Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
January-2018 Volume 39 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2018 Volume 39 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Frankincense, pine needle and geranium essential oils suppress tumor progression through the regulation of the AMPK/mTOR pathway in breast cancer

  • Authors:
    • Peng Ren
    • Xiang Ren
    • Lei Cheng
    • Lixin Xu
  • View Affiliations / Copyright

    Affiliations: The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116044, P.R. China, College of Stomatology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China
    Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 129-137
    |
    Published online on: November 1, 2017
       https://doi.org/10.3892/or.2017.6067
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

BC (BC), as the most common malignancy in women worldwide, is associated with high morbidity and mortality. However, chemoresistance and toxicity are the main causes that limit the success of treatment in aggressive BC cases. Thus, there is a vital need to identify and develop novel therapeutic agents. Frankincense, pine needle and geranium essential oils have been reported to play critical biological activities in cancer. However, to the best of our knowledge whether frankincense, pine needle and geranium essential oils have any effect on the progression of BC in MCF-7 cells remains unclear. In the present study, we assessed the possible effects of frankincense, pine needle and geranium essential oils on cell viability, proliferation, migration and invasion as well as the possible mechanisms. MCF-7 cells were treated with oils, and associations with BC were investigated. In the present study, we clearly revealed that frankincense, pine needle and geranium essential oils suppressed cell viability, proliferation, migration and invasion in human BC MCF-7 cells. Further data demonstrated that frankincense, pine needle and geranium essential oils induced apoptosis, but did not affect cell cycle progression. Consistent with the in vitro activities, frankincense essential oil was effective in inhibiting tumor growth and inducing tumor cell apoptosis in a human BC mouse model. In addition, these 3 essential oils modulated the activity of the AMPK/mTOR signaling pathway. In conclusion, the present study indicated that frankincense, pine needle and geranium essential oils were involved in the progression of BC cells possibly through the AMPK/mTOR pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Rahimi Z, Yari K and Rahimi Z: Matrix metalloproteinase-9 −1562T allele and its combination with MMP-2 −735 C allele are risk factors for BC. Asian Pac J Cancer Prev. 16:1175–1179. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Fox P, Balleine RL, Lee C, Gao B, Balakrishnar B, Menzies AM, Yeap SH, Ali SS, Gebski V, Provan P, et al: Dose escalation of tamoxifen in patients with low endoxifen level: Evidence for therapeutic drug monitoring - The TADE study. Clin Cancer Res. 22:3164–3171. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Sabol M, Trnski D, Uzarevic Z, Ozretic P, Musani V, Rafaj M, Cindric M and Levanat S: Combination of cyclopamine and tamoxifen promotes survival and migration of mcf-7 BC cells - interaction of hedgehog-gli and estrogen receptor signaling pathways. PLoS One. 9:e1145102014. View Article : Google Scholar : PubMed/NCBI

4 

Poeckel D and Werz O: Boswellic acids: Biological actions and molecular targets. Curr Med Chem. 13:3359–3369. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Ammon HP: Boswellic acids in chronic inflammatory diseases. Planta Med. 72:1100–1116. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Syrovets T, Büchele B, Krauss C, Laumonnier Y and Simmet T: Acetyl-boswellic acids inhibit lipopolysaccharide-mediated TNF-alpha induction in monocytes by direct interaction with IkappaB kinases. J Immunol. 174:498–506. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Büchele B and Simmet T: Analysis of 12 different pentacyclic triterpenic acids from frankincense in human plasma by high-performance liquid chromatography and photodiode array detection. J Chromatogr B Analyt Technol Biomed Life Sci. 795:355–362. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Siemoneit U, Pergola C, Jazzar B, Northoff H, Skarke C, Jauch J and Werz O: On the interference of boswellic acids with 5-lipoxygenase: Mechanistic studies in vitro and pharmacological relevance. Eur J Pharmacol. 606:246–254. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Burdine L and Kodadek T: Target identification in chemical genetics: The (often) missing link. Chem Biol. 11:593–597. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Kwak CS, Moon SC and Lee MS: Antioxidant, antimutagenic, and antitumor effects of pine needles (Pinus densiflora). Nutr Cancer. 56:162–171. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Jeong JB, Seo EW and Jeong HJ: Effect of extracts from pine needle against oxidative DNA damage and apoptosis induced by hydroxyl radical via antioxidant activity. Food Chem Toxicol. 47:2135–2141. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Lis-Balchin M and Deans SG: Antimicrobial effects of hydrophilic extracts of Pelargonium species (Geraniaceae). Lett Appl Microbiol. 23:205–207. 1996. View Article : Google Scholar : PubMed/NCBI

13 

Ben Slima A, Ali MB, Barkallah M, Traore AI, Boudawara T, Allouche N and Gdoura R: Antioxidant properties of Pelargonium graveolens L'Her essential oil on the reproductive damage induced by deltamethrin in mice as compared to alpha-tocopherol. Lipids Health Dis. 12:302013. View Article : Google Scholar : PubMed/NCBI

14 

Boukhatem MN, Kameli A, Ferhat MA, Saidi F and Mekarnia M: Rose geranium essential oil as a source of new and safe anti-inflammatory drugs. Libyan J Med. 8:225202013. View Article : Google Scholar : PubMed/NCBI

15 

Shim JU, Oh PS and Lim KT: Anti-inflammatory activity of ethanol extract from Geranium sibiricum Linne. J Ethnopharmacol. 126:90–95. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Singla AK, Bondareva A and Jirik FR: Combined treatment with paclitaxel and suramin prevents the development of metastasis by inhibiting metastatic colonization of circulating tumor cells. Clin Exp Metastasis. 31:705–714. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Ni X, Suhail MM, Yang Q, Cao A, Fung KM, Postier RG, Woolley C, Young G, Zhang J and Lin HK: Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resins induces human pancreatic cancer cell death in cultures and in a xenograft murine model. BMC Complement Altern Med. 12:2532012. View Article : Google Scholar : PubMed/NCBI

18 

Satoh MS and Lindahl T: Role of poly(ADP-ribose) formation in DNA repair. Nature. 356:356–358. 1992. View Article : Google Scholar : PubMed/NCBI

19 

Kim EJ, Choi YK, Han YH, Kim HJ, Lee IK and Lee MO: RORα suppresses proliferation of vascular smooth muscle cells through activation of AMP-activated protein kinase. Int J Cardiol. 175:515–521. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Laplante M and Sabatini DM: mTOR signaling in growth control and disease. Cell. 149:274–293. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Wu M, Li T, Chen L, Peng S, Liao W, Bai R, Zhao X, Yang H, Wu C, Zeng H, et al: Essential oils from Inula japonica and Angelicae dahuricae enhance sensitivity of MCF-7/ADR BC cells to doxorubicin via multiple mechanisms. J Ethnopharmacol. 180:18–27. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Kumar D, Sukapaka M, Babu GD and Padwad Y: Chemical composition and in vitro cytotoxicity of essential oils from leaves and flowers of Callistemon citrinus from western Himalayas. PLoS One. 10:e01338232015. View Article : Google Scholar : PubMed/NCBI

23 

Wilson AJ, Saskowski J, Barham W, Khabele D and Yull F: Microenvironmental effects limit efficacy of thymoquinone treatment in a mouse model of ovarian cancer. Mol Cancer. 14:1922015. View Article : Google Scholar : PubMed/NCBI

24 

Parbin S, Shilpi A, Kar S, Pradhan N, Sengupta D, Deb M, Rath SK and Patra SK: Insights into the molecular interactions of thymoquinone with histone deacetylase: Evaluation of the therapeutic intervention potential against BC. Mol Biosyst. 12:48–58. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Ke X, Zhao Y, Lu X, Wang Z, Liu Y, Ren M, Lu G, Zhang D, Sun Z, Xu Z, et al: TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling. Oncotarget. 6:32610–32621. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Park YS, Lee JH, Bondar J, Harwalkar JA, Safayhi H and Golubic M: Cytotoxic action of acetyl-11-keto-beta-boswellic acid (AKBA) on meningioma cells. Planta Med. 68:397–401. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Shao Y, Ho CT, Chin CK, Badmaev V, Ma W and Huang MT: Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture. Planta Med. 64:328–331. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Liu JJ, Nilsson A, Oredsson S, Badmaev V and Duan RD: Keto- and acetyl-keto-boswellic acids inhibit proliferation and induce apoptosis in Hep G2 cells via a caspase-8 dependent pathway. Int J Mol Med. 10:501–505. 2002.PubMed/NCBI

29 

Zhao W, Entschladen F, Liu H, Niggemann B, Fang Q, Zaenker KS and Han R: Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells. Cancer Detect Prev. 27:67–75. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Liu JJ, Nilsson A, Oredsson S, Badmaev V, Zhao WZ and Duan RD: Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis. 23:2087–2093. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Pang X, Yi Z, Zhang X, Sung B, Qu W, Lian X, Aggarwal BB and Liu M: Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. Cancer Res. 69:5893–5900. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Lu M, Xia L, Hua H and Jing Y: Acetyl-keto-beta-boswellic acid induces apoptosis through a death receptor 5-mediated pathway in prostate cancer cells. Cancer Res. 68:1180–1186. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Syrovets T, Gschwend JE, Büchele B, Laumonnier Y, Zugmaier W, Genze F and Simmet T: Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo. J Biol Chem. 280:6170–6180. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Frank MB, Yang Q, Osban J, Azzarello JT, Saban MR, Saban R, Ashley RA, Welter JC, Fung KM and Lin HK: Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity. BMC Complement Altern Med. 9:62009. View Article : Google Scholar : PubMed/NCBI

35 

Suhail MM, Wu W, Cao A, Mondalek FG, Fung KM, Shih PT, Fang YT, Woolley C, Young G and Lin HK: Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human BC cells. BMC Complement Altern Med. 11:1292011. View Article : Google Scholar : PubMed/NCBI

36 

Jin HO, Hong SE, Woo SH, Lee JH, Choe TB, Kim EK, Noh WC, Lee JK, Hong SI, Kim JI, et al: Silencing of Twist1 sensitizes NSCLC cells to cisplatin via AMPK-activated mTOR inhibition. Cell Death Dis. 3:e3192012. View Article : Google Scholar : PubMed/NCBI

37 

Inoki K, Corradetti MN and Guan KL: Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet. 37:19–24. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Pezze P Dalle, Ruf S, Sonntag AG, Langelaar-Makkinje M, Hall P, Heberle AM, Navas P Razquin, van Eunen K, Tölle RC, Schwarz JJ, et al: A systems study reveals concurrent activation of AMPK and mTOR by amino acids. Nat Commun. 7:132542016. View Article : Google Scholar : PubMed/NCBI

39 

Polak P and Hall MN: mTOR and the control of whole body metabolism. Curr Opin Cell Biol. 21:209–218. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Henry WS, Laszewski T, Tsang T, Beca F, Beck AH, McAllister SS and Toker A: Aspirin suppresses growth in PI3K-mutant BC by activating AMPK and inhibiting mTORC1 signaling. Cancer Res. 77:790–801. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Lipovka Y, Chen H, Vagner J, Price TJ, Tsao TS and Konhilas JP: Oestrogen receptors interact with the α-catalytic subunit of AMP-activated protein kinase. Biosci Rep. 35:e002642015. View Article : Google Scholar : PubMed/NCBI

42 

Liu P, Ye F and Xie X, Li X, Tang H, Li S, Huang X, Song C, Wei W and Xie X: mir-101-3p is a key regulator of tumor metabolism in triple negative BC targeting AMPK. Oncotarget. 7:35188–35198. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ren P, Ren X, Cheng L and Xu L: Frankincense, pine needle and geranium essential oils suppress tumor progression through the regulation of the AMPK/mTOR pathway in breast cancer. Oncol Rep 39: 129-137, 2018.
APA
Ren, P., Ren, X., Cheng, L., & Xu, L. (2018). Frankincense, pine needle and geranium essential oils suppress tumor progression through the regulation of the AMPK/mTOR pathway in breast cancer. Oncology Reports, 39, 129-137. https://doi.org/10.3892/or.2017.6067
MLA
Ren, P., Ren, X., Cheng, L., Xu, L."Frankincense, pine needle and geranium essential oils suppress tumor progression through the regulation of the AMPK/mTOR pathway in breast cancer". Oncology Reports 39.1 (2018): 129-137.
Chicago
Ren, P., Ren, X., Cheng, L., Xu, L."Frankincense, pine needle and geranium essential oils suppress tumor progression through the regulation of the AMPK/mTOR pathway in breast cancer". Oncology Reports 39, no. 1 (2018): 129-137. https://doi.org/10.3892/or.2017.6067
Copy and paste a formatted citation
x
Spandidos Publications style
Ren P, Ren X, Cheng L and Xu L: Frankincense, pine needle and geranium essential oils suppress tumor progression through the regulation of the AMPK/mTOR pathway in breast cancer. Oncol Rep 39: 129-137, 2018.
APA
Ren, P., Ren, X., Cheng, L., & Xu, L. (2018). Frankincense, pine needle and geranium essential oils suppress tumor progression through the regulation of the AMPK/mTOR pathway in breast cancer. Oncology Reports, 39, 129-137. https://doi.org/10.3892/or.2017.6067
MLA
Ren, P., Ren, X., Cheng, L., Xu, L."Frankincense, pine needle and geranium essential oils suppress tumor progression through the regulation of the AMPK/mTOR pathway in breast cancer". Oncology Reports 39.1 (2018): 129-137.
Chicago
Ren, P., Ren, X., Cheng, L., Xu, L."Frankincense, pine needle and geranium essential oils suppress tumor progression through the regulation of the AMPK/mTOR pathway in breast cancer". Oncology Reports 39, no. 1 (2018): 129-137. https://doi.org/10.3892/or.2017.6067
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team