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Genome-wide analysis of the three-way interplay among gene expression, estrogen receptor expression and chemotherapeutic sensitivity in breast cancer

  • Authors:
    • Dong-Xu He
    • Xiao-Li Wu
    • Chun-Xiao Lu
    • Xiao-Ting Gu
    • Guang-Yuan Zhang
    • Xin Ma
    • De-Quan Liu
  • View Affiliations / Copyright

    Affiliations: National Engineering Laboratory for Cereal Fermentation Technology and Wuxi Medical School, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China, Department of Breast Surgery, The Third Affiliated Hospital, Kunming Medical University, Kunming, Yunnan 650031, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3392-3402
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    Published online on: October 12, 2017
       https://doi.org/10.3892/or.2017.6033
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Abstract

The expression of estrogen receptor α (ER) in breast cancers may be indicative of a favorable prognosis and most of these cancers respond to anti-estrogens or aromatase inhibitors. However, ER-positive (ER+) breast cancers receiving anti-hormone and/or chemotherapy sometimes lose their ER expression, which leads to the evolution of the disease to higher aggressiveness and drug resistance. In the present study, an ER-modified signature (EMS) was developed from the expression profile of a chemoresistant MCF-7 breast cancer cell line that lost ER expression during long-term treatment with a chemotherapeutic agent. The EMS could discriminate the ER-negative (ER-) breast cancer cells from the ER+ ones, which included seven pathways essential for the ER- cell development. Furthermore, the EMS indicated a more malignant subgroup of the ER- cells by discriminating the chemoresistant ER- cells from the chemosensitive ones. In addition, the classified chemoresistant ER- patients demonstrated worse prognosis. In conclusion, we developed a new method to discriminate subgroups of ER- breast cancer cells.
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Copy and paste a formatted citation
Spandidos Publications style
He D, Wu X, Lu C, Gu X, Zhang G, Ma X and Liu D: Genome-wide analysis of the three-way interplay among gene expression, estrogen receptor expression and chemotherapeutic sensitivity in breast cancer. Oncol Rep 38: 3392-3402, 2017.
APA
He, D., Wu, X., Lu, C., Gu, X., Zhang, G., Ma, X., & Liu, D. (2017). Genome-wide analysis of the three-way interplay among gene expression, estrogen receptor expression and chemotherapeutic sensitivity in breast cancer. Oncology Reports, 38, 3392-3402. https://doi.org/10.3892/or.2017.6033
MLA
He, D., Wu, X., Lu, C., Gu, X., Zhang, G., Ma, X., Liu, D."Genome-wide analysis of the three-way interplay among gene expression, estrogen receptor expression and chemotherapeutic sensitivity in breast cancer". Oncology Reports 38.6 (2017): 3392-3402.
Chicago
He, D., Wu, X., Lu, C., Gu, X., Zhang, G., Ma, X., Liu, D."Genome-wide analysis of the three-way interplay among gene expression, estrogen receptor expression and chemotherapeutic sensitivity in breast cancer". Oncology Reports 38, no. 6 (2017): 3392-3402. https://doi.org/10.3892/or.2017.6033
Copy and paste a formatted citation
x
Spandidos Publications style
He D, Wu X, Lu C, Gu X, Zhang G, Ma X and Liu D: Genome-wide analysis of the three-way interplay among gene expression, estrogen receptor expression and chemotherapeutic sensitivity in breast cancer. Oncol Rep 38: 3392-3402, 2017.
APA
He, D., Wu, X., Lu, C., Gu, X., Zhang, G., Ma, X., & Liu, D. (2017). Genome-wide analysis of the three-way interplay among gene expression, estrogen receptor expression and chemotherapeutic sensitivity in breast cancer. Oncology Reports, 38, 3392-3402. https://doi.org/10.3892/or.2017.6033
MLA
He, D., Wu, X., Lu, C., Gu, X., Zhang, G., Ma, X., Liu, D."Genome-wide analysis of the three-way interplay among gene expression, estrogen receptor expression and chemotherapeutic sensitivity in breast cancer". Oncology Reports 38.6 (2017): 3392-3402.
Chicago
He, D., Wu, X., Lu, C., Gu, X., Zhang, G., Ma, X., Liu, D."Genome-wide analysis of the three-way interplay among gene expression, estrogen receptor expression and chemotherapeutic sensitivity in breast cancer". Oncology Reports 38, no. 6 (2017): 3392-3402. https://doi.org/10.3892/or.2017.6033
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