J Cancer Prev.
19:97–102. 2014. View Article : Google Scholar : PubMed/NCBI
|
10
|
Bokoch GM and Knaus UG: NADPH oxidases:
Not just for leukocytes anymore! Trends Biochem Sci. 28:502–508.
2003. View Article : Google Scholar : PubMed/NCBI
|
11
|
Bokoch GM and Diebold BA: Current
molecular models for NADPH oxidase regulation by Rac GTPase. Blood.
100:2692–2696. 2002. View Article : Google Scholar : PubMed/NCBI
|
12
|
Geiszt M and Leto TL: The Nox family of
NAD(P)H oxidases: Host defense and beyond. J Biol Chem.
279:51715–51718. 2004. View Article : Google Scholar : PubMed/NCBI
|
13
|
Herrera B, Fernández M, Roncero C, Ventura
JJ, Porras A, Valladares A, Benito M and Fabregat I: Activation of
p38MAPK by TGF-beta in fetal rat hepatocytes requires radical
oxygen production, but is dispensable for cell death. FEBS Lett.
499:225–229. 2001. View Article : Google Scholar : PubMed/NCBI
|
14
|
Chiu C, Maddock DA, Zhang Q, Souza KP,
Townsend AR and Wan Y: TGF-β-induced p38 activation is mediated by
Rac1-regulated generation of reactive oxygen species in cultured
human keratinocytes. Int J Mol Med. 8:251–255. 2001.PubMed/NCBI
|
15
|
Rhyu DY, Yang Y, Ha H, Lee GT, Song JS, Uh
ST and Lee HB: Role of reactive oxygen species in TGF-β1-induced
mitogen-activated protein kinase activation and
epithelial-mesenchymal transition in renal tubular epithelial
cells. J Am Soc Nephrol. 16:667–675. 2005. View Article : Google Scholar : PubMed/NCBI
|
16
|
Korbecki J, Baranowska-Bosiacka I,
Gutowska I and Chlubek D: The effect of reactive oxygen species on
the synthesis of prostanoids from arachidonic acid. J Physiol
Pharmacol. 64:409–421. 2013.PubMed/NCBI
|
17
|
Hiraga R, Kato M, Miyagawa S and Kamata T:
Nox4-derived ROS signaling contributes to TGF-β-induced
epithelial-mesenchymal transition in pancreatic cancer cells.
Anticancer Res. 33:4431–4438. 2013.PubMed/NCBI
|
18
|
Ungefroren H, Groth S, Sebens S, Lehnert
H, Gieseler F and Fändrich F: Differential roles of Smad2 and Smad3
in the regulation of TGF-β1-mediated growth inhibition and cell
migration in pancreatic ductal adenocarcinoma cells: Control by
Rac1. Mol Cancer. 10:672011. View Article : Google Scholar : PubMed/NCBI
|
19
|
Ungefroren H, Lenschow W, Chen WB,
Faendrich F and Kalthoff H: Regulation of biglycan gene expression
by transforming growth factor-beta requires MKK6-p38
mitogen-activated protein kinase signaling downstream of Smad
signaling. J Biol Chem. 278:11041–11049. 2003. View Article : Google Scholar : PubMed/NCBI
|
20
|
Groth S, Schulze M, Kalthoff H, Fändrich F
and Ungefroren H: Adhesion and Rac1-dependent regulation of
biglycan gene expression by transforming growth factor-beta.
Evidence for oxidative signaling through NADPH oxidase. J Biol
Chem. 280:33190–33199. 2005. View Article : Google Scholar : PubMed/NCBI
|
21
|
Carl C, Flindt A, Hartmann J, Dahlke M,
Rades D, Dunst J, Lehnert H, Gieseler F and Ungefroren H: Ionizing
radiation induces a motile phenotype in human carcinoma cells in
vitro through hyperactivation of the TGF-beta signaling pathway.
Cell Mol Life Sci. 73:427–443. 2016. View Article : Google Scholar : PubMed/NCBI
|
22
|
Meurer SK, Lahme B, Tihaa L, Weiskirchen R
and Gressner AM: N-acetyl-L-cysteine suppresses TGF-β
signaling at distinct molecular steps: The biochemical and
biological efficacy of a multifunctional, antifibrotic drug.
Biochem Pharmacol. 70:1026–1034. 2005. View Article : Google Scholar : PubMed/NCBI
|
23
|
't Hart BA, Copray S and Philippens I:
Apocynin, a low molecular oral treatment for neurodegenerative
disease. Biomed Res Int. 2014:2980202014.PubMed/NCBI
|
24
|
Takekawa M, Tatebayashi K, Itoh F, Adachi
M, Imai K and Saito H: Smad-dependent GADD45beta expression
mediates delayed activation of p38 MAP kinase by TGF-beta. EMBO J.
21:6473–6482. 2002. View Article : Google Scholar : PubMed/NCBI
|
25
|
Ungefroren H, Sebens S, Groth S, Gieseler
F and Fändrich F: Differential roles of Src in transforming growth
factor-β regulation of growth arrest, epithelial-to-mesenchymal
transition and cell migration in pancreatic ductal adenocarcinoma
cells. Int J Oncol. 38:797–805. 2011. View Article : Google Scholar : PubMed/NCBI
|
26
|
Samarakoon R, Overstreet JM and Higgins
PJ: TGF-β signaling in tissue fibrosis: Redox controls, target
genes and therapeutic opportunities. Cell Signal. 25:264–268. 2013.
View Article : Google Scholar : PubMed/NCBI
|
27
|
Boudreau HE, Casterline BW, Rada B,
Korzeniowska A and Leto TL: Nox4 involvement in TGF-β and
SMAD3-driven induction of the epithelial-to-mesenchymal transition
and migration of breast epithelial cells. Free Radic Biol Med.
53:1489–1499. 2012. View Article : Google Scholar : PubMed/NCBI
|
28
|
Tobar N, Guerrero J, Smith PC and Martínez
J: NOX4-dependent ROS production by stromal mammary cells modulates
epithelial MCF-7 cell migration. Br J Cancer. 103:1040–1047. 2010.
View Article : Google Scholar : PubMed/NCBI
|
29
|
Vaquero EC, Edderkaoui M, Pandol SJ,
Gukovsky I and Gukovskaya AS: Reactive oxygen species produced by
NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells. J
Biol Chem. 279:34643–34654. 2004. View Article : Google Scholar : PubMed/NCBI
|
30
|
Aldieri E, Riganti C, Polimeni M, Gazzano
E, Lussiana C, Campia I and Ghigo D: Classical inhibitors of NOX
NAD(P)H oxidases are not specific. Curr Drug Metab. 9:686–696.
2008. View Article : Google Scholar : PubMed/NCBI
|
31
|
Manickam N, Patel M, Griendling KK, Gorin
Y and Barnes JL: RhoA/Rho kinase mediates TGF-β1-induced kidney
myofibroblast activation through Poldip2/Nox4-derived reactive
oxygen species. Am J Physiol Renal Physiol. 307:F159–F171. 2014.
View Article : Google Scholar : PubMed/NCBI
|
32
|
Meng D, Lv DD and Fang J: Insulin-like
growth factor-I induces reactive oxygen species production and cell
migration through Nox4 and Rac1 in vascular smooth muscle cells.
Cardiovasc Res. 80:299–308. 2008. View Article : Google Scholar : PubMed/NCBI
|
33
|
Zhang B, Liu Z and Hu X: Inhibiting cancer
metastasis via targeting NAPDH oxidase 4. Biochem Pharmacol.
86:253–266. 2013. View Article : Google Scholar : PubMed/NCBI
|
34
|
Hordijk PL: Regulation of NADPH oxidases:
The role of Rac proteins. Circ Res. 98:453–462. 2006. View Article : Google Scholar : PubMed/NCBI
|