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Article

Complementary actions of melatonin on angiogenic factors, the angiopoietin/Tie2 axis and VEGF, in co‑cultures of human endothelial and breast cancer cells

  • Authors:
    • Alicia González-González
    • Alicia González
    • Carolina Alonso-González
    • Javier Menéndez-Menéndez
    • Carlos Martínez-Campa
    • Samuel Cos
  • View Affiliations / Copyright

    Affiliations: Department of Physiology and Pharmacology, School of Medicine, University of Cantabria and Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 39011 Santander, Spain
  • Pages: 433-441
    |
    Published online on: November 2, 2017
       https://doi.org/10.3892/or.2017.6070
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Abstract

Melatonin exerts oncostatic activity in breast cancer through antiangiogenic actions. There, the aim of the present study was to ascertain whether melatonin modulates, in a coordinated action, angiopoietin-1 (ANG-1), ANG-2, their cognate Tie2 receptor and VEGF in co-cultures of human endothelial cells (HUVECs) and breast cancer (MCF-7) cells. To accomplish this we used co-cultures of human breast cancer cells (MCF-7) or non-malignant human mammary epithelial cells (MCF‑10A) with endothelial cells (HUVECs). The presence of breast cancer cells increased HUVEC proliferation and 1 mM melatonin prevented this effect. ANG-1, ANG-2 and VEGF levels in co-culture media and mRNA expression were upregulated and Tie2 mRNA expression was downregulated in the HUVECs and MCF-7. Melatonin (1 mM) downregulated ANG-1, ANG-2 and VEGF levels in the co-culture media and mRNA expression in both types of cells and upregulated Tie2 mRNA expression in HUVECs. ANG-1, ANG-2, Tie2 and VEGF mRNA expression were not modified during HUVEC/MCF-10A co-culture. Estradiol (10 nM) increased ANG-1, ANG-2 and VEGF mRNA expression in HUVECs and melatonin (1 mM) counteracted this effect. We conclude that melatonin simultaneously coordinates downregulation of angiopoietins with a reduction in VEGF, which could be an effective therapeutic strategy for blocking tumor angiogenesis.
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1 

Bergers G and Benjamin LE: Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 3:401–410. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Bareschino MA, Schettino C, Colantuoni G, Rossi E, Rossi A, Maione P, Ciardiello F and Gridelli C: The role of antiangiogenetic agents in the treatment of breast cancer. Curr Med Chem. 18:5022–5032. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Cook KM and Figg WD: Angiogenesis inhibitors: Current strategies and future prospects. CA Cancer J Clin. 60:222–243. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Danza K, Pilato B, Lacalamita R, Addati T, Giotta F, Bruno A, Paradiso A and Tommasi S: Angiogenetic axis angiopoietins/Tie2 and VEGF in familial breast cancer. Eur J Hum Genet. 21:824–830. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Senger DR, Van de Water L, Brown LF, Nagy JA, Yeo KT, Yeo TK, Berse B, Jackman RW, Dvorak AM and Dvorak HF: Vascular permeability factor (VPF, VEGF) in tumor biology. Cancer Metastasis Rev. 12:303–324. 1993. View Article : Google Scholar : PubMed/NCBI

6 

Gu Q, Wang D, Wang X, Peng R, Liu J, Jiang T, Wang Z, Wang S and Deng H: Basic fibroblast growth factor inhibits radiation-induced apoptosis of HUVECs. I. The PI3K/AKT pathway and induction of phosphorylation of BAD. Radiat Res. 161:692–702. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Gingis-Velitski S, Zetser A, Flugelman MY, Vlodavsky I and Ilan N: Heparanase induces endothelial cell migration via protein kinase B/Akt activation. J Biol Chem. 279:23536–23541. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V and Ferrara N: Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem. 273:30336–30343. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Fagiani E and Christofori G: Angiopoietins in angiogenesis. Cancer Lett. 328:18–26. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Cao Y, Sonveaux P, Liu S, Zhao Y, Mi J, Clary BM, Li CY, Kontos CD and Dewhirst MW: Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth. Cancer Res. 67:3835–3844. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Thomas M and Augustin HG: The role of the Angiopoietins in vascular morphogenesis. Angiogenesis. 12:125–137. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Tait CR and Jones PF: Angiopoietins in tumours: The angiogenic switch. J Pathol. 204:1–10. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Thurston G and Daly C: The complex role of angiopoietin-2 in the angiopoietin-tie signaling pathway. Cold Spring Harb Perspect Med. 2:a0065502012. View Article : Google Scholar : PubMed/NCBI

14 

Bhadada SV, Goyal BR and Patel MM: Angiogenic targets for potential disorders. Fundam Clin Pharmacol. 25:29–47. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Hill SM and Blask DE: Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. Cancer Res. 48:6121–6126. 1988.PubMed/NCBI

16 

Cos S and Sánchez-Barceló EJ: Melatonin and mammary pathological growth. Front Neuroendocrinol. 21:133–170. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Blask DE, Sauer LA and Dauchy RT: Melatonin as a chronobiotic/anticancer agent: Cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapy. Curr Top Med Chem. 2:113–132. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Reiter RJ: The pineal and its hormones in the control of reproduction in mammals. Endocr Rev. 1:109–131. 1980. View Article : Google Scholar : PubMed/NCBI

19 

Molis TM, Spriggs LL and Hill SM: Modulation of estrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells. Mol Endocrinol. 8:1681–1690. 1994. View Article : Google Scholar : PubMed/NCBI

20 

Cos S, Blask DE, Lemus-Wilson A and Hill AB: Effects of melatonin on the cell cycle kinetics and ‘estrogen-rescue’ of MCF-7 human breast cancer cells in culture. J Pineal Res. 10:36–42. 1991. View Article : Google Scholar : PubMed/NCBI

21 

Allegra M, Reiter RJ, Tan DX, Gentile C, Tesoriere L and Livrea MA: The chemistry of melatonin's interaction with reactive species. J Pineal Res. 34:1–10. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Fraschini F, Demartini G, Esposti D and Scaglione F: Melatonin involvement in immunity and cancer. Biol Signals Recept. 7:61–72. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Leon-Blanco MM, Guerrero JM, Reiter RJ, Calvo JR and Pozo D: Melatonin inhibits telomerase activity in the MCF-7 tumor cell line both in vivo and in vitro. J Pineal Res. 35:204–211. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Martínez-Campa CM, Alonso-González C, Mediavilla MD, Cos S, González A and Sanchez-Barcelo EJ: Melatonin down-regulates hTERT expression induced by either natural estrogens (17beta-estradiol) or metalloestrogens (cadmium) in MCF-7 human breast cancer cells. Cancer Lett. 268:272–277. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Blask DE, Dauchy RT, Sauer LA, Krause JA and Brainard GC: Growth and fatty acid metabolism of human breast cancer (MCF-7) xenografts in nude rats: Impact of constant light-induced nocturnal melatonin suppression. Breast Cancer Res Treat. 79:313–320. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Blask DE, Dauchy RT and Sauer LA: Putting cancer to sleep at night: The neuroendocrine/circadian melatonin signal. Endocrine. 27:179–188. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Alvarez-García V, González A, Martínez-Campa C, Alonso-González C and Cos S: Melatonin modulates aromatase activity and expression in endothelial cells. Oncol Rep. 29:2058–2064. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Alvarez-García V, González A, Alonso-González C, Martínez-Campa C and Cos S: Regulation of vascular endothelial growth factor by melatonin in human breast cancer cells. J Pineal Res. 54:373–380. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Alvarez-García V, González A, Alonso-González C, Martínez- Campa C and Cos S: Antiangiogenic effects of melatonin in endothelial cell cultures. Microvasc Res. 87:25–33. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Cos S, Alvarez-García V, González A, Alonso-González C and Martínez-Campa C: Melatonin modulation of crosstalk among malignant epithelial, endothelial and adipose cells in breast cancer (Review). Oncol Lett. 8:487–492. 2014.PubMed/NCBI

31 

Kajdaniuk D, Marek B, Kos-Kudła B, Zwirska-Korczala K, Ostrowska Z, Buntner B and Szymszal J: Does the negative correlation found in breast cancer patients between plasma melatonin and insulin-like growth factor-I concentrations imply the existence of an additional mechanism of oncostatic melatonin influence involved in defense? Med Sci Monit. 8:CR457–CR461. 2002.PubMed/NCBI

32 

Fandrey J and Genius J: Reactive oxygen species as regulators of oxygen dependent gene expression. Adv Exp Med Biol. 475:153–159. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Lobov IB, Brooks PC and Lang RA: Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo. Proc Natl Acad Sci USA. 99:pp. 11205–11210. 2002; View Article : Google Scholar : PubMed/NCBI

34 

Mosmann T: Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods. 65:55–63. 1983. View Article : Google Scholar : PubMed/NCBI

35 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Liang Y and Hyder SM: Proliferation of endothelial and tumor epithelial cells by progestin-induced vascular endothelial growth factor from human breast cancer cells: Paracrine and autocrine effects. Endocrinology. 146:3632–3641. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Holash J, Wiegand SJ and Yancopoulos GD: New model of tumor angiogenesis: Dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene. 18:5356–5362. 1999. View Article : Google Scholar : PubMed/NCBI

38 

Currie MJ, Gunningham SP, Han C, Scott PA, Robinson BA, Harris AL and Fox SB: Angiopoietin-1 is inversely related to thymidine phosphorylase expression in human breast cancer, indicating a role in vascular remodeling. Clin Cancer Res. 7:918–927. 2001.PubMed/NCBI

39 

Sánchez-Barceló EJ, Cos S, Fernández R and Mediavilla MD: Melatonin and mammary cancer: A short review. Endocr Relat Cancer. 10:153–159. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Cos S, González A, Martínez-Campa C, Mediavilla MD, Alonso-González C and Sánchez-Barceló EJ: Estrogen-signaling pathway: A link between breast cancer and melatonin oncostatic actions. Cancer Detect Prev. 30:118–128. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Cos S, González A, Martínez-Campa C, Mediavilla MD, Alonso-González C and Sánchez-Barceló EJ: Melatonin as a selective estrogen enzyme modulator. Curr Cancer Drug Targets. 8:691–702. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Lissoni P, Rovelli F, Malugani F, Bucovec R, Conti A and Maestroni GJ: Anti-angiogenic activity of melatonin in advanced cancer patients. Neuro Endocrinol Lett. 22:45–47. 2001.PubMed/NCBI

43 

Cui P, Luo Z, Zhang H, Su Y, Li A, Li H, Zhang J, Yang Z and Xiu R: Effect and mechanism of melatonin's action on the proliferation of human umbilical vein endothelial cells. J Pineal Res. 41:358–362. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Dai M, Cui P, Yu M, Han J, Li H and Xiu R: Melatonin modulates the expression of VEGF and HIF-1α induced by CoCl2 in cultured cancer cells. J Pineal Res. 44:121–126. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Cos S, Martínez-Campa C, Mediavilla MD and Sánchez-Barceló EJ: Melatonin modulates aromatase activity in MCF-7 human breast cancer cells. J Pineal Res. 38:136–142. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Alvarez-García V, González A, Alonso-González C, Martínez- Campa C and Cos S: Melatonin interferes in the desmoplastic reaction in breast cancer by regulating cytokine production. J Pineal Res. 52:282–290. 2012. View Article : Google Scholar : PubMed/NCBI

47 

González A, Alvarez-García V, Martínez-Campa C, Alonso-González C and Cos S: Melatonin promotes differentiation of 3T3-L1 fibroblasts. J Pineal Res. 52:12–20. 2012. View Article : Google Scholar : PubMed/NCBI

48 

Cui P, Yu M, Luo Z, Dai M, Han J, Xiu R and Yang Z: Intracellular signaling pathways involved in cell growth inhibition of human umbilical vein endothelial cells by melatonin. J Pineal Res. 44:107–114. 2008.PubMed/NCBI

49 

García-Santos G, Antolín I, Herrera F, Martín V, Rodríguez-Blanco J, del Pilar Carrera M and Rodríguez C: Melatonin induces apoptosis in human neuroblastoma cancer cells. J Pineal Res. 41:130–135. 2006. View Article : Google Scholar : PubMed/NCBI

50 

Sainz RM, Mayo JC, Tan DX, León J, Manchester L and Reiter RJ: Melatonin reduces prostate cancer cell growth leading to neuroendocrine differentiation via a receptor and PKA independent mechanism. Prostate. 63:29–43. 2005. View Article : Google Scholar : PubMed/NCBI

51 

Longatti P, Perin A, Rizzo V, Comai S, Giusti P and Costa CV: Ventricular cerebrospinal fluid melatonin concentrations investigated with an endoscopic technique. J Pineal Res. 42:113–118. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Maestroni GJ and Conti A: Melatonin in human breast cancer tissue: Association with nuclear grade and estrogen receptor status. Lab Invest. 75:557–561. 1996.PubMed/NCBI

53 

Hashimoto T, Wu Y, Boudreau N, Li J, Matsumoto M and Young W: Regulation of tie2 expression by angiopoietin - potential feedback system. Endothelium. 11:207–210. 2004. View Article : Google Scholar : PubMed/NCBI

54 

Ye F, Florian M, Magder SA and Hussain SN: Regulation of angiopoietin and Tie-2 receptor expression in non-reproductive tissues by estrogen. Steroids. 67:305–310. 2002. View Article : Google Scholar : PubMed/NCBI

55 

Harfouche R, Echavarria R, Rabbani SA, Arakelian A, Hussein MA and Hussain SN: Estradiol-dependent regulation of angiopoietin expression in breast cancer cells. J Steroid Biochem Mol Biol. 123:17–24. 2011. View Article : Google Scholar : PubMed/NCBI

56 

Holopainen T, Saharinen P, D'Amico G, Lampinen A, Eklund L, Sormunen R, Anisimov A, Zarkada G, Lohela M, Heloterä H, et al: Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis. J Natl Cancer Inst. 104:461–475. 2012. View Article : Google Scholar : PubMed/NCBI

57 

Brown JL, Cao ZA, Pinzon-Ortiz M, Kendrew J, Reimer C, Wen S, Zhou JQ, Tabrizi M, Emery S, McDermott B, et al: A human monoclonal anti-ANG2 antibody leads to broad antitumor activity in combination with VEGF inhibitors and chemotherapy agents in preclinical models. Mol Cancer Ther. 9:145–156. 2010. View Article : Google Scholar : PubMed/NCBI

58 

Hashizume H, Falcón BL, Kuroda T, Baluk P, Coxon A, Yu D, Bready JV, Oliner JD and McDonald DM: Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth. Cancer Res. 70:2213–2223. 2010. View Article : Google Scholar : PubMed/NCBI

59 

Leow CC, Coffman K, Inigo I, Breen S, Czapiga M, Soukharev S, Gingles N, Peterson N, Fazenbaker C, Woods R, et al: MEDI3617, a human anti-Angiopoietin 2 monoclonal antibody, inhibits angiogenesis and tumor growth in human tumor xenograft models. Int J Oncol. 40:1321–1330. 2012.PubMed/NCBI

60 

Mazzieri R, Pucci F, Moi D, Zonari E, Ranghetti A, Berti A, Politi LS, Gentner B, Brown JL, Naldini L, et al: Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. Cancer Cell. 19:512–526. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
González-González A, González A, Alonso-González C, Menéndez-Menéndez J, Martínez-Campa C and Cos S: Complementary actions of melatonin on angiogenic factors, the angiopoietin/Tie2 axis and VEGF, in co‑cultures of human endothelial and breast cancer cells. Oncol Rep 39: 433-441, 2018.
APA
González-González, A., González, A., Alonso-González, C., Menéndez-Menéndez, J., Martínez-Campa, C., & Cos, S. (2018). Complementary actions of melatonin on angiogenic factors, the angiopoietin/Tie2 axis and VEGF, in co‑cultures of human endothelial and breast cancer cells. Oncology Reports, 39, 433-441. https://doi.org/10.3892/or.2017.6070
MLA
González-González, A., González, A., Alonso-González, C., Menéndez-Menéndez, J., Martínez-Campa, C., Cos, S."Complementary actions of melatonin on angiogenic factors, the angiopoietin/Tie2 axis and VEGF, in co‑cultures of human endothelial and breast cancer cells". Oncology Reports 39.1 (2018): 433-441.
Chicago
González-González, A., González, A., Alonso-González, C., Menéndez-Menéndez, J., Martínez-Campa, C., Cos, S."Complementary actions of melatonin on angiogenic factors, the angiopoietin/Tie2 axis and VEGF, in co‑cultures of human endothelial and breast cancer cells". Oncology Reports 39, no. 1 (2018): 433-441. https://doi.org/10.3892/or.2017.6070
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Spandidos Publications style
González-González A, González A, Alonso-González C, Menéndez-Menéndez J, Martínez-Campa C and Cos S: Complementary actions of melatonin on angiogenic factors, the angiopoietin/Tie2 axis and VEGF, in co‑cultures of human endothelial and breast cancer cells. Oncol Rep 39: 433-441, 2018.
APA
González-González, A., González, A., Alonso-González, C., Menéndez-Menéndez, J., Martínez-Campa, C., & Cos, S. (2018). Complementary actions of melatonin on angiogenic factors, the angiopoietin/Tie2 axis and VEGF, in co‑cultures of human endothelial and breast cancer cells. Oncology Reports, 39, 433-441. https://doi.org/10.3892/or.2017.6070
MLA
González-González, A., González, A., Alonso-González, C., Menéndez-Menéndez, J., Martínez-Campa, C., Cos, S."Complementary actions of melatonin on angiogenic factors, the angiopoietin/Tie2 axis and VEGF, in co‑cultures of human endothelial and breast cancer cells". Oncology Reports 39.1 (2018): 433-441.
Chicago
González-González, A., González, A., Alonso-González, C., Menéndez-Menéndez, J., Martínez-Campa, C., Cos, S."Complementary actions of melatonin on angiogenic factors, the angiopoietin/Tie2 axis and VEGF, in co‑cultures of human endothelial and breast cancer cells". Oncology Reports 39, no. 1 (2018): 433-441. https://doi.org/10.3892/or.2017.6070
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