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Article

Influence of miR-7a and miR-24-3p on the SOX18 transcript in lung adenocarcinoma

  • Authors:
    • Mateusz Olbromski
    • Adam Rzechonek
    • Jedrzej Grzegrzolka
    • Natalia Glatzel-Plucinska
    • Angelika Chachaj
    • Bozena Werynska
    • Marzenna Podhorska-Okolow
    • Piotr Dziegiel
  • View Affiliations / Copyright

    Affiliations: Department of Histology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland, Department of Thoracic Surgery, Wroclaw Medical University, 50-368 Wroclaw, Poland, Department of Clinic of Internal and Occupational Diseases and Hypertension, Wroclaw Medical University, 50-368 Wroclaw, Poland, Department of Pulmonology and Pulmonary Tumors, Wroclaw Medical University, 50-368 Wroclaw, Poland
  • Pages: 201-208
    |
    Published online on: November 6, 2017
       https://doi.org/10.3892/or.2017.6077
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Abstract

The molecular pathogenesis of the development of non-small cell lung carcinomas (NSCLCs) is extremely complex. Understanding the molecular basis of the development of this malignant tumor may enable the use of targeted therapy, which may result in a better treatment outome for these patients. Adenocarcinoma (AC) is the most common NSCLC subtype, equally common among smokers and non-smokers, and its pathogenesis remains unknown. The SOX18 protein is an important protein that plays a role in the development of blood and lymphatic vessels during the process of embryogenesis. Recent studies have also shown that the SOX18 protein may play a significant role in tumors, including lung cancers. In the present study, we analyzed the expression of the SOX18 protein and the mRNA level in postoperative samples of AC and non-malignant lung tissues (NMLTs), and a disparity in both levels was observed. Based on our previous observations that miR-7a and miR-24-3p are able to modulate SOX18 expression in NSCLC, the main aim of this study was to verify the miRNA modulation of the SOX18 transcript with the use of the MirTrap System in established lung cancer cell lines NCI-H1703, NCI-H522 and A549. The SOX18 mRNA expression level was significantly lower in AC than that noted in the NMLTs (P<0.0001). However, the protein levels were higher in AC cases compared to levels noted in the NMLTs (P<0.0001). Additionally, correlations between the RQ values of SOX18 in NMLT and AC cases (r=0.8195, P=0.0001), and between miR-7a and miR24-3p in AC cases (r=0.4344, P=0.0016), were noted. In conclusion, we confirmed that miR-7a and miR-24-3p are more highly expressed in NMLTs than in the AC samples, and that they modulate the SOX18 transcript in NSCLC cells.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Jemal A, Saraiya M, Patel P, Cherala SS, Barnholtz-Sloan J, Kim J, Wiggins CL and Wingo PA: Recent trends in cutaneous melanoma incidence and death rates in the United States, 1992–2006. J Am Acad Dermatol. 65 Suppl 1:S17–S25.e1-3. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Jemal A, Thun M, Yu XQ, Hartman AM, Cokkinides V, Center MM, Ross H and Ward EM: Changes in smoking prevalence among U.S. adults by state and region: Estimates from the Tobacco Use Supplement to the Current Population Survey, 1992–2007. BMC Public Health. 11:5122011. View Article : Google Scholar : PubMed/NCBI

5 

Yano M, Sasaki H, Moriyama S, Hikosaka Y, Yokota K, Kobayashi S, Hara M and Fujii Y: Post-operative acute exacerbation of pulmonary fibrosis in lung cancer patients undergoing lung resection. Interact Cardiovasc Thorac Surg. 14:146–150. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Yano M, Sasaki H, Moriyama S, Kawano O, Hikosaka Y and Fujii Y: Prognostic factors of pathologic stage IB non-small cell lung cancer. Ann Thorac Cardiovasc Surg. 17:58–62. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Yano T, Haro A, Shikada Y, Maruyama R and Maehara Y: Non-small cell lung cancer in never smokers as a representative ‘non-smoking-associated lung cancer’: Epidemiology and clinical features. Int J Clin Oncol. 16:287–293. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Brownson RC, Alavanja MC, Caporaso N, Simoes EJ and Chang JC: Epidemiology and prevention of lung cancer in nonsmokers. Epidemiol Rev. 20:218–236. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Kołodziej Ł, Boczar T, Bohatyrewicz A and Zietek P: Outcome of operative treatment for supination-external rotation Lauge-Hansen stage IV ankle fractures. Chir Narzadow Ruchu Ortop Pol. 75:231–235. 2010.(In Polish). PubMed/NCBI

10 

Kadara H, Kabbout M and Wistuba II: Pulmonary adenocarcinoma: A renewed entity in 2011. Respirology. 17:50–65. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Gubbay J, Collignon J, Koopman P, Capel B, Economou A, Münsterberg A, Vivian N, Goodfellow P and Lovell-Badge R: A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature. 346:245–250. 1990. View Article : Google Scholar : PubMed/NCBI

12 

Sakamoto Y, Hara K, Kanai-Azuma M, Matsui T, Miura Y, Tsunekawa N, Kurohmaru M, Saijoh Y, Koopman P and Kanai Y: Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos. Biochem Biophys Res Commun. 360:539–544. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Wegner M: From head to toes: The multiple facets of Sox proteins. Nucleic Acids Res. 27:1409–1420. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Bowles J, Schepers G and Koopman P: Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. Dev Biol. 227:239–255. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Chung MI, Ma AC, Fung TK and Leung AY: Characterization of Sry-related HMG box group F genes in zebrafish hematopoiesis. Exp Hematol. 39:986–998.e5. 2011. View Article : Google Scholar : PubMed/NCBI

16 

François M: Sox18 orchestrates the commitment of the lymphatic vessels. Med Sci (Paris). 25:127–129. 2009.(In French). View Article : Google Scholar : PubMed/NCBI

17 

François M, Caprini A, Hosking B, Orsenigo F, Wilhelm D, Browne C, Paavonen K, Karnezis T, Shayan R, Downes M, et al: Sox18 induces development of the lymphatic vasculature in mice. Nature. 456:643–647. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Francois M, Koopman P and Beltrame M: SoxF genes: Key players in the development of the cardio-vascular system. Int J Biochem Cell Biol. 42:445–448. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Milivojevic M, Petrovic I, Kovacevic-Grujicic N, Popovic J, Mojsin M and Stevanovic M: Construction and functional analysis of novel dominant-negative mutant of human SOX18 protein. Biochemistry (Mosc). 78:1287–1292. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Zhu Y, Li Y, Jun Wei JW and Liu X: The role of Sox genes in lung morphogenesis and cancer. Int J Mol Sci. 13:15767–15783. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Saitoh T and Katoh M: Expression of human SOX18 in normal tissues and tumors. Int J Mol Med. 10:339–344. 2002.PubMed/NCBI

22 

Eom BW, Jo MJ, Kook MC, Ryu KW, Choi IJ, Nam BH, Kim YW and Lee JH: The lymphangiogenic factor SOX 18: a key indicator to stage gastric tumor progression. Int J Cancer. 131:41–48. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Young N, Hahn CN, Poh A, Dong C, Wilhelm D, Olsson J, Muscat GE, Parsons P, Gamble JR and Koopman P: Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development. J Natl Cancer Inst. 98:1060–1067. 2006. View Article : Google Scholar : PubMed/NCBI

24 

DeSantis C, Siegel R, Bandi P and Jemal A: Breast cancer statistics, 2011. CA Cancer J Clin. 61:409–418. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Jethon A, Pula B, Olbromski M, Werynska B, Muszczynska-Bernhard B, Witkiewicz W, Dziegiel P and Podhorska-Okolow M: Prognostic significance of SOX18 expression in non-small cell lung cancer. Int J Oncol. 46:123–132. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Pula B, Kobierzycki C, Solinski D, Olbromski M, Nowak-Markwitz E, Spaczynski M, Kedzia W, Zabel M and Dziegiel P: SOX18 expression predicts response to platinum-based chemotherapy in ovarian cancer. Anticancer Res. 34:4029–4037. 2014.PubMed/NCBI

27 

Pula B, Olbromski M, Wojnar A, Gomulkiewicz A, Witkiewicz W, Ugorski M, Dziegiel P and Podhorska-Okolow M: Impact of SOX18 expression in cancer cells and vessels on the outcome of invasive ductal breast carcinoma. Cell Oncol (Dordr). 36:469–483. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Kasinski AL and Slack FJ: miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma. Cancer Res. 72:5576–5587. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Yin H, Sheng Z, Zhang X, Du Y, Qin C, Liu H, Dun Y, Wang Q, Jin C, Zhao Y, et al: Overexpression of SOX18 promotes prostate cancer progression via the regulation of TCF1, c-Myc, cyclin D1 and MMP-7. Oncol Rep. 37:1045–1051. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M, et al: MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 65:7065–7070. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Devaraj S and Natarajan J: miRNA-mRNA network detects hub mRNAs and cancer specific miRNAs in lung cancer. In Silico Biol. 11:281–295. 2011-2012.

32 

Ferracin M, Bassi C, Pedriali M, Pagotto S, D'Abundo L, Zagatti B, Corrà F, Musa G, Callegari E, Lupini L, et al: miR-125b targets erythropoietin and its receptor and their expression correlates with metastatic potential and ERBB2/HER2 expression. Mol Cancer. 12:1302013. View Article : Google Scholar : PubMed/NCBI

33 

Goswami S, Tarapore RS, Strong AM Poenitzsch, TeSlaa JJ, Grinblat Y, Setaluri V and Spiegelman VS: MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor (MITF) mRNA is inhibited by coding region determinant-binding protein (CRD-BP). J Biol Chem. 290:384–395. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Jiang C, Hu X, Alattar M and Zhao H: miRNA expression profiles associated with diagnosis and prognosis in lung cancer. Expert Rev Anticancer Ther. 14:453–461. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Mairinger FD, Ting S, Werner R, Walter RF, Hager T, Vollbrecht C, Christoph D, Worm K, Mairinger T, Sheu-Grabellus SY, et al: Different micro-RNA expression profiles distinguish subtypes of neuroendocrine tumors of the lung: results of a profiling study. Mod Pathol. 27:1632–1640. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Markou A, Sourvinou I, Vorkas PA, Yousef GM and Lianidou E: Clinical evaluation of microRNA expression profiling in non small cell lung cancer. Lung Cancer. 81:388–396. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Yoo JK, Jung HY, Lee JM, Yi H, Oh SH, Ko HY, Yoo H, Kim HR, Song H, Kim S, et al: The novel miR-9500 regulates the proliferation and migration of human lung cancer cells by targeting Akt1. Cell Death Differ. 21:1150–1159. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Lovell-Badge R: The early history of the Sox genes. Int J Biochem Cell Biol. 42:378–380. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Downes M, François M, Ferguson C, Parton RG and Koopman P: Vascular defects in a mouse model of hypotrichosis-lymphedema-telangiectasia syndrome indicate a role for SOX18 in blood vessel maturation. Hum Mol Genet. 18:2839–2850. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Luo M, Guo XT, Yang W, Liu LQ, Li LW and Xin XY: Inhibition of tumor angiogenesis by cell-permeable dominant negative SOX18 mutants. Med Hypotheses. 70:880–882. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Castillo SD and Sanchez-Cespedes M: The SOX family of genes in cancer development: Biological relevance and opportunities for therapy. Expert Opin Ther Targets. 16:903–919. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Olbromski M, Grzegrzolka J, Jankowska-Konsur A, Witkiewicz W, Podhorska-Okolow M and Dziegiel P: MicroRNAs modulate the expression of the SOX18 transcript in lung squamous cell carcinoma. Oncol Rep. 36:2884–2892. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Dammann R, Strunnikova M, Schagdarsurengin U, Rastetter M, Papritz M, Hattenhorst UE, Hofmann HS, Silber RE, Burdach S and Hansen G: CpG island methylation and expression of tumour-associated genes in lung carcinoma. Eur J Cancer. 41:1223–1236. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Azhikina T, Kozlova A, Skvortsov T and Sverdlov E: Heterogeneity and degree of TIMP4, GATA4, SOX18, and EGFL7 gene promoter methylation in non-small cell lung cancer and surrounding tissues. Cancer Genet. 204:492–500. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Alonso MM, Diez-Valle R, Manterola L, Rubio A, Liu D, Cortes-Santiago N, Urquiza L, Jauregi P, de Munain A Lopez, Sampron N, et al: Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas. PLoS One. 6:e267402011. View Article : Google Scholar : PubMed/NCBI

46 

Otsubo T, Akiyama Y, Yanagihara K and Yuasa Y: SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis. Br J Cancer. 98:824–831. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Lang Y, Xu S, Ma J, Wu J, Jin S, Cao S and Yu Y: MicroRNA-429 induces tumorigenesis of human non-small cell lung cancer cells and targets multiple tumor suppressor genes. Biochem Biophys Res Commun. 450:154–159. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Li J, Tan Q, Yan M, Liu L, Lin H, Zhao F, Bao G, Kong H, Ge C, Zhang F, et al: miRNA-200c inhibits invasion and metastasis of human non-small cell lung cancer by directly targeting ubiquitin specific peptidase 25. Mol Cancer. 13:1662014. View Article : Google Scholar : PubMed/NCBI

49 

Salim H, Akbar NS, Zong D, Vaculova AH, Lewensohn R, Moshfegh A, Viktorsson K and Zhivotovsky B: miRNA-214 modulates radiotherapy response of non-small cell lung cancer cells through regulation of p38MAPK, apoptosis and senescence. Br J Cancer. 107:1361–1373. 2012. View Article : Google Scholar : PubMed/NCBI

50 

Sun Q, Hang M, Guo X, Shao W and Zeng G: Expression and significance of miRNA-21 and BTG2 in lung cancer. Tumour Biol. 34:4017–26. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Xie C, Han Y, Liu Y, Han L and Liu J: miRNA-124 down-regulates SOX8 expression and suppresses cell proliferation in non-small cell lung cancer. Int J Clin Exp Pathol. 7:7518–7526. 2014.PubMed/NCBI

52 

Zhang C, Ge S, Hu C, Yang N and Zhang J: MiRNA-218, a new regulator of HMGB1, suppresses cell migration and invasion in non-small cell lung cancer. Acta Biochim Biophys Sin (Shanghai). 45:1055–1061. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Cermenati S, Moleri S, Cimbro S, Corti P, Del Giacco L, Amodeo R, Dejana E, Koopman P, Cotelli F and Beltrame M: Sox18 and Sox7 play redundant roles in vascular development. Blood. 111:2657–2666. 2008. View Article : Google Scholar : PubMed/NCBI

54 

Duong T, Koltowska K, Pichol-Thievend C, Le Guen L, Fontaine F, Smith KA, Truong V, Skoczylas R, Stacker SA, Achen MG, et al: VEGFD regulates blood vascular development by modulating SOX18 activity. Blood. 123:1102–1112. 2014. View Article : Google Scholar : PubMed/NCBI

55 

Duong T, Proulx ST, Luciani P, Leroux JC, Detmar M, Koopman P and Francois M: Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice. Cancer Res. 72:3105–3114. 2012. View Article : Google Scholar : PubMed/NCBI

56 

Fontaine F, Overman J, Moustaqil M, Mamidyala S, Salim A, Narasimhan K, Prokoph N, Robertson AA, Lua L, Alexandrov K, et al: Small-molecule inhibitors of the SOX18 transcription factor. Cell Chem Biol. 24:346–359. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Lv J and Xu L, Xu Y, Qiu M, Yang X, Wang J, Yin R and Xu L: Expression of MiRNA-221 in non-small cell lung cancer tissues and correlation with prognosis. Zhongguo Fei Ai Za Zhi. 17:221–225. 2014.(Abstract in English). PubMed/NCBI

58 

Brock M, Samillan VJ, Trenkmann M, Schwarzwald C, Ulrich S, Gay RE, Gassmann M, Ostergaard L, Gay S, Speich R, et al: AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension. Eur Heart J. 35:3203–3211. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Selvamani A, Sathyan P, Miranda RC and Sohrabji F: An antagomir to microRNA Let7f promotes neuroprotection in an ischemic stroke model. PLoS One. 7:e326622012. View Article : Google Scholar : PubMed/NCBI

60 

Song MS and Rossi JJ: The anti-miR21 antagomir, a therapeutic tool for colorectal cancer, has a potential synergistic effect by perturbing an angiogenesis-associated miR30. Front Genet. 4:3012014. View Article : Google Scholar : PubMed/NCBI

61 

Faghihi MA, Zhang M, Huang J, Modarresi F, Van der Brug MP, Nalls MA, Cookson MR, St-Laurent G III and Wahlestedt C: Evidence for natural antisense transcript-mediated inhibition of microRNA function. Genome Biol. 11:R562010. View Article : Google Scholar : PubMed/NCBI

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Olbromski M, Rzechonek A, Grzegrzolka J, Glatzel-Plucinska N, Chachaj A, Werynska B, Podhorska-Okolow M and Dziegiel P: Influence of miR-7a and miR-24-3p on the SOX18 transcript in lung adenocarcinoma. Oncol Rep 39: 201-208, 2018.
APA
Olbromski, M., Rzechonek, A., Grzegrzolka, J., Glatzel-Plucinska, N., Chachaj, A., Werynska, B. ... Dziegiel, P. (2018). Influence of miR-7a and miR-24-3p on the SOX18 transcript in lung adenocarcinoma. Oncology Reports, 39, 201-208. https://doi.org/10.3892/or.2017.6077
MLA
Olbromski, M., Rzechonek, A., Grzegrzolka, J., Glatzel-Plucinska, N., Chachaj, A., Werynska, B., Podhorska-Okolow, M., Dziegiel, P."Influence of miR-7a and miR-24-3p on the SOX18 transcript in lung adenocarcinoma". Oncology Reports 39.1 (2018): 201-208.
Chicago
Olbromski, M., Rzechonek, A., Grzegrzolka, J., Glatzel-Plucinska, N., Chachaj, A., Werynska, B., Podhorska-Okolow, M., Dziegiel, P."Influence of miR-7a and miR-24-3p on the SOX18 transcript in lung adenocarcinoma". Oncology Reports 39, no. 1 (2018): 201-208. https://doi.org/10.3892/or.2017.6077
Copy and paste a formatted citation
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Spandidos Publications style
Olbromski M, Rzechonek A, Grzegrzolka J, Glatzel-Plucinska N, Chachaj A, Werynska B, Podhorska-Okolow M and Dziegiel P: Influence of miR-7a and miR-24-3p on the SOX18 transcript in lung adenocarcinoma. Oncol Rep 39: 201-208, 2018.
APA
Olbromski, M., Rzechonek, A., Grzegrzolka, J., Glatzel-Plucinska, N., Chachaj, A., Werynska, B. ... Dziegiel, P. (2018). Influence of miR-7a and miR-24-3p on the SOX18 transcript in lung adenocarcinoma. Oncology Reports, 39, 201-208. https://doi.org/10.3892/or.2017.6077
MLA
Olbromski, M., Rzechonek, A., Grzegrzolka, J., Glatzel-Plucinska, N., Chachaj, A., Werynska, B., Podhorska-Okolow, M., Dziegiel, P."Influence of miR-7a and miR-24-3p on the SOX18 transcript in lung adenocarcinoma". Oncology Reports 39.1 (2018): 201-208.
Chicago
Olbromski, M., Rzechonek, A., Grzegrzolka, J., Glatzel-Plucinska, N., Chachaj, A., Werynska, B., Podhorska-Okolow, M., Dziegiel, P."Influence of miR-7a and miR-24-3p on the SOX18 transcript in lung adenocarcinoma". Oncology Reports 39, no. 1 (2018): 201-208. https://doi.org/10.3892/or.2017.6077
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