|
1
|
Arnold M, Pandeya N, Byrnes G, Renehan
PAG, Stevens GA, Ezzati PM, Ferlay J, Miranda JJ, Romieu I, Dikshit
R, et al: Global burden of cancer attributable to high body-mass
index in 2012: A population-based study. Lancet Oncol. 16:36–46.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Protani M, Coory M and Martin JH: Effect
of obesity on survival of women with breast cancer: Systematic
review and meta-analysis. Breast Cancer Res Treat. 123:627–635.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Onstad MA, Schmandt RE and Lu KH:
Addressing the role of obesity in endometrial cancer risk,
prevention, and treatment. J Clin Oncol. 34:4225–4230. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Larsson SC and Wolk A: Obesity and colon
and rectal cancer risk: A meta-analysis of prospective studies. Am
J Clin Nutr. 86:556–565. 2007.PubMed/NCBI
|
|
5
|
Moghaddam AA, Woodward M and Huxley R:
Obesity and risk of colorectal cancer: A meta-analysis of 31
studies with 70,000 events. Cancer Epidemiol Biomarkers Prev.
16:2533–2547. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Considine RV, Sinha MK, Heiman ML,
Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee
LJ, Bauer TL, et al: Serum immunoreactive-leptin concentrations in
normal-weight and obese humans. N Engl J Med. 334:292–295. 1996.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Stattin P, Lukanova A, Biessy C, Söderberg
S, Palmqvist R, Kaaks R, Olsson T and Jellum E: Obesity and colon
cancer: Does leptin provide a link? Int J Cancer. 109:149–152.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Chia VM, Newcomb PA, Lampe JW, White E,
Mandelson MT, McTiernan A and Potter JD: Leptin concentrations,
leptin receptor polymorphisms, and colorectal adenoma risk. Cancer
Epidemiol Biomarkers Prev. 16:2697–2703. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Jaffe T and Schwartz B: Leptin promotes
motility and invasiveness in human colon cancer cells by activating
multiple signal-transduction pathways. Int J Cancer. 123:2543–2556.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Fenton JI, Hord NG, Lavigne JA, Perkins SN
and Hursting SD: Leptin, insulin-like growth factor-1, and
insulin-like growth factor-2 are mitogens in ApcMin/+ but not
Apc+/+ colonic epithelial cell lines. Cancer Epidemiol Biomarkers
Prev. 14:1646–1652. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Knüpfer H and Preiss R: Serum
interleukin-6 levels in colorectal cancer patients - a summary of
published results. Int J Colorectal Dis. 25:135–140. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Fenton JI, Hursting SD, Perkins SN and
Hord NG: Interleukin-6 production induced by leptin treatment
promotes cell proliferation in an ApcMin/+ colon epithelial cell
line. Carcinogenesis. 27:1507–1515. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Becker C, Fantini MC, Schramm C, Lehr HA,
Wirtz S, Nikolaev A, Burg J, Strand S, Kiesslich R, Huber S, et al:
TGF-beta suppresses tumor progression in colon cancer by inhibition
of IL-6 trans-signaling. Immunity. 21:491–501. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Chung B, Matak P, McKie AT and Sharp P:
Leptin increases the expression of the iron regulatory hormone
hepcidin in HuH7 human hepatoma cells. J Nutr. 137:2366–2370.
2007.PubMed/NCBI
|
|
15
|
Nemeth E, Rivera S, Gabayan V, Keller C,
Taudorf S, Pedersen BK and Ganz T: IL-6 mediates hypoferremia of
inflammation by inducing the synthesis of the iron regulatory
hormone hepcidin. J Clin Invest. 113:1271–1276. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Nelson RL: Iron and colorectal cancer
risk: Human studies. Nutr Rev. 59:140–148. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Mainous AG III, Gill JM and Everett CJ:
Transferrin saturation, dietary iron intake, and risk of cancer.
Ann Fam Med. 3:131–137. 2005. View
Article : Google Scholar : PubMed/NCBI
|
|
18
|
Ward DG, Roberts K, Brookes MJ, Joy H,
Martin A, Ismail T, Spychal R, Iqbal T and Tselepis C: Increased
hepcidin expression in colorectal carcinogenesis. World J
Gastroenterol. 14:1339–1345. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Brookes MJ, Hughes S, Turner FE, Reynolds
G, Sharma N, Ismail T, Berx G, McKie AT, Hotchin N, Anderson GJ, et
al: Modulation of iron transport proteins in human colorectal
carcinogenesis. Gut. 55:1449–1460. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Radulescu S, Brookes MJ, Salgueiro P,
Ridgway RA, McGhee E, Anderson K, Ford SJ, Stones DH, Iqbal TH,
Tselepis C and Sansom OJ: Luminal iron levels govern intestinal
tumorigenesis after Apc loss in vivo. Cell Reports. 2:270–282.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Brookes MJ, Boult J, Roberts K, Cooper BT,
Hotchin NA, Matthews G, Iqbal T and Tselepis C: A role for iron in
Wnt signalling. Oncogene. 27:966–975. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Bekri S, Gual P, Anty R, Luciani N, Dahman
M, Ramesh B, Iannelli A, Staccini-Myx A, Casanova D, Ben Amor I, et
al: Increased adipose tissue expression of hepcidin in severe
obesity is independent from diabetes and NASH. Gastroenterology.
131:788–796. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
McClung JP and Karl JP: Iron deficiency
and obesity: The contribution of inflammation and diminished iron
absorption. Nutr Rev. 67:100–104. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Tussing-Humphreys LM, Liang H, Nemeth E,
Freels S and Braunschweig CA: Excess adiposity, inflammation, and
iron-deficiency in female adolescents. J Am Diet Assoc.
109:297–302. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Nemeth E, Tuttle MS, Powelson J, Vaughn
MB, Donovan A, Ward D McVey, Ganz T and Kaplan J: Hepcidin
regulates cellular iron efflux by binding to ferroportin and
inducing its internalization. Science. 306:2090–2093. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Maachi M, Piéroni L, Bruckert E, Jardel C,
Fellahi S, Hainque B, Capeau J and Bastard JP: Systemic low-grade
inflammation is related to both circulating and adipose tissue
TNFalpha, leptin and IL-6 levels in obese women. Int J Obes Relat
Metab Disord. 28:993–997. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Kaplan J, Ward DM and De Domenico I:
Identification of the hepcidin binding site on ferroportin US
Patent 8530619 B2. October 26–2007, issued September 10, 2013.
|
|
28
|
Andrews M and Arredondo M: Hepatic and
adipocyte cells respond differentially to iron overload, hypoxic
and inflammatory challenge. Biometals. 25:749–759. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Tussing-Humphreys LM, Nemeth E, Fantuzzi
G, Freels S, Holterman AX, Galvani C, Ayloo S, Vitello J and
Braunschweig C: Decreased serum hepcidin and improved functional
iron status 6 months after restrictive bariatric surgery. Obesity
(Silver Spring). 18:2010–2016. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Aparicio T, Kotelevets L, Tsocas A,
Laigneau JP, Sobhani I, Chastre E and Lehy T: Leptin stimulates the
proliferation of human colon cancer cells in vitro but does not
promote the growth of colon cancer xenografts in nude mice or
intestinal tumorigenesis in ApcMin/+ mice. Gut. 54:1136–1145. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Aleksandrova K, Nimptsch K and Pischon T:
Obesity and colorectal cancer. Front Biosci (Elite Ed). 5:61–77.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Aleksandrova K, Boeing H, Jenab M,
Bueno-de-Mesquita HB, Jansen E, van Duijnhoven FJ, Rinaldi S,
Fedirko V, Romieu I, Riboli E, et al: Leptin and soluble leptin
receptor in risk of colorectal cancer in the European Prospective
Investigation into Cancer and Nutrition cohort. Cancer Res.
72:5328–5337. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Stattin P, Palmqvist R, Söderberg S,
Biessy C, Ardnor B, Hallmans G, Kaaks R and Olsson T: Plasma leptin
and colorectal cancer risk: A prospective study in Northern Sweden.
Oncol Rep. 10:2015–2021. 2003.PubMed/NCBI
|
|
34
|
Tamakoshi K, Toyoshima H, Wakai K, Kojima
M, Suzuki K, Watanabe Y, Hayakawa N, Yatsuya H, Kondo T, Tokudome
S, et al: Leptin is associated with an increased female colorectal
cancer risk: A nested case-control study in Japan. Oncology.
68:454–461. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Ueda T, Shimada E and Urakawa T: Serum
levels of cytokines in patients with colorectal cancer: Possible
involvement of interleukin-6 and interleukin-8 in hematogenous
metastasis. J Gastroenterol. 29:423–429. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Komoda H, Tanaka Y, Honda M, Matsuo Y,
Hazama K and Takao T: Interleukin-6 levels in colorectal cancer
tissues. World J Surg. 22:895–898. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Hsu CP, Chen YL, Huang CC, Chou CC, Liu
CL, Hung CH, Kao TY and Chung YC: Anti-interleukin-6 receptor
antibody inhibits the progression in human colon carcinoma cells.
Eur J Clin Invest. 41:277–284. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Kamai T, Tomosugi N, Abe H, Arai K and
Yoshida K: Increased serum hepcidin-25 level and increased tumor
expression of hepcidin mRNA are associated with metastasis of renal
cell carcinoma. BMC Cancer. 9:2702009. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Pinnix ZK, Miller LD, Wang W, D'Agostino R
Jr, Kute T, Willingham MC, Hatcher H, Tesfay L, Sui G, Di X, et al:
Ferroportin and iron regulation in breast cancer progression and
prognosis. Sci Transl Med. 2:43ra562010. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Le NTV and Richardson DR: The role of iron
in cell cycle progression and the proliferation of neoplastic
cells. Biochim Biophys Acta. 1603:31–46. 2002.PubMed/NCBI
|
